History Of Injury Research Articles

Clinical characteristics and visual outcomes of animal-induced ocular injuries: a prospective multicenter study in Iran.

Animal-induced ocular injuries represent an under-documented health problem that may pose significant visual complications. This study aimed to investigate the clinical characteristics and outcomes of ocular injuries caused by animals. This multicenter prospective study enrolled patients with a history of animal-induced ocular injuries presenting to the ophthalmology departments of two tertiary hospitals over a one-year period. All participants underwent comprehensive assessments by ophthalmologists, and the following data were collected: demographic information, animal species involved, injury details, pre- and post-treatment visual data, management strategies, and follow-up outcomes. Seventy-two patients (62.5% male) were included in the study. Insects were the most common species, causing 37.5% of ocular injuries. The type of animal involved was significantly associated with injury patterns (p < 0.0001), visual impairments at presentation (p < 0.05), and need for surgery (p < 0.001). Insects predominantly caused periorbital soft tissue injuries; birds primarily affected the anterior segment; dogs and cats mainly led to adnexal injuries; and equines often involved both anterior and posterior segments. Equine-related injuries resulted in the most severe visual impairments, requiring surgical interventions in all cases. At the same time, the majority of cases involved with other animal species experienced no visual impairment. The number of patients without visual impairment increased from 46 cases (63.9%) at the time of presentation to 58 (80.6%) at discharge after treatment. At follow-up, eight patients (11.1%) experienced complications, including traumatic cataract (n = 6, 8.3%), endophthalmitis (n = 3, 4.2%), corneal scarring (n = 1, 1.4%), and retinal detachment (n = 1, 1.4%). Rooster pecking was the leading cause of complications, including endophthalmitis and traumatic cataract. This study revealed that depending on the type of animal causing the injury, animal-induced ocular injuries present with diverse characteristics, requiring appropriate treatment approaches and potentially resulting in different outcomes. These findings may promote public awareness and improve preventive strategies and clinical guidelines development.

Metabolic syndrome is associated with reduced default mode network functional connectivity in young post-9/11 Veterans.

Metabolic syndrome is a collection of health factors that increases risk for cardiovascular disease. A condition of aging, metabolic syndrome is associated with reduced brain network integrity, including functional connectivity alterations among the default mode, regions vulnerable to neurodegeneration. Prevalence of metabolic syndrome is elevated in younger populations including post-9/11 Veterans and individuals with posttraumatic stress disorder, but it is unclear whether metabolic syndrome affects brain function in earlier adulthood. Identifying early effects of metabolic syndrome on brain network integrity is critical, as these impacts could contribute to increased risk for cognitive disorders later in life for Veterans. The current study examined whether metabolic syndrome and its individual components were associated with default mode functional connectivity. We also explored the contribution of posttraumatic stress disorder and traumatic brain injury on these metabolic syndrome-brain relationships. Post-9/11 Veterans with combat deployment history (95 with and 325 without metabolic syndrome) underwent functional magnetic resonance imaging to capture seed-based resting-state functional connectivity within the default mode. The metabolic syndrome group demonstrated reduced positive functional connectivity between the posterior cingulate cortex seed and the bilateral superior frontal gyrus. Data-driven analyses demonstrated that metabolic syndrome components, particularly cholesterol and central adiposity, were associated with widespread reductions in default mode network connectivity. Functional connectivity was also reduced in participants with metabolic syndrome but without current posttraumatic stress disorder diagnosis and with traumatic brain injury history. These results suggest that metabolic syndrome disrupts resting-state functional connectivity decades earlier than prior work has shown.

Target Attainment and Population Pharmacokinetics of Cefazolin in Patients with Invasive Staphylococcus aureus Infections: A Prospective Cohort Study.

