Reconstruction Of History Research Articles

Re-heating the “First” Thanksgiving: the Thanksgiving episode as settler colonial narrative

Thanksgiving-themed episodes of cooking television open up questions about the interrelations of food, history, power, and culture. This study addresses such questions through textual and thematic analysis of 46 Thanksgiving-themed episodes of reality cooking competition programmes on US cable TV, exploring how the Thanksgiving episode operates as a site for the deployment of the culinary as a category by which the past is re/created. I argue that the Thanksgiving episode represents history through two frames: “tradition” and “reenactment.” Reading the Thanksgiving episode as a site of history's reconstruction illuminates popular media's involvement in the socio-historical-political machinery of contemporary life.

Virtual histology based on 3D X-ray microscopy imaging for non-destructive age-at-death estimation of incinerated teeth from the Tophet of Motya (Sicily, 6th century BC)

The reconstruction of infant biological history and mortality profiles provides biocultural insights into adulthood morbidity, maternal health, parental caregiving practices, and social dynamics. However, interpreting biological data from cremated infant remains in archaeological contexts can be challenging due to their often poor preservation and potential biases. Tophets, sanctuaries for distinct burial of cremated infant remains present in several Phoenician-Punic colonies in the Mediterranean area, offer an ideal case study. This study presents the first virtual histology performed in X-ray Microscopy-based imaging (XRM) on a sample of crowns of cremated deciduous teeth from the Tophet of Motya (Sicily, 6th century BC). The observation of the Neonatal Line (NL) in enamel tissue offers important informations on the community demographic profile, age-at-death classes and life-histories of the buried individuals. Results are consistent with previous studies on other human remains found in the main Tophets in Mediterranean basin and highlight the importance of using non-invasive techniques to collect and analyse data that are useful for the interpretation of newborns and infants burial practices.

A reference genome for the Harpy Eagle reveals steady demographic decline and chromosomal rearrangements in the origin of Accipitriformes

The Harpy Eagle (Harpia harpyja) is an iconic species that inhabits forested landscapes in Neotropical regions, with decreasing population trends mainly due to habitat loss, and currently classified as vulnerable. Here, we report on a chromosome-scale genome assembly for a female individual combining long reads, optical mapping, and chromatin conformation capture reads. The final assembly spans 1.35 Gb, with N50scaffold equal to 58.1 Mb and BUSCO completeness of 99.7%. We built the first extensive transposable element (TE) library for the Accipitridae to date and identified 7,228 intact TEs. We found a burst of an unknown TE ~ 13–22 million years ago (MYA), coincident with the split of the Harpy Eagle from other Harpiinae eagles. We also report a burst of solo-LTRs and CR1 retrotransposons ~ 31–33 MYA, overlapping with the split of the ancestor to all Harpiinae from other Accipitridae subfamilies. Comparative genomics with other Accipitridae, the closely related Cathartidae and Galloanserae revealed major chromosome-level rearrangements at the basal Accipitriformes genome, in contrast to a conserved ancient genome architecture for the latter two groups. A historical demography reconstruction showed a rapid decline in effective population size over the last 20,000 years. This reference genome serves as a crucial resource for future conservation efforts towards the Harpy Eagle.

Dynamics of Structures and Historical Reconstruction of the Albazin Fort on the Amur River

Dynamics of Structures and Historical Reconstruction of the Albazin Fort on the Amur River

Climatic controls of fire activity in the red pine forests of eastern North America

Large-scale modes of climate variability influence forest fire activity and may modulate the future patterns of natural disturbances. We studied the effects of long-term changes in climate upon the fire regime in the red pine forests of eastern North America using (a) a network of sites with dendrochronological reconstructions of fire histories over 1700–1900 A.D., (b) reconstructed chronologies of climate indices (1700–1900), and (c) 20th century observational records of climate indices, local surface climate and fire (1950s-2021). We hypothesized that (H1) there are states of atmospheric circulation that are consistently associated with increased fire activity, (H2) these states mark periods of increased climatological fire hazard, and (H3) the observed decline in fire activity in the 20th century is associated with a long-term decline in the frequency of fire-prone states.At the annual scale, years with significantly higher fire activity in the reconstructed and modern fire records were consistently associated with the positive phases of the Pacific North American pattern (PNA), either independently or in combination with the positive phase of the El Niño-Southern Oscillation index (ENSO). During years with both ENSO and PNA in their positive state, the region experienced positive mid-tropospheric heights and temperature anomalies resulting in drought conditions. The fire-prone climate states identified in the reconstructed records became less frequent in 1850 but re-emerged in the 20th century. While our study did not demonstrate a direct influence of climate on the observed decrease in fire activity in the 20th century, it does reveal a clear climate signal embedded within the fire history reconstruction of the region over the past centuries. This study underscores the importance of considering large-scale climatic patterns in understanding historical fire regimes and highlights their role for future fire dynamics in the region and shaping ecological effects of future fires.

