High Potential Risk Research Articles

Drug-induced heart failure: a real-world pharmacovigilance study using the FDA adverse event reporting system database

ObjectiveAlthough there are certain drug categories associated with heart failure (HF), most of the associated risks are unclear. We investigated the top drugs associated with HF and acute HF (AHF) reported in the FDA Adverse Event Reporting System (FAERS).MethodsWe reviewed publicly available FAERS databases from 2004 to 2023. Using the search terms “cardiac failure” or “cardiac failure acute” and classifying cases by drug name, we processed and analyzed drug reports related to HF or AHF.ResultsFrom 2004 to 2023, 17,379,609 adverse drug events were reported by FAERS, of which 240,050 (1.38%) were reported as HF. Among those with HF, the male-to-female ratio was 0.94% and 52.37% were >65 years old; 46.2% were from the United States. There were 5,971 patients with AHF. We identified 38 drugs and 13 drug classes with a potential high risk of causing HF, and 41 drugs and 19 drug classes were associated with AHF. The median onset times of HF and AHF were 83 days (IQR: 11–416) and 49 days (IQR: 8–259), respectively. The Weibull shape parameter (WSP) test showed early failure-type profile characteristics.ConclusionThis study highlights key drugs associated with drug-induced HF and AHF, emphasizing the importance of early risk assessment and close monitoring, particularly during the initial stages of treatment. These findings contribute to a better understanding of drug-induced HF and provide a basis for future research on its underlying mechanisms.

Characteristics, risk factors and a risk prediction model of tocilizumab-induced hypofibrinogenemia: a retrospective real-world study of inpatients

ObjectiveThe occurrence of hypofibrinogenemia after tocilizumab treatment has attracted increasing attention, which may cause bleeding and even life-threatening. This study aims to explore the risk factors for tocilizumab-induced hypofibrinogenemia (T-HFIB) and construct a risk prediction model.MethodsA total of 221 inpatients that received tocilizumab from 2015 to 2023 were retrospectively collected and divided into T-HFIB group or control group. The risk factors for T-HFIB were obtained by logistic regression equation and used to establish the nomogram.ResultsT-HFIB was observed in 121 of 221 patients (54.75%). Multifactorial logistic regression analysis revealed that infection (OR = 2.002, 95%CI:1.018 ~ 3.935), COVID-19 (OR = 3.752, 95%CI:1.264 ~ 11.139), CAR-T therapy (OR = 4.409, 95%CI:2.017 ~ 0.894), and concomitant glucocorticoids (OR = 5.303, 95%CI:0.227 ~ 0.894) were identified as independent risk factors for T-HFIB, while high baseline fibrinogen level (OR = 0.813, 95%CI:0.670 ~ 0.988) and concomitant antirheumatic drugs (OR = 0.451, 95%CI:0.227 ~ 0.894) were identified as protective factors. A nomogram was established, and area under the curve (AUC) of prediction model was 0.772 (95%CI:0.709 ~ 0.836). Calibration curve showed a good prediction accuracy for the occurrence of T-HFIB.ConclusionThe infection, COVID-19, CAR-T therapy, and concomitant glucocorticoids were independent risk factors for T-HFIB, while high baseline fibrinogen and concomitant antirheumatic drugs were protective factors. This nomogram can help early identify the patients at potential high risk of developing T-HFIB.

Zoonotic Disease: Knowledge, Attitude and Practice of Dairy Farm Owner in Wolaita Sodo District, Ethiopia.

