Higher Percentage Of Responses Research Articles

Tofacitinib in the treatment of moderate to severe ulcerative colitis in Colombian pediatric patients: Real world experience

IntroductionThere are no studies on efficacy of tofacitinib for moderate-severe ulcerative colitis (UC) in pediatric patients in Latin America. The aim of this study was to describe the efficacy and safety, in real world, treated with tofacitinib in our setting. Materials and methodsCase series of pediatric patients with UC who received treatment with tofacitinib in induction phase for 8 weeks and then maintenance therapy between November 2021 and February 2023. Results4 female patients, median age 14.5 (SD 2.1; RIQ12.5–16.5) years, all with prior biologic exposure, all 4 with prior use of anti-TNF, and 2/4 with prior use of anti-integrin. Clinical, biochemical and endoscopic remission was obtained in 3/4 at induction. Information was obtained from 3 patients in 6-month maintenance, 2/3 remained in clinical, biochemical and endoscopic remission and 1/3 has not achieved biochemical or endoscopic remission. Information was obtained from 1 patient in 12-month maintenance, achieving clinical and biochemical remission, however, endoscopic remission has not been achieved. One patient was initiated for severe acute UC with risk of colectomy, with significant improvement after 7 days, reaching therapeutic objectives at induction. No serious adverse events were reported in any of the cases. ConclusionsEfficacy and safety are demonstrated with tofacitinib in pediatric patients. With high percentage of response in induction treatment, sustained over time, and safe. In the context of severe acute hospitalized UC, it has a role as a potential rescue therapy due to its rapid action.

Corroborative Activities and Recognition Between Community Comprehensive Care Unit’s Nurses and Care Managers in Supporting Discharge of Elderly from Hospital – A Secondary Publication

Objective: The purpose of this study was to clarify the collaborative activities and mutual recognition between community comprehensive care unit nurses (Ns) and care managers (CM) in supporting the discharge of the elderly from the hospital. Methods: A total of 300 nurses working in community comprehensive care wards and 360 care managers working in B City in A Prefecture were surveyed using an anonymous self-administered questionnaire. Results: The highest percentage of responses regarding necessary collaborative activities with multiple professions in supporting hospital discharge were the same for Ns and CMs. The items regarding practice with the highest percentages were “relationship as a team” for Ns, and “user-centered awareness” for CM. While these professionals were willing to share information about their patients’ lives after discharge, the percentage of those explaining their expertise was low. It is thought that collaborative activities focusing on these aspects would lead to more appropriate discharge support.

Should We Offer Web, Paper, or Both? A Comparison of Single- and Mixed-Response Mode Treatments in a Mail Survey

Abstract This article leverages a five-treatment response mode experiment (paper-only, web-only, sequential web-mail, choice, and choice-plus [choice with a promised incentive for responding online]) that was conducted within a nationally representative survey. Because this survey’s sample was drawn from respondents to another nationally representative survey, we have rich frame data that includes multiple indicators of comfort using the internet for our sample members and we can compare their response behavior across two surveys. We find that the paper-only treatment yielded a lower response rate than most of the other treatments, but there were not significant differences between the response rates for the other treatments. Among our mixed-mode treatments, the sequential web-mail treatment had the highest percentage of response by web and the lowest cost per response. When focusing on the subgroups that we expected to be the least—and the most—comfortable with the internet, we found that the paper-only treatment generally performed worse than the others, even among subgroups expected not to be comfortable with the internet. We generally did not find significant differences in the effect of response mode treatment on the response rate or percentage of response by web between the subgroups who were the most and least comfortable with the internet. In terms of the consistency of response mode choice over time, our results suggest that some people respond consistently—but also that response mode preferences are weak enough that they can be influenced by the way in which the modes are offered. We ultimately recommend using a sequential web-mail design to minimize costs while still providing people who cannot or will not respond by web with another response mode option. We also find evidence that there may be a growing lack of interest in responding by paper; more research is needed in this area.