Pollen atlas and morphological analysis of the selected types from southeastern Tibet, China

The accuracy of fossil pollen identification is crucial for understanding past plant diversity, vegetation landscape and associated climate change, while dispersed/fossil pollen assignments heavily rely on how robust modern pollen reference is. There is high species richness in southeastern Tibet, China, however, pollen morphological studies in this area are still poorly documented. Here, we present pollen atlas of 57 species (40 genera, 22 families) collected from the Ranwu Lake Basin. Pollen grains were imaged with light microscope (LM, 100X oil-immersion objective lens) and scanning electron microscope (SEM). All pollen types are ordered and presented according to different aperture types and sculpture patterns, facilitating comparison with fossil pollen. Moreover, we selected some representative species mainly based on potential palaeoecological importance, including Sibiraea (Rosaceae), Koenigia cathayana (Polygonaceae), Stellera chamaejasme (Thymelaeaceae), Hordeum vulgare subsp. vulgare and Poa annua (Poaceae), to discuss their pollen identification characteristics for the first time and assess potential applications in Quaternary palaeoecological interpretation. This study enriches modern pollen atlas for Quaternary pollen analysis in the study area and the adjacent regions. Our results provide robust modern reference in pollen-based reconstruction of vegetation history, palaeoclimate and palaeoenvironment, and tracing pollen signal of local human activities as well.

Reconstructive evolutionary morphology: Tracing the historical process of modifications of complex systems driven by natural selection through changing ecological conditions.

There is general consensus among evolutionary biologists that natural selection drives phenotypic modifications within populations over generational time. How to reconstruct this historical process, however, has been discussed mostly in theoretical terms, and recommendations and explanations on how to translate such theoretical insights into practice are needed. The present study aims at providing a theory-supported practical guide on how to reconstruct historical evolutionary processes by applying a morphology-centered approach through a series of interdependent steps of descriptive morphology, functional analysis, ecological observation, integration of paleoecological data, and evolutionary synthesis. Special attention is given to the development of tests regarding the accuracy, closeness to reality, and plausibility of the hypotheses at every level of the reconstructive process. This morphology-centered approach had its beginnings in the wake of the evolutionary synthesis and is part of the scientifically necessary process of reciprocal testing of hypotheses generated by different methods and data for the reconstruction of evolutionary history.

Forward and inverse river contaminant transport modeling using group preserving scheme

Environmental concerns have necessitated the development of computational models predicting pollutant dispersion in natural water systems. Due to the ill-posed nature of the inverse contaminant transport equation, solving this equation using all stable and convergent inverse methods is impossible. Factors such as river geometry, unsteady and non-uniform flow, and tidal influences add to the complexity of the inverse problem. These factors have prompted the evaluation of Group Preserving Scheme for environmental applications. The inverse solution method derives a general equation for solving ordinary differential equations by addressing a dynamical system at negative time steps, ensuring convergence. Three test cases have been presented to evaluate Backward Group Preserving Scheme (BGPS). These have included validation using observational data from Missouri River, inverse simulation in a tidal river, and sensitivity analysis of parameters such as pollutant patterns, advection, dispersion, and decay coefficients. The dataset includes calibrated data from Missouri River, which demonstrated high accuracy, with Mean Relative Error (MRE) ranging from 2.8% to 5.0% for the inverse model. Under tidal conditions, accuracy decreases over time but remains robust, with a Nash–Sutcliffe efficiency of 0.77–0.96 and an MRE of 0.9%–5.9%. Sensitivity analysis revealed optimal model performance for Péclet numbers greater than 500. The model performed best with gradual, wide-peaked pollutant patterns and moderate decay rates (Damköhler number between 5 and 10). BGPS proves effective for transport simulation and concentration history reconstruction in complex rivers, including those with tidal influences, offering a robust tool for water contamination analysis in various flow conditions.