Lack of knowledge regarding zoonotic transmission, prevention and control measures is a potential high risk for the occurrence of zoonotic diseases. The study aimed to assess knowledge, attitude and practices of dairy farm participants concerning zoonoses. A cross-sectional study was conducted from March to August 2022 in and around Sodo town, using a questionnaire among dairy farm participants (n = 123). The structured questionnaire consisted of 48 items to evaluate knowledge (12), attitude (10) and practices (6) related to zoonotic disease-risks from livestock products and birth products was administered to the systematically and randomly selected respondents. Linear regression analyses were used to assess relations between the explanatory variables and the three indexes. The overall positive response for knowledge, attitude and practice subscores were 65%, 74% and 59% respectively. 93% of participants know that disease can transmit from animal to human. Besides, eating uncooked meat (92%), drinking raw milk (85%) and collecting aborted foetuses and placenta with bare hand (80%) are known sources of infection. Participants who thought zoonotic diseases can be treated, controlled and prevented were 78%, 80% and 81%, respectively. Among participants, 74% showed positive attitude towards risk of acquiring disease through the consumption of raw meat and milk. The participants who believed that apparently healthy animals can be a source of infection were 42%. Education level was positively associated with better knowledge, attitude and practice towards zoonoses. Furthermore, farm type, size and respondent's residence were also associated with better practice of zoonotic disease prevention (p < 0.05). Despite good knowledge, attitude and practice about zoonotic diseases' control and prevention, there are some serious knowledge and practice shortcomings. Awareness creation and training programs for the members of the dairy producers on zoonotic diseases and their transmission mechanism might help the effort in public health significance of zoonotic disease prevention.

Analysis of The Risk of Work Accidents on Oil Palm Harvesting Employees at Afdeling Golf in PT. Subur Abadi Wana Agung

Many accidents in oil palm plantations are caused by risks such as harvesting activities. Even though the K3 system has been implemented, accidents still occur because there is a high potential risk of work accidents, so companies need to manage them so that the level of work accidents can be reduced. Research objectives: identify potential dangers and risks of work accidents for harvest employees, carry out an assessment and analysis of the level of value of the risk of harvesting work activities using the HIRARC method and recommend ways to control the potential risk of work accidents during harvesting based on the K3 risk management hierarchy, namely substitution, elimination, PPE and administration. Activities identified as having potential dangers and risks are sharpening tools, cutting fruit, cutting midribs, transporting fruit to TPH, and arranging fruit in TPH. There are 2 levels of risk assessment, namely low risk low risk (sharpening tools, cutting fruit at risk of being injured by thorns and the risk of material waste being exposed to sore eyes, arranging fruit in TPH), medium risk, medium risk (cutting the fronds at risk of falling fronds, swelling from wasp stings and fever, transporting fruit to TPH), and controlling risks such as substitution, elimination, using PPE, administration and being careful when working and paying attention to land conditions.

Spatio-Temporal Distribution of PM2.5 and PM10 Concentrations and Assessment of Public Health Risk in the Three Most Polluted Provinces of Iran

This study examines the spatio-temporal variations of ambient air pollution from fine particulates below 2.5 µm (PM2.5) and particulate matter below 10 µm (PM10) in three of the most polluted provinces in Iran, namely Tehran, Isfahan, and Khuzestan, over a 6-year period (2016–2021). The results reveal distinct patterns of PM10 and PM2.5 concentrations since in Tehran, the highest PM10 and PM2.5 levels occur in winter, while PM2.5 is lowest from March to May. Khuzestan experiences the highest pollution levels in summer due to dust storms, while Isfahan exhibits pollution levels and annual patterns similar to Tehran. Strong correlations are observed between PM10 and PM2.5 concentrations at stations in Tehran and Khuzestan Provinces, suggesting common sources and variation in both coarse and fine PM, with average PM2.5/PM10 ratios of 0.39–0.42, suggesting the dominance of dust. Furthermore, the analysis identifies the role of atmospheric stability, wind speed, and dust storms in controlling the PM levels in the three provinces. Lifetime cancer risks have been identified as unacceptably high, exceeding the threshold limit of 10−4, while Hazard Quotient (HQ) values above 1 indicate a high non-carcinogenic potential risk, particularly at stations in Khuzestan Province. The Excess Lifetime Cancer Risk (ELCR) values for PM2.5 exposure in the most populated Tehran Province range from 139.4 × 10−6 to 263.2 × 10−6, underscoring significant cancer risks across various monitoring sites. This study emphasizes the urgent need for targeted pollution control measures in each province to effectively mitigate the adverse health effects associated with high PM concentrations.