This study aimed to determine cefazolin target attainment in patients with invasive Staphylococcus aureus (S. aureus) infections and to develop a population pharmacokinetic (PK) model. Adult patients with invasive S. aureus infections treated with cefazolin bolus infusions were included. Unbound and total trough and mid-dose cefazolin concentrations were measured, and strain-specific MICs were determined. The primary outcome was the proportion of patients attaining 100% fT>MIC at all time points evaluated. A population PK model was developed, using non-linear mixed-effects modelling. Overall, 51 patients were included, with a total of 226 unbound and total cefazolin concentrations measured (mean: 4.4 per patient). The median daily dosage in patients with an estimated glomerular filtration rate of >60 mL/min/m2 was 8 g. The median age was 74 years (interquartile range (IQR) 57-82) and 26% were female. A history of chronic kidney disease and acute kidney injury were present in 10/51 (19.6%) and 6/51 (11.7%), respectively. Achievement of 100% fT>MIC occurred in 86% of the patients and decreased to 45% when a target of 100% fT>4xMIC was evaluated. The mean unbound cefazolin fraction was 27.0% (standard deviation (SD) 13.4). Measured and estimated mean cefazolin trough concentrations differed significantly [13.1 mg/L (SD 23.5) vs. 7.4 mg/L (SD 7.9), p < 0.001]. In the population PK model, elevated estimated creatinine clearance and bolus instead of continuous application were covariates for target non-attainment. In conclusion, cefazolin target achievement was high, and the measurement of the unbound cefazolin concentration may be favored. The Monte Carlo simulations indicated that target attainment was significantly improved with continuous infusion.

Comprehensive study on central precocious puberty: molecular and clinical analyses in 90 patients.

Defects in MKRN3, DLK1, KISS1, and KISS1R and some disorders, such as Temple syndrome (TS14), cause central precocious puberty (CPP). Recently, pathogenic variants (PVs) in MECP2 have been reported to be associated with CPP. We aimed to clarify the contribution of (epi)genetic abnormalities to CPP and clinical and hormonal features in each etiology. We conducted targeted sequencing for MKRN3, DLK1, MECP2, KISS1, and KISS1R and methylation analysis for screening of imprinting disorders such as TS14 associated with CPP in 90 patients with CPP (no history of brain injuries and negative brain MRI) and collected their clinical and laboratory data. We measured serum DLK1 levels in three patients with TS14 and serum MKRN3 levels in two patients with MKRN3 genetic defects, together with some etiology-unknown patients with CPP and controls. We detected eight patients with TS14 (six, epimutation; one, mosaic maternal uniparental disomy chromosome 14; one, microdeletion) and three patients with MKRN3 genetic defects (one, PV; one, 13-bp deletion in the 5'-untranslated region (5'-UTR); one, microdeletion) with family histories of paternal early puberty. There were no patients with PVs identified in MECP2, KISS1, or KISS1R. We confirmed low serum MKRN3 level in the patient with a deletion in 5'-UTR. The median height at initial evaluation of TS14 patients was lower than that of all patients. Six patients with TS14 were born small for gestational age (SGA). (Epi)genetic causes were identified in 12.2% of patients with CPP at our center. For patients with CPP born SGA or together with family histories of paternal early puberty, (epi)genetic testing for TS14 and MKRN3 genetic defects should be considered. (271/250).

Which jump test is most sensitive for classifying ACL injury history in fatigued or non-fatigued athletes?

