Efficient thermal management is crucial for numerous applications, from electronics cooling and automobile systems to aerospace systems, necessitating the exploration of advanced heat transfer technologies like TPMS structures. Compared to conventional heat exchangers and heat sinks, lattice structures have improved by around 20–30 % performance. However, the variation in performance of the various lattice structures, such as FRD, G-Prime, etc., is yet unknown. Thus, this study investigates the thermo-hydraulic performance of various Triply Periodic Minimal Surface (TPMS) structures, including novel G-Prime and FRD geometries, through numerical simulations and experimental validation. The TPMS geometries were modeled using LattGen software and voxelized with 20 % relative density. Computational Fluid Dynamics (CFD) simulations were performed using Ansys Fluent with the k-epsilon turbulence model, and experiments were conducted on 3D-printed samples for validation. The numerical results reveal that G-Prime-2 and FRD Prime exhibit the highest heat transfer performance while demonstrating higher pressure drops than other TPMS geometries. Experimental validation agrees with numerical predictions, confirming the superior thermo-hydraulic performance of G-Prime-2 and FRD Prime for heat transfer enhancement applications. The results contribute to understanding TPMS thermo-hydraulic performance and enable informed geometry selection for thermal management applications.