Visualization study of the effects of polycarboxylates on CO2 hydrate generation and interfacial property.

Marine carbon sequestration, with its high potential and low risk of leakage, is an attractive technology for effectively addressing global climate change and reducing greenhouse gas emissions. A current concern about marine sequestration lies in the potential negative effects of the carbon sequestration process on the marine environment. CO2 hydrate sequestration is considered to be one of the most stable method of sequestration, and researchers are actively searching for promoters that facilitate hydrate sequestration and are friendly to the marine environment. Therefore, the development and utilization of environment-friendly promoters are of great significance for marine carbon sequestration by the hydrate method. In this study, two novel kinetic promoters, polycarboxylates (SP-409 and SPC-100), were applied. The changes in kinetic properties of CO2 hydrate generation and gas-liquid interfacial properties were investigated under different promoter types and concentrations, temperatures, and pressures. Visual observation reveals that the formation of hydrate first occurs at the gas-liquid interface and on the reactor wall, then gradually starts to diffuse into the interior of the solution, forming a white cylindrical solid with a hollow interior. After a comprehensive comparison of temperatures, pressures, and concentrations, the SP-409 solution promoted hydrate generation better than the SPC-100 solution, and the optimal promotion concentration was 1000ppm. In addition, there is an exponential relationship between the rate of hydrate formation and interfacial tension (IFT), which means that the rate of hydrate generation can be quickly estimated from the interfacial tension data at a certain temperature and pressure.

Genomic characterization and histologic analysis of uterine leiomyosarcoma arising from leiomyoma with bizarre nuclei.

Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with a benign clinical course. In contrast, leiomyosarcoma (LMS) is a high-grade, malignant neoplasm characterized by high recurrence rates and poor survival. While LM-BN and LMS show distinct morphologies, they share similar immunoprofiles and molecular alterations, with both considered 'genomically unstable'. Rare cases of LM-BN associated with LMS have been reported; however, the histogenesis and molecular relationship between these two tumors remains unclear. In this study, we assessed 11 cases of LMS arising in conjunction with LM-BN confirmed by histology and immunohistochemistry (IHC), further analyzed by clinical, histologic, and molecular characteristics of these distinct components. LM-BN and LMS had similar p16 and p53 IHC patterns, but LMS had a higher Ki-67 index and lower estrogen and progesterone eceptor expression. Digital image analysis based on cytologic features revealed spatial relationships between LMS and LM-BN. Genomic copy number alterations (CNAs) demonstrated the same clonal origin of LMS arising from existing LM-BN through conserved CNAs. LMS harbored highly complex CNAs and more frequent losses of the TP53, RB1, and PTEN genomic regions than LM-BN (p = 0.0031), with CDKN2A/B deletion identified in LMS only. Mutational profiling revealed many shared oncogenic alterations in both LM-BN and LMS; however, additional mutations were present within LMS, indicative of tumor progression through progressive genomic instability. Analysis of spatial transcriptomes defined uniquely expressed gene signatures that matched the geographic distribution of LM-BN, LMS, and other cell types. Our findings indicate for the first time that a subset of LMS arises from an existing LM-BN, and highly complex genomic alterations could be potential high risks associated with disease progression in LM-BN. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Phlebotomine Sandflies (Diptera: psychodidae) in Different Localities of Dhamar Governorate,Yemen.

