History Habits Research Articles

Are history of dietary intake and food habits of patients with clinical symptoms of COVID 19 different from healthy controls? A case-control study.

BackgroundCoronavirus disease 2019 (COVID-19) is an infectious disease that put unprecedented significant strain on clinical services and healthcare systems. The aim of the present research was to assess dietary food groups and also food habits of patients with clinical symptoms of COVID 19 and healthy controls.MethodsThis case–control research was carried out on 505 participants (279 subjects with clinical symptoms of COVID-19 and 226 controls), in age 18–65 years. Dietary food group's intake last year was investigated by a food frequency questionnaire. Food habits were asked by a general information questionnaire. The strength of the association between food group's intakes with the odds ratios (ORs) of COVID-19 was assessed using Logistic regression models.ResultsAfter adjusting for physical activity in the logistic regression models, intake of dough and yogurt had a significantly protective role on occurrence of COVID19 (OR = 0.62; 95% confidence interval (CI) = 0.44–0.87; P = 0.006) (OR = 0.74; 95% CI = 0.56–0.98; P = 0.044), respectively. No significant differences were seen in food habits between the two groups in the last year ago.ConclusionsHigh risk population for COVID19, advised to consume enough amount of yogurt and dough at the time of this pandemic.

Prevalence and determinants of breast and cervical cancer screening among women aged between 30 and 49 years in India: Secondary data analysis of National Family Health Survey - 4.

">Breast and cervical cancers are the two leading causes of cancer-related morbidity and mortality in India. Early diagnosis of these cancers through screening offers the best chance to achieve successful treatment outcomes. Hence, the current study was done to determine the prevalence and predictors of breast and cervical cancer screening among women aged 30-49 years in India. We have analyzed the most recent National Family Health Survey-4 data (NFHS-4) gathered from Demographic Health Survey program. Stratification and clustering in the sample design were accounted using svyset command. Adjusted prevalence ratio (aPR) with 95% confidence interval (CI) was reported. In total, 336,777 women aged 30-49 years were included. Proportion of women aged 30-49 years with history of breast cancer examination in their lifetime was 12.9% (95% CI: 12.6-13.2%), while it was 29.8% (95% CI: 29.3-30.3%) for cervical cancer. It was found that women aged 45-49 years (aPR=1.09), married (aPR=2.18), higher educational level (aPR=1.28), richest quantile (aPR=1.96), no history of pill use (aPR=1.24), obese (aPR=1.06), and healthy dietary habits (aPR=1.47) were more likely to be screened for breast cancer. Predictors for cervical cancer screening were higher age group (aPR=1.06), married (aPR=2.94), secondary educational level (aPR=1.05), richest quantile (aPR=2.24), nonpill user (aPR=1.24), nontobacco user (aPR=1.07), and lower parity (aPR=1.09). A total of 1 out of 10 women in reproductive age group were screened for breast cancer while less than one in three for cervical cancer. Hence, it is important to spread awareness and increase access to screening services to achieve early diagnosis and better treatment outcomes.

Study of ABO blood grouping and secretor status among habituals – A case control study

The study was conducted to analyse ABO blood group and secretor status using saliva among habituals and healthy controls. The relationship between ABO blood group, secretor status of habituals and oral potentially malignant disorders (OPMDs) was assessed. Salivary secretor status was studied in 100 individuals. Clinical and habit history was noted. Group I had 50 age and sex matched healthy controls; group II had 50 individuals having habit history, with or without PMD. With 1ml of unstimulated saliva from each, Wiener agglutination test was performed to know blood group and secretor status. The relationship between ABO blood groups, secretor status, and OPMDs was assessed using Chi-square test and odds ratio. Group I had blood groups A (44%), B (32%), O (14%), AB (10%) and group II had A (32%), B (26%), O (34%), AB (8%). Non-secretor status in group I was 18% and group II, 82%. In Group II, 20% nonsecretors presented with PMD, predominantly oral submucous fibrosis followed by leukoplakia and lichen planus. A definite correlation between salivary secretor status and development of PMD indicates non-secretors possess greater risk of developing oral lesions. Among the habituals, blood groups B and O were at higher risk than A and AB.