Determining the ability of artificial intelligence to establish authorship of artistic ukrainian texts using significant fragments

Artificial intelligence is becoming an integral part of everyday life and profes-sional activity of a person. Bing, as an intelligent search system, can serve as a tool for determining the authorship of artistic text in Ukrainian. Bing helps to uncover in-formation about a text fragment and its author, although the search results may be inaccurate or incomplete. This work aims to explore the effectiveness of determining the authorship of ar-tistic texts using modern artificial intelligence tools based on significant fragments of works. Ten Ukrainian authors with a rich body of artistic works, reflecting various as-pects of Ukrainian culture and history, were selected for the experiment. Random fragments up to 500 words in length were selected from various works of these au-thors. An experiment was conducted to determine the authorship of 360 fragments. Using the Python programming language and the skpy package, software was created that sends queries and receives responses from the Bing bot embedded in Microsoft Skype. The presence of the author’s name and the corresponding title of the work were checked in the response texts. This work introduces, for the first time, a method of verifying the authorship of Ukrainian-language text fragments using the Bing bot equipped with artificial intelli-gence. A comparative analysis was conducted and experiments were carried out to identify the authorship of significant long fragments. It was found that long fragments allow the author of the artistic Ukrainian text to be determined with high accuracy. Ivan Franko has the highest percentage of re-sponses where the author’s name and the title of the work were mentioned - 87%. The proposed hypothesis regarding the effectiveness of artificial intelligence in establishing authorship of works has not been confirmed. Artificial intelligence has slightly lower efficiency than expected, which indirectly exposes its means of opera-tion. Namely, when establishing authorship, a sequential research comparison of the proposed fragment with a bank of works that are widespread in the Internet environ-ment is not performed.

Behavioral Characteristics of Children with Autistic Disorders

This study aims to describe the Behavioral characteristics of children with Autistic disorders, at the Autism Center in Sulaimani Governorate. This study investigates the behavioral traits of children who have been diagnosed with autism at the Sulaimani Autism Center in the Sulaimani governorate. The research period spans from November 2013 to May 2014. The findings of the study revealed that children exhibit difficulties in social interaction, with the highest percentage of responses being observed in the item "Marked impairment in the use of multiple nonverbal behaviors such as eye-to-eye gaze, facial expression, body postures, and gestures to regulate social interaction," accounting for 88%. This was closely followed by the item "Stereotyped and repetitive use of language or idiosyncratic language," which accounted for 82% of the responses. The prevalence of communication impairments in children is greatest in the category of "Delay in, or complete absence of, the development of spoken language (without any effort to utilize alternative forms of communication such as gestures or mime)," accounting for 80% of cases. In relation to the restricted repetitive and stereotyped patterns of behavior, interests, and activities, it has been observed that children exhibit the highest frequency towards the item "Preoccupation with one or more stereotyped and restricted patterns of interest that is abnormal either in intensity or focus," accounting for 62% of cases. Furthermore, the item "Stereotyped and repetitive motor mannerisms (e.g., hand or finger flapping or twisting or complex whole-body movements)" has the lowest frequency.

Tofacitinib en el tratamiento de la colitis ulcerosa moderada a grave en pacientes pediátricos colombianos: experiencia en mundo real

IntroductionThere are no studies on efficacy of tofacitinib for moderate-severe ulcerative colitis (UC) in pediatric patients in Latin America. The aim of this study was to describe the efficacy and safety, in real world, treated with tofacitinib in our setting. Materials and methodsCase series of pediatric patients with UC who received treatment with tofacitinib in induction phase for 8 weeks and then maintenance therapy between November 2021 and February 2023. ResultsFour female patients, median age 14.5 (SD 2.1; RIQ 12.5-16.5) years, all with prior biologic exposure, all 4 with prior use of anti-TNF, and 2/4 with prior use of anti-integrin. Clinical, biochemical and endoscopic remission was obtained in 3/4 at induction. Information was obtained from 3 patients in 6-month maintenance, 2/3 remained in clinical, biochemical and endoscopic remission and 1/3 has not achieved biochemical or endoscopic remission. Information was obtained from 1 patient in 12-month maintenance, achieving clinical and biochemical remission, however, endoscopic remission has not been achieved. One patient was initiated for severe acute UC with risk of colectomy, with significant improvement after 7 days, reaching therapeutic objectives at induction. No serious adverse events were reported in any of the cases. ConclusionsEfficacy and safety are demonstrated with tofacitinib in pediatric patients. With high percentage of response in induction treatment, sustained over time, and safe. In the context of severe acute hospitalized UC, it has a role as a potential rescue therapy due to its rapid action.