The present study aimed to reveal the cutaneous leishmaniasis disease caused by Leishmania tropica, which is endemic in Dhamar Governorate and has become an outbreak in the country's northeastern in Yemen. In this study, sandflies (Diptera: psychodidae) were collected from two villages ,Al-Hamh and Al-Ahsaa. Sandflies were collected once a month from May to November 2023, using sticky traps that were put in both home and non-home locations.385specimens were collected (62.08%females/ 37.92% males). The sample comprised five species, divided into two classes: Phlebotomus (65.88%), formed by Phlebotomus sergenti (51.17%),Phlebotomus papatasi (12.47%)and Phlebotomus alexandri(4.16%) and Sergentomyia (34.12%),based on Sergentomyia taizi(22.34%) and Sergentomyia africana(9.87%).Ph. sergenti predominated in Al-Hamh and Al-Ahsaa followed by Se. taizi and Ph. papatasi. Over the course of their eight-month active life cycle, which ran from May to November, the population dynamics displayed a bimodal pattern, with the two examined stations noticing their first peak in June and the second peak occurring in October for Al-Ahsaa and August for Al-Hamh. This activity indicated a high potential risk of Leishmania tropica and Leishmania major. This study can help build suitable and efficient vector control plans by providing information on the abundance, richness, seasonal trend, sex ratio, and degree of presence of various sand fly species in this dynamic area.

Distribution characteristics, sources and risk assessment of heavy metal(oid)s in road dust from a typical lead-zinc mining area in South China.

Although the construction of green mines has effectively reduced soil pollution issues, dust contaminants continue to pose potential risks to human health and environment. This study investigated the concentrations, sources, and human health risks of metal(oid)s present in road dust across different functional zones of the largest lead-zinc mine in Guangdong Province, China, namely the Fankou lead-zinc mine. First, a systematic collection of 45 dust samples from six functional zones was conducted, focusing on the concentrations of ten heavy metal(oid)s (HMs), including As, Cd, Pb, and Zn etc. The results indicate that mining and smelting activities at the Fankou lead-zinc mine dictate the accumulation and distribution of HMs in the dust across the various functional zones. Except for Mn, Cr, and Thallium (Tl), the concentrations of other HMs significantly exceed the soil background values. These HMs primarily originate from mixed sources, including natural, traffic, and industrial activities. In particular, the presence of As, Cd, Pb, and Zn in the dust resulted in moderate to severe pollution, posing extremely high potential ecological risks. Furthermore, the bioavailable concentrations of HMs in the dust were analyzed using two in vitro gastrointestinal simulation methods: Physiologically Based Extraction Test (PBET) and Simplified Bioaccessibility Extraction Test (SBET), allowing for a further assessment of metal bioavailability and estimation of (non)carcinogenic risk probabilities for humans. The bioaccessible heavy metal contents extracted through SBET and PBET were relatively low, with most samples exhibiting bioaccessibility below 40%. In comparison to the total concentrations of HMs in the dust, the estimated non-carcinogenic risks (HQ and HI) and carcinogenic risks (CR) associated with bioavailability (PBET and SBET) for As, Cd, Cu, Sb, Pb, and Zn were significantly reduced, falling within safe values for both adults and children. However, the carcinogenic risk posed by total As remains a concern for local adults and children, indicating that the potential carcinogenic risk of As should not be overlooked. Therefore, additional protective measures should be considered to reduce resident exposure to dust, particularly in the core production areas of the mining district.

Public surface disinfection every 2 hours can reduce the infection risk of norovirus in airports up to 83.

