High Positive Correlation Research Articles

Psychometric Evaluation of the Stuttering Anticipation Scale in Turkish (SAS-TR).

Anticipation is a covert aspect of stuttering that plays a crucial role in the lives of adults who stutter (AWS). It can influence anxiety levels or provide an opportunity for self-regulation. For assessing anticipation in stuttering, The Stuttering Anticipation Scale (SAS) was developed. This study aims to develop a Turkish version of the SAS (SAS-TR) and evaluate its validity and reliability. Ninety-four AWS (aged 18-40 years) participated in the study. They completed SAS-TR and demographic information form either face-to-face or online. The internal consistency, test-retest reliability, and construct validity of the SAS-TR were assessed. Exploratory factor analysis (EFA) was also conducted as part of the construct validity evaluation. The SAS-TR scale demonstrated high internal consistency (Cronbach's alpha = 0.947) and high test-retest reliability (ICC = 0.973). SAS-TR total score and its sub-dimensions showed acceptable to high positive correlations among themselves (ranging from r = 0.209 to r = 0.962). Factor loadings for the SAS-TR items ranged between 0.572 and 0.899, exceeding 0.300 and indicating suitability for EFA. The SAS-TR exhibits valid and reliable properties for Turkish-speaking AWS. It is recommended for use in both research and clinical settings to enhance understanding of anticipatory behaviors in this population.

Synergistic effects of carbon and heat under disturbance of human activities: Evidence from a resource-based city of China.

For resource-based cities, the rapid development of industrialization and urbanization has led to significant carbon emissions (CEs), accelerated the rise of urban land surface temperatures (LSTs) and hindered sustainable urban development. This study constructed a model to measure the carbon-heat relationship to clarify the complex relationship between LSTs and CEs in resource-based cities. The results show that:1) High-temperature areas are primarily concentrated around the urban center and large industrial zones, with average LSTs reaching a peak of 35.7°C in 2015, indicating severe temperature polarization; 2) CEs exhibited an overall upward trend with a diffusion effect, particularly pronounced in the urban center and industrial zones. Areas with extremely significant, strong significant, and generally significant growth in CEs accounted for 4.64%, 3.81%, and 81.35%, respectively, showing a concentrated increase in the urban center; 3) A positive correlation between CEs and LSTs of the city was identified, and the distribution of urban heat island and the high value area of CEs are concentrated and similar; 4) The synergistic effects between LSTs and CEs varied between urban center, suburban and peripheral areas, due to human activities. Areas with a high positive correlation between CEs and LSTs are concentrated in urban centers and peripheral areas, while for urban suburbs, the correlation is weak or even absent. To mitigate the negative effects of carbon-heat accumulation, urban centers should avoid high population concentrations, and the carbon sink potential of green spaces near industrial zones and peripheral areas should be fully utilized. These insights provide actionable strategies for sustainability of resource-based cities, particularly in the governance of urban thermal environments and the mitigation of CEs.

Heat-induced Pleurotus ostreatus protein gel improved by konjac glucomannan: physicochemical, gel and structural properties

This study investigated the influence of konjac glucomannan (KGM) on the physicochemical and structural properties of Pleurotus ostreatus protein (POP) gels, and explored the potential mechanism. Results demonstrated that konjac glucomannan (KGM) addition reduced turbidity, increased zeta potential and particle size, and promoted solution stability. Lower KGM addition (0.1%~0.6%) significantly improved the hardness, elasticity, chewiness, water holding capacity (WHC), storage modulus, and loss modulus of POP gels, especially for the 0.6% KGM addition. However, higher addition of KGM (0.8%~1.0%) decreased the textural properties and WHC of POP gels. Secondary structure analysis showed that adding 0.6% KGM increased the α-helix content from 13.76% to 17.82%, while the β-sheet content increased from 31.06% to 45.45%. Molecular forces and scanning electron microscopy showed that the addition of KGM enhanced the hydrogen bond and disulfide bond, promoting the formation of a denser network structure with good uniformity of the composite gels. Principal component and correlation analysis showed that hardness and WHC of the gels had high positive correlation with hydrogen bond, disulfide bond, β-sheet and random coil. This study provided a foundation for using KGM/POP composite gels in plant-based substitutes.

