Aim: This research work was done during the Indian festive season of 2020 to assess the attitude, mentality and psychological pattern of Indians. Also, the effect of yoga and meditation in combating the Covid-19 pandemic related stress was analyzed in the present research work. As Paracetamol and Diclofenac are OTC medications which are widely available without doctor’s prescription, the potential of self-medication for these drugs amidst the pandemic need to be studied, this study further attempted to analyze the rate and extent of self-medication of these drugs among Indians. Materials and Methods: An e-questionnaire survey bearing questions on pandemic-related mental stress, sleep duration, yoga, meditation practice, and extent of self-medication in combating the pandemic was floated to the residents of Bengaluru to collect their response. The collected data were analyzed using Statistical Package for the Social Sciences software version 17. Results: A mixed response regarding their stress, anxiety, and fear expressed on a higher scale was the same before or during Covid could be perceived. The sleep pattern before and during CoVid had no significant variation (p>0.05) and appeared the same. All the respondents agreed that they spend considerable time with electronic gadgets during the Covid lockdown period. Most of the respondents (60%) practice yoga and meditation occasionally or daily. The high rate of self-medication with Paracetamol and Diclofenac drugs among Indian people in the current pandemic situation shows they are OTC and readily available. The self-medication practice is of real concern as it may cause a long-term impact on the consumers.