Norovirus, primarily transmitted via fomite route, poses a significant threat to global public health and the economy. Airports, as critical transportation hubs connecting people from around the world, has high potential risk of norovirus transmission due to large number of public surfaces. A total of 21.3 hours of video episodes were recorded across nine functional areas at the airport, capturing 25,925 touches. A surface transmission model based on a Markov chain was developed. Using the beta-Poisson dose-response model, the infection risk of norovirus and the effectiveness of various interventions in different airports' areas were quantified. Without any preventive measures, restaurants at airports exhibited the highest risk of norovirus transmission, with an infection probability of 8.8×10-3% (95% CI, 1.5×10-3% -2.1×10-2%). This means approximately 4.6 (95% CI, 0.8-10.9) out of 51,494 passengers who entered the restaurants would be infected by an infected passenger. Comparing with no surface disinfection, disinfecting public surfaces every 2 hours can reduce the risk of norovirus infection per visit to the airport by 83.2%. In contrast, comparing with no hand washing, handwashing every 2 hours can reduce the infection risk per visit to the airport by only 2.0%, making public surface disinfection significantly more effective than handwashing. If the mask-wearing rate increases from 0% to 50%, the infection risk of norovirus would be decreased by 48.0% (95% CI, 43.5-52.3%). Furthermore, using antimicrobial copper/copper-nickel alloy coatings for most public surfaces could reduce the infection risk by 15.9%-99.2%.

Spatial and seasonal abundance and characteristics of microplastics along the Red River to the Gulf of Tonkin, Vietnam

This study aimed to examine the occurrence of microplastics in surface water and sediment samples collected from Hanoi to the Ba Lat estuary along the Red River, the second-largest river in Vietnam (surface area: 156,451 km2). 21 stations were sampled during the dry (March 2023) and rainy (September 2023) seasons. The analytical procedure involved: digestion with hydrogen peroxide, flotation with potassium carbonate, and overflow filtration. The filters were analyzed by microscopy (Nikon SMZ645) to describe shapes and colors and by μ-FTIR (PerkinElmer Spotlight 400) to determine polymer types and abundances. Results showed that microplastic quantities throughout the river ranged from 10 to 203 items.m−3 in surface water and from 653 to 8069 and 990 to 21,610 items.kg−1 dried weight (d.w.) in sediment during the rainy and dry seasons, respectively. MPs were classified into two main shape groups: fiber and fragment, with fibers being predominant, representing 82.0 % and 75.5 % of microplastics in water and sediment, respectively. The primary colors identified were white/transparent, black, and blue. Particles between 13 and 200 μm were the predominant size class, accounting for 64.1 % and 72.4 % of the microplastics in water and sediment, respectively. Polyethylene, polypropylene, and polyethylene terephthalate were the main polymers, accounting for 71.5 % and 72.2 % of the microplastics in water and sediment, as revealed by μ-FTIR analyses. Overall, in the Red River, the MP pollution load is moderate, but the type of particles detected represents a high to dangerous polymer risk, resulting in a very high potential ecological risk on the river.

ERGONOMIC RISKS IN SEMI-MECHANIZED CUTTING OPERATIONS IN THE SOUTHERN AMAZON

Sustainable forest management in the Amazon must be carried out to guarantee the maintenance of forest resources and the safety and health of workers. In this region, workers are subject to various ergonomic risks that compromise their quality of life. In this context, the objective was to assess the ergonomic risks to which workers are exposed when cutting trees of different densities. Assessments of occupational heat exposure levels and physical workload were performed using a portable digital IBUTG thermometer and heart rate monitor, respectively. The IBUTG limits indicated the workers’ exposure to thermal overload. The tree-cutting operation did not indicate a high physical workload or potential postural risks, without the requirement for immediate action to change the work routine. Thermal overload is a factor that requires the adoption of mitigating ergonomic measures to preserve the health of workers in the Amazon region.

Combined Effects of Air Pollution and Changes in Physical Activity With Cardiovascular Disease in Patients WithDyslipidemia.

