Exploring the dynamic behaviour of high-rise buildings presented a critical challenge. In this study, Fuzzy Logic and Genetic Algorithm (FLGA) were employed to comprehensively investigate the structural response of high-rise buildings (HRBs) for adaptive vibration control systems employing semiactive damper devices. The study integrated a fuzzy logic inference system with a Genetic Algorithm (GA) to create FLGA, which was then employed in a 3-story shear building under real earthquake conditions and multi-dimensional wind loads. The analytical model for a semi-active tuned mass damper (STMD) was examined and evaluated before integrating it into the proposed FLGA system. The results indicated that FLGA reduced story acceleration by an average of 20% and story drift by approximately 50% while efficiently controlling the structure within allowable movement limits and resident comfort criteria under multi-directional wind loads. The suggested optimal controller mitigated both displacement and acceleration responses by 15 to 20% without amplification. The study demonstrated FLGA's effectiveness as a model-free control strategy for managing structural response uncertainties.