ABSTRACT The estimation of total suspended matter (TSM) concentration is crucial in monitoring, evaluating, and protecting water quality. Many empirical and semi-analytical models have been established for clear or extremely turbid water bodies; however, only a few are applicable to inland, extremely turbulent deep rivers. Using in situ data from the water of the Manwan reservoir, we developed a robust algorithm to estimate the TSM concentration in the Manwan reservoir, with a root mean square error (RMSE) ≤ 4.43 mg L−1 and a mean absolute percentage error (MAPE) of 23.2%, indicating the feasibility of the empirical model for estimating TSM. The empirical model was then applied to 251 Small Satellite Constellation for Environment and Disaster Monitoring and Forecasting loaded with the Charge Coupled Device (HJ-CCD) images to derive TSM distribution maps from 2009 to 2018. The estimated TSM concentrations exhibited significant spatial and seasonal changes, revealing relationships among TSM, wind speed, and precipitation. The spatial heterogeneity was significantly higher downstream than upstream in the reservoir due to watershed inputs and anthropogenic dredging activity. The temporal heterogeneity of TSM, significantly higher in summer and autumn than in winter and spring, was mainly caused by seasonal rainfall. Our study shows that the empirical model for HJ-CCD images can be used to quantitatively monitor the TSM in inland rivers.