Objective: The current study aimed to evaluate the effect of diode laser irradiation (980 nm) and warm air drying(50°C) on shear bond strength between Lithium di-silicate (IPS e.max; Ivoclar) and human dentin using both(Etch & Rinse) adhesive, Adper™ Single Bond 2 (3M ESPE) and (Self-etch) adhesive, Single Bond UniversalTM(3M ESPE) before adhesive polymerization. Material and Methods: 54 sound lower molars were sectioned toobtain flat dentinal surfaces. Specimens were divided into 2 equal groups (n=27): Group 1 (ER) and Group 2(SE) according to bonding approach. Each subgroup was subdivided according to dentin surface treatment into3 equal subgroups (n=9): Control (Co), Diode laser irradiation (L) and Warm air drying (W). All specimenswere adhesively cemented to IPS e.max® CAD discs using RelyX™ Ultimate Clicker™(3M ESPE) resin cement.Samples were then subjected to pre-loading in a thermodynamic manner. All samples were tested for shearbond strength using computer-controlled material testing machine. Data analysis was performed using two-way(ANOVA) (p< 0.05) followed by pair-wise Tukey’s post-hoc tests. Results: In (SE) group, the subgroup (W) hadthe highest shear bond strength values followed by (Co) subgroup and the least was (L) subgroup with statisticallysignificant difference. As for (ER) group, the subgroup (W) had the highest shear bond strength values followedby (Co) subgroup and the least was (L) subgroup with no statistically significant difference. Conclusion: Warmair drying for (SE) bonding approach increased shear bond strength of Lithium di-silicate to human dentin andcan be introduced as a new effective protocol.KEYWORDSAdhesives; Diode laser; IPS e.max; Shear bond strength; Warm air drying.