INTRODUCTION: Gastric polyps are encountered in approximately 6% of endoscopic procedures. Most of the patients are asymptomatic, some of them can present with complications. We present a rare case of a large hyperplastic polyp resulting in iron deficiency anemia. CASE DESCRIPTION/METHODS: A 57 year-old man with past medical history of diabetes mellitus came in with complaints of 1 week history of dizziness, dyspnea on exertion and fatigue. Associated symptoms included persistent nausea and few episodes of non-bilious, non-bloody emesis. Patient denied melena or hematochezia. He endorsed weight loss of 8 lbs in 4 months. Vitals were grossly stable. Labs significant for Hb 6.7, Hct 23.8, and MCV 62. Patient was subsequently transfused with blood. Iron panel revealed severe iron deficiency with serum Iron 10, TIBC 443, Ferritin 4.6, Transferrin saturation 10. Colonoscopy was unremarkable however EGD revealed a large ulcerated polypoid mass, measuring about 10 to 15 cm in antrum concerning for early carcinoma. Pathology returned positive for hyperplastic polyp with no signs of dysplasia. Based on the large size of polyp, partial gastrectomy was done. On follow up, Hb increased and pt reported clinical improvement. DISCUSSION: Hyperplastic polyps constitute 75% of all the gastric polyps encountered. Hyperplastic polyps result from hyperplasia of epithelium secondary to chronic gastritis. Usually they range from 0.5 to 2 cm. About 1.4% of these polyps can reach a size large enough to cause iron deficiency anemia secondary to chronic bleeding. The risk of malignancy increases with size >1 cm and require surgical resection. Yun et al reported a rare case of 1.5 cm hyperplastic polyp which was a cause of iron deficiency anemia. We describe a case of a large 10-15 cm hyperplastic polyp causing GI bleeding subsequently resulting in iron deficiency anemia. We recommend that physicians should be aware of this rare complication as polypectomy will benefit therapeutically in preventing future complications such as chronic bleeding.