Sedentary behavior elevates cardiovascular disease (CVD) risk in patients with dyslipidemia. Increasing physical activity (PA) is recommended alongside pharmacological therapy to prevent CVD, though benefits across environmental conditions are unclear. We analyzed data from 113 918 newly diagnosed patients with dyslipidemia (2009-2012) without prior CVD, sourced from the Korea National Health Insurance Service. Ambient particulate matter (PM) 2.5 and PM10 levels were collected from the National Ambient Air Monitoring System in South Korea. Changes in PA, measured in metabolic equivalents of task-min/wk before and after dyslipidemia diagnosis, were evaluated for associations with air pollution levels and CVD risk using Cox proportional hazards regression. Patients were followed from January 1, 2013, until CVD onset, death, or December 31, 2021. Among patients exposed to low to moderate PM2.5 levels (≤25 μg/m3), increasing PA from inactive to ≥1000 metabolic equivalents of tasks-min/wk was associated with a lower risk of CVD (adjusted hazard ratio, 0.82 [95% CI, 0.70-0.97]; P for trend=0.022). In high PM2.5 (>25 μg/m3) conditions, increasing PA from inactive and decreasing PA from ≥1000 metabolic equivalents of task-min/wk was associated with reduced (P for trend=0.010) and elevated (P for trend=0.028) CVD risks, respectively. For PM10, increased PA was linked to reduced CVD risk (P for trend=0.002) and decreased PA to elevated risk (P for trend=0.042) in low to moderate PM10 (≤50 μg/m3) conditions, though benefits diminished at high PM10 (>50 μg/m3) exposures. Promoting PA, while considering the high potential cardiovascular risk associated with air pollution, may be an effective intervention against CVD in patients with dyslipidemia.

Heavy metal pollution from standardized e-waste dismantling activities: Pollution index, risk assessment and intervening measures

Due to the e-waste complexity and recycling technology limitations, more and more attention has been paid to the inevitable pollution in the standardized recycling process. This study systematically explores the heavy metals (HMs) (from surface dust) pollution characteristics and exposure risk of a typical e-waste dismantling plant (EDP) in South China. Further, this study explores the real level of health risks through valence analysis of a typical HM (Cr), and seeks effective measures to reduce exposure risk through behavioral science methods. The current results showed that the concentration of seven HMs in surface dust of the EDP is between ND-1.91 × 104 mg/kg. All the HM assessment models showed that the EDP has a certain degree of HM pollution. The highest non-carcinogenic risk (2.10) and carcinogenic risk (1.60 ×10−4) caused by the EDP were higher than the reference dose, indicating the high potential exposure risk of surface dust. However, the valence analysis showed that the health risk may be overestimated due to the fact that the existing carcinogenic risk of Cr is calculated in the form of Cr (VI). The behavioral science method showed that improving workers' standardized behavior habits and intentions is an effective way to avoid workers' exposure to HMs.

Evaluation and Proposal Repair Safety Culture Maturity Use Safety Model Canvas in Manufacturing Companies

PT. Rajawali Sumber Rejeki is one of the manufacturing companies that produces cigarettes in Indonesia. The cigarette production process involving large machines has a high potential risk of accidents for employees. This study assesses and proposes improvements to the company's safety culture maturity as a material for evaluating the company's K3 policy so that the number of work accidents in the production process can be minimized. The safety culture maturity assessment involves safety culture variables, namely commitment, leadership, responsibility, competence, engagement &amp; involvement, information &amp; communication, risk, and organizational learning. Data collection was carried out by distributing questionnaires to 60 employees working in the company. Three expert judgments were also involved as determinants of the weight of the safety culture maturity variable using the AHP (Analytical Hierarchy Process) method. In addition, fuzzy theory is also used to reduce the subjectivity of the company's safety culture maturity assessment results. Then the improvement proposal is given with a safety model canvassing based on the results of the safety culture maturity assessment. The results of the study showed that the safety culture maturity of PT. Rajawali Sumber Rejeki is 3.5 which is included in the Complaint level. Based on the safety canvassing model that has been created, the priority for improving the safety culture maturity variables from the first to the last is organizational learning, competence, commitment, information &amp; communication, risk, engagement &amp; involvement, responsibility, and finally the leadership variable.