Material Culture in Vernacular/Semi−Vernacular Arabic from Medieval Tunisia: A Preliminary Inventory of Lexical Data in the Kitāb Riyāḍ al-Nufūs fī Ṭabaqāt ʽUlamāʼ al-Qayrawān wa-Ifrīqiya by Abū Bakr al-Qayrawānī al-Mālikī (dead after 464/1072)

Abstract: This short paper presents lexical data in vernacular Arabic collected in a text by the Medieval Tunisian writer Abū Bakr al-Qayrawānī al-Mālikī. After a presentation of the author, it is reminded the interest there would be in studying the material in vernacular Arabic from Tunisia in order to contribute to a better knowledge of the social history of linguistic habits. The textual material is exposed in Arabic script and divided into four main sections. The textual Arabic information is translated and sometimes, we add explanations on the significance of some words. Lastly, in a provisional conclusion, maybe the reader can appreciate how is necessary going on with this kind of research which tries to reassess the need to take into account the vernacular Arabic data compiled in written sources and the notion of language contact in Medieval Tunisia, mainly between Arabic, Berber, and Latin/Romance languages.

Analysis of factors causing appearance of food hypersensitivity in young children in Lviv oblast

Food hypersensitivity in young children is a topical issue, since it encompasses a wide range of clinical symptoms and requires a personified approach in diagnostic, therapeutic and preventive measures. A progressive increase in different forms of food hypersensitivity is associated with many factors, particularly malnutrition and harmful ecological conditions. Epigenetic and genetic factors, which potentially can be related to food hypersensitivity and allergy, are being thoroughly studied. In this complex situation, the detection of risk factors for disease development is important for offering patients proper recommendations on diet, living conditions and lifestyle. Aim of the research: to perform analysis of factors, which cause appearance of food hypersensitivity in young children in Lviv oblast. Materials and methods. A study of the number of children with food intolerance was conducted using a specially compiled questionnaire. Thus, 4500 questionnaires were distributed in pre-school and medical establishments to question parents. The questionnaire had 34 questions that were grouped into four parts: general information and detailed information in parts A, B, and C. The general information part of the questionnaire included questions about the region where the child lived, passport data of the child (age, gender) and presence of serious disease (either past or present). Part A had questions about serious diseases that a child had suffered; part B asked about the child’s genealogical and medical history and presence of harmful habits in the family; part C had questions about the environment and living conditions of the child, as well as nutrition and its relation to the development of clinical symptoms of disease. Results. Analysis of 3214 questionnaires was conducted, which enabled to obtain information from parents on anamnesis and living conditions of young children. Values of 56 factors were analyzed, calculating correlation coefficients with a formation of food hypersensitivity for each of them. Statistical analysis allowed distinguishing 15 signs among these factors, which significantly correlated with the formation of food hypersensitivity in young children. Conclusions. The investigation enabled not only to detect factors that affect formation of food hypersensitivity in young children, but also to suggest a mathematical model of individual calculation of risk factors for this pathology. Data of conducted mathematical analysis can be used for elaboration of a complex of prophylaxis measures on development of food hypersensitivity in young children in Lviv oblast.

Non-specific Chief Complaints Among Oral Submucous Fibrosis Patients at Outpatient Department and Pan Shop at Rural Region in India.

ABSTRACTAim:The first communication with a healthcare professional is critical for determining the correct diagnosis, particularly when it comes to patients’ description of symptoms. This study aimed at exploring the primary symptoms observed in oral submucous fibrosis patients with non-specific complaints visiting outpatient department and pan shop at Kanpur, India.Materials and Methods:It was a cross-sectional study involving a two-stage sampling to select clinically diagnosed oral submucous fibrosis (OSF) patients from the outpatient department and pan shop customers (PSCs) at rural healthcare centers. A total of 321 participants were selected based on convenience sampling. Patient demographics, history of relevant habits with a period, and socioeconomic status were all documented. The extent of mouth opening was used to grade OSF cases. Data were analyzed using MedCalc Version 19.7.2 with χ2, Wilcoxon signed-rank, and t-tests used, as appropriate, to calculate P-values.Results:Out of the 184 OSF-OPD patients, only 59 (32.06%) described relevant disease symptoms of OSF: in stage III, 28.5% or stage IV, 38.7%. One hundred and twenty-five patients (67.93%) reported chief complaints (CCs) unrelated to OSF, and all of these cases were diagnosed with an early stage of OSF (stage I: 72.41% and stage II: 61.53%). Out of the total 137 PSCs, 74 PSCs have had prior dental consultations, but only 44 (32.11%) people had sought medical help because of OSF-related CCs.Conclusion:A limited number of studies were conducted in this area, particularly in the rural population of central India. Our study found that considerable amount of main complaints from OSF patients was unrelated to their symptoms. There is insufficient knowledge of OSF symptoms among rural population, which further restricts early detection of the disease.

