Hip Geometry Research Articles

Genetic variation in the LRP4 gene influences bone mineral density and hip geometry

Genetic variation in the LRP4 gene influences bone mineral density and hip geometry

Genetic variation near the GDF5 gene is associated with hip geometry

Genetic variation near the GDF5 gene is associated with hip geometry

Genetic variation in secreted frizzled related protein 4 (sFRP4) is associated with femoral neck BMD and hip geometry parameters in Danish men — Results from the Odense Androgen Study

Genetic variation in secreted frizzled related protein 4 (sFRP4) is associated with femoral neck BMD and hip geometry parameters in Danish men — Results from the Odense Androgen Study

Knee and hip joint forces – sensitivity to the degrees of freedom classification at the knee

Previous research has demonstrated that the number of degrees of freedom (DOF) modelled at a given joint affects the antagonistic muscle activity predicted by inverse dynamics optimization techniques. This higher level of muscle activity in turn results in greater joint contact forces. For instance, modelling the knee as a 3 DOF joint has been shown to result in higher hip and knee joint forces commensurate with a higher level of muscular activity than when the knee is modelled with 1 DOF. In this study, a previously described musculoskeletal model of the lower limb was used to evaluate the sensitivity of the knee and hip joint contact forces to the DOF at the knee during vertical jumping in both a 1 and a 3 DOF knee model. The 3 DOF knee was found to predict higher tibiofemoral and hip joint contact forces and lower patellofemoral joint contact forces. The magnitude of the difference in hip contact force was at least as significant as that found in previous research exploring the effect of subject-specific hip geometry on hip contact force. This study therefore demonstrates a key sensitivity of knee and hip joint contact force calculations to the DOF at the knee. Finally, it is argued that the results of this study highlight an important physiological question with practical implications for the loading of the structures of the knee; that is, the relative interaction of muscular, ligamentous, and articular structures in creating moment equilibrium at the knee.

A formula to predict patients’ gluteus medius muscle volume from hip joint geometry

The volume of the gluteus medius muscle (GMV) has been shown to be closely related to hip joint function. A defined relation between joint geometry and GMV would allow a calculation of the patient-specific GMV providing reference values to individually determine the goals for rehabilitation programs after total hip arthroplasty (THA).The aim of this study was to investigate correlations between hip geometry and GMV.One hundred and two (50 female, age: 58.53 (18–86)) pelvic computed tomography (CT) scans were analyzed to determine femoral offset (FO), body weight lever arm (BWLA) and the GMV. Relationships between demographic data, FO and GMV were analyzed using correlation and regression analysis.The mean GMV was found to be 289±72cm3, the mean FO measured was 4.14±0.55cm; and the mean value for BWLA measured was 8.88±0.4cm. A formula to calculate the GMV with a good coefficient of determination (R2=0.681) (p<0.0001) was derived.In conclusion, the formula obtained predicts individual GMV with good model fit and could be used to individually determine rehabilitation goals. Moreover, the correlation found could account for a hand in hand development of FO and GMV during growth and a continuous functional relationship thereafter.

Recent progress in bone imaging for osteoporosis research

Advances in bone imaging techniques have provided tools for analyzing bone structure at the macro-, micro- and nano-level. Quantitative assessment of macrostructure can be achieved using dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), particularly volumetric quantitative CT (vQCT). In vivo quantitative techniques for assessing the microstructure of trabecular bone non-invasively and non-destructively include high-resolution CT (HR-CT) and high-resolution magnetic resonance (HR-MR). Compared with MR imaging, CT-based techniques have the advantage of directly visualizing the bone in the axial skeleton, with high spatial resolution, but the disadvantage of delivering a considerable radiation dose. Micro-CT (μCT), which provides a higher resolution of the microstructure and is principally applicable in vitro, has undergone technological advances such that it is now able to elucidate the physiological skeletal change mechanisms associated with aging and determine the effects of therapeutic intervention on the bone microstructure. In particular, synchrotron μCT (SR-CT) provides a more detailed view of trabecular structure at the nano-level. For the assessment of hip geometry, DXA-based hip structure analysis (HSA) and CT-based HSA have been developed. DXA-based HSA is a convenient tool for analyzing biomechanical properties and for assuming cross-sectional hip geometry based on two-dimensional (2D) data, whereas CT-based HSA provides these parameters three-dimensionally in robust relationship with biomechanical properties, at the cost of greater radiation exposure and the lengthy time required for the analytical procedure. Further progress in bone imaging technology is promising to bring new aspects of bone structure in relation to bone strength to light, and to establish a means for analyzing bone structural properties in the everyday clinical setting.