Introduction &amp; Purpose In fast-paced clinical decision-making, jump-landing movement assessments are rarely used to guide return-to-sport (RTS) decisions after an anterior cruciate ligament (ACL) injury. While these tests are crucial for identifying deficits in movement execution (e.g., dynamic valgus, extended knee, knee internal rotation) that could predispose to ACL re-rupture (Kaplan &amp; Witvrouw, 2019), identifying these deficits can be challenging. To integrate RTS movement assessments into clinical practice, the first step is to identify the most sensitive jump-landing test that can best expose remaining deficits in neuromuscular control and resulting landing kinematics associated with ACL injury. Further, RTS tests are mostly performed in a non-fatigued state although fatigued individuals often fail to reach the RTS criteria (Dingenen &amp; Gokeler, 2017). This exploratory study aimed to rank common jump-landing tests in their ability to identify (sensitivity and classification rate) deficits in whole-body landing kinematics following ACL injury, under both fatigued and non-fatigued conditions. Methods A total of 43 volunteers were recruited into ACL group (n = 21, 11 females, 3.9 years post ACL injury) and control group (n = 22, 12 females). 3D motion data (Vicon, 250 Hz) were recorded during a single-leg forward hop (SH), single-leg countermovement jump (CMJ), single-leg triple crossover hop (COH), and single-leg 90° medial rotation hop (MRH) before and after a fatigue-inducing intervention (single-leg squats and step-ups). Thirteen joint angles (50 ms after initial contact) from the lower body, trunk, and pelvis representing the landing kinematics were calculated in OpenSim. A correlation analysis was performed to check for multicollinearity issues. Eight distinct logistic regression models (four jumps, fatigued/non-fatigued, α = .05) were computed to predict ACL injury history based on a combination of joint angles. For each model, a backward stepwise method was employed to determine which combination of joint angles resulted in the highest classification rates. Results ACL injury history was successfully predicted in seven (χ² &gt; 4.4, p &lt; .036) of the eight logistic regression models (Figure 1). The SH in the fatigued condition (χ² = 22.5, p = .008) demonstrated the highest sensitivity of 85.7% and a classification rate of 86%. Significant predictors for this model were knee rotation (Odds ratios [OR] = 1.537), hip abduction (OR = 1.385), hip rotation (OR = 1.525), and ankle flexion (OR = 0.771). The CMJ (non-fatigued) showed the second-highest sensitivity of 81% and a classification rate of 81.4% (p = .027). Significant predictors were knee rotation (OR = 1.440), hip abduction (OR = 1.428), hip rotation (OR = 1.297), and pelvis rotation (OR = 0.664). The MRH in the non-fatigued condition exhibited the lowest sensitivity, and no classification was possible in the non-fatigued COH model (χ² = 3.6, p = .056). Discussion &amp; Conclusion The fatigued SH was the most sensitive jump-landing test for classifying groups and detecting kinematic differences due to previous ACL injury. Thus, we recommended the SH over other tests for RTS decision-making, as it is most likely to reveal kinematic abnormalities. Higher classification rates in the fatigued condition support RTS testing in fatigued states to better identify movement deficits. To integrate jump-landing assessments into RTS decisions in a feasible way, our future work will involve 3D motion capture using pose estimation algorithms on video data.

Colletotrichum keratitis: An important fungal infection of nine human eyes

Colletotrichum is a relatively uncommon cause of human infection. Previous findings on Colletotrichum keratitis were scarce, and most diagnoses were based on morphological distinction, perhaps underestimating the incidence of Colletotrichum species. This research describes the clinical characteristics and treatment outcomes of 9 cases of Colletotrichum keratitis discovered in our hospital using next-generation sequencing (NGS).We reviewed 78 patients with NGS-proven fungal keratitis between September 1, 2021 and May 31, 2023, 9 patients (11.5 %) were verified as infected with Colletotrichum species, and their medical records were reviewed to identify the clinical characteristics. NGS revealed that 3 patients were infected with C. truncatum, 3 patients with C. gloeosporioides, and the other 3 patients with C. fructicola. Seven patients had a history of corneal plant trauma (all three patients with C. fructicola had corneal injury history due to chestnut burrs), one patient was infected by mosquitoes flying into the eye, and one patient had an unknown origin. Seven patients underwent penetrating keratoplasty, while two patients underwent lamellar keratoplasty. Eight patients healed after keratoplasty, but one required evisceration due to recurrence of fungal infection in the anterior chamber and intractable discomfort.In conclusion NGS allows for more precise diagnosis and enhances epidemiological awareness of Colletotrichum keratitis, which is not as rare as previously reported.

Prevalence and determinants of occupational depression, anxiety, and stress among Ethiopian healthcare workers