An 8-year retrospective analysis of oral submucous fibrosis in patients visiting dental College, Secunderabad

Background: Oral submucous fibrosis (OSMF) is a chronic, progressive, scarring precancerous condition of the oral cavity seen predominantly in the Indian subcontinent and South East Asia. In India, the prevalence of OSMF has been increased over the past four decades from 0.03% to 6.42%. Aim: The study aims to provide an 8-year retrospective analysis of OSMF in patients visiting dental college, Secunderabad. Materials and Methods: A retrospective analysis was conducted from 2008 to 2016 in dental college, Secunderabad. Data were collected from patient's outpatient records from the department of oral medicine and radiology, year wise in the perspective of demographic details, history of nutritional deficiency, adverse habits, symptoms, clinical features, site involved, and mouth opening. There were no inclusion or exclusion criteria. All the cases which were provisionally diagnosed to be OSMF were included. The data were analyzed with SPSS package version 24. Chi-square test has been applied to check the association of different parameters such as gender, nutritional deficiency, adverse habits, area, palpable fibrous bands, and mouth opening with age.P< 0.05 was considered statistically significant. Results: The total patients were found to be 107. The mean age of the patients was 38 ± 12. Among the total patients, 86% were males and 14% were females. Among them, 3.7% were unskilled workers. Almost all of them (99%) reported no nutritional deficiency. Majority (51.4%) were having betel nut chewing habit, followed by tobacco chewing, intake of spicy food, smoking, and alcohol. Nearly 43% had limited mouth opening, followed by burning sensation and other symptoms. Palpable fibrous bands were present in 4.1% of the patients. Nearly 83.2% have been affected with OSMF in the buccal mucosa site. Grade 1 (>20 mm) mouth opening was present in 12.1% of the patients, 7.5% were having Grade 2 (11–19 mm), and 3.7% had Grade 3 (<10 mm) mouth opening. A significant association was found between age and adverse habits (P = 0.023). There was no significant association between age and sex (P = 0.924), nutritional deficiency (P = 0.766), area (P = 0.567), palpable fibrous bands (P = 0.221), and mouth opening (P = 0.155). Conclusion: Majority of the patients with OSMF were males who were < 30 years, having betel nut chewing habit and Grade 1 mouth opening.

Comparing the efficacy of chemiluminescence with lugol's iodine versus toluidine blue in the diagnosis of dysplasia in tobacco associated oral lesions - A diagnostic study.

Chemiluminescence is the production of light as a result of a chemical reaction. Oral potentially malignant disorders (OPMDs) include both precancerous lesions and conditions that carry an increased risk of cancer. There are different etiological and risk factors for OPMDs such as smoking, alcohol consumption, infections such as viral and fungal, sun exposure and certain other genetic factors. The most common etiological factor for OPMDs is tobacco usage. Chemiluminescence is a light-based detection system and is very useful for detecting OPMDs for early intervention. Because it is a non-invasive procedure, it can be used to evaluate dysplastic changes in various OPMDs at their initial stage for timely intervention. Vital staining has also been used as a chair-side marker for delineating normal and dysplastic oral mucosal tissues. To compare the efficacy of chemiluminescence with Lugol's iodine to that with toluidine blue in diagnosing dysplastic changes in tobacco associated oral lesions. A total of 84 patients with clinically suspicious oral mucosal lesions and OPMDs with tobacco habit history were included and randomly assigned to either of the diagnostic study groups (Group A: chemiluminescence with Lugol's iodine or Group B: chemiluminescence with toluidine blue). All these patients were subjected to a histopathological examination (reference standard). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristics (ROC) were 91.7%, 66.7%, 84.6%, 80%, and 0.792 for chemiluminescence with Lugol's iodine group (P = 0.001) respectively whereas for chemiluminescence with toluidine blue, the sensitivity, specificity, PPV, NPV and ROC were 100%, 60%, 93.3%, 100% and 0.800 (P = 0.002), respectively. The combination of chemiluminescence with toluidine blue had a better diagnostic efficiency in detecting dysplasia in tobacco-associated oral lesions when compared to the group of chemiluminescence with Lugol's iodine.