The effect of the work-family conflict, subjective socio-economic status, and physical activity on the perceived quality of life of working women in Iran: the mediating role of quality of work life

IntroductionThe conflict between work and family responsibilities has created many challenges for working women in Iran. This study aimed to examine the effect of work-family conflict (WFC), subjective socio-economic status (SSS), and physical activity (PA) and quality of working life (QWL) on the quality of life (QOL) of working women in Kermanshah, Iran.MethodsThis cross-sectional study was conducted with 392 working women in Kermanshah, the most populous city in western Iran. The data gathering tool was a six-part questionnaire, including demographic checklist, PA scale, a question on SSS, WFC scale, QWL questionnaire, and QOL questionnaire. Data were analyzed by SPSS and AMOS software.ResultsThe majority of participants (69.4%) were inactive or had low levels of PA during their leisure times. The highest positive correlation was observed between QWL and QOL (r = 0.309, p-value < 0.001). The highest direct effect among the variables belonged to the SSS on QWL (β = 0.41, p-value = 0.001) and QOL (β = 0.20, p-value < 0.001). Furthermore, the analysis of indirect effects indicated that QWL played a mediating role between SSS and QOL (β = 0.092, p-value < 0.001).ConclusionThe findings of this study revealed that variables such as SSS, PA, and QWL had significant direct effects on QOL. However, WFC had no significant effect on QOL. Moreover, QWL had a significant positive mediating role between SSS and QOL.

How does investor sentiment impact systemic risk contagion across industries? Evidence from the Chinese stock market

ABSTRACT This study uses daily data across 24 sectors in China to investigate the contagion effect of systemic risk among industries. The data include industry returns, sentiment and marginal expected shortfalls (MES) from 1 January 2016 to 31 December 2022. A multi-source heterogeneous (MSH) data fusion method and an empirical Bayesian approach are employed to construct MSH data and build a complex network based on a graphical Gaussian model. The findings confirm high positive correlations and a significant clustering effect among industries in the Chinese stock market due to upstream and downstream supply chains and shareholding relationships. Moreover, the study reveals that systemic risk contagion is significantly associated with extreme events and the dissemination of investor sentiment. We calculate industry’s systemic risk receiver (SSR) index, rank the industries based on their SSR index values and select the 10 highest ranked as systemically important industries. This study offers valuable insights for regulators and policymakers seeking to bolster macro-prudential oversight and implement targeted supervision initiatives.

Cavitated concentrates as a stimulating factor for the productivity of dairy cows

The article presents the results of the experiment on the positive effect of cavitated concentrates (grain mixture and wheat bran) in the diet of dairy cows of the Red Steppe breed on nutritional value, palatability and bioavailability of nutrients. Biochemical analysis of cavitated grain mixture and wheat bran, in terms of dry matter of the original raw materials indicates that with equivalent energy values, there were some changes in biochemical indicators. Thus, the content of crude protein and crude fat increased by 8.5 and 2.5%; 6.4 and 1.09% in favor of cavitated feeds. The content of crude fiber and starch in the grain mixture decreased by 3.5 and 3.7%, in wheat bran - by 19.4 and 3.9%. The increase for sugars in the grain mixture was 15.2 g, in wheat bran - by 6.2 g. The feed intake of the diet, on average during the experiment compared to the control, was higher in cows of the I and II experimental groups: for roughage - by 2.3 and 3.7%, for succulent - 3.6 and 6.0%. During the record period of the experiment, the milk productivity of cows receiving a diet with traditional concentrate preparation was 2070 kg, which is 22.9% less than that of their peers receiving a cavitated grain mixture with the diet, and 26.2% less than that of animals receiving cavitated wheat bran. At the same time, having small differences in the content of fat and protein in milk (3.48-3.55% and 3.28-3.30%), the increase in milk yield in experimental groups I and II affected the yield of "milk fat" and "protein mass fraction". Thus, these indicators were 72.45 in the control, 90.35 in I and 90.88 kg and 68.1; 84.0; 85.7 kg in II, which is higher in comparison with the control by 24.7 and 23.3%; 25.4 and 25.8%. A positive relationship was revealed between the content of metabolizable energy in the diet and daily milk yield, with an increase in this indicator in the diet by 2.51 and 2.76%, the daily milk yield increased by 22.9 and 26.2%, respectively. A high positive correlation was found between the amount of protein in milk and the sugar content in the diet (r=0.99), indicating a high degree of interdependence. The content of exchange energy in the diet correlated with the amount of fat in daily milk yield (r=0.99).