Studies on the prevalence and factors of depression, and anxiety symptoms from a work-ascribed or causal perspective are not available and studies on the prevalence of occupational stress in Ethiopia are limited. Therefore, this study aimed to determine the prevalence of occupational depression, job anxiety, and occupational stress, and to identify their determinants in healthcare workers. We conducted a multicenter cross-sectional study in selected public hospitals in the Central and Southern Ethiopia from 16th January to 28th February 2023. We used stratified random sampling to select 9 public hospitals from three strata: primary, general and tertiary hospitals. We collected data using scales of perceived occupational stress, occupational depression inventory, and job anxiety. We performed a confirmatory factor analysis followed by determining the prevalence of those mental symptoms and identifying independent factors using multiple ordinal logistic regression. Among 1426 healthcare workers, the overall prevalence of occupational depressive, job anxiety, and occupational stress symptoms were 39.0%, 57.6%, and 68.0%, respectively. Females, medical specialists, participants with a history of disease or injury, those with low job dissatisfaction, higher sleeping disorder scores, higher life-threatening events (LTEs) scores, and longer working hours were more likely to report occupational depressive symptoms. Participants with poor perceived health significantly increased the odds of reporting job anxiety symptoms. Participants with low job satisfaction, a history of workplace verbal violence, higher scores for sleep disorders, and higher LTEs score had significantly greater odds of reporting both job anxiety and occupational stress symptoms. Younger participants were also more likely to report occupational stress symptoms. Our study highlights the need to prioritize workplace mental health interventions for healthcare workers. The study also suggested the need to address gender, educational level, job satisfaction, and sleep hygiene, develop coping mechanisms for LTEs, prevent workplace violence, and manage of working hours per week to enhance the mental well-being of healthcare workers in Ethiopia.

The Australian Music Students Health Survey: impact of past experience on student attitudes to health education

Abstract Widespread research over four decades has shown that musicians suffer physical and psychological injuries that can begin during childhood and early adulthood. A survey of 268 Australian tertiary music students revealed their perceptions of the importance of health education as part of their education. While students rated health knowledge as highly important, they considered its inclusion in their education to be less significant. Thirty-six percent reported current physical pain or injury, and 41% reported current psychological health issues. Significant correlations emerged between students’ reported injury history and prioritisation of health education and particular health topics. This has implications for tertiary music education providers regarding policies for the integration of health education into the curriculum.

Low back pain or injury before collegiate athletics, a potential risk factor for non-contact athletic injuries.

Majority of research surrounding the predictive value of clinical measurements and assessments for future athletic injury does not differentiate between contact and non-contact injuries. We assessed the association between clinical measures and questionnaire data collected prior to sport participation and the incidence of non-contact lower extremity (LE) injuries among Division III collegiate athletes. Prospective cohort study. University setting, NCAA Division III. 488 Division III freshmen athletes were recruited to participate in the study during their preseason physical examinations. 10,983 public schools. Prospective incidence of non-contact Lower extremity Injury. Athletes completed questionnaires to collect demographics and musculoskeletal pain history. Clinical tests, performed by trained examiners, included hip provocative tests, visual appraisal of a single leg squat to identify dynamic knee valgus, and hip range of motion (ROM). Injury surveillance for each athlete's collegiate career was performed. The athletic training department documented each athlete-reported, new onset injury and documented the injury location, type, and outcome (days lost, surgery performed). Univariable Generalized Estimating Equations (GEE) models were used to analyze the relationship between each clinical measure and the first occurrence of non-contact LE injury. An exchangeable correlation structure was used to account for repeated measurements within athletes (right and left limbs). Of the 488 athletes, 369 athletes (75%) were included in the final analysis. 69 non-contact LE injuries were reported. Responding "Yes" to "Have you ever had pain or an injury to your low back" was associated with an increased risk of non-contact LE, odds ratio = 1.59 (95%CI 1.03- 2.45, p=.04). No other clinical measures were associated with increased injury risk. A history of prior low back pain or injury was associated with an increased risk of sustaining a non-contact LE injury while participating in NCAA Division III athletics.

“Don’t miss the globe” – Study of diagnostic accuracy of computed tomography in detecting open globe injury