New insight into the palaeoenvironmental dynamics as a background of the human history in the Nemunas River delta region, W Lithuania, throughout the Lateglacial and Early Holocene

A new reconstruction of the Lateglacial – Early Holocene paleoenvironmental dynamics as a background of the habitation history in the territory of the Nemunas River Delta (NRD) was based on the geological-geomorphological, grain-size, isotope (14C), pollen and diatom data supplemented by archaeological information obtained within the framework of the project „Man and Baltic Sea in the Meso-Neolithic: Relict Coasts and Settlements Below and Above Present Sea Level. ReCoasts&amp;People“. The existence of extended proglacial lakes formed during the onset of the Lateglacial was succeeded by a period of low water estuaries or freshwater lagoons as early as 13.8 cal kyr BP. Simultaneously, groups of the Final Palaeolithic population, representing the classic Swiderian culture, inhabited the area. As shores of the Yoldia Sea and Ancylus Lake were situated further westwards (-11 to -24 – -29 m NN), wetlands and lake systems alongside with shallow boggy basins and fluvial streams predominated in the local landscape throughout the Early Holocene. Archaeological data suggest an episodic human activity in the territory while part of the archaeological sites might have been covered by sediments during the further intervals of the Holocene. Since the Early Holocene an extended peat bogs have become an important part of the landscape here.

Practices, Attitude &amp; Perceived Barriers of Dental Students in Substance Use Screening &amp; Interventions in Dental Practice: A Cross-Sectional Study

Context: Tobacco, the leading preventable cause of death including alcohol and illicit drug abuse, cause morbidity and mortality. Dentists deal with such patients &amp; can/ should intervene, preventing any deleterious habits with apt knowledge and training.&#x0D; Aims: The study assesses the knowledge, attitude and practices amongst dental students to manage patients with tobacco, alcohol and substance abuse in a clinical set up.&#x0D; Methodology: A cross-sectional questionnaire (self-administered 22 items) survey was conducted among 300 dental students (Undergraduates, Interns, Postgraduates) in a dental college, North India to assess their knowledge, attitude and practices regarding substance abuse- tobacco, alcohol and other illicit drugs. Data were analyzed using SPSS version 16.0 and subjected to Chi-square test to determine the significant difference between the dental study groups (p≤ 0.05)&#x0D; Results: There were 37.1% males and 62.9% of females. Final years (33.8%), interns (29.8%) and Post graduates (36.5%) completed the questionnaire. 85.5% Postgraduates, 74.3% final years and 71.9% interns knew where to refer the patients of substance abuse which was statistically significant (p≤ 0.05).A majority (91.1%) of interns prescribe or provide tobacco cessation, followed by 87.1% final years and 78.2% post graduates that were significant values.&#x0D; Conclusions: Although there’s huge awareness on the management of patients with substance abuse habits, only a few practice it on patients correctly. Lack of training and its application due to many barriers have been discussed in detail pointing out the disparity in the number of patients with habit history being screened and to those being managed.