Self-Efficacy and Self-Esteem of Ukrainian Citizens During the War

Introduction: War significantly limits people’s autonomous functioning in many life aspects. As a result of the Russian Federation’s invasion of Ukraine, the quality of life of Ukrainian citizens has significantly deteriorated. In times of war, self-efficacy and self-esteem play a key role in dealing with difficult, unpredictable situations. It is, therefore, important to undertake research in this area. Research Aim: The aim of the conducted research was to diagnose self-efficacy and self-esteem of Ukrainian residents during the war, and to determine the relationship between these two variables. Method: The authors have used a quantitative research approach and a diagnostic survey as a data collection method. The sample consisted of 1,783 respondents coming from all provinces of Ukraine. Two research tools were used: Schwarzer and Jerusalem’s Generalized Self-Efficacy Scale and Rosenberg’s Self-Esteem Scale. Results: The analyses have shown that Ukrainian residents participating in the studydisplayvarious levels of self-efficacy and fairly favourable self-esteem. The results of the study indicate the existence of a high positive correlation between the analysed variables. Conclusions: Perceived self-efficacy impacts specific actions people take in unpredictable situations, whether they pay attention to opportunities or difficulties. In times of war, self-efficacy is prerequisite to being active when the situation requires one to engage in changing an unfavourable course of events. This activity is reinforced by the individual’s possession of a positive self-esteem.

Perceived Occupational Hazard Preparation among Third Year Marine Transportation Students of AIMS

The study aimed to assess the preparedness of third-year Bachelor of Science in Marine Transportation (BSMT) students of Asian Institute of Maritime Studies (AIMS) for occupational hazards through competency-based training programs. A quantitative descriptive-correlational research design was utilized to collect data from 39 purposively sampled students regarding their demographic profiles, perceptions of skills acquisition, and self- reported preparedness levels. Questionnaires were developed based on the Standards of Training, Certification and Watchkeeping for Seafarers (STCW) guidelines to measure students' mastery of skills relating to elementary first aid, survival techniques, and safety responsibilities. Descriptive statistics provided a summary of the skills acquisition and self-reported preparedness while Pearson's R analyzed the relationship between the skills acquired in preparation for occupational hazards and preparedness when onboard the vessel. Results indicated that most respondents were male, aged 21-23. The students strongly agree that the training effectively developed their abilities adhering to international standards. Moderate to high positive correlation between skill acquisition and preparedness suggested that the training enhanced the self-assessed hazard response capabilities of the students. Accordingly, maritime education adequately equipped graduates as regulated. Significant associations validated the competency-focused pedagogies of the BSMT program. The study rejected the null hypothesis, finding a significant relationship between acquired skills and preparedness for actual occupational hazards. This underscores the value of interactive, application-focused teaching methods, such as those implemented by AIMS, in building the confidence of maritime students to respond effectively to onboard dangers.

Human Resource Management (HRM) and Corporate Social Responsibility (CSR): Integrating Social Goals with Employee Engagement

The integration of corporate social responsibility (CSR) and human resource management (HRM) in Pakistani firms is examined in this study, with an emphasis on the effects of CSR-driven efforts on employee engagement. 300 workers from a variety of industries, including manufacturing, services, and education, were surveyed using a standardized questionnaire as part of a quantitative research design. Employee engagement metrics (job satisfaction, motivation, and organizational commitment), HRM practices (employee training, performance evaluation, and inclusivity), and CSR practices (community development, environmental sustainability, and ethical governance) made up the three sections of the questionnaire. An online survey platform and in-person distribution was used to gather data, guaranteeing a balanced representation of demographic groupings and industries. A high positive correlation between CSR activities and employee engagement was shown through statistical analysis, including regression and correlation tests. Notable impacts were seen in community development and ethical governance projects. The results emphasize how important it is for Pakistani companies to match HRM strategies with social objectives in order to create an inclusive and purpose-driven work environment.

Diagnostic Limitations of Applying a Human Portable Blood Glucose Meter in the Detection of Hypoglycemia in Pregnant Ewes.