Prediction of Ki-67 expression and malignant potential in gastrointestinal stromal tumors: novel models based on CE-CT and serological indicators

PurposeTo identify more reliable imaging and serological indicators for predicting Ki-67 expression and malignant potential in gastrointestinal stromal tumors, as well as to develop a preoperative prediction model with clinical utility.Patients and methodsThis study retrospectively analyzed patients with gastrointestinal stromal tumors (GIST) diagnosed at the First Affiliated Hospital of Jinzhou Medical University between May 2018 and May 2024. Univariate logistic analyses, two-way stepwise regression, P-value stepwise regression, and LASSO regression were employed to screen for Ki-67 high expression and high malignant potential risk factors associated with GIST. Models were established using various regression methods; Nomograms, calibration curves, and clinical decision curves were generated for the two best prediction models.ResultsTwo-way stepwise regression analysis revealed that diameter (P=0.037; OR=1.22; 95% CI: 1.01 - 1.46), growth pattern (extraluminal type: P=0.028; OR=3.54; 95% CI: 1.14 - 10.94), enhancement model (P=0.099; OR=0.39; 95% CI: 0.12 - 1.20), EVFDM (P=0.069; OR=0.43; 95% CI: 0.17 - 1.07), PLR (P=0.099; OR=3.06; 95% CI: 0.81 - 11.59), and OPNI (P=0.058; OR=2.38; 95% CI: 0.97 - 5.84) are identified as independent risk factors for Ki-67 expression. Utilizing the two-way stepwise regression model to predict Ki-67 expression, the area under the curve (AUC) for the training group was 0.865 (95% CI: 0.807-0.922), while for the validation group it was 0.784 (95% CI: 0.631-0.937). The Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC) for the training group were 153.360 and 174.619, respectively. Two-way stepwise regression analysis revealed that volume (P < .001, OR = 1.06; 95% CI: 1.03 - 1.09), contour (P = 0.066; OR = 0.17; 95% CI: 0.05 - 0.62), ulcer (P = 0.094; OR = 0.16; 95% CI: 0.03 - 0.98), IBSC (P = 0.008; OR = 5.27; 95% CI: 1.57 - 17.69), and OPNI (P = 0.045; OR = 0.22; 95% CI: 0.05 - 0.96) are independent risk factors for malignant potential. Utilizing the two-way stepwise regression model to predict malignant potential, the AUC for the training group was 0.950 (95% CI: 0.920 - 0.980), while for the validation group it was 0.936 (95% CI: 0.867 - 1.000). The AIC and BIC values for the training group were 96.330 and 114.552, respectively.ConclusionDiameter, growth pattern, enhancement pattern, EVFDM, PLR, and OPNI are independent risk factors for GIST with high Ki-67 expression. Additionally, volume, contour, ulceration, IBSC, and OPNI serve as independent risk factors for GIST with high malignant potential. The preoperative models developed using CT images can predict the malignant potential and Ki-67 expression status of GIST to a certain extent. When combined with serological indicators, these models' predictive performance can be further enhanced.

Strain As An Indicator For Stress Fractures In Racehorses

Abstract The horse racing industry, despite its financial significance, grapples with significant welfare issues, particularly stress fractures in racehorses. Third metacarpal (MC3) bone fractures, constituting about one-third of all limb fractures, severely impact horse health and performance. The frequent occurrence of condylar fractures in the MC3, often resulting in bone comminution, poses high risks-sometimes necessitating euthanasia, and complicates the management and recovery processes for the rest. Comprehensive methods for quantitatively determining fracture risks in horses are lacking, with strain measurements on the MC3 during racing conditions showing promise as an indicator of high loads and potential fracture risks. This study investigated the mechanical properties of MC3 under high compressive loads. Six MC3 bones from euthanized horses were instrumented with strain gauge rosettes at four key locations: Lateral Condyle (CondL), Medial Condyle (CondM), Dorsal DistoLateral (DisL) and Dorsal DistoMedial (DisM). Each bone underwent a pre-loading phase and five cycles of 12kN sinusoidal loading to replicate galloping forces. Strain patterns were observed before and after introducing an artificial slot in the lateral condylar groove to simulate a fatigue crack. A strong correlation was found between load and minimum principal strain in both intact and fatigue crack-induced (FCI) bones, with R-squared values over 0.99. Post-FCI, 83% of bones exhibited an increase in the minimum principal strain-load response slope, indicating uniform changes in material behavior. Additionally, a rise in post-FCI y-intercept values across MC3 locations indicated higher initial strain and possible changes in bone properties.