Additive manufacturing of novel aluminium matrix composites with enhanced strength and processability via boron nitride functionalization

The present work systematically investigates the effects of BN nanopowder functionalization on the processability, microstructure and tensile response of the custom Powder Bed Fusion Laser Beam (PBF-LB) Al alloy ‘AMALLOY3D’. The results show that a minor addition of BN (0.3% by weight) not only produces near fully dense parts (99.91%), but is also paired with improved flowability, enhancing the overall processability. Electron backscatter diffraction (EBSD) analysis revealed the transformation to a fully equiaxed grain structure in the BN-functionalized material, resulting in a 40% increase in yield strength. Energy dispersive spectroscopy using a scanning transmission electron microscope (STEM-EDS) was employed to reveal the intricate secondary phases’ arrangements. These observations coupled with the help of the CALPHAD approach led to the reconstruction of the solidification history of AMALLOY3D and the BN-functionalized material. The present study unravels the complex dynamics leading to the columnar-to-equiaxed transition in BN-reinforced AMCs, proving that such unique microstructures and exceptional tensile properties can be achieved without compromising PBF-LB processability.

First multi-proxy chronostratigraphy of the lower Cambrian Byrd Group, Transantarctic Mountains and correlation within East Gondwana

Antarctica and Australia were sutured together at the equator during the major pulse of animal biodiversification associated with the Cambrian radiation. However, the lack of detailed systematic chemostratigraphic and biostratigraphic sampling of lower Cambrian sedimentary successions from Antarctica has significantly impeded precise age determination and correlation with Cambrian strata on other palaeocontinents. This study is the first to present integrated, simultaneously sampled biostratigraphic and chemostratigraphic (δ13C isotopes) data from the same measured stratigraphic sections through the lower Cambrian Byrd Group in the Transantarctic Mountains. Shelly fossil assemblages (brachiopods, tommotiids, molluscs, bradoriids, trilobites) from the Holyoake Range and Churchill Mountains facilitate direct correlation with the Dailyatia odyssei Zone of South Australia (Cambrian Stages 3–4), and trilobites provide strong correlation between the Starshot Formation and the Cymbric Vale Formation in western New South Wales. A new ID-TIMS radiometric date of 514.96 ± 0.16 Ma from a tuff in the lower Cymbric Vale Formation is similar to dates from tuff beds in the Third Plain Creek Member of the Mernmerna Formation in the Flinders Ranges, providing an important absolute-age tie point between these lower Cambrian successions. Chemostratigraphic data from the upper Shackleton Limestone in the Holyoake Range capture a negative δ13C excursion that can be correlated to negative values within the multi-peaked MICE (cycles V–VIII in Siberia). Integrated faunal and chemostratigraphic data indicate a Cambrian Stages 3–4 age, giving robust chronostratigraphic context for the upper Shackleton Limestone–Holyoake Formation–Starshot Formation succession for the first time, permitting reconstruction of the depositional history of the lower Cambrian of Antarctica and global correlation of Byrd Group strata.

Temperature history reconstruction in steel box girders using limited data and proper orthogonal decomposition-based dimension reduction representation

The monitoring temperature history of steel box girders inevitably contains gaps or anomalies due to the malfunctions of the structural health monitoring system. Traditional methods for reconstructing temperature histories face the challenge in accounting for the randomness of temperature variations caused by the uncertainty of complex environmental factors. This research proposes a framework for reconstructing the long-term temperature of steel box girders by combining the limited measurements with a proper orthogonal decomposition (POD) based dimension reduction representation approach, to account for the stochastic nature of daily temperature variations. Unlike the conventional Monte Carlo-based POD method, the developed POD-based dimension reduction representation approach effectively reduces the number of elementary random variables from thousands to two by introducing random functions serving as constraints, overcoming the challenge of high-dimensional random variables inherent in the Monte Carlo methods. The proposed approach divides the measured temperature histories into random high-frequency (HF) and deterministic low-frequency (LF) components and establishes the theoretical models of power spectral density and coherence functions of HF temperature components to accommodate the generation of HF temperature component samples, and finally reconstructs temperature samples by superimposing the LF components and generated HF component samples. The results from a practical example demonstrate that the statistical characteristics of representative HF temperature component samples generated by the POD-based dimension reduction representation align well with the corresponding targeted values, and the proposed method outperforms the traditional POD method, yielding a 60% efficiency enhancement without compromising computational accuracy. The developed framework owns apparent superiority in accuracy compared to the traditional POD and the long short-term memory methods, particularly in continuous and extensive missing data. Moreover, the reconstructed temperature samples with assigned probabilities present complete probability information from the level of total probability. These results advance the probabilistic methods in tackling long-term temperature history reconstruction.

