Let A and B be closed operators on Banach spaces X and Y. Assume that A and B have nonempty resolvent sets and that the spectra of A and B are unbounded. Let α be a uniform cross norm on X ⊗ Y. Using the Gelfand theory and resolvent algebra techniques, a spectral mapping theorem is proven for a certain class of rational functions of A and B. The class of admissable rational functions (including polynomials) depends on the spectra of A and B. The theory is applied to the cases A ⊗ I + I ⊗ B and A ⊗ B where A and B are the generators of bounded holomorphic semigroups.