Pregnant ewes are susceptible to hypoglycemia and ketosis; therefore, monitoring glycemic status is extremely important. Portable blood glucose meters (PBGMs) can assist in quickly and conveniently identifying glycemic disturbances in this species, provided that they meet the criteria of analytical accuracy. This study evaluated the performance of a human PBGM (Accu-Chek Performa®, Roche Diagnostics, Basel, Switzerland) in the glycemic evaluation of 34 pregnant ewes at days 90 and 120 of pregnancy in comparison with the results of glycemia determination by a reference method (RM). The device showed a high positive correlation (r = 0.71, 95%CI = 0.57-0.82, p < 0.0001) with the RM; however, 96.6% of the PBGM results (58.5 ± 9.82 mg/dL) were higher (p < 0.0001) than those obtained in the laboratory (48.6 ± 9.31 mg/dL). The PBGM tested was considered analytically inaccurate according to ISO 15197:2013, which states that when glucose levels are below 100 mg/dL, 95% of the measurements should deviate by no more than 15 mg/dL from the RM value, and 1/3 of the PBGM results were above this limit. Hypoglycemia (<50 mg/dL) was documented in 60.29% of samples tested on with the RM, but only 17.64% of results were below 50 mg/dL using the PBGM. Due to these limitations, Accu-Check Performa® results should be interpreted cautiously in pregnant sheep suspected of hypoglycemia.

The effects of some chemical compounds on the sound absorbing ability of tree bark.

Tree bark is an important natural polymer for sound absorption. The main components in the bark of different tree species are polymers with high molecular weight such as cellulose, hemicellulose, and lignin. The aim of this study is to determine the noise reduction coefficient (NRC), lignin, alcohol-benzene solubility (ABS), carbon (C), and nitrogen (N) contents in samples taken from the bark of different tree species-black locust (Robinia pseudoacacia), narrow-leaved ash (Fraxinus angustifolia), stone pine (Pinus pinea), silver lime (Tilia tomentosa), sweet chestnut (Castanea sativa), sessile oak (Quercus petraea), and maritime pine (Pinus pinaster) and to investigate the relationship between these chemical properties and sound absorption measurements. Tree species showed a statistically significant difference in terms of all measured variables. In the correlation matrix obtained as a result of the analysis, only ABS showed a significant and the highest positive correlation with the NRC, with a correlation coefficient of r = 0.812. ABS in bark is seen as the most important chemical factor regarding sound retention, indicating the abundance of extractives in barks of different tree species. An investigation into the relationship between sound retention and different extractive substance and contents of different extractive substances in bark is recommended for further studies.

Enhancing Talent Retention of TVET Colleges’ Lecturers through Specific Talent Management Dimensions

"Talent management (TM) is a critical strategic issue for higher education institutions (HEIs) in South Africa (SA) given its impact on institutional performance, however, retaining academic talent remains a challenge in this highly competitive work environment. This study aimed to investigate talent retention (TR) of lecturers through specific TM dimensions (i.e., talent training and development (TT&amp;D), performance management (PM), and compensation) at public technical and vocational education and training (TVET) colleges in the North West province, SA. A quantitative research approach was adopted, employing a cross-sectional study that collected data from 124 lecturers using self-completed questionnaires. This study’s results revealed that a substantial number of respondents were considering leaving their employment, citing dissatisfaction with TT&amp;D, PM, compensation, and TR practices at public TVET colleges. A high positive correlation between TT&amp;D and TR, and between compensation and TR, and a moderate positive correlation between PM and TR were established in this study. Policymakers and practitioners can refer to the findings of this study to better understand and improve TR through enhanced TT&amp;D, PM, and compensation practices. Strategic development of policies intended for improving TT&amp;D, PM, compensation, and TR practices at public TVET colleges is thus highlighted. "

Establishing the degree of control in patients with atopic dermatitis with the atopic dermatitis control tool (ADCT).

Atopic dermatitis (AD) is a disease of multifactorial etiology that affects the quality of life of those afflicted. The degree of control of patients with AD over 12 years of age was determined with the Atopic Dermatitis Control Instrument (ADCT). This observational, cross-sectional, descriptive study included patients with AD who were evaluated with a self-administered instrument, the ADCT. Pearson's Chi square and Student's t-tests were used for categorical variables. The association between continuous variables was analyzed with the Pearson and Spearman correlations. A total of 55 patients with AD were included-42 women (76.4%) and 13 men (23.6%). The median age was 24 years (12-63). Regarding the degree of disease control, it was adequate in 23 (41.8%) patients and inadequate in 32 (58.2%). The patient's sex, age, work activity, residence, and level of education were not statistically significant factors for the degree of control. The most prevalent comorbidity was allergic rhinitis with a higher percentage in those with adequate control (p = 0.049). Treatment with corticosteroids was associated with good disease control (p <0.001). A high positive correlation (r = 0.770, p < 0.001) was found between the SCORAD score and the ADCT score for symptom control. SCORAD and POEM scores showed a direct proportional relationship (r = 0.791; p < 0.001). The ADCT allowed us to determine the degree of control of atopic dermatitis and develop treatment strategies.