Abstract: PURPOSE: The purpose is to determine the computed tomography (CT) characteristics of open globe injury and establish the relative accuracy and reliability of various features on CT. Second, to assess the significance of a difference in the anterior chamber depths (ACDs) on CT in cases of open globe injury. METHODS: The diagnostic database of our radiology department was retrospectively reviewed to obtain details of patients with a history of blunt or penetrating injury to the orbit between September 2018 and March 2021. A total of 190 patients (144 males and 46 females) were included. A radiologist analyzed the CT scans without prior knowledge of ophthalmologic findings or surgical outcomes. Operative and ophthalmic examination findings were considered the gold standard for comparison. RESULTS: Out of 190 injured globes, the final clinical diagnosis confirmed 54 (28.4%) open globe injuries and 136 (71.5%) closed globe injuries. Between the two groups, intraocular hemorrhage, lens dislocation, lens injury or absence, intraocular foreign body, intraocular air, wall/contour defect, and ACD change were considered statistically significant (P &lt; 0.05). The average sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CT in diagnosing open globe injury were 71.3%, 98.5%, 83.6%, 95.75%, and 94.9%, respectively. CONCLUSION: Globe contour deformity or defect, intraocular hemorrhage, and a change in ACD were the three most predictive signs of open globe injury. CT is of valuable help in a multi-trauma setting and in an uncooperative patient for ophthalmological examination to draw attention to globe injury. However, CT examination alone is insufficient in detecting all cases of open globe injury. There is a need for a more collaborative approach among emergency physicians, ophthalmologists, and radiologists.

B - 40 Sleep Mediates Anxiety and PTSD Symptoms in Service Members with a History of Mild Traumatic Brain Injury

Abstract Objective Depression, anxiety, and post-traumatic stress disorder (PTSD) are prevalent in individuals with a history of mild traumatic brain injury (mTBI). US military service members (SMs) are at increased risk of sleep deficiency, which may influence the relationship between mTBI and psychological outcomes. This analysis examines the interaction of sleep quantity and mTBI on symptoms of depression, anxiety, and PTSD. Method A sample of 177 non-treatment seeking SMs completed the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and the Post Traumatic Stress Disorder Checklist (PCL-5) and reported the number of hours slept the prior night (“sleep quantity”). The sample included SMs with and without a self-reported history of mTBI. Hierarchical regressions on BDI, BAI, and PCL-5 total scores were computed with group and sleep quantity (model 1) and their interaction (model 2) as predictors and age as a covariate. Results The interaction of mTBI and sleep quantity on BAI (p = 0.019) and PCL-5 (p = 0.070) total scores was significant and marginally significant, respectively, wherein the negative association between sleep quantity and symptom reporting was stronger in the mTBI group than controls. No interaction between mTBI and sleep quantity was observed for BDI total score (p = 0.578). Conclusion Worse psychological symptoms in SMs with a history of mTBI is related to lower sleep quantity. It may benefit these SM to address sleep deficiency or other sleep problems to improve these symptoms. Improving sleep may provide a means of indirectly targeting the adverse psychological outcomes common among SMs with mTBI, particularly anxiety-related problems.

B - 36 Investigating High-Definition Transcranial Direct Current Stimulation for Remediating Word Finding Difficulty in Civilians with a History of Chronic Traumatic Brain Injury: a Pilot Study

Abstract Objective Verbal-retrieval deficits often occur after traumatic brain injury (TBI), but no effective treatment is available. In this study, High-Definition Transcranial Direct Current Stimulation (HD-tDCS) was applied to examine its potential effects on cognitive, especially verbal-retrieval, performance in individuals with chronic TBI. Method Four adults (mean age 48 years; 3 females) with self-reported word-finding difficulty confirmed by objective measures following mild to moderate non-military TBIs sustained over a year ago underwent a double-blind, cross-over, randomized, sham-controlled trial. Each participant received 10 sessions of active HD-tDCS and sham stimulation over the superior medial frontal cortex. A battery of neuropsychological tests was administered including verbal-retrieval measures (i. e. letter fluency, category fluency, Boston Naming Test/BNT) at baseline, immediately, and 8 weeks post-treatment. Post-treatment performance was compared to baseline using 2-tailed paired t-tests. Results Improvements on letter fluency were observed between baseline and immediate assessments post active HD-tDCS, approaching statistical significance (p = 0.076, Cohen’s d = 0.957, 7.5 ± 5.7 more items). No immediate effects with sham HD-tDCS (p &amp;gt; 0.10, 1.5 ± 3.5 more items) and no sustained effects (8 weeks after) were found with either active or sham HD-tDCS (ps &amp;gt; 0.10). Additionally, no significant changes were observed for category fluency or BNT (all ps &amp;gt; 0.10). Conclusion While our pilot study suggests a potential benefit for improved letter fluency immediately following active HD-tDCS compared to sham, the lack of sustained improvement after 8 weeks and the observed variability across different tests acknowledges the need for future larger-scale investigation across multiple cognitive domains.