Melting of Totten Glacier, East Antarctica since the Last Glacial Maximum Revealed by Beryllium Isotope Ratios of Marine Sediment

The Totten Glacier of East Antarctica drains a basin containing about 3.5 m of sea-level rise equivalent ice. While Totten Glacier is generally considered somewhat more stable than the rapidly retreating sectors of the West Antarctic Ice Sheet, such as the Amundsen Sea Embayment and Getz Ice Shelf, our understanding of its intricate dynamics and interaction with the Southern Ocean since the Last Glacial Maximum remains incomplete. Situated in a precarious position grounded below sea level, Totten Glacier represents a critical yet enigmatic component of East Antarctic ice dynamics. Its susceptibility to marine ice sheet instability raises concerns, as positive feedback from grounding line retreat could trigger irreversible ice discharge or even complete collapse. A meticulous reconstruction of the retreat history of the Totten Glacier is imperative to comprehensively grasp the glacier's response to present and future climate changes.Here, we present a beryllium isotope ratio analysis of marine sediment from the continental slope proximal to Totten Glacier, the first such record from this location, supplemented by grain size data from the same sediment core. The results, when evaluated together with nearby proxy records, reveal that the initial deglaciation of the Totten Glacier sector of the East Antarctic Ice Sheet began at ca. 21 ka BP. The rapid deglaciation from ca. 7 ka BP that followed is determined to be caused by the intrusion of modified Circumpolar Deep Water, leading to melting at the grounding zone of the Totten Glacier and causing instability of the glacier system. The southward shift and intensification of Antarctic easterlies may be one of the causes of this intrusion. These results contribute to the body of knowledge regarding the dynamical response of marine-terminating glaciers to climate variability during the last deglaciation.

Freshwater crabs from Crete: a unique key for the reconstruction of the biogeographical history of Potamon Savigny, 1816 (Brachyura, Potamidae) in the Aegean region

Abstract The Aegean region is biogeographically complex for freshwater crabs of the genus Potamon Savigny, 1816. Especially Potamon kretaion Giavarini, 1943 has a remarkably different distribution pattern compared to its congeners: With its exclusive occurrence on the island of Crete, it is the only Potamon species that is endemic to an Aegean island, and its range is geographically disjunct from its sister group, including Potamon ibericum (Bieberstein, 1809) and Potamon bilobatum Brandis, Storch and Türkay, 2000, with a Ponto-Caspian distribution. In addition, the morphology of the first gonopods differs substantially from that of closely related species. Therefore, the aim of this study was to (1) develop a new plausible hypothesis for the dispersal history of the genus Potamon into the Aegean area based on a re-analysis of gonopodal characters and existing phylogenetic data, and under consideration of recent palaeogeographical hypotheses, and (2) test whether the first gonopods of P. kretaion — being substantially different from its closest relatives — represent the ancestral or derived character state within Aegean Potamon. The results revealed a close link between the distribution of freshwater crabs and the biogeographical history of the Aegean region and that P. kretaion shows plesiomorphic characteristics of the first gonopods. These findings indicate that the original population of Pontipotamon (including P. kretaion) was isolated on Crete about 9 Mya, spread northwards during the Messinian salinity crisis and was separated in the original populations of P. kretaion and P. ibericum by the flooding of the Mediterranean Sea 5.33 Mya.