Synergistic effects of Vermi-Co extracts mixture with cytokinins on shoot regeneration of Lindernia minima (Benth.) Mukerjee—An endangered medicinal plant

The present investigation illustrates the synergistic growth effect of Vermi-Co (Vermicast and Coconut-water) extracts mixture with cytokinins on in vitro shoot regeneration of Lindernia minima. Due to less distribution threat status, this plant species has been considered as an endangered plant by IUCN (International Union for Conservation of Nature). Hence, it is necessary to conserve and to develop an efficient plant regeneration protocol for the rapid multiplication of L. minima. The nodal explants were inoculated on (¼) quarter-strength MS (Murashige and Skoog) medium supplemented with different concentrations (0.5 – 2.5 mg L-1) of BA (6-Benzyladenine), KIN (Kinetin) and TDZ (Thidiazuron) combined with various percentages of (5%, 15%, and 25%) Vermi-Co extracts mixture. Among the concentrations tested, 1.5 mg L-1 TDZ with 15% of Vermi-Co extracts mixture produced the maximum percentage of response with the highest (19.5 ± 0.20 shoots/explant) number of shoots and (10.2 ± 0.14 cm) shoot length. Then, the well-elongated shoots were transferred to rooting medium (quarter-strength MS) supplemented with 0.5 – 3.0 mg L-1 of IBA (Indole -3- butyric acid) and IAA (Indole -3- acetic acid). The highest percentage of response (98%) and maximum number of roots were observed in 1.5 mg L-1 IBA with 11.5 ± 0.29 roots per shoot and 6.6 ± 0.28 cm root length. Finally, well-developed plants were successfully transferred to the natural field condition with a survival rate of 97%. The present research revealed that, the combined growth stimulating effect of Vermi-Co extracts mixture combined with cytokinins increased the number of shoots and shoot length on shoot regeneration of L. minima from nodal explants. Our findings will be very useful for regeneration of Lindernia minima through plant tissue culture.

Evaluation of the effect of different culture systems on photomixotrophic capacity during in vitro multiplication of pitahaya (Hylocereus undatus)

Pitahaya (Hylocereus undatus) micropropagation is an alternative for obtaining invigorated plants with high phytosanitary quality. The objective of this research was to evaluate different culture systems on photomixotrophic capacity during in vitro multiplication and their effect on survival in the acclimatization stage of H. undatus. Different temporary immersion systems (TIS) were used: temporary immersion bioreactors (TIB), Ebb-and-Flow bioreactor, Recipient for Automated Temporary Immersion (RITA), and semi-solid (SS) culture medium. At 60 d of culture, the percentage of explant response, developmental variables, chlorophyll and carotene content, stomatal index (SI), percentage of closed stomata (CS), PEP (Phosphoenolpyruvate) and Rubisco (Ribulose-1,5-bisphosphate carboxylase oxygenase) content and the percentage of survival in the greenhouse acclimatization stage were evaluated. The culture systems with the highest percentage of response were the SS culture medium (96%), Ebb-and-Flow (93%) and RITA (90%). The Ebb-and-Flow and RITA bioreactors showed the highest number of shoots, with 9.5 and 9.0, respectively, the greatest length, with 2.62 and 2.71 cm, the highest chlorophyll, with 0.30 and 0.28 mg g–1 FW, and carotenoid content, with 2.25 and 2.20 mg g–1 FW. The SS medium culture system showed the highest SI with (57%), while the TIB had the highest CS, with (85%). The Ebb-and-Flow and RITA culture systems showed the highest PEP content, with 15 and 18 nmol g–1 FW, respectively; whereas, for Rubisco content, no differences were found in the different culture systems. The Ebb-and-Flow and RITA culture systems presented the highest survival rate, with 99.6% during acclimatization. The use of Ebb-and-Flow and RITA bioreactors are a biotechnological alternative for in vitro propagation of H. undatus and guarantee high survival rates during acclimatization without going through a rooting stage.

PEOPLE’S KNOWLEDGE ABOUT THE IMPORTANCE OF ENVIRONMENTAL EDUCATION

Environmental Education is essential in people’s lives. Not all students have had the opportunity to participate in Environmental Education projects during their normal study time, however, today many students are involved in projects that help them build social values and protect the planet. The objective of this research was, through an electronic questionnaire, to verify the degree of knowledge that people have about Environmental Education. In total, 1,024 people from all Brazilian states responded to the questionnaire, with the highest percentage of responses from the female audience, aged between 15 and 45 years, who studied in public schools. Most participants have satisfactory knowledge about what Environmental Education is, however a high number of people stated that they have never participated in an Environmental Education project.