A - 3 The Relationship between Memory and Depression In an Elderly Chinese Cohort: a Baseline Analysis

Abstract Objective Explore the relationship between depression and memory aged 60 years and older while controlling for age, gender, and education. Method This study utilized data from the Characterization of Dementia in Asian-Pacific Islanders study by Bruce Miller, M.D., and Howie Rosen, M.D., at the Memory and Aging Center at UCSF. Inclusion criteria included participants age 60+ who completed the Benson Figure Test, GDS-30, and the Chinese Version Verbal Learning Test (CVVLT) in English, Cantonese, or Mandarin. Exclusion criteria included participants under age 60 and or experience history of neurological strokes or injuries, and disabilities related to memory. The final sample yielded 136 participants, including 41 (30.1%) males, 95 (69.9%) females, 120 (88.2%) right-handed, 3 (2.2%) left-handed, and 7 (5.1%) ambidextrous. Average age of participants was 71.46 (SD = 7.26). A memory composite score was computed based on average of performances on the Benson Figure Task delay and the CVVLT 10-minute delay. Raw GDS-30 scores represented depression. Results There was a weak positive correlation between memory composite scores, gender, and education, and a weak negative correlation between memory composite scores, age, and GDS-30 scores. Conclusions Findings indicate some evidence for a relationship between depression and memory in elderly Chinese populations. However, the sample was skewed, and consisted of less depressed and higher memory functioning participants. Despite these limitations, it is pertinent to explore how healthcare providers may outreach to this population to monitor risk factors, improve timeliness of dementia diagnosis, and maximize treatment of reversible causes, adherence to treatment plans, and help families care plan.

B - 39 Resilience in Active Duty US Military Service Members: Factor Analysis and Prediction of Psychological Symptoms in a Mild Traumatic Brain Injury Sample

Abstract Objective The factor structure of the Connor-Davidson Resilience Scale (CD-RISC) varies between cultures, settings, and samples, yet has not been assessed in an active-duty United States (US) military sample. We used factor analysis to characterize resilience in a generalizable sample of active-duty service members (ADSMs) and explored its associations with self-reported psychological outcomes in ADSMs with a history of mild traumatic brain injury (mTBI). Method Exploratory factor analysis (EFA) of the 25-item CD-RISC was performed on a non-clinical convenience sample of 212 active duty SMs followed by a confirmatory factor analysis (CFA) for model validation. Hierarchical regressions compared the relationships among the resulting factors and total scores on the Post Traumatic Stress Disorder Checklist (PCL-5), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) between subgroups with self-reported history of mTBI (n = 60) and TBI-negative controls (n = 54). Results EFA returned a 4-factor, 19-item solution. After modifications to improve model fit, CFA validated a 4-factor, 17-item solution: Fortitude, Resoluteness, Decisiveness, and Dedication. The interaction of TBI history with the Decisiveness and Dedication factors significantly predicted BDI and PCL-5 total scores (p &amp;lt; 0.05), but not BAI total scores. Fortitude and Resoluteness did not differentially predict any psychological outcomes between groups. Conclusion Four latent factors of resilience that are unique to ADSMs were identified and validated from the 25-item CD-RISC. Decisiveness and Dedication more strongly predicted depressive and PTSD symptoms in ADSMs with a history of mTBI than in controls, suggesting these factors of resilience are especially critical for better psychological outcomes following mTBI in military populations.

