Hill Criteria Research Articles

Theoretical Forming Limit Diagram Based on Induced Stress in the Thickness Direction

The conventional theoretical forming limit diagram (FLD) based on the plane stress state has defects due to the neglect of the stress in the thickness direction of the sheet. It is urgent to study the FLD which considers the stress in the thickness direction. Through the finite element simulation, it is further confirmed that the stress in the thickness direction will be induced in the deformation process. At the same time, the effect of the induced stress in the thickness direction on FLD is not the same as that always applied stress in the thickness direction during the deformation process. Based on the Modified Maximum Force Criterion (MMFC) instability theory, C-H instability theory, Mises and Hill48 yield criterion, the effects of the two stresses on FLD are compared. The induced stress in the thickness direction also affects the sensitivity of the coefficient of normal anisotropy r, but does not significantly change the effect of the stress-strain index n on Forming Limit Curves (FLC). The theoretical calculations of the three materials TRIP780, AA5182, and 5754O are compared with the experimental data, which proves that the FLD which considers induced stress in the thickness direction is more accurate than the FLD of the plane stress.

Homogenization simulation of material extruded lattice structures

The paper investigates the mechanical behavior of structural elements of a material extruded component using a multiscale analysis based on a homogenization method. The development and validation of a homogenization model start with designing a tailor-made lattice structure. The material model is described using elastoplastic properties and Hill's yield criterion. The numerical validation of the homogenized model and its comparison with the full detail is also described.

A Novel Yield Criterion for Nickel-Based Superalloys

Abstract With the significant evolution of modern gas turbine engines, selection of high-temperature resistant alloys in the hot section is known to be the fundamental solution to enhance the capabilities of these engines. In general, the high-temperature components are mainly comprised of polycrystalline, directionally solidified, and single crystal superalloys. Single crystal (SX) superalloys were developed in the 1980s to achieve high fatigue resistance and substantial creep rupture strength by eliminating grain boundaries. Directional solidification methods enabled the solidification arrangement of the materials to be comprised of columnar grains which are aligned parallel to the 〈001〉 direction. These casting types have been frequently used with nickel-based superalloys (NBSAs) to develop modern gas turbine blades. In this work, the yield behavior of generic SX and directionally solidified (DS) NBSAs is studied. By observing various SX and DS alloys, it was concluded with need for a novel criterion that can present anisotropic and tensile/compressive asymmetric yield surfaces. This novel criterion is comprised of the criterion proposed by Hill for anisotropic materials and the method developed by Drucker and Prager for alloys that have different tensile and compressive yield strengths. Additional terms to Hill's criterion are introduced to capture the coupling effect of normal stress and shear stress when the applied loads are not in the direction of principal axes of the material coordinate system for single crystal alloys. The parameters for the criterion are obtained from simple uniaxial tension and compression experiments. Results are compared with various well-established yield criterions. Additionally, the novel criterion is utilized to capture the effective stress and strain of multi-axial loading of turbine blades under nonisothermal conditions

The yielding behavior of TU00 pure copper under impact loading

Characterizing the high strain rate behavior of metals under complex stress states has always been a challenging subject in solid mechanics. In this paper, dynamic tension-torsion tests with various stress ratios are performed by a newly developed combined tension-torsion Hopkinson bar (C-THB) system. Together with the quasi-static results, the initial yielding envelopes at different strain rates are illustrated for the first time. Tresca, von Mises and Hill yield criterion are established and evaluated. A universal model describing the strain rate hardening of material under complex stress states is proposed. Based on this model, a modified Hill yield criterion is deduced for pure copper (TU00), which fits well with the experimental yielding envelope at different strain rates.

AN ANISOTROPIC EXTENSION FOR A THERMOVISCOPLASTIC GTN DUCTILE DAMAGE MODEL

In this work, a thermoviscoplastic GTN ductile damage model is extended to account for anisotropic plastic behavior. The novel feature of the proposed model is the enrichment of a GTN model, with the Hill's yield criterion accounting for hardening, softening, strain-rate effect, plastic work heating, thermal diffusion, and void shearing mechanism. The anisotropy is introduced by changing the equivalent stress definition, which provides greater flexibility to the model. The resultant modifications in the yield criterion and in the damage evolution equations are described. Two numerical problems involving plates subjected to tension loading that leads to ductile damage and eventual fracture are presented and discussed in order to validate the present approach. A mixed finite element formulation is adopted together with the fully damaged zone technique to represent the ductile fracture. Results obtained through computational simulations highlight the effect of the anisotropic parameters on mechanical behavior in terms of the global stress-strain curve and the local evolution of plastic strains, porosity and temperature. We conclude that the proposed anisotropic model is simple to implement yet provides more flexibility in capturing complex ductile fracture processes.