Calcium Plus Vitamin D Supplementation Has Limited Effects on Femoral Geometric Strength in Older Postmenopausal Women: The Women’s Health Initiative

Calcium plus vitamin D (CaD) supplementation has a modest but significant effect on slowing loss of femoral bone mass and reducing risk of hip fractures in adherent postmenopausal women. The goal of this study was to determine if CaD supplementation influences hip structural parameters that are associated with fracture risk. We studied 1,970 postmenopausal women enrolled in the Women's Health Initiative randomized controlled trial of CaD at one of three bone mineral density (BMD) clinical centers. Hip structural analysis software measured BMD and strength parameters on DXA scans at three regions: femoral narrow neck, intertrochanter, and shaft. Random effects models were used to test the average differences in hip BMD and geometry between intervention and placebo. There was greater preservation of hip BMD at the narrow neck with CaD relative to placebo across 6 years of intervention. CaD also altered the underlying cross-sectional geometry at the narrow neck in the direction of greater strength, with small increases in cross-sectional area and section modulus and a decrease in buckling ratio with CaD relative to placebo. While trends at both the intertrochanter and shaft regions were similar to those noted at the narrow neck, no significant intervention effects were evident. There was no significant interaction of CaD and age or baseline calcium levels for hip structural properties. CaD supplementation is associated with modest beneficial effects on hip structural features at the narrow neck, which may explain some of the benefit of CaD in reducing hip fracture risk.

Age trends for hip geometry in Chinese men and women and the association with femoral neck fracture

Hip dual-energy X-ray absorptiometry (DXA) images were used to calculate hip bone mineral density (BMD) and hip geometry parameters of 18,502 healthy Chinese people (14,435 women and 4,067 men), 254 subjects sustained a femoral neck fracture and 254 age- and sex-matched controls. Our study showed that thinning of the cortical shell and deterioration of the strength index (SI) in femoral neck with aging in both Chinese men and women. SI may be a risk factor for hip fracture in Chinese women. The purpose of this study was to evaluate age-related trends in the hip geometry of healthy Chinese men and women and to examine whether changes in hip geometric parameters is one of the risk factors of hip fracture. We recruited 14,435 women and 4,067 men as the study population. There were 254 subjects (216 women, 38 men) who had sustained a femoral neck fracture; 254 age- and sex-matched healthy persons served as controls. Hip DXA images were used to calculate hip BMD and hip geometry parameters, including the hip axis length (HAL), cross-sectional moment of inertia (CSMI), cross-sectional area (CSA), neck-shaft angle (NSA) and femoral SI. Hip BMD, CSMI, CSA and SI showed significantly negative correlations with age. However, after adjustment for height and weight, HAL increased with age, and there was no strong correlation between CSMI and age in either sex. In both genders, hip BMD and CSA were significant lower in fracture cases compared with controls. After adjustment for hip BMD, in women only smaller SI (odds ratio [OR] 1.53; 95% confidence interval [CI], 1.04-2.26) was predictive of hip fracture but in men, none of the geometry parameters was associated with hip fracture risk. This study demonstrated thinning of the cortical shell and deterioration of the resistance to bending and SI with aging in femoral neck in Chinese men and women. SI may be a risk factor for hip fracture that is independent of BMD measurement in Chinese women.