Prevalence of Gestational Diabetes Mellitus among pregnant women attending for antenatal care- A Hospital based study

GDM is a condition in which high blood glucose level is exhibited in a women during pregnancy without a previous diagnosis of Diabetes Mellitus. Indian women are considered to be more prone for developing GDM. The increasing prevalence of GDM may be due to obesity, family history of Diabetes Mellitus, sedentary lifestyle, genetic predisposition and dietary habits. The screening and management of GDM in the general population remain controversial with conflicting guidelines and treatment protocols. Adequate blood sugar control in GDM women might reduce various maternal, foetal and neonatal complications. Prospective Observational study was done to find out the prevalence and risk factors of GDM. The study was conducted in the OBG department of the study center and pregnant women with 24-28 weeks of gestation attending for antenatal care were included. The results obtained from the study says the prevalence of GDM was found to be 16% in the study center, which is at par with South Indian prevalence. This study concludes that GDM is largely associated with a family history of diabetes mellitus, obesity and higher maternal age in that particular study setup.

Dental Caries Prediction Based on a Survey of the Oral Health Epidemiology among the Geriatric Residents of Liaoning, China.

Background Dental caries is one of the most common chronic diseases observed in elderly patients. The development of preventive strategies for dental caries in elderly individuals is vital. Objective The objective of the present study was to construct a generalized regression neural network (GRNN) prediction model for the risk assessment of dental caries among the geriatric residents of Liaoning, China. Methods A stratified equal-capacity random sampling method was used to randomly select 1144 elderly (65-74 years) residents (gender ratio 1 : 1) of Liaoning, China. Data for the oral assessment, including caries characteristics, and questionnaire survey from each participant were collected. Multivariate logistic regression analysis was then performed to identify the independent predictors. GRNN was applied to establish a prediction model for dental caries. The accuracy of the unconditional logistic regression and the GRNN early warning model was compared. Results A total of 1144 patients fulfilled the requirements and completed the questionnaires. The caries rate was 68.5%, and the main associated factors were toothache history, residence area, smoking, and drinking. We randomly divided the data for the 1144 participants into a training set (915 cases) and a test set (229 cases). The optimal smoothing factor was 0.7, and the area under the receiver operating characteristic curve for the GRNN model was 0.626 (95% confidence interval, 0.544 to 0.708), with a P value of 0.002. In terms of consistency, sensitivity, and specificity, the GRNN model was better than the traditional unconditional multivariate logistic regression model. Conclusion Geriatric (65-74 years) residents of Liaoning, China, have a high rate of dental caries. Residents with a history of toothache and smoking habits are more susceptible to the disease. The GRNN early warning model is an accurate and meaningful tool for screening, early diagnosis, and treatment planning for geriatric individuals with a high risk of caries.

Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer.

Matrix metalloproteinases (MMPs) are a group of zinc dependent enzymes that are involved in tumor cell invasion and metastasis. The role of MMP-2 and -9 genetic polymorphism in different malignancies has been the subject of numerous studies. The present research has attempted to discover any positive correlation between MMP-2 and MMP-9 SNPs and prostate cancer (PCa) in patients with a history of either diabetes or smoking habits. 112 PCa-patients and 150 unrelated healthy-controls that matched for age and sex were selected for present case-control study. MMP-2 -1575G/A and MMP-9 -1562 C/T polymorphisms detected by PCR-RFLP, serum tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2), testosterone, prostate-specific antigen (PSA), free-prostate-specific-antigen (fPSA), and fPSA/PSA levels were detected by ELISA and enzyme assay, respectively. MMP-2 and MMP-9 activities were measured by gelatin-zymography. Covariates were considered as age, status of cigarette smoking, and a possible history of diabetes mellitus (DM). The frequency of -1575 MMP-2 A/A + A/G and -1562 MMP-9 C/T + T/T genotypes were higher in PCa-patients with DM (74.3%,p = 0.003) and with smoking habits (72.5%,p = 0.005). These genotypes were associated with the increased risk of prostate cancer in smokers (3.52-folds) and in individuals with history of DM (4.34-folds). A significant positive association was found between level of TIMPs (TIMP -1 and TIMP-2) and BMI in PCa-patients and also between testosterone levels and MMP-9 activity in healthy control subjects. For the first time, this study demonstrated that activities of MMP-2 -1575G/A and MMP-9 -1562C/T variants in association with smoking and diabetes are considered significant risk factors for PCa.