A novel syndrome associated with prenatal fentanyl exposure

A novel syndrome was suspected in individuals sharing short stature, microcephaly, distinctive facial features, and congenital anomalies. We enrolled 6 patients in an institutional review board approved study and evaluated medical history, findings, facial photographs, and test results across this original cohort. Four additional cases with similar findings were contributed by clinicians from outside institutions, bringing the number of reported cases to 10 and supporting the existence of this novel syndrome.The 6 individuals enrolled into the institutional review board approved study shared microcephaly, short stature, and distinctive facial features. Congenital malformations included cleft palate, talipes equinovarus or rocker bottom feet, and chordee or hypospadias. Short, broad thumbs, single palmar crease, and mild 2,3 toe syndactyly were present. A hypoplastic corpus callosum was noted in 3 of 5 with appropriate evaluation. Their growth and physical findings were suggestive of Smith-Lemli-Opitz syndrome. Biochemical studies shortly after delivery indicated abnormalities in the cholesterol metabolism pathway that subsequently resolved. No shared genomic or genetic cause was identified. All individuals were born after a pregnancy complicated by prenatal exposure to nonprescription opioids, particularly fentanyl, suggesting fentanyl as a teratogen.Prenatal fentanyl exposure possibly interfered with cholesterol metabolism, giving rise to findings resembling Smith-Lemli-Opitz syndrome. This novel syndrome is clinically recognizable. Four additional cases contributed clinically shared similar findings, increasing the number of cases to 10 and supporting a novel syndrome associated with prenatal fentanyl exposure. Assessment of Shepard and Bradford Hill criteria could be consistent with fentanyl as teratogen, though caution is necessary before assigning causality and data replication is needed.

PS-P05-7: WEIGHT OF EVIDENCE OF LONG-TERM EFFECTS OF HEAVY METALS ON THE CARDIOVASCULAR SYSTEM AT A POPULATION LEVEL

Background/Objectives: Heavy metals chronic exposure is a major contributor to cardiovascular diseases (CVD) at the population level, and regions with high levels of heavy metals contamination showed increased rate of mortality rate from cardiovascular diseases. Among different heavy metals; Arsenic, Lead, Mercury, and Cadmium are the most toxic to human health. The purpose of the study was to weigh the amount of evidence presented in the literature for an association between each heavy metal and five cardio-vascular diseases: coronary heart disease, cerebrovascular disease, peripheral arterial disease, hypertension, and atherosclerosis. Methods: Literature review was done. PubMed, google scholar, and science direct were searched using keywords cardiovascular diseases and 4 heavy metals, separate and all together. Irrelevant articles were excluded, and only relevant epidemiological articles were included. Bradford Hill criteria of causality was used to assess the association of each of the heavy metals with the five CVD. Results: The results of recent studies showed that the correlation between the four heavy metals and CVD are inconsistent with those of earlier studies and the general picture of the correlation between exposure to heavy metals and CVD presented by these studies is either inconsistent or not conclusive. Conclusion: Among the nine-criterion mentioned by Sir Bradford Hill, this study was only compatible with two out of nine criterions mentioned. The first criterion is the strength of the association, and the second criterion is the consistency of the association. Other criterions are not compatible with this study. Although this study tried to examine the effect of 4 heavy metals on CVD, most studies linked only 1 heavy metal to 1 or 2 CVD, due to the interactive effects of heavy metals, and the absence of clear understanding to the mode of action. Nonetheless, there is a great need to do further research and explore more about the effect of these 4 metals on CVD.

Neurotrauma: 2023 Update.

