Event Abstract Back to Event History of psychosis in Bipolar Disorder: Any effects in sensorimotor gating and cognition? Stella Giakoumaki1*, Panos Roussos1, Andreas Vardiampasis1, Zoe Fousteri1 and Panos Bitsios1 1 University of Crete, Electrical and Electronics Engineering Department, Brain Research Laboratory, Greece Introduction: Bipolar Disorder (BD) and Schizophrenia (SCZ) are distinct psychiatric disorders with a considerable overlap in neurophysiological and neuropsychological deficits and gross brain anatomy, indicating shared aspects of pathophysiology. BD patients often also present with psychotic symptoms during episodes of mania. In this study we examined potential differences in sensorimotor gating and cognition in remitted SCZ and BD-I patients with/without history of psychotic symptoms. Methods: Sixteen SCZ patients, 11 BD patients with history of psychosis (HP+), 12 BD patients without history of psychosis (HP-) and 19 age-, education- and gender-matched healthy controls were examined. Sensorimotor gating as measured with Prepulse Inhibition (PPI) was assessed with 85-dB prepulses at 30-, 60-, and 120-ms lead-intervals. Subjects also underwent a battery of cognitive tasks assessing attention (Stroop Interference Test-SIT, Degraded Continuous Performance task-D-CPT, Span of Apprehension Task-SAT) and executive function (Verbal and Category Fluency). Results: The controls showed higher PPI compared to the clinical groups (Ps<0.05). They also presented with superior performance in SIT and D-CPT compared to SCZ (P<0.005 and P<0.001, respectively) and BD HP+ (P<0.05 and P<0.001, respectively) but not BD HP- (Ps>0.06) patients. Healthy controls also performed better in the SAT compared to all clinical groups (Ps<0.007) while in Verbal and Category Fluency they outperformed the SCZ (Ps<0.001) but not the BD patients (Ps>0.07). Conclusions: Schizophrenia and all BD patients presented with reduced gating and poorer global cognitive performance compared to the healthy controls. History of psychosis in BD affected selective and sustained attention (as measured with SIT and D-CPT) similar to SCZ, supporting evidence that these functions can serve as putative endophenotypes of psychosis. Executive cognition and attention span appear to be spared in remitted BD HP- patients Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Giakoumaki S, Roussos P, Vardiampasis A, Fousteri Z and Bitsios P (2009). History of psychosis in Bipolar Disorder: Any effects in sensorimotor gating and cognition?. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.361 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Jun 2009; Published Online: 23 Jun 2009. * Correspondence: Stella Giakoumaki, University of Crete, Electrical and Electronics Engineering Department, Brain Research Laboratory, Heraklion, Greece, sgiakoumaki@uoc.gr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Stella Giakoumaki Panos Roussos Andreas Vardiampasis Zoe Fousteri Panos Bitsios Google Stella Giakoumaki Panos Roussos Andreas Vardiampasis Zoe Fousteri Panos Bitsios Google Scholar Stella Giakoumaki Panos Roussos Andreas Vardiampasis Zoe Fousteri Panos Bitsios PubMed Stella Giakoumaki Panos Roussos Andreas Vardiampasis Zoe Fousteri Panos Bitsios Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.