The 2016–2018 Greek-Swedish archaeological project at Thessalian Vlochos, Greece

The Vlochos Archaeological Project (2016–2018) was a Greek-Swedish archaeological investigation of the remains of the ancient urban site at Vlochos in western Thessaly, Greece. Employing a wide array of non-invasive methods, the project succeeded in completely mapping the visible remains, which had previously not been systematically investigated. The extensive remains of multi-period urban fortifications, a Classical-Hellenistic city, a Roman town, and a Late Antique fortress were identified, evidence of the long history of habitation on this site. Since comparatively little fieldwork has been conducted in the region, the results significantly increase our knowledge of the history and archaeology of Thessaly.

Is there a unique symptom in lower urinary tract dysfunction in children?

Lower urinary tract symptoms (LUTS), particularly urgency, incontinence and intermittency are common in children and it is suggested that the specific symptoms may be used for definite diagnosis for LUT dysfunction (LUTD). This study was performed to investigate the relationship between each LUTD and its associated symptoms, using uroflowmetry/electromyography (UF/EMG) as a diagnostic tool. Each patient was categorized into one of four LUT conditions which were overactive bladder (OAB), dysfunctional voiding (DV), underactive bladder and primary bladder neck dysfunction (PBND), according to UF/EMG results. Patients' complaints and findings were documented by using voiding dysfunction symptom score, bladder diary, urine analysis and ultrasonography. In addition, a detailed history of bowel habits (including use of Rome III criteria) was obtained. There were 189 children of which 106 were female. The OAB was the largest group including 91 patients, followed by the DV group which had 61 patients. The symptoms specific to any LUTD group were constipation and hesitancy (P < .05). Hesitancy was present in 89.4% with PBND and constipation was present in 78.6% of patients with DV. None of other symptoms were able to differentiate any LUTD group from the other. While certain symptoms are often presumed by clinicians to imply specific diagnoses, the main outcome of this study is that there is a generally weak correlation between the specificity of symptoms and LUTD. Symptoms-based approach may lead to misdiagnosis in LUTD. Thus, it may be essential to focus on the underlying pathologies and UF/EMG test may help this.

Non-Habit Induced Oral Cancer: A Review

The purpose of this article is to review non-habit induced oral cancers in India and study its interrelationshipsand risk factors on the health of an individual. Oral Cancer is a major issue related to the health of anindividual inevery country around the world and has a wide variation in the global burden of the disease. Itis a noteworthy issue regarding public health in India and accounts for 30% of the total cumulative cancersreported across the country. Consumption of tobacco and alcohol leads the etiological factors responsiblefor causing Oral Cancers, but, at times non-habit induced oral cancers have also been recorded. This articlefocuses on the various etiological factors responsible for causing oral malignancies in individuals havingno history of alcohol and tobacco-related habits and highlights their interrelationship and pathophysiologyresponsible for causing malignancies.

S1628 Metastatic Prostate Adenocarcinoma With a Unique GI Presentation

INTRODUCTION: Prostate adenocarcinoma is one of the most common forms of cancer in men. Common areas of metastasis include bone and lymph nodes. However, several less common sites of invasion exist which require histological confirmation, especially in patients with a history of prostate cancer. Misdiagnosis can lead to inappropriate treatment and complications. We present a rare case of metastatic prostate adenocarcinoma in the rectum discovered during colonoscopy. CASE DESCRIPTION/METHODS: An 85-year-old patient with a history of prostate adenocarcinoma (Gleason 3 + 3 = 6) status post brachytherapy, cryosurgery, and intermittent androgen deprivation therapy (ADT) presented with a one year history of altered bowel habits, intermittent rectal pain, and bleeding. CT colonogram showed a low rectal mass with lobulated margins extending into perirectal fat. Colonoscopy revealed a rectal infiltrating mass 4-5 cm from the anal verge. Biopsy and immunohistochemistry confirmed poorly differentiated AE-1/AE-3 and NKX3.1 positive adenocarcinoma of prostatic origin. Axumin PET Scan demonstrated abnormal uptake in the left perirectal and left pelvic lymph nodes. Due to lack of obstructive symptoms, the patient was started on systemic therapy with Enzalutamide 160 mg PO daily with follow up PSA every 2-3 months to monitor progress. DISCUSSION: Rectal metastasis of prostate adenocarcinoma is a rare finding with few cases reported in the literature. This is likely because Denovilliers’ fascia serves as an anatomic barrier between the rectum and the prostate. Literature review suggests several potential routes of dissemination to the rectum including direct invasion of Denovilliers’ fascia, lymphatic dissemination, and seeding of the tissue during needle biopsy. Patients may present with symptoms of bowel obstruction, rectal pain or bleeding, and changes in bowel habits typical of rectal tumors without urological symptoms of prostate tumors. Immunohistochemical examination is imperative in making a definitive diagnosis. Treatment methods in prior case reports include chemotherapy, radiation, hormone therapy, and surgical intervention with neoadjuvant ADT. It is not clear if rectal metastasis in prostate adenocarcinoma portends a poor prognosis. Collation of data from these rare cases, including our own, may help define the prognosis and appropriate management of such a metastatic tumor.