Classifying Cockroaches According to Forewings: Pitfalls and Implications for Fossil Systematics

A reliable character system is crucial to taxonomy and systematics, and it promises valid downstream inferences, e.g., estimates of diversity and disparity, reconstruction of evolutionary history, and even stratigraphic correlations. Modern taxonomy and systematics of extant cockroaches requires an integrative study involving multiple lines of evidence with emphasis on genital and reproductive characteristics and molecular data. In contrast, many fossil cockroach taxa published recently are based solely on forewings. Many studies have shown that forewing-based taxa are questionable. In order to find out how much of the phylogenetic signal we could ascertain from venational similarity, and how confident we could be, this study used forewing characters to reconstruct phylogenies of the genera of well-recognized family-group taxa. The intuitively reconstructed phylogeny of 75 extant genera failed to recover those taxa or their relationships. Parsimony analyses of various datasets all yielded strong polyphyly and chaotic relationships. In conclusion, the forewing of cockroaches is not a universally competent character system. The underlying causes are the complicated nature of veins and the limitations of current analytical techniques. The uncertainty in forewing-based taxonomy and systematics has been underestimated in the literature. Forewing-based fossil taxa warrant re-evaluation; some of them are herein deemed nomina dubia in their current state.

History and the Development of Historical Scholarship in Africa

Abstract How has historical scholarship fared in Africa? What is the state of decolonization and deconstruction historiography in the production of historical knowledge on the continent? What role does the state play in aiding or undermining historians’ access to official historical data and the production of historical knowledge in postcolonial Africa? This article engages these questions. It harps on the reconstruction of African intellectual history as a daunting postcolonial challenge, and argues that historians on Africa need to engage with and reexamine the development of the discipline of history in Africa in relation to the debates on decolonization and the enterprise of history-writing in the production of historical knowledge and historical scholarship across the continent. This illuminates the understanding of the history of contemporary Africa. It also throws fresh light on the continent’s remote past as a way of establishing its connections with the present. Complementary to the problems of writing the history of contemporary Africa, this work argues that to appreciate and understand the problems of history-writing on Africa, we need to focus on the development and limitations of the discipline across the institutional sites of the universities in postcolonial Africa.

Semi-automated minimization of brick-mortar segmentation errors in 3D historical wall reconstruction

In current practices of geometric modeling and building information modeling (BIM) of architectural heritage, point cloud data acquired from site surveys is segmented into parts that correspond to actual building elements. Deep learning methods are used to automate the segmentation processes; however, each historical building presents unique challenges due to distinct construction techniques, irregular applications, deformations, and wear on the surveyed surfaces, and due to these peculiarities, segmented point cloud data may display local errors in the detection of individual architectural elements. This paper presents a method for post-processing segmented point cloud data to semi-automatically detect building elements such as bricks in historical walls. Results show that this approach, which involves testing neighborhoods of points and classified areas to identify and correct misclassified points, diminishes segmentation errors and reconstructs bricks close to their original form.

Population genetic structure and demographic history reconstruction of introduced flathead catfish (Pylodictis olivaris) in two US Mid-Atlantic rivers.

Population genetic analysis of invasive populations can provide valuable insights into the source of introductions, pathways for expansion, and their demographic histories. Flathead catfish (Pylodictis olivaris) are a prolific invasive species with high fecundity, long-distance dispersal, and piscivorous feeding habits that can lead to declines in native fish populations. In this study, we analyse the genetics of invasive P. olivaris in the Mid-Atlantic region to assess their connectivity and attempt to reconstruct the history of introduced populations. Based on an assessment across 13 microsatellite loci, P. olivaris from the Susquehanna River system (N = 537), Schuylkill River (N = 33), and Delaware River (N = 1) have low genetic diversity (global Hobs = 0.504), although we detected no evidence of substantial inbreeding (FIS = -0.083 to 0.022). P. olivaris from these different river systems were genetically distinct, suggesting separate introductions. However, population structure was much weaker within each river system and exhibited a pattern of high connectivity, with some evidence of isolation by distance. P. olivaris from the Susquehanna and Schuylkill rivers showed evidence for recent genetic bottlenecks, and demographic models were consistent with historical records, which suggest that populations were established by recent founder events consisting of a small number of individuals. Our results show the risk posed by small introductions of P. olivaris, which can spread widely once a population is established, and highlight the importance of prevention and sensitive early detection methods to prevent the spread of P. olivaris in the future.