Personal Competence Formation in Education: The Effectiveness of the Development and Use of Gamified Learning Based on the Metaverse

This research aims to evaluate the effectiveness of the educational method in the formation of student personal competence. The study also identifies differences in perception between students from megacities and regions of China and Russia. The authors analysed the students’ experience and knowledge in the field of gamification in the metaverse, as well as their perception of the metaverse as an educational tool. Accordingly, the research method is a survey based on the questionnaire “The Effectiveness of Using Virtual Video Metaverse-Based Games in Education” developed by the authors. The results of the study showed that more than half of the students rated the method of using virtual video games in the educational process as effective (45%) or very effective (35%). A correlational analysis and linear regression were conducted to assess the relationship between students’ satisfaction levels with the use of virtual video games in education and their perception of the effectiveness of this teaching method. Data were analyzed using a standard significance level of p &lt; 0.05 to determine statistical significance. A high positive correlation was found between students’ satisfaction levels and their perception of the effectiveness of using virtual video games in education. The study also revealed that by using gamified learning in the educational process, students develop a variety of skills and gain new knowledge (46%). The results of this study suggest a high potential for the use of gamified learning (video games) in modern education. It is crucial to understand this potential and differences in perception between students from different regions to develop more effective educational programs based on socio-economic factors and increasingly available educational resources. The findings also necessitate further efforts in developing strategies to deal with barriers and limitations. There is an urgent need to optimize the use of metaverses in education according to local socio-cultural characteristics.

Vitamin D and Metabolic Health: A Study of Lipid and Glucose Profiles in Benghazi, Libya

Vitamin D is an essential fat-soluble vitamin and it acts in the body like a steroid hormone with a multitude of functions. Vitamin D deficiency is common in Benghazi, Libya especially among females and in the older age groups. Recent reports have found that hypo 25-(OH) D is associated with many diseases. The relationship between vitamin D status and dyslipidemia and diabetes is unclear. The objective of this study was to investigate the role of vitamin D level in all lipid parameters, fasting blood glucose and cumulative blood glucose levels in Libyan adult sample. Clinical investigatory data of (110) random subjects was obtained from Alrazi laboratory in Benghazi, Libya over a four-month period. The mean concentration of TC, VLDL-C, TG levels, FBG and (Hb1AC) levels were higher in (25(OH)D) deficient group, when compared to subjects with sufficient 25(OH)D group. While the mean concentration of HDL-C and LDL-C were lower in deficient group. A higher percentage of subjects who had high TG, VLDL, FBG and low HDL in 25(OH)D deficient group in compare to sufficient group. While, a lesser percentage of subjects who had high TC and LDL in 25(OH)D deficient group in compare to sufficient group. However, there are a statistically significant correlation of 25(OH)D deficiency and overall elevation of all lipid parameters serum levels, concurrent elevation of VLDL and triglycerides and concurrent elevation of VLDL and FBG. Our results may indicate that there is a negative correlation between vitamin D deficiency and high TG, VLDL, FBG and positive correlation with TC and LDL and HDL.

Exploring the Effectiveness of Supervision in Enhancing Management of Educational Facilities in Secondary Schools in Akinyele Local Government of Oyo State

The study explored the effective use of supervision of educational facilities management in bringing effective and efficient teaching and learning processes in schools in Akinyele local government. Ex-post facto design was adopted Multi-stage sampling technique was used to select fifteen principals, thirty vice-principals, forty-five heads of departments and one hundred and fifty students making two hundred and forty participated in the study. Two validated instruments were employed, and data collected were analyzed by frequency count and Pearson correlation. 119 (49.6%) of the respondents indicated bimonthly supervision of their school, followed by 62 (25.8%) monthly, 46 (19.2%) weekly, and 13 (5.4%) never indicated that their schools have never been supervised. There is a high positive correlation between education supervision and availability of facilities in schools (r = 0.770; P = 0.000). There is a high positive correlation between education supervision and access to facilities (r = 0.838; P = 0.000). There is a high positive correlation between education supervision and usability of facilities in schools (r = 0.863; P = 0.000). 196 (81.7%) proper utilisation of education facilities top the roles of supervisors in management of educational facilities as indicated by respondents. Watch dog follows this for lazy teachers 184 (76.7%). School and education supervision affect the availability, adequacy, access to as well as utilization of education facilities; therefore, school supervision should be continuous with a view to making the availability of education facilities more adequate, accessible, and utilized.

