Case studies and series have several important functions such as illustrating models for assessment and intervention, describing new clinical challenges and phenomena, including outcomes of treatments for rare conditions or clinical presentations, documenting the feasibility and preliminary efficacy of innovative interventions, and extending the clinical effectiveness and generalizability of empirically supported interventions and evidence-based assessment (Drotar, 2009a, 2010). A previous editorial issued an invitation to authors for submissions of case studies to the Journal of Pediatric Psychology (JPP) and suggested strategies to enhance their publishability (Drotar, 2009a). Since then, we have seen an increase in submissions and successful publication of case studies on such topics as multisystemic therapy to reduce HIV transmission risk behavior (Letourneau, Ellis, Naar-King, Cunningham, & Fowler, 2010), behavioral sleep interventions for autism and primary insomnia (Moon, Corkum, & Smith, 2011), and acceptance and commitment therapy to enhance psychological adaptation to pediatric sickle cell disease (Masuda, Cohen, Wicksell, Kemani, & Johnson, 2011). Our experiences in reviewing case study submissions and working with authors in revising their manuscripts have underscored significant challenges in writing and reviewing case studies including confusion about specific information that should be included in the report, how it should be organized, and how case report submissions should be evaluated. To facilitate authors’ tasks in preparing case studies and reviewers’ tasks in reviewing them, the purpose of this article is to provide additional guidance for submissions of case reports and series and for reviews of such manuscripts. This guidance pertains to case reports that have a narrative format and present data on clinical outcomes as well as those that utilize single subject methodology and designs. The latter also require specialized data analytic methods (see Rapoff & Stark, 2008 for a description).