2022 was a productive year for research in traumatic brain injury (TBI) and resultant neuropathology. After an extensive review, we present related studies and publications which we felt were of particular importance to the neuropathology community. First, 2022 was highlighted by important advancements in the diagnosis and, moreover, our understanding of chronic traumatic encephalopathy (CTE). Important publications include a pair concluding that CTE primarily concerns neuronal accumulation of phosphorylated tau (ptau), but that glial ptau accumulation often helps to facilitate diagnosis. In addition, a new large community study from Australia continues the indication that CTE is relatively uncommon in the community, and the first large-cohort study on brains of military personnel similarly demonstrates that CTE appears to be uncommon among service members and does not appear to explain high rates of neuropsychiatric sequelae suffered by the warfighter. The causation of CTE by impact-type TBI was supported by the application of the Bradford Hill criteria, within the brains of headbutting bovids, and interestingly within an artificial head model exposed to linear impact. Finally, a large-scale analysis of APOE genotypes contends that gene status may influence CTE pathology and outcomes. In experimental animal work, a study using mouse models provided important evidence that TDP-43 facilitates neurodegenerative pathology and is implicated in cognitive dysfunction following TBI, and another study using a swine model for concussion demonstrated that evidence that axonal sodium channel disruption may be a driver of neurologic dysfunction after concussion. Finally, we end with memoriam to Dr. John Q. Trojanowski, a giant of neurodegenerative research and an important contributor to the neurotrauma literature, who we lost in 2022.

Causal Criteria in Medical and Biological Disciplines: History, Essence, and Radiation Aspects. Report 4, Part 1: The Post-Hill Criteria and Ecolgoical Criteria.

Part 1 of Report 4 is focused on the development and modifications of causal criteria after A.B.Hill (1965). Criteria from B. MacMahon et al. (1970-1996), regarded as the first textbook for modern epidemiology, were considered, and it was found that the named researchers did not offer anything new despite the frequent mention of this source in relation to the theme. A similar situation emerged with the criteria of M. Susser: the three obligatory points of this author, "Association" (or "Probability" of causality), "Time order," and "Direction of effect," are trivial, and two more special criteria, which are the development of "Popperian Epidemiology," i.e., "Surviability" of the hypothesis when it is tested by different methods (included in the refinement in Hill's criterion "Consistency of association") and "Predictive performance" of the hypothesis are more theoretical and hardly applicable for the practice of epidemiology and public health. The same restrictions apply to the similar "Popperian" criteria of D.L. Weed, "Predictability" and "Testability" of the causal hypothesis. Although the universal postulates of A.S. Evans for infectious and noninfectious pathologies can be considered exhaustive, they are not used either in epidemiology or in any other discipline practice, except for the field of infectious pathologies, which is probably explained by the complication of the ten-point complex. The little-known criteria of P. Cole (1997) for medical and forensic practice are the most important. The three parts of Hill's criterion-based approaches are important in that they go from a single epidemiological study through a cycle of studies (coupled with the integration of data from other biomedical disciplines) to re-base Hill's criteria for assessing the individual causality of an effect. These constructs complement the earlier guidance from R.E. Gots (1986) on establishing probabilistic personal causation. The collection of causal criteria and the guidelines for environmental disciplines (ecology of biota, human ecoepidemiology, and human ecotoxicology) were considered. The total dominance of inductive causal criteria, both initial and in modifications and with additions, was revealed for an apparently complete base of sources (1979-2020). Adaptations of all known causal schemes based on guidelines have been found, from Henle-Koch postulates to Hill and Susser, including in the international programs and practice of the U.S. Environmental Protection Agency. The Hill Criteria are used by the WHO and other organizations on chemical safety (IPCS) to assess causality in animal experiments for subsequent extrapolation to humans. Data on the assessment of the causality of effects in ecology, ecoepidemiology, and ecotoxicology, together with the use of Hill's criteria for animal experiments, are of significant relevance not only for radiation ecology, but also for radiobiology.

Forming limit of AZ31B magnesium alloy under in-plane complex biaxial loading paths with cruciform specimens

This paper focused on the forming limit curves (FLC) of the AZ31B magnesium alloy sheet metal under different complex loading paths in-plane. Compared with simple loading paths, the study of forming limit of sheet metal under complex loading paths was more practical. In this study, biaxial tensile test of the cruciform specimen was utilized to acquire the FLC after the cruciform specimen was subjected to uniaxial pre-tensile process along rolling direction, which experimentally characterize the forming limits under different pre-strain values of 1.15%, 2.34%, 4.0%, and 5.4%. Subsequently, based on the constitutive model, Hill48 yield criterion and shear failure criterion, the theoretical FLCs of AZ31B magnesium alloy sheet metal was be calculated. Meanwhile, the normal biaxial tensile tests were also simulated by Abaqus to obtain the limit strains by Finite Element Analysis (FEA). Extracting limit strains from the fracture region in FEA model when the first derivative of the strain difference with respect to time reached the maximum value between the first principal strain of necked element and the first principal strain of the element adjacent to the necked zone. As a result, the experimental FLCs was qualitatively consistent with the result of theoretical model and FEA model. In addition, the FLCs of AZ31B magnesium alloy sheet moved to the upper left of forming limit diagram with the increase of the pre-strain, which indicated that the pre-strain process along the rolling direction could significantly improve the formability of the sheet metal.