335 - BEHÇET DISEASE PRESENTING WITH ACUTE PSYCHOSIS

ObjectivesUsing as a starting point a clinical case, the authors performed a literature review to clarify the relationship between Behçet disease and acute psychosis.MethodsAnalysis of the patient's clinical process and brief review of the latest available literature on the subject, published in PubMed/Medline databases.ResultsMale patient, 55 years old, brought to the emergency room by fever, headache, hetero-aggressive behavior, disinhibited behavior, mood swings, euphoria, persecutory delusions and insomnia, in the last 4 days. He had no insight into his illness. There was no personal or family history of psychiatric illness and toxicological habits were irrelevant. Due to the personal history of posterior uveitis with bilateral macular edema, retinal vasculitis, genital aphthosis, papulo-vesicular lesions and recurrent bipolar aphthosis, the hypothesis of neuro-behçet was raised.ConclusionsBehçet's disease can present with neurological involvement - neuro -behçet - and can manifest itself with several psychiatric symptoms (euphoria, lack of insight, disinhibited behavior, agitation or psychomotor retardation, persecutory delusions, obsessive thoughts, anxiety, depression, insomnia or memory changes). Fever and headache usually appear in the prodromal stage and can be signs of onset or recurrence of the disease. The prevalence of neuro-behçet ranges from 2 to 50% and usually occurs 1 to 10 years after the first symptoms of the disease. Since it appears as the first manifestation of the disease in only 3% of cases, it is difficult to diagnose. The literature suggests that symptoms are generally resistant to treatment with conventional psychotropic drugs and so it is an important cause of morbidity and mortality.”

MULTI-SCALAR TERRITORIALIZATION IN KAZAKHSTAN’S NORTHERN BORDERLAND

Terms used in the study of people/place bonding too often circumscribe thinking to either the most readily conceived and tangibly experienced scale of place – home/neighborhood – or to the most politically prevalent scale of place – the state. In doing so, researchers ignore the influence of places that help constitute identity between and above the aforementioned scales. A more elastic conceptualization of place attachment allows for mutability of place-identities and their capacity to be both multi-sited and varying in scale. With a long history of ethnic Russian habitation from the Tsarist through Soviet eras, the northern oblasts of Kazakhstan emerged as a borderland of potential irredentism akin to eastern Ukraine. Calls for secession and annexation have, however, been minimal thus rendering the region’s amalgam of place identities a ready case for considering relational geographies of borderland place-attachment.

Pedigree Analysis: An Important Diagnostic Tool for Calculating the Risk Factor in Infertile Men of Indian Population

The problem of male infertility is widespread in the modern world and it is of utmost importance to look for risk factors and its early diagnosis so that corrective measures can be taken early on. The pedigree chart analysis is a very important tool in this regard which gives us the pictorial representation of the disease within the family. The research work was conducted in the Department of Research, Jawaharlal Nehru Cancer Hospital, and Research Center. Three-generation medical history of healthy control and infertile subjects were taken by preparing a pedigree chart in the form of pictorial representation. Physical examination was done for the Anthropometrical studies and other sexual inconvenience of the enrolled subjects. In the subjects enrolled for study the prevalence of infertility was found to be significantly high in families having a history of infertility and other habits in their generation line.