Background: Gastrointestinal tumors make a large proportion of the neoplasms. The histological types of tumor at different gastrointestinal site also differ by incidence and prognosis. Cancer is a major cause of morbidity and mortality, with approximately 18 million new cases and 9.5 million cancer related deaths in 2018. Histopathology is the gold standard for the diagnosis and early diagnosis leads to good prognosis. Material and Method: The present study was conducted in Histopathology section, Pathology department, Government Medical College, Bhavnagar after getting approval from Scientic research committee and Ethical committee. Received specimen were studied grossly and after tissue processing microscopic examination was noted from the slides prepared. Data was recorded and analysis was done using Epi info software. 111 Result: specimens were studied. Out of which, maximum cases were in the age group of 21-40 years(29.73%). Majority were females (69.37%). The most common were non-neoplastic lesions (91.29%) and among them appendicitis was most common (55.86%). Malignancy was found in 4.50% and adenocarcinoma was the most common diagnosis. The most common lesion in our s Conclusion: tudy was non-neoplastic lesion.Acute appendicitis was found to be the most common non-neoplastic lesion and among malignant lesion, most common was adenocarcinoma. Early detection of suspected lesions by biopsy for histopathological examination is helpful for timely diagnosis, better management and good prognosis.