Investigation and Analysis of Obesity Treatment and Obesity Management Behavior in Korean Medicine Clinics

After the completion of obesity treatment, customer (patient) satisfaction was high, and it was found that if obesity treatment was added to the existing treatment at Korean medicine clinics, sales would increase. And the respondents answered that if obesity management is implemented, sales seem to be increased at a high rate. If providing information on effective obesity management methods that have been verified in the beauty field to Korean medicine doctors, a high proportion of them were willing to combine the current obesity treatment with cosmetic therapy, and also responded that the possibility of mutual fusion and collaboration in the future is high. There were many positive answers about whether or not obesity management at korean medicine clinics would contribute to opportunities for field training and employment for students enrolled in the beauty field. Also, if obesity treatment and obesity management are mutually fused or collaborated, they also showed a high positive rate on whether they think the sales of the beauty industry and the Korean medicine medical tourism industry will increase. A high percentage of responses also showed that if obesity treatment and obesity management were mutually fused or collaborated, it would help to increase the preference and vitalization of the Korean medicine medical industry and beauty tourism industry by domestic and foreign tourists.

노인의 여가활동과 인지건강

A survey was conducted to examine the status of leisure activities among the elderly and to seek policy proposals to support leisure activities in terms of cognitive health.
 A survey on the status of leisure activities was conducted in 3,500 elderly people aged ≥65 years, living in Gyeonggi-do, in the form of one-on-on interviews from June 16 to July 17, 2021. The population was set based on the current output areas and number of households in Gyeonggi-do by the National Statistics Office, and the sample was extracted into 10 layers considering region, gender, and age.
 The most common leisure activity for the elderly aged ≥65 years was rest (73.4%), and the percentage of respondents who performed activities alone (38.7%) without companions was the highest. The most frequent participation in leisure activities was “several times a week,” and the average leisure expenditure per session was 11,122 won. During the leisure activity period, most (98.9%) of the respondents were more than one year old , and the proportion of use of religious facilities and other facilities, such as open spaces, was high. Regarding satisfaction with leisure activities, the response rate for “general satisfaction” (58.0%) was the highest. The most desired leisure activity was tourism (28.9%), followed by hobby entertainment (23.35%), and rest (17.6%). Only 0.7% of the respondents participated in volunteer activities, and the reason for not participating that had the highest percentage of response is “not interested” (45.2%). In Gyeonggi-do, 99.3% of the smartphone or cell phone users did not have Internet access, and the utilization rates of text reception (93.3%) and transmission (83.1%) were the highest . The economic expenditure burden (3.41 points) was the most common factor interrupting leisure activities, followed by climate condition (3.34 points) and lack of time (2.92 points).
 Active leisure activities relieve loneliness in old age, improve physical and cognitive health, and help maintain social relationships. Considering the geographical and physical limitations of the elderly, it is necessary to consider an alternative for managing cognitive health through the development of leisure content using electronic devices. In addition, the motivation of the elderly and the development of leisure careers are necessary, along with the role of the public domain in designing various community-centered programs.

혁신학교 교원의 학교 교육활동에 대한 참여의식 분석

This study was conducted to analyze the participation consciousness of innovative school teachers. Since innovative schools are model schools that try to improve schools by delegating authority to teachers to manage schools voluntarily, so the teachers' consciousness of participation is very important. 160 teachers from kindergartens, elementary schools, and middle schools that operated innovative school for more than four years in Chungcheongnam province responded to the survey questionnaire about consciousness of participation. As a result of the analysis, the need of innovative schools for school development was strongly recognized by responding with 4.28 points out of 5. 74.4% of respondents answered they voluntarily participate in the innovative schools, but 31.3% of teachers answered they participate passively. 67.5% answered that the reason for participating in innovative schools is because they provide students with various educational activities. For the development of innovative schools, teachers considered democratic decision-making important, and managers recognized that learning-oriented classes are important. Senior teachers had a higher percentage of responses that optimizing school work was important. Participants responded that since it is an innovative school, democratic consultation culture, school work optimization, professional learning community, and learning-oriented classes are possible. The innovative schools are an innovative movement in which teachers voluntarily participate in solving school problems. Most of the teachers of innovative schools agree with and actively participate in the innovative movement, but some teachers do not agree with this spirit and participate passively. In order to become a model for autonomous school-centered public education innovation pursued by innovative schools, efforts should be made to recognize and improve the problems of teachers who do not agree with innovative schools.