B - 50 Traumatic Brain Injury in Patients with Psychogenic Non-epileptic Seizures and Functioning

Abstract Objective Past studies reveal that many patients with psychogenic non-epileptic seizures (PNES) also have a traumatic brain injury (TBI) history, but the specific influence of prior TBI on patients is presently under examination. This study aims to investigate the relationship between patients with PNES with a TBI history and symptoms/functioning, compared to those without a TBI history. Method Data collected from patients seen for comprehensive neuropsychiatric evaluation was analyzed, including TBI history, TBI severity, and Global Assessment of Functioning (GAF) scores. The GAF scale allows assignment of a numerical rating to patients based on their psychological and social functioning. Results Patients with PNES without TBI (n = 120; mean age 51) had higher average GAF scores (52.4) compared to those with TBI (n = 164, mean age 54, mean GAF 50) (p = 0.0059). Across PNES patients with a history of TBI, those with mild TBI exhibited notably lower GAF scores (43.2) than those with moderate (48.87) or severe (50) history of TBI. Conclusion Patients with PNES and a history of TBI had lower (worse) GAF scores than those without TBI, and worse in cases of mild TBI. Further exploration of demographic variables, education, and employment status will address potential confounds. Understanding the complex interplay between PNES and TBI may improve diagnosis and management strategies, with further research in advancing clinical practice.

B - 26 Exploring the Relationship between Traumatic Brain Injury History and Cognitive Impairment in a Diverse Community-Based Sample

Abstract Objective Research suggests that traumatic brain injury (TBI) with/without loss of consciousness (LOC) may impact cognition later in life; however, there is a paucity of research investigating this association in diverse samples. This study evaluated whether a history of TBI and LOC is associated with neurocognitive impairment in a racially diverse, community-based sample. Methods Participants from a population-based multiethnic cohort (N = 769; Mage = 61.8; Meduc = 14.5; 61% Female; 45% Black, 40% White, 10.6% Hispanic/Latinx, and 1.6% Asian) completed a brief neurocognitive assessment and the Texas Evaluation of Concussion History (TECH) survey. Descriptive statistics were gathered to determine the prevalence of concussion history (+/− LOC) across ethno-racial groups. Multiple logistic regression analyses examined whether concussion history +/− LOC was associated with a later consensus diagnosis of cognitive impairment. Results Thirty-two percent of the sample reported concussion history (Mconcuss = 2.55), 49.5% of which involved LOC. Fewer Black individuals reported concussion (25.3%) and LOC (35.7%) compared to their White (43.3%, LOC = 55.7%) and Hispanic/Latinx (33.1%, LOC = 58.1%) counterparts (ps &amp;lt; 0.01). Self-reported concussion history (OR = 1.12, 95%CI = [0.79–1.6], p = 0.53) and LOC (OR = 1.3, 95%CI = [0.75–2.3], p = 0.34), controlling for age, sex, education, and ethno-racial background, did not predict later cognitive diagnosis (impaired/not impaired). Conclusion Findings revealed differential rates of self-reported concussion among racial/ethnic groups, but history of concussion +/− LOC was not associated with subsequent cognitive diagnosis in this sample. Although concussion history was not associated with cognitive diagnosis in this sample, future research is needed to explore the impact of the number and severity of TBI on later cognition.

Relationship between Physical Characteristics and Morphological Features of the Articular Radius Surface: A Retrospective Single-Center Study.

Preoperative planning is important for the osteosynthesis of distal radius fractures. Challenges arise for patients presenting with bilateral wrist injuries or a history of contralateral wrist injuries. In such cases, the estimation of the distal radius morphology and the determination of the plate size from the preoperative physical characteristics could prove beneficial. The objective of this study was to investigate the correlation between the physical characteristics and the morphology of the distal radius articular surface. A total of 79 wrist computed tomography (CT) images (41 women and 38 men) were evaluated. Physical characteristics, such as height, weight, and body mass index (BMI), were recorded. Three-dimensional CT analysis was performed to investigate the transverse and anteroposterior diameters of the distal radius. Pearson's correlation coefficient was used to assess the relationships between height, weight, and BMI and the transverse and anteroposterior diameters of the distal radius. A moderate to strong correlation was found in the overall analysis between body height and transverse diameter (r = 0.66). There were also moderate correlations between body height and anteroposterior diameter (r = 0.45) as well as weight and transverse diameter (r = 0.41), both of which were statistically significant (p < 0.001). Our findings indicate a statistically significant correlation between height, weight, and morphology of the distal radius. When analyzed by sex, the correlation between body height and the transverse diameter of the distal radius was found to be relatively strong in women (r = 0.47, p = 0.002), suggesting that it could be a useful indicator for preoperative planning, such as estimating plate size.