Bone Integration of New “Stemless” Hip Implants (Proxima Vs. Nanos). A DXA Study: Preliminary Results

The development of short femoral prostheses has the advantage to preserve bone and soft tissues, restore hip geometry, permit mini-invasive techniques and allow quickly return to an active life, but very few studies described bone reaction to these new designed prostheses. The aim of the present study was to evaluate the osseointegration of two different partial neck retained stemless hip prosthesis at one year after surgery, measured by the changes of periprosthetic bone mineral density (BMD) in 5 regions of interest (ROIs) using a dual-energy X ray absorptiometry (DXA) device. The signs of stress-shielding were evaluated by standard radiographs. Thirty-two uncemented primary total hip arthroplasty (THA) patients allocated into 2 groups were evaluated. In the first group (n=19) a Proxima (De-Puy-J&J) hip stem was implanted. In the second group (n=12) a Nanos (Smith & Nephew) hip stem was used. We found that both the implants preserve metaphyseal bone stock and increase periprosthetic BMD. In Nanos prostheses a significant higher BMD values were observed in region of interest (ROI) 3 and 4 (p<0.05). No differences were found in ROIs 1, 2, and 5. Proxima stem seem to produce a physiological strain distribution in the femur. No signs of stress-shielding were present in both the implants. In conclusion, this preliminary DXA analysis showed a physiological integration of both the stems that reproduces the biomechanical stress of proximal femur. New designed short stem implants showed optimal osseointegration after one year, and therefore appears an excellent alternative to traditional long stem hip prostheses.

A Comparison of Two Implant Systems in Restoration of Hip Geometry in Arthroplasty

Restoration of hip offset and leg length during THA is often limited by available implant geometries. The recent introduction of femoral components with a modular junction at the base of the neck (two modular junction components) has expanded the options to restore femoral offset and leg length. We asked (1) whether a femoral component with two modular junctions would predict by templating more frequent restoration of preoperative offset and leg length abnormalities than one with single modular junctions; and (2) how our use of these options compared with national sales data. We retrospectively reviewed the preoperative templating data in 100 primary THAs using single modular junction implants with only a neutral version stem and 100 THAs using two modular junction implants. We compared the frequency with which the desired leg length and offset were completely restored by preoperative templating in the two groups. Offset and leg lengths were restored to within 1 mm in 85% of cases with two modular junction implants and 60% of cases with single modular junction implants. An anteverted or a retroverted neck was used in 25% of cases with the two modular junction stems. The national sales data revealed femoral neck components with version were used in 28% of cases. The use of a femoral component with two modular junctions resulted in more frequent ability to restore femoral offset and leg length than a single modular junction. The advantage of clinical flexibility should be tempered by the potential concerns of prosthetic mechanical failure (which has been reported in another implant system with two modular junctions), increased third-body wear and corrosive debris, and increased prosthetic cost. Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.

Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers

Sports training characterized by impacts or weight-bearing activity is well known to induce osteogenic effects on the skeleton. Less is known about the potential effects on bone strength and geometry, especially in female adolescent athletes. The aim of this study was to investigate hip geometry in adolescent soccer players and swimmers compared to normal values that stemmed from a control group. This study included 26 swimmers (SWIM; 15.9±2years) and 32 soccer players (SOC; 16.2±0.7years), matched in body height and weight. A group of 15 age-matched controls served for the calculation of hip parameter Z-scores. Body composition and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry (DXA). DXA scans were analyzed at the femoral neck by the hip structure analysis (HSA) program to calculate the cross-sectional area (CSA), cortical dimensions (inner endocortical diameter, ED; outer width and thickness, ACT), the centroid (CMP), cross-sectional moment of inertia (CSMI), section modulus (Z), and buckling ratio (BR) at the narrow neck (NN), intertrochanteric (IT), and femoral shaft (FS) sites. Specific BMDs were significantly higher in soccer players compared with swimmers. At all bone sites, every parameter reflecting strength (CSMI, Z, BR) favored soccer players. In contrast, swimmers had hip structural analysis (HSA) Z-scores below the normal values of the controls, thus denoting weaker bone in swimmers. In conclusion, this study suggests an influence of training practice not only on BMD values but also on bone geometry parameters. Sports with high impacts are likely to improve bone strength and bone geometry. Moreover, this study does not support the argument that female swimmers can be considered sedentary subjects regarding bone characteristics.

Age trends for hip geometry in Chinese men and women and the association with femoral neck fracture

Summary Hip dual-energy X-ray absorptiometry (DXA) images were used to calculate hip bone mineral density (BMD) and hip geometry parameters of 18,502 healthy Chinese people (14,435 women and 4,067 men), 254 subjects sustained a femoral neck fracture and 254 age- and sex-matched controls. Our study showed that thinning of the cortical shell and deterioration of the strength index (SI) in femoral neck with aging in both Chinese men and women. SI may be a risk factor for hip fracture in Chinese women.

