Persons with profound visual impairments and other disabilities, such as neuromotor and intellectual disabilities, may encounter serious orientation and mobility problems even in familiar indoor environments, such as their homes (Joffee & Rikhye, 1991; Lancioni & Oliva, 1999; Lancioni et al., 2007, 2008; Uslan, Russell, & Weiner, 1988). Teaching these persons to develop maps of their daily environment, using miniature replicas of the areas or some landmarks as orientation cues, may be difficult (Emerson & Corn, 2006; Joffee, 1995; Lancioni et al., 2007; Martinsen, Tellevik, Elmerskog, & Storlilckken, 2007). The difficulty may be even greater when the persons are in wheelchairs and thus have limited opportunities to explore the surrounding space and related cues (Lancioni et al., 2007). A potentially effective alternative to the aforementioned maps could be the use of orientation technology, specifically, orientation systems that rely on directional cues (Lancioni et al., 2007; Uslan et al., 1988). These systems are intended to guide or direct persons to their destinations without requiring spatial or travel abilities other than those of orienting to the sources that are providing cues (Lancioni et al., 2007, 2008). Although such systems can be useful, efforts are needed to enhance their flexibility and simplicity so that they can more easily suit different environmental and personal situations (Scherer, Sax, Vanbiervliet, Cushman, & Scherer, 2005). Recently, we designed a system to be simpler than previous systems. It uses cues only at destinations (that is, a single sound source per destination) and involves a portable, electronic control device with keys to activate the cues at the sources or destinations. Two participants with multiple disabilities used the system successfully (Lancioni et al., 2008). The current study assessed such a system with a wheelchair user, a woman, with minimal residual vision and a moderate intellectual disability. Contrary to the aforementioned participants, the wheelchair user described in this report could not efficiently find doors to rooms by following the walls of a room or corridor with her hand. Moreover, she could not discriminate and use the keys of the control device. To deal with these disadvantages, we marked the doors to rooms with orange lights and used a larger control device with wider keys for activating destinations. The keys for activating the destinations were covered with small (discriminated) objects representing the activities that were available at the destinations; these objects were encircled with light-emitting diodes. The diodes on a key remained illuminated until that key was selected. METHOD Participant The participant (Gloria) was 27 years old and in a wheelchair, which she could slowly propel on her own, because of her spastic tetraparesis and hip problems. She also had optic nerve atrophy and minimal residual vision, so she could see objects at a distance of about 1 meter (approximately 3 feet) and light sources at a distance of about 2 meters (approximately 6.5 feet) (Morse, Teresi, Rosenthal, Holmes, & Yatzkan, 2004). She was rated as having a moderate intellectual disability with a verbal IQ score of 47 on the Wechsler Adult Intelligence Scale. Gloria could understand and produce simple sentences about daily events and persons. Her age equivalent for daily living skills was lower than 3 years on the Vineland Adaptive Behavior Scales-Interview Edition (Sparrow, Balla, & Cicchetti, 1984). Gloria was known for her orientation problems and her reliance on staff for reaching relevant destinations within her daily environment. She lived at home with her parents and attended a day activity center, where she engaged in vocational activities such as assembling key holders and wool decorations, and in leisure activities. Approval for this study was granted by the Scientific and Ethics Committee of the Lega F. …