EFFECT OF 2,4-D AND NAA ON SOMATIC EMBRYOGENESIS FROM APICAL PORTION OF GROUNDNUT (ARACHIS HYPOGAEA L.)

Somatic embryogenesis was carried out epicotyl portion of the mature embryo/apical portion. The somatic embryo induction medium containing 2,4-D or NAA (10.0 to 50.0 mg/l). Of the two concentrations tested 2,4-D (30.0mg/l) recorded the highest percentage of response followed by NAA (30.0mg/l). But the highest number of somatic embryo were recorded in 30.0mg/l of 2,4-D followed by NAA. The apical portion of the mature embryo formed direct embryos without any intervention of callus. The maximum percentage of embryogenic cultures were noticed in 30.0mg/l of 2,4-D followed by NAA at 30.0mg/l. for the differentiation of somatic embryos, the embryogenic masses were transferred to medium without any growth regulator. The maximum number of somatic embryos per culture was recorded in 30 mg/l of 2,4-D followed by 30.0 mg/l of NAA. Keywords: Arachis hypogaea L.,Somatic Embryogenesis, 2,4-D and NAA

Chimeric Anti CD-20 Monoclonal Antibody-Rituximab in Refractory Childhood Idiopathic Thrombocytopenic Purpura: An Indian Experience.

The treatment of chronic idiopathic thrombocytopenic purpura (ITP) continues to be a challange. A significant proportion of patients continue to be symptomatic despite all available means of therapy. Recently Rituximab, a chimeric anti CD-20 monoclonal antibody has been shown to be an effective mode of therapy in such patients with an overall response rate of appx 50 %.We studied the efficacy and side effects of this therapeutic modality in 10 children (6 girls) with chronic ITP. The patients belonged to pediatric age group (median age: 9 years, range 4–18 years) with 4 children less than 10 years of age. All the patients were screened for systemic illnesses and different secondary causes leading to thrombocytopenia. They all had been treated with standard therapies using conventional and high dose steroids, ciclosporin cyclophosphamide, vincristine, periodic use of high dose IVIG and splenectomy in 6 patients, but had continued to be symptomatic with recurrent mucocutaneous bleeds and markedly low platelet counts (< 20x 109/L). All patients received intravenous Rituximab at a dose of 375 mg/M2 as weekly dose for 4 consecutive weeks. The infusion related side effects were a few (n= 3) and minor. They included urticarial rash (1) and fever(2) that responded to antipyretics. None of these were severe enough to interrupt the treatment. A complete response was defined as a platelet count > 100 x 109/L, partial response (PR) as count > 50x109/L and a minor response as a count < 50x109/L but without the need of continued treatment. Patients showing no significant rise in platelet count were marked as showing no response. Of the 10 evaluable children, 9 (90%) showed overall response; 4 (40%) showed complete response and 4 (40 %) showed partial response. Two (20%) patients showed minor responses. Patients have been under follow up for last 3 years. The patients with CR and PR have been in remission for longer periods (as much as 150 weeks ).The side effects due to the therapy have been few and very mild. Besides infusional reactions in 3 patients (Transient fever in 2 and mild rash in 1) there were no significant toxicities. No correlation could be found between clinical/laboratory parameters with the responsiveness or the duration of response except that patients showing a higher degree of response continued to be in remission for a longer period as compared to the ones with lesser degree of response. The high percentage of response in our patients as compared to the ones in other studies could be due to the fact that our patients belonged to a younger age group. Probably children show a better response.In conclusion, Rituximab offers a safe and convenient modality of treatment in symptomatic children with refractory ITP. Its use is certainly cost effective even in a developing country in view of the good degree of a sustained response in these refractory patients wherein all modalities of treatment have failed.

What teachers need to know and be able to do: A view from teachers, students, and principals in the Brazilian context.