Age-specific reference values of hip geometric indices from a representative sample of the Japanese female population: Japanese Population-based Osteoporosis (JPOS) Study

We analyzed 2,107 hip dual-energy X-ray absorptiometry (DXA) images from the Japanese Population-based Osteoporosis Study with the Hip Structure Analysis (HSA) program to obtain age-specific reference values of HSA indices for the Japanese female population. These references may help physicians accurately assess HSA results and aid researchers in making interracial comparisons of the indices. Hip geometry is expected to improve hip fracture risk assessment, which is usually assessed by bone mineral density (BMD) alone. We aimed to establish a reference database for Japanese women. We studied 2,107 Japanese women (15-79 years old) with no history of bone metabolism-related diseases from the Japanese Population-based Osteoporosis Study performed in 1996. Hip geometry was conducted on DXA images with the HSA program, which yielded data for cross-sectional area (CSA), subperiosteal diameter (PD), endocortical diameter (ED), mean cortical thickness (CT), section modulus (SM), and buckling ratio at the narrow neck (NN), intertrochanter (IT), and femoral shaft (FS) regions. Mean HSA indices were determined for each 5-year age group after adjustment for height and weight based on most recent Japanese population values. Age-related changes in HSA indices were evident for the 50-54 year group in the NN and IT regions and for the 55-59 year group in the FS region; these changes increased with age thereafter. Age-related changes in CSA and CT were almost identical to that of BMD. Japanese subjects exhibited BMD and CT values similar to those reported for US non-Hispanic white women, but had 16-23% smaller SM values. CSA and CT were highly correlated with conventional BMD, whereas ED, SM, and PD showed lower correlations. Age-specific reference values of HSA indices for the Japanese female population were obtained. This database will form the foundation for accurate HSA result evaluation.

Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents

This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2–L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p < .005 for all, adjusted p < .05). Similar inverse associations were observed in females for all the preceding parameters except WB-BA and L2–L4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors. © 2010 American Society for Bone and Mineral Research.

Hip geometry variation is associated with bone mineralization pathway gene variants: The framingham study

Mineralization of bone matrix is an important process in bone formation; thus defects in mineralization have been implicated in bone mineral density (BMD) and bone structure alterations. Three central regulators of phosphate balance, ALPL, ANKH, and ENPP1, are central in the matrix mineralization process; therefore, the genes encoding them are considered important candidates genes for BMD and bone geometry. To test for an association between these three candidate genes and BMD and bone geometry traits, 124 informative singlenucleotide polymorphisms (SNPs) were selected and genotyped in 1513 unrelated subjects from the Framingham offspring cohort. Initial results showed that SNP rs1974201 in the gene ENPP1 was a susceptibility variant associated with several hip geometric indices, with the strongest p value of 3.8 × 10(7) being observed for femoral neck width. A few modest associations were observed between SNPs in or near ALPL and several bone traits, but no association was observed with ANKH. The association signals observed for SNPs around rs1974201 were attenuated after conditional analysis on rs1974201. Transcription factor binding-site prediction revealed that the HOXA7 binding site was present in the reference sequence with the major allele, whereas this potential binding site is lost in the sequence with the minor allele of rs1974201. In conclusion, we found evidence for association of bone geometry variation with an SNP in ENPP1, a gene in the mineralization pathway. The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation.