Impact of Leadership Styles on Healthcare Team Performance and Patient Satisfaction

Introduction: The impact of Leadership on healthcare team performance and patient satisfaction has been highly researched within the healthcare industry. However, literature examining the specific leadership styles and their effects on these outcomes is limited. The present study was conducted to analyze the impact of different leadership styles on healthcare team performance and patient satisfaction.Methods: Data were collected from 200 healthcare providers and 500 patients using a quantitative research design in numerous healthcare institutions. Leadership styles were assessed using the Multifactor Leadership Questionnaire. Team performance was measured using the Team Performance Scale, and patient satisfaction was measured using the modified Consumer Assessment of Healthcare Providers and Systems survey. Results: Results revealed a high positive correlation between transformational leadership and team performance, demonstrating the direct effect of leaders who stimulate and engage their group. Autocratic leadership, however, was negatively correlated with making and can have implications for the dynamics of the team and, subsequently, their performance. A positive relationship between transformational and democratic leadership and clinical nurse satisfaction was shown.Conclusions: The results of this research indicate that leadership styles are vital factors that affect healthcare teams' functioning and patient satisfaction. It demonstrates how healthcare leaders can positively impact their teams and patients by employing transformational and democratic styles. That strong leadership can improve the quality of healthcare delivered.

Comparative analysis of phenotypic and genetic correlations between zootechnical traits in domestic reindeer

The study was conducted to determine the possibility of using phenotypic correlations between traits as an indirect indicator of genetic correlations in domestic reindeer (Rangifer tarandus L.). The assessment of phenotypic parameters of the exterior and live weight of reindeer was carried out at the Yamal Experimental Station, a separate structural subdivision of the Federal State Budgetary Scientific Institution, the Tyumen Scientific Center, Siberian Branch of the Russian Academy of Sciences. The object of the study was a population sample of 94 adult females of the Nenets breed, selected at random, without constitution defects and having a calf. in October 2020. A total of 94 does (adult females) aged 3 to 9 years were examined. The animals were well-fed, had a calf and had no visible constitution defects. The sample showed high positive phenotypic correlations between “height at withers” and “height at elbow” (=0.84), “height at withers” and “chest depth” (=0.71), “live weight” and “chest girth” (=0.63), as well as between “live weight” and “chest depth” (=0.6). Genetic correlations between traits calculated using genotypes of microsatellite markers showed comparable results. For the pair of measurements “height at withers” and “height at elbow”, the genetic correlation was about 0.83, and for the pair “height at withers” and “chest depth” it was about 0.71. The results of comparative analysis between phenotypic and genetic correlation matrices demonstrated a high degree of consistency. It has been shown that phenotypic correlations can potentially be used as an indirect indicator of genetic correlations for reindeer selection for live weight and linear body dimensions.

Monitoring the Course of Acute Pyelonephritis Complicated by Diabetes Mellitus in the Experiment