Commentary: On the reliability of causal claims.

Causal assessments in epidemiology are a complex process due to the many methods involved. The general scientific method lords over the process joined by study designs and statistical methods. Other methods include those that evaluate quality and bias along with the research synthesis methods such as the systematic narrative review, meta-analysis, and the criteria-based methods. When different investigators apply these methods to the same evidence and come up with different causal assessments, as described in the review by Goodman et al. in this issue, a key question becomes, how can the differences be explained? A prime candidate involves different methodologic choices. A deeper question emerges from this same situation: are the methods used for causal assessments reliable? Reliability is a hallmark of scientific practice. The methods used to make claims about causality should be reliable. Given the complexity of the causal assessment process, an objective evaluation of reliability is challenging but clearly worth the effort. Fortunately, Hill's criterion of analogy, much maligned in epidemiology, provides a clue. This commentary explores the issue of the reliability of causal claims using the Goodman et al. systematic review as its foil along with the claims by EPA, IARC, and ATSDR about the relationship between perchloroethylene and non-Hodgkin lymphoma, the claims Goodman et al. believe are wrong.

Association of Delirium with Long‐term Cognitive Decline: An Update

AbstractBackgroundDelirium has been associated with a variety of unfavorable outcomes, including increasing length of stay in the hospital, poor functioning, and death. We compiled the literature and conducted a meta‐analysis (Goldberg et al, JAMA Neurol, 2021) in order to determine if delirium was also associated with long term cognitive decline. Twenty‐three studies that included over 3500 delirium and 6900 control patients were included in the meta‐analysis. Cognitive assessments were conducted on average at 2.3 years after the episode of delirium. We found that the overall effect size G was .45 (P<.001) indicating that patients who experienced delirium performed significantly worse than controls who did not experience delirium.MethodWe will search the literature on cognitive changes after delirium from Jan 1, 2019 onward. We will include all relevant studies with the same inclusion criteria as our prior study (namely an episode of delirium, cognitive assessment 3 or more months after the episode, and a control group). We will then compute the effect size G for each individual study in order to determine if the values are consistent with our previous findings. We will also examine if delirium meets Bradford Hill criteria for playing a causal role in cognitive decline in association studies.Second, we will review the literature on cognitive changes after delirium in individuals experiencing SARS‐CoV‐2 infection, given the many reports of patients experiencing delirium in the ICU while ventilated. We will derive G for these studies, so long as they incorporate a control group that adjusts for disease severity and virus positivity.ResultWe will present results of this new review in terms of G for individual studies, overall G when these are added to the original meta‐analysis, and a Bradford Hill criteria checklist. For delirium after SARS‐Cov‐2 infection we will rely on a narrative description.ConclusionFirst, we will examine trends in reports of the magnitude cognitive changes after delirium over the past three years, as well as examine if newer or more comprehensive methodologies are being deployed. Second, we will examine the extent of cognitive changes after delirium in the context of severe COVID‐19.

Multi-Criteria Evaluation of the Failure of CFRP Laminates for Frames in the Automotive Industry.

Methods to predict the fracture of thin carbon fibre-reinforced polymers (CFRPs) under load are of great interest in the automotive industry. The manufacturing of composites involves a high risk of defect occurrence, and the identification of those that lead to failure increases the functional reliability and decreases costs. The performance of CFRPs can be significantly reduced in assembled structures containing stress concentrators. This paper presents a hybrid experimental-numerical method based on the Tsai-Hill criterion for behavior of thin CFRPs at complex loadings that can emphasize the threshold of stress by tracing the σ-τ envelope. Modified butterfly samples were made for shearing, traction, or shearing-with-traction tests in the weakened section by changing the angle of force application α. ANSYS simulations were used to determine the zones of maximum stress concentration. For thin CFRP samples tested with stacking sequences [0]8 and [(45/0)2]s, the main mechanical characteristics have been determined using a Dynamic Mechanical Analyzer (DMA) and ultrasound tests. A modified Arcan device (AD) was used to generate data in a biaxial stress state, leading to the characterization of the material as a whole. The generated failure envelope allows for the prediction of failure for other combinations of normal and shear stress, depending on the thickness of the laminations, the stacking order, the pretension of the fasteners, and the method used to produce the laminations. The experimental data using AD and the application of the Tsai-Hill criterion serve to the increase the safety of CFRP components.

