Background: Intracity commercial drivers play a vital role in transportation systems in many urban centers. However, their occupation puts them at risk for HIV infection due to various factors. Despite their increased vulnerability, intracity commercial drivers face significant challenges in accessing HIV prevention, testing, and treatment services. Method: This was an observational community-based cross-sectional descriptive study conducted among intracity commercial drivers in Kano State, Nigeria through multistage sampling technique. Result: the mean age and standard deviation of respondents was 42.0 ± 11.3. About two-third (67.7%) had good aggregate knowledge score and more than half (57.4%) of the study participant had good uptake and utilization of HIV/AIDs preventive services. After adjusting for the confounding effects using logistic regression analysis; educational status of secondary school (AOR=2.25, 95% CI=1.21–13.25) and post-secondary (AOR=4.10,95%CI=2.22-17.88), monthly income of between N50,0001 – N100,000.00 (AOR=2.02, 95%CI=1.74-19.33) and >N100,000.00 (AOR=4.01, 95%CI=3.11-27.33), working experience of 11 – 20 years (AOR=3.25, 95%CI= 1.16-22.56) and >20 years (AOR=6.05, 95%CI= 3.03-26.77) and good aggregate knowledge scores on HIV/AIDs preventive measures (AOR=4.02 (2.13 – 14.55), 95%CI=2.13-14.55) remained significant predictors of uptake/utilization of HIV/AIDs preventive measures. Conclusion: All agencies responsible for HIV/AIDs control and their partners should take appropriate measures including various strategies to educate this occupational group on sexuality and reproductive health. Also, the establishment of STI clinics in strategic locations, as well as making condoms available, accessible, affordable, and acceptable for use by this group of people in our society, should all be part of the prevention strategy.