The study of the pathogenesis of the dysfunction of the urinary system in АP nowadays includes the study of the body’s reaction in response to a transient infection, the level of molecular mediators of inflammation and protective cellular mechanisms under the conditions of the action of uropathogens, taking into account the nature of the course of the disease, which justifies the need to develop new approaches to complex treatment. The objective: to determinate the pathogenetic role of eicosanoids in the implementation of apoptosis processes in the structural elements of the kidneys by using a mathematical model for predicting the course of АP and concomitant hyperglycemia under drug exposure. Materials and methods. Experimental studies were conducted on Wistar line rats weighing 200-300 g at the age of 8-9 months. The animals were divided into 8 groups. The experiment was carried out in accordance with the “General Ethical Principles for Experiments on Animals”. To determine the correlations between the content of prostaglandin E2, leukotriene B4 and the level of fragmented DNA (fDNA) in the kidneys, the experimental data obtained during the determination of the proinflammatory effects of eicosanoids and the level of fragmented DNA in acute pyelonephritis in rats complicated by hyperglycemic state under conditions of pharmacocorrection were used. Rats with AP complicated by hyperglycemic state (type II) received etiotropic drug treatment (EDT) – intramuscular antibacterial drug of cephalosporin series (cefoperazone sodium salt) at a dose of 60 mg/kg animal weight per day and etiopathogenic drug treatment (EPDT) – intramuscular antibacterial drug (cefoperazone sodium salt), and orally – a drug of the group of immunomodulators, metabolism-correcting, energotropic action – ribonucleic acid at the rate of 21 mg/kg per day and intramuscularly a drug of the group of antiaggregants, inhibitors of free radical processes, membrane protector, (2-ethyl-6-methyl-3 – hydroxypyridine succinate) 4.5 mg/kg of animal weight per day for 14 days after modeling of AP. The content of prostaglandin E2, leukotriene B4 and fDNA in the kidneys of rats was studied 28 days after the start of the modeling. Results. Data on the presence of a direct correlation between pro-inflammatory factors – eicosanoids (prostaglandin E2 and leukotriene B4) and the level of fragmented DNA (fDNA) in the kidney tissue of rats with acute pyelonephritis (AP) complicated by diabetes mellitus (DM) in the experiment are given. In the kidneys of animals, with АP, a significant increase in the level of fragmented DNA and the above-mentioned eicosanoids was found relative to the norm. In rats with АP, concomitant diabetes of type II and especially type I contributed to a significant increase in the level of fDNA in the kidneys and an increase in the content of pro-inflammatory eicosanoides – prostaglandin E2 and leukotriene B4 compared to the norm. At the same time, the presence of a high positive correlation between the level of DNA degradation and the accumulation of prostaglandin E2 and leukotriene B4 in the kidney tissue was established in АP with concomitant type I and II diabetes, which convincingly testifies to the pathogenetic role of pro-inflammatory factors of eicosanoids in the implementation of apoptosis processes. Conclusion. The data obtained can be considered as a clinical and biochemical experimental justification of the informative value of establishing the relationship between the nature of the course of the infectious and inflammatory process in the kidneys in conditions of concomitant DM by the content of eicosanoids and the level of DNA fragmentation in the kidneys and the possibility of using the correlation between these indicators in predicting the course of AP and concomitant DM, as well as in assessing the effectiveness of etiopathogenetic drug treatment. The used mathematical model with logistic regression makes it possible to predict the probability of an unfavorable course of the disease and the effectiveness of medication based on the obtained data regarding the presence or absence of laboratory signs of the studied pathological condition.

Bioactive Compounds, Antioxidant Properties, and Antimicrobial Profiling of a Range of West Algerian Honeys: In Vitro Comparative Screening Prior to Therapeutic Purpose.

Honey is a complex natural nutrient with well-established therapeutic properties recognized in traditional medicine. The purpose of the current work was to compare, in vitro, the bioactive compounds, antioxidants, and antimicrobial properties of 37 honey samples collected from the western region of Algeria and to identify the best sample for potential therapeutic purposes. Estimation of bioactive compounds was carried out by determining the total phenolic and flavonoid contents. Large variability among the samples was observed regarding the total phenolic content (from 24.17 ± 1.38 to 122.15 ± 3.55 mg GAE/100 g honey) and total flavonoid content (from 0.07 ± 0.01 to 33.49 ± 4.90 mg QE/100 g honey). Additionally, antioxidant activity, evaluated by four spectrophotometric assays, displayed fluctuating results among the samples. High positive correlations were observed between β-carotene and DPPH (0.766) and between β-carotene and ABTS (0.600), while inverse correlations were observed between bioactive compounds and antioxidant activity, except for the FRAP method. The antimicrobial activity, determined by well-diffusion assays, exhibited a dose-dependent antibacterial effect, with significant inhibition toward methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa reference strains. However, no activity was observed against Candida albicans strains. The MIC and MBC values were identical in most samples (range: 60 to 80% w/v) and predominantly exhibited bactericidal effects. The content of bioactive compounds played a significant role in the antibacterial properties. To summarize, the best honey sample for potential therapeutic purposes corresponded to mild white mustard (S6) and might be used as an alternative in therapeutic applications.