Penerapan Program Kesehatan dan Keselamatan Kerja dalam Aktivitas Kerja Coal Hauling di PT. XYZ

The implementation of an occupational health and safety (K3) program can be an effort for mining companies to make efforts to prevent accidents in mining work activities such as coal hauling. Based on this, the purpose of this study was to analyze the implementation of K3 (occupational health and safety) on coal hauling activities by PT. XYZ with HAZOP and HIRARC methods. The research was carried out using data collection methods such as interviews, observations, and document studies. Furthermore, the data were analyzed using the HAZOP and HIRARC methods, which are data analysis methods that aim to determine the potential hazards that exist in mining work activities. The results showed that through the HAZOP analysis showed that there were 12 sources of danger in 5 work activities in the Coal hauling section. These 12 hazard sources are divided into 4 hazard categories with 56% high risk, 24% moderate risk, 15% extreme conditions, and 5% low risk. Based on this, it can be seen that the potential hazard by causing work accidents is quite significant. Meanwhile, the HIRARC analysis shows that there are 6 sources of danger with 9 potential work accidents which are divided into 4 categories of hazards as much as 51% high risk 4 potential risks, 21% extreme risk with 1 high value potential risk, 18% low risk with 3 potential risks, and 10% medium risk with 1 potential hazard. This potential and source of danger has and will continue to allow for the occurrence of losses, both material and physical injury to employees.

A novel all-solid-waste binder prepared by salt-alkali synergistic activation system constructed from phosphogypsum, soda residue and calcium carbide slag

Conventional alkali-activated slag materials apply strong industrial alkalis with high cost and potential corrosion risk. Alternatively, this study utilized industrial solid waste phosphogypsum, soda residue, and calcium carbide slag to construct a salt-alkali synergistic activated system. A new salt-alkali synergistic activation effect was formed by the SO42− introduced by PG together with the Cl− and OH− provided by SR and CS, which promoted the hydration reaction. AFt, Friedel's salt, C-(A)-S-H, and other hydration products were generated and congregated, and a new all-solid-waste binder was created with 3d/28d strengths of 17.9/43.9 MPa, meeting the P·O 42.5 cement strength standard requirements. By conducting compressive strength and drying shrinkage tests on mortar and paste specimens with varying ratios, and employing XRD, TG-DTG, FTIR, and SEM-EDS analyses, the mechanical attributes of the binder were systematically assessed, and its hydration process was elucidated.

State-of-the-Art Review of Continuum Mechanics-Based Modelling of Soil Surface Erosion

AbstractSoil surface erosion can shape the morphography of rivers and estuaries in the natural environment and induce high potential risks to structures in engineering. Numerical simulations based on continuum mechanics theory can provide reliable assessments of the evolution of surface erosion from the perspective of a large-scale view. However, current studies on continuum mechanics-based modelling are still limited. This paper comprehensively reviews such numerical simulations of soil surface erosion. This review begins by discussing the fundamental physical mechanisms of surface erosion. Subsequently, it explores the basic physics-based conservation equations controlling soils and fluids in surface erosion. Then, the empirical formulae depicting the different stages of surface erosion are presented. Building on these mathematical foundations, this paper reviews various numerical methods for surface erosion modelling from a continuum mechanics perspective. Finally, this paper discusses the advantages and limitations of the numerical methods. This work can provide researchers convenience for using numerical models on surface erosion simulations.