Preliminary Structural Design of Coreless Spoiler by Topological Optimization

Most spoilers are made from a sandwich structure with a honeycomb component as its core. However, the honeycomb core is sensitive to water ingress, causing damage to the control surface due to its weak moisture-resistance behavior. This study aimed to conduct the design and analysis of an improved composite structure for a coreless spoiler. A spoiler design of an aircraft, the A320, was used for the case study. The weaknesses of a coreless spoiler were identified through finite element analysis via Abaqus software. Multi-spar and multi-rib designs were studied and compared for topological optimization. The variables used for evaluation were the Tsai–Hill failure index and the critical buckling load. The design with the most potential was considered for parametric optimization to obtain the most satisfactory configuration. The results showed that the upper skin of the spoiler without a honeycomb core failed the Tsai–Hill criteria. Furthermore, the results show that the multi-spar configuration outperformed the multi-rib configuration. The final multi-spar configuration achieved a mass reduction of 24% from the original spoiler and an additional 6% mass reduction by re-designing the internal structures without violating the design criteria. In conclusion, the weaknesses of the spoiler without a honeycomb core have been identified, and an improved design for a coreless spoiler has been proposed.

Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil

Epyrifenacil (trademark name: Rapidicil®), a novel protoporphyrinogen oxidase (PPO)-inhibiting herbicide, induces hepatocellular adenomas and carcinomas in male CD-1 mice after 78 weeks treatment. The mode of action (MOA) of these mouse liver tumors and their relevance to humans was assessed based on the 2006 International Programme on Chemical Safety (IPCS) Human Relevance Framework. Epyrifenacil is not genotoxic and induced liver tumors via the postulated porphyria-mediated cytotoxicity MOA with the following key events: (#1) PPO inhibition; (#2) porphyrin accumulation; (#3) hepatocellular injury; with (#4) subsequent regenerative cell proliferation; and ultimately (#5) development of liver tumors. This article evaluates the weight of evidence for this MOA based on the modified Bradford Hill criteria. The MOA data were aligned with the dose and temporal concordance, biological plausibility, coherence, strength, consistency, and specificity for a porphyria-mediated cytotoxicity MOA while excluding other alternative MOAs. Although the postulated MOA could qualitatively potentially occur in humans, we demonstrate that it is unlikely to occur in humans because of quantitative toxicodynamic and toxicokinetic differences between mice and humans. Therefore, this MOA is considered not relevant to humans, utilizing the IPCS Human Relevance Framework; consequently, a nonlinear, threshold dose response would be appropriate for human risk assessment.

Nonlinear kinematic hardening constitutive model based on Hill48 yield criterion and its application in reverse deep drawing

Nonlinear kinematic hardening constitutive model based on Hill48 yield criterion and its application in reverse deep drawing

Telomere Length as a Marker of Biological Aging: A Critical Review of Recent Literature.

Aging is characterized as a syndrome of deleterious, progressive, universal, and irreversible function changes affecting every structural and functional aspect of the organism and accompanied by a generalized increase in mortality. Although a substantial number of candidates for biomarkers of aging have been proposed, none has been validated or universally accepted. Human telomeres constitute hexameric repetitive DNA sequence nucleoprotein complexes that cap chromosome ends, regulating gene expression and modulating stress-related pathways. Telomere length (TL) shortening is observed both in cellular senescence and advanced age, leading to the investigation of TL as a biomarker for aging and a risk factor indicator for the development and progression of the most common age-related diseases. The present review underlines the connection between TL and the pathophysiology of the diseases associated with telomere attrition. We performed a structured search of the PubMed database for peer-reviewed research of the literature regarding leukocyte TL and cardiovascular diseases (CVD), more specifically stroke and heart disease, and focused on the relevant articles published during the last 5 years. We also applied Hill's criteria of causation to strengthen this association. We analyzed the recent literature regarding TL length, stroke, and CVD. Although approximately one-third of the available studies support the connection, the results of different studies seem to be rather conflicting as a result of different study designs, divergent methods of TL determination, small study samples, and patient population heterogeneity. After applying Hill's criteria, we can observe that the literature conforms to them weakly, with chronology being the only Hill criterion of causality that probably cannot be contested. The present review attempted to examine the purported relation between leukocyte TL and age-related diseases such as CVD and more specific stroke and heart disease in view of the best established, comprehensive, medical and epidemiological criteria that have characterized the focused recent relevant research. Although several recommendations have been made that may contribute significantly to the field, a call for novel technical approaches and studies is mandatory to further elucidate the possible association.

