Abstract Cardiovascular disease (CVD) covers any disease of the circulatory system, namely the heart (cardio) or blood vessels (vascular), includes heart attack, angina and peripheral vascular heart disease, however antioxidants are vital substances that possess the ability to protect the body from damage caused by free radicals induce oxidative stress. This study aimed to find out the possible mechanisms of correlation between CVD and antioxidants. The results showed that total protein (TP),total antioxidant status (TAS), albumin levels, catalase (CAT), superoxide dismutase (SOD) have significance decreased in patients compared to control the group. Cardiovascular Diseases Correlation with Antioxidants in Hilla City, Iraq Free radicals are very reactive chemical species with an unpaired electron. Because of their reactivity lipids, proteins and DNA can be damaged by the radical's action. In consequence, they are responsible for many diseases, such as cancer, cardiovascular disorder, atherosclerosis,asthma,arthritis, neurodegenerative disorders: Alzheimer's, Parkinson's diseases and dementia[ 1]. As a first level of defense, the AOS includes enzymes, mostly intracellular located, such as several forms of superoxide dismutase (SOD), catalase (CAT) and a group of macromolecules including albumin [2]. The chemistry of antioxidants involves the mechanism of action of antioxidant that two mechanisms of action have been proposed for antioxidants. The first is a chain-breaking mechanism by which the primary antioxidants donate electrons to the free radicals present in the system, example lipid radicals. The second mechanism involves removal of ROS (reactive oxygen species) and RNS (reactive nitrogen species) initiator by quenching chain initiator catalyst [3] On this basis, there are five known antioxidant mechanisms which describe antioxidant reactions[ 4, 5].