Proximal hip geometry and hip fracture risk assessment in a Korean population

The association between proximal femoral geometry and hip fracture risk were investigated. The risk of intertrochanteric fractures increased 1.64-fold and 2.32-fold with 1 standard deviation (sd) increase of hip axis length and neck-shaft angle, respectively, while the risk of femur neck fracture 2.03-fold with 1 sd decrease in femoral head offset. The purpose of this study was to determine the association between proximal femoral geometry (PFG) and the risk of hip fracture in femur neck (FN) and intertrochanteric (IT) fractures in a Korean population. The study included 151 patients (57 patients with IT fractures, 43 patients with FN fractures, and 51 control patients). Data on BMD, PFG parameters (hip axis length [HAL], neck-shaft angle [NSA], neck length, femoral head offset, neck diameter, shaft diameter (SD), and demographics [age, gender, height, and body weight]) were collected. Descriptive statistics and odds ratios of PFG parameters corrected with demographic variables were obtained using logistic regressions. HAL (p = 0.046) and NSA (p = 0.003) were significantly greater in the patients with IT fracture than in the control patients, while neither parameter was significantly greater in patients with FN fractures than the control patients. The femoral head offset was significantly shorter in the patients with FN fractures (p = 0.003) compared with the control patients. In patients with IT fractures, the fracture risk increased 1.64-fold (p = 0.048) with a 1 sd increase of the HAL, while it increased 2.32-fold (p = 0.003) with a 1 sd increase of the NSA. In FN fractures, the fracture risk increased 2.03-fold (p = 0.012) with a 1 sd decrease in femoral head offset. Our study showed that some PFG parameters as well as BMD values predict hip fractures in a Korean population, and their evaluation may be useful in the understanding of the biomechanics of hip fractures.

Hip bone mineral density and geometry in minimally traumatic hip fracture patients

Hip bone mineral density and geometry in minimally traumatic hip fracture patients

Prediction of hip fracture risk based on hip geometry parameters in the Hiroshima cohort

Prediction of hip fracture risk based on hip geometry parameters in the Hiroshima cohort

Variation in the PTH Gene, Hip Fracture, and Femoral Neck Geometry in Elderly Women

Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied single-nucleotide polymorphisms present in the major genes in the PTH pathway (PTH, PTHrP, PTHR1, PTHR2) in relation to bone mineral density (BMD) and fracture incidence. We found that haplotypes of the PTH gene were associated with fracture risk independent of BMD. In the present study, we evaluated the relationship between PTH haplotypes and femoral neck bone size. Hip structure analysis and BMD of the femoral neck was assessed by DXA in elderly women from the Malmö Osteoporosis Prospective Risk Assessment study. Data on hip fracture, sustained as a result of low trauma, after the age of 45 years were also analyzed. Haplotypes derived from six polymorphisms in the PTH locus were analyzed in 750 women. Carriers of haplotype 9 had lower values for hip geometry parameters cross-sectional moment of inertia (P = 0.029), femoral neck width (P = 0.049), and section modulous (P = 0.06), suggestive of increased fracture risk at the hip. However, this did not translate into an increased incidence of hip fracture in the studied population. Women who suffered a hip fracture compared to those who had not had longer hip axis length (HAL) (P < 0.001). HAL was not significantly different among haplotypes. Polymorphisms in the PTH gene are associated with differences in aspects of femoral neck geometry in elderly women; however, the major predictor of hip fracture in our population was HAL, to which PTH gene variation does not contribute significantly.

Association of body composition and muscle function with hip geometry and BMD in premenopausal women

Background: Muscle mass and function are related to bone mineral density (BMD) but associations with bone geometry and BMD at differently loaded hip regions are less well-known.Aim: To examine associations of muscle strength, maximal impact forces and body composition with hip bone density and geometry.Subjects and methods: In 88 sedentary, premenopausal women (32.6 ± 8.5 years), fat-free mass (FFM), isometric knee extension strength (IKES), and peak landing ground reaction force (GRF) were measured. BMD at the proximal femur and sub-regions, section modulus (Z), and cross-sectional area (CSA) were estimated using dual X-ray absorptiometry.Results: BMD at hip sites was significantly associated with body mass, IKES, GRF and FFM (r = 0.31–0.50) whilst Z and CSA were correlated with FFM (r = 0.67 and 0.62, respectively). In multivariate models, variables explaining most variance were body mass for lower neck and shaft BMD (25% and 17%, respectively), IKES for upper neck BMD (21%), GRF for trochanter (19%) and total hip BMD (18%) and FFM for femoral neck Z, CSA and BMD (54%, 38% and 20%, respectively).Conclusion: BMD at superolateral hip sites was most strongly related to muscle function and maximal impact forces, BMD at inferiomedial hip sites to body mass, and hip geometry to FFM.