The aim of this study was to determine the main characteristics of a “good teacher” through the use of questionnaires designed to assess teaching skills and competences, considering the point of view of teachers, principals, and students. In total, 82 teachers, 14 principals, and 625 middle-school students from 5 public schools in São Paulo state participated in this study. Two questionnaires were applied, one designed for teachers and principals and the other for students. First, teachers and principals completed their specific questionnaire, after which the other questionnaire was applied to the students. Both questionnaires contained multiple choice questions related to eight distinct subsections. The questions were answered through the use of a Likert scale, varying from 1 (“totally disagree”) to 5 (“totally agree”). The comparisons of the frequency of responses among all questionnaire subsections between teachers and principals were analyzed using a Chi-Square and the z-test, with P-values adjusted to the Bonferroni method. The statistical significance level was set as P < 0.05. The subsection “class atmosphere” presented the highest percentage of response “totally agree”, closely followed by “professional engagement”. Significant differences (P < 0.05) in responses were observed between teachers and principals for “teaching planning and practice”, “use of time and material resources to develop classes”, and “professional engagement” domains. In summary, it was demonstrated that some teaching characteristics might be more important than others, with some of these characteristics exhibiting significant differences between groups. Nevertheless, it is crucial to emphasize that all assessed educational domains may be recognized as critical teaching qualities, as all of them presented high levels of “totally agree” responses.

Effects of Social Media on Enotourism. Two Cases Study: Okanagan Valley (Canada) and Somontano (Spain)

The aim of this article is to analyze the social media effects on enotourism. Two territories of similar extension and with historical coincidences in their development have been selected: the Okanagan Valley, Canada, and the region of Somontano, Spain. Methodologically, an analysis of the content on Twitter has been performed, collecting 1377 tweets. The conclusion is that wineries create sentimental and experiential links with the users, avoiding commercial communications. Specifically, Okanagan wineries establish a relevant conversation network on Twitter based on the high percentage of responses, which is 31.3%, but this is not so in the case of Somontano, which is 12.8%. The tourist attractions most used to create a bond are the wine landscape and the gastronomy in the case of both territories. The tourism sustainability variable remains a minor matter in the emission of messages on Twitter.

In vitro propagation, genetic stability and alkaloids analysis of acclimatized plantlets of Thalictrum foliolosum

Thalictrum foliolosum is an endemic herb known for its medicinal properties and used for various clinical applications including ophthalmic, skin disease and dyspepsia. Due to its medicinal properties, the plants are uprooted hence can be prone to extinction. In the present study, a reproducible in vitro propagation protocol has been developed using axillary shoot buds and nodal segments. Seedling derived axillary shoot buds were cultured in Murashige and Skoog’s (MS) medium supplemented with 2.24 µmol of 6-benzylaminopurine (BAP) and readily produced maximum shoot (7.2 ± 0.40) with the highest percentage of response (91.42%). Also, nodal explants (field-grown plant) developed maximum shoots (3.2 ± 0.48) on MS medium containing 4.49 µmol BAP with a combination of 0.54 µmol α-naphthaleneacetic acid (NAA). Best growth and foliage development was achieved at 2.24 µmol BAP with 0.54 µmol NAA in presence of 0.3% activated charcoal and 113.4 µmol ascorbic acid. Micropropagated shoots showed maximum percentage (63.30%) of rooting in half-strength MS medium containing 1.23 µmol indole-3-butyric acid (IBA) and acclimatized in soilrite and leaf manure (2:1) during 4 weeks. Monomorphic bands developed by random amplification of polymorphic DNA (RAPD) and simple sequence repeats (SSR) markers confirmed the genetic stability of in vitro established plants. Additionally, HPLC analysis showed higher benzylisoquinoline (BIQ) alkaloids content in in vitro established plant root extracts. The micropropagation protocol developed in this study provides an alternative strategy for germplasm conservation and protection which at the same time can also be exploits for the production of pharmacologically active compounds. An efficient protocol for the production of genetically stable tissue-raised planting material of Thalictrum foliolosum has been developed for its conservation and pharmaceutical uses.