A Novel Study on the Functional Capacity of Athletes and Its Influence on Their Fear of Pain and Injuries

This study investigates the multifaceted phenomenon of kinesiophobia, characterized by an irrational fear of movement, particularly prevalent among individuals with chronic pain. The research delves into various factors influencing kinesiophobia, including demographic variables, psychological experiences, and physical characteristics. Employing the Tampa Scale of Kinesiophobia, the study assesses fear levels and their correlation with pain perception and functional capacity. Findings reveal a significant relationship between kinesiophobia and psychological exhaustion, reduced alertness, and self-esteem issues, particularly among athletes. Moreover, factors such as fatigue, overextension, sleep quality, and nutritional habits are identified as contributing to the manifestation of kinesiophobia. Furthermore, our study employs meticulous data preprocessing and neural network modeling, achieving an accuracy of 94.54%, to explore predictive factors such as age, gender, and fear-related attitudes. Notably, while injury history emerges as a significant predictor of kinesiophobia, gender does not exert a substantial influence. Notably, while injury history emerges as a significant predictor of kinesiophobia, gender does not exert a substantial influence. The analysis underscores the complex interplay of physical, psychological, and environmental factors in shaping kinesiophobia and highlights the importance of tailored interventions targeting fear-related attitudes and promoting well-being and rehabilitation strategies in individuals affected by this condition.

Lateral and Medial Elbow Tendinopathy and Previous Injuries to Adjacent Joints: A Multicenter Observational Study.

Lateral and medial elbow tendinopathies are common soft tissue disorders affecting 1-3% of the general population, causing significant pain and functional impairment in the elbow and upper limb. While often associated with overuse and repetitive strain, their exact etiology, including potential associations with prior injuries in adjacent joints, remains unclear. This preliminary study aims to explore the distribution of lateral and medial elbow tendinopathies and investigate the occurrence of previous lesions in adjacent joints among diagnosed individuals, providing foundational insights for future research. A multicenter cross-sectional observational study was conducted involving 90 subjects diagnosed with lateral and/or medial elbow tendinopathy. The data collection occurred during the initial consultations, including demographic information, clinical assessments, and history of prior injuries in adjacent joints. Among the sample, 44.4% reported prior injuries to adjacent joints in the affected upper limb, with 45.6% of these injuries identified as musculotendinous in nature. The analysis also showed that the type of elbow tendinopathy was significantly associated with sex (p = 0.01) and occupational origin (p = 0.022). While a notable percentage of the subjects reported prior musculoskeletal injuries in the same limb, the study's geographic limitations and reliance on self-reported data introduce potential recall bias. These preliminary findings suggest a possible relationship between prior adjacent joint injuries and elbow tendinopathy. Further research with larger sample sizes and more rigorous study design is needed to confirm these observations and explore the underlying mechanisms.

Lifetime history of head injury is associated with reduced perivascular space number in acute mild traumatic brain injury.

Traumatic brain injury impairs function of the glymphatic system, a perivascular network involved in waste clearance. Enlarged perivascular spaces visible on MRI are an emerging biomarker of glymphatic function. This study characterized enlarged perivascular spaces in acute head injury with 7 T MRI. Healthy controls (n = 8) and patients (n = 11) with mild traumatic brain injury underwent MRI within 7 days of injury and were evaluated for lifetime history of head injury, neurobehavioral symptoms and sleep disturbances. MRI-visible perivascular spaces were quantified and assessed according to published criteria. The number of enlarged perivascular spaces was significantly higher in traumatic brain injury patients than controls (P = 0.015). Among healthy controls, 6/8 scored 'none' or 'mild' on the perivascular space rating scale, while 10/11 patients scored 'moderate', 'frequent' or 'severe'. There was an inverse relationship between perivascular space number and number of lifetime head injuries. Patients with more prior head injuries exhibited fewer enlarged perivascular spaces (P = 0.014). These results indicate that mild head injury results in acute alterations in perivascular space number, and this effect is mediated by previous head injury history. Enlarged perivascular spaces may reflect a glymphatic response that is diminished after multiple head injuries, although this will require further study.