Colexification of “thunder” and “dragon” in Sino-Tibetan languages

ABSTRACT This paper explores the colexification of “thunder” and “dragon” in languages spoken in the Qinghai-Tibetan region. A sample of 372 languages from Sino-Tibetan, Dravidian, Indo-European, Mongolic-Khitan, Tungusic, and Turkic was collected. These languages were classified into colexifying and dislexifying languages, depending on whether the two concepts are associated with shared lexical forms. The findings reveal that 47 languages in the sample exhibit thunder-dragon colexification; most of them are Bodic and Na-Qiangic languages, with a few Sinitic, Mongolic, and Turkic languages. This areal pattern results from both inheritance and language contact. For the latter factor, Tibetan influence plays a significant role, as evidenced by the borrowing observed in non-Bodic languages. The linguistic boundary of thunder-dragon colexification aligns with the territory of the historical Tibetan Empire. Moreover, based on historical linguistic reconstruction from Old Chinese, the colexification is a likely feature of Proto-Sino-Tibetan, well preserved in Bodic languages but lost in Sinitic ones. However, some modern Sinitic dialects, particularly the Wu dialects, still maintain the relic connection between “dragon” and “lightning.” Finally, the findings suggest that thunder-dragon colexification originated from North China, and dragon is the mythologized form of thunder and lightning by the Proto-Sino-Tibetan people during the Neolithic period.

Evolution of megadrought and pluvial events in the Qaidam Basin and Hexi Corridor, Northwest China, during the period 455–2100 CE

AbstractMillennium‐long hydroclimate reconstructions in the Qaidam Basin (QB) and Hexi Corridor (HXC) suggest markedly differing moisture change trends between the two regions in the 20th century; however, it remains unclear whether these current moisture states are exceptional in a long‐term context, and how megadrought and pluvial events have evolved in these regions. Here, we used previously published historical hydroclimate reconstructions combined with model‐based future moisture simulations to assess past, current and future hydroclimate anomalies in a long‐term context (i.e., 455–2100 CE), and investigate the evolution of megadrought and pluvial events. Compared with the QB, moisture variability in the HXC was higher and more prone to the occurrence of severe and long‐lasting megadrought and pluvial events. Megadroughts in the QB mainly occurred in the Little Ice Age (1200–1800 CE) accompanied by lower temperatures, whereas in the HXC, megadroughts mostly occurred during the Medieval Climate Anomaly (800–1200 CE) accompanied by higher temperatures. The Significant Zero crossing of derivatives (SiZer) and Time of Emergence (TOE) analyses were used to reveal the initiation of recent humidity changes and the duration above the natural variability threshold. We found that the QB has experienced a significant wetting trend since the middle of the 20th century, with this trend exceeding the range of natural hydroclimate variability in 1975 CE. The HXC became drier from the early 20th century, but has become wetter since the late 20th century; this trend may exceed the natural hydroclimate variability range by 2032 CE. We also found that the duration and severity of megadrought and pluvial events are positively correlated in each region. Given the higher past hydrological variability in the HXC compared with the QB, our study implies that future extreme hydrological events are more likely to occur in the former of these two regions.

Identification of Novel Potential Predisposing Variants in Familial Acute Myeloid Leukemia.

Myeloid neoplasms, including acute myeloid leukemia, have been traditionally among the less investigated cancer types concerning germline predisposition. Indeed, myeloid neoplasms with germline predisposition are challenging to identify because often display similar clinical and morphological characteristics of sporadic cases and have similar age at diagnosis. However, a misidentifications of familiarity in myeloid neoplasms have a critical impact on clinical management both for the carriers and their relatives. We conducted a family segregation study, in order to identify novel cancer predisposing genes in myeloid neoplasms and classify novel identified variants. We performed a thorough genomic analysis using a large custom gene panel (256 genes), the Myelo-Panel, targeted on cancer predisposing genes. In particular, we assessed both germline and somatic variants in four families, each with two siblings, who developed hematological neoplasms: seven acute myeloid leukemia and one Philadelphia-positive chronic myeloid leukemia. In each family, we identified at least one novel potentially predisposing variant, affecting also genes not included in the current European LeukemiaNet guidelines for AML management. Moreover, we suggest reclassification of two germline variants as pathogenic: likely pathogenic p.S21Tfs*139 in CEPBA and VUS p.K392Afs*66 in DDX41. We believe that predisposition to hematological neoplasms is still underestimated and particularly difficult to diagnosed. Considering that misidentification of familiarity in myeloid neoplasms have a critical impact on the clinical management both for the carriers and their relatives, our study highlights the importance of revision, in this clinical context, of clinical practices that should include thorough reconstruction of family history and in-depth genetic testing.