Reliability-based numerical analysis of glulam beams reinforced by CFRP plate

Most existed researches consider deterministic numerical analysis when dealing with structural models. However, the test results reveal that uncertainties are existing in most cases regarding some considerations such as material randomness and the lack of experience. Therefore, proposing a probabilistic design models have got attention of researchers according to its important role in predicting accurate performance of the structures. The aim of the proposed work is to consider reliability-based analysis in numerical modelling of glulam beams reinforced with CFRP plates as well as unreinforced glulam beams by considering the properties of used timber material as random variables having mean value and standard deviation taking into consideration that the findings of this study have shown that the reliability index is worked efficiently as a limit which controls the process. Hill yield criterion model is adopted with respect to the data which is obtained from the experimental tests in order to validate the models. Furthermore, a detailed comparison between the reinforced and unreinforced glulam beams are proposed to see the effect of introducing the CFRP plates as a reinforcement material. The results of this study have successfully given a deep understanding of how the uncertainties plays a crucial role on the resulted deformations and stresses in which it was founded by making a comparison between deterministic and probabilistic numerical analysis.

Development of an adverse outcome pathway network for breast cancer: a comprehensive representation of the pathogenesis, complexity and diversity of the disease.

Adverse outcome pathways (AOPs), introduced in modern toxicology, intend to provide an evidence-based representation of toxicological effects and facilitate safety assessment of chemicals not solely based on laboratory animal in vivo experiments. However, some toxicological processes are too complicated to represent in one AOP. Therefore, AOP networks are developed that help understanding and predicting toxicological processes where complex exposure scenarios interact and lead to the emergence of the adverse outcome. In this study, we present an AOP network for breast cancer, developed after an in-depth survey of relevant scientific literature. Several molecular initiating events (MIE) were identified and various key events that link the MIEs with breast cancer were described. The AOP was developed according to Organization of Economic Co-Operation and Development (OECD) guidance, weight of evidence was assessed through the Bradford Hill criteria and confidence was tested by the OECD key questions. The AOP network provides a straightforward understanding of the disease onset and progression at different biological levels. It can be used to pinpoint knowledge gaps, identify novel therapeutic targets and act as a stepping stone for the development of novel in vitro test methods for hazard identification and risk assessment of newly developed chemicals and drugs.

Identification of Anisotropic Yield Functions Using FEMU and an Information-Rich Tensile Specimen

To fully exploit the predictive accuracy of advanced anisotropic yield functions, a large number of classical mechanical tests is required for calibration purposes. The Finite Element Model Updating (FEMU) technique enables to simultaneously extract multiple anisotropic parameters when fed with heterogeneous strain fields obtained from a single information-rich experiment. This inverse approach has the potential to mitigate the experimental calibration effort by resorting to a single, yet more complex experiment augmented with Digital Image Correlation. In this paper, we inversely identify the sought anisotropic parameters of two selected yield functions for a low carbon steel sheet based on the previously designed information-rich tensile specimen. The experimentally acquired strain field data is used to inversely identify the Hill48 yield criterion and the Yld2000-2d yield function, respectively. The results are compared with conventional calibration methods for both anisotropic yield functions. The inverse identification is then thoroughly studied using virtual experiments enabling to disentangle the effect of the material model error and the strain reconstruction error (DIC), respectively. It is shown that the material model error dominates the inverse identification of the Hill48 yield criterion. The reduced material model error for the Yld2000-2d yield function enables obtain inversely identified anisotropic parameters that are closer to the reference parameters. The paper clearly shows the importance of the predictive accuracy of the selected anisotropic yield function when applying inverse identification. Keywords: Anisotropic yield criteria; Material parameters identification; Heterogeneous mechanical tests; Inverse identification; DIC.