Chondroprotector transdermal magnetophoresis for osteoarthritis of the knee

Treatment of osteoarthritis (OA) is a relevant problem of rheumatology. Despite a significant number of medical approaches and the creation of new drugs, the effectiveness of treatment remains unsatisfactory, which necessitates the creation of complex treatment programs. Pulse low-frequency magnetotherapy is a modern method that makes it possible to potentiate the therapeutic effects of chondroprotectors for transdermal administration using magnetophoresis technology. To evaluate the efficacy and tolerability of combination therapy using chondroprotective magnetophoresis using 'running' pulsed magnetic field (RPMF) and application of chondroxide (transdermal gel form) in patients with knee OA. A randomized, placebo-controlled clinical trial included 65 patients with grade II - III knee OA according to the Kellgren-Lwrence classification. The 1st group included 25 patients who received local therapy - chondroxide magnetophoresis using RPMF (20 mT, frequency 6.25 Hz, exposure time 20 min, No. 12); in the 2nd group - 20 patients who underwent placebo-magnetotherapy of chondroxide; in the 3rd group - 20 patients who used RPMF without local chondroprotective therapy. We used VAS, WOMAC scales, EQ-5D questionnaire, OMERACT-OARSI criterion in order to analyze the results. A pronounced analgesic effect of the treatment was registered (according to the VAS and WOMAC scales) in patients receiving magnetotherapy (p<0.01). A significant improvement in functional parameters (according to WOMAC) was noted, more pronounced in patients who used chondroxide magnetophoresis (p<0.001). During the course of treatment, a positive effect of magnetotherapy on the indicators of quality of life (according to EQ-5D) was registered. A high percentage of response (68.1%) to therapy using magnetophoresis of the transdermal form of chondroxide (according to OMERACT-OARSI) was demonstrated. No adverse reactions were registered during treatment. The use of the local therapy method in the form of magnetophoresis of the transdermal form of the chondroxide is an effective and safe treatment technology that improves the functional state and quality of life of patients with OA of the knee joint.

User awareness of ict enabled information services: a comparative study of university libraries of Delhi and NCR

The authors through this paper aimed to compare the user awareness of ICT enabled information services of university libraries Delhi & NCR (National Capital Region). The universities covered in the study are central and deemed universities of Delhi and NCR, selected from NIRF 2017 of MHRD. The in-depth review of literature helped in preparing the tools for the study. Content analysis of websites of university libraries helped to find out the ICT enabled information services being facilitated by the universities under study. The survey using a structured questionnaire helped in the collection of users data. Out of the many ICT enabled information services facilitated by the selected libraries, only five ICT enabled information services were selected through content analysis of websites. The five selected services were used to compare user awareness. The authors collected data into two categories, which were 'Aware' & 'Not aware'. The Google spreadsheet was used as a statistical tool to analyse data and represent it pictorially. The study findings revealed that a higher number of percentage of users of deemed university libraries (84.80%) are aware of the selected information services in comparison to (69.88%) users of central universities. In the category of 'not aware', the higher percentage of responses (30.12%) are from central universities in comparison to deemed universities (15.20%). It highlights that users of central university libraries are less aware of the ICT enabled information services. These are lagging behind in making their users aware in comparison to deemed university libraries by a margin of (14.92%). The scenario needs to be addressed by central university libraries.

"Brazilian Butt Lift" Performed by Board-Certified Brazilian Plastic Surgeons: Reports of an Expert Opinion Survey.

Gluteal fat augmentation has increased worldwide, and so have major complications. Brazilian plastic surgeons have been performing this procedure for more than 30 years, and more often every year. Therefore, the authors performed a study among board-certified plastic surgeons, members of the Brazilian Society of Plastic Surgery, to evaluate their techniques; identify their preferences, complications, and outcomes with this procedure; and make some recommendations. An anonymous Web-based survey consisting of 16 questions was sent to 5655 members in July of 2017. A supplementary survey was subsequently sent to obtain more information about major complications. A total of 853 responses were analyzed. The highest percentage of responses in the different categories were as follows: fat decantation for processing, injection with a 3-mm-diameter cannula, use of superior incisions, subcutaneous fat grafting only, and with a volume of 200 to 399 ml of fat per buttock. The majority of surgeons received training in this procedure during residency. The most common complications were contour irregularities. The estimated mortality rate was one in 20,117 cases, and the rate of nonfatal fat embolism was one in 9530. The risk of death was 16 times greater when fat was injected intramuscularly. Based on this survey, the authors recommend injecting fat only subcutaneously, by means of superior incisions, using cannulas 3 mm in diameter or more. They find that by following these recommendations, this procedure can be as safe as any other. More research to establish guidelines and increase its safety is necessary.