Contribution to Emergency Nursing Practice •Describes the emergency nurse’s role in public health screening initiatives. •Quantifies specific strategies to optimize HIV testing in the emergency department, including the key role of nursing. •Provides description of Centers for Disease Control and Prevention HIV testing guidelines and their translation into practice. Contribution to Emergency Nursing Practice •Describes the emergency nurse’s role in public health screening initiatives. •Quantifies specific strategies to optimize HIV testing in the emergency department, including the key role of nursing. •Provides description of Centers for Disease Control and Prevention HIV testing guidelines and their translation into practice. Contribution to Emergency Nursing Practice •Describes the emergency nurse’s role in public health screening initiatives. •Quantifies specific strategies to optimize HIV testing in the emergency department, including the key role of nursing. •Provides description of Centers for Disease Control and Prevention HIV testing guidelines and their translation into practice. Madeleine Whalen is Clinical Nurse, Johns Hopkins Hospital, Baltimore, MD. Bhakti Hansoti is Physician and Assistant Professor, Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Yu-Hsiang Hsieh is Associate Professor, Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Mustapha Saheed is Medical Director and Assistant Professor, Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Dani Signer is Senior Research Program Coordinator, Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Richard Rothman is Professor and Vice-Chair of Research, Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.