High Impact Factor Research Articles

Research interest on dental sealant in dentistry based on the 100 most cited articles: bibliometric analysis.

The aim of this study was to identify and analyze the characteristics of the 100 most cited articles about dental sealants (DS) in dentistry. In September 2023, a search was performed in the Web of Science Core Collection (WoS-CC) database. The following information was extracted from each article: number and density of citations, year of publication, authorship, journal, impact factor, keywords, study design, theme, continent, country, and institution. The citations of the WoS-CC were compared with those of the Scopus and Google Scholar databases. The VOSviewer software was used to generate collaborative networks. The number of citations ranged from 33 to 205. The articles were published between 1961 and 2016. Buonocore MG (7%) was the most prominent author among the most cited. The Journal of the American Dental Association was the most frequent journal (25%) and Journal of Dental Research (7.6) had the highest impact factor. Most studies had interventional (41%) and laboratory (31%) designs, mainly addressing DS effectiveness in the prevention and control of dental caries (86%). There was a predominance of publications from North America (46%) and the USA was the country with the highest number of articles (44%). The most frequent institutions were the Centers for Disease Control and Prevention (USA) and the University of Rochester (USA) (6% each). "Retention" was the most frequent keyword. In conclusion, the 100 most cited articles were mostly interventional and laboratory studies, addressing the retention and efficacy of DS. Most of the articles were concentrated in North America and Europe, demonstrating a little collaboration from other continents.

A bibliometric analysis of macrophages associated with non-alcoholic fatty liver disease research from 2005 to 2023

Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition associated with the risk of progressing to decompensated cirrhosis and hepatocellular carcinoma. While macrophages play a crucial role in the development of NAFLD, their heterogeneity and plasticity allow them to undertake diverse roles in immune response, tissue repair, and maintaining tissue homeostasis. Thus, the exact involvement of macrophages in the onset and progression of NAFLD remains to be further explored. This study aims to employ bibliometric analysis to elucidate the role of macrophages in the pathogenesis of NAFLD, analyze research focal points in this domain, and speculate on future research trends. The literature search, conducted using the Web of Science Core Collection, encompassed articles and reviews related to macrophages and NAFLD published between 2005 and 2023. A bibliometric analysis of 1264 extracted publications was performed using VOSviewer 1.6.17 and Citespace 6.1. R2, evaluating parameters such as spatial and temporal distribution, authors, thematic categories, topic distribution, references, and keywords. The findings revealed a steady global increase in publications in this field, with the United States contributing the most followed by China. The University of California System produced the highest volume of publications, while the Journal of Hepatology had the highest impact factors among the top 10 publishing journals. Tacke Frank emerged as both the most prolific author and the most cited. Co-occurrence and burst analysis of keywords and references highlighted the hotspots in this research area, emphasizing the mechanisms of NAFLD pathogenesis, metabolic regulation, immune modulation, and oxidative stress. Maintaining hepatic homeostasis by liver macrophages and macrophage polarization were identified as trending research directions in this field. Based on the bibliometric analysis, continued attention toward NAFLD therapeutic research involving hepatic macrophages is anticipated. As the mechanisms underlying NAFLD pathogenesis are further elucidated, the development of more treatment approaches related to macrophage immunology and metabolic regulation may expand therapeutic options. This study offers valuable insights into the current state and future trends in the field, providing beneficial guidance to researchers aiming to make significant contributions.

Key developments and hotspots of exosomes in Alzheimer's disease: a bibliometric study spanning 2003 to 2023.

Alzheimer's disease (AD) is a degenerative illness of the central nervous system that is irreversible and is characterized by gradual behavioral impairment and cognitive dysfunction. Researches on exosomes in AD have gradually gained the attention of scholars in recent years. However, the literatures in this research area do not yet have a comprehensive visualization analysis. The aim of this work is to use bibliometrics to identify the knowledge constructs and investigate the research frontiers and hotspots related to exosomes in AD. From January 2003 until June 2023, we searched the Web of Science Core Collection for literature on exosomes in AD. We found 585 papers total. The bibliometric study was completed using VOSviewer, the R package "bibliometrix," and CiteSpace. The analysis covered nations, institutions, authors, journals, and keywords. Following 2019, the articles on exosomes in AD increased significantly year by year. The vast majority of publications came from China and the US. The University of California System, the National Institutes of Health, and the NIH National Institute on Aging in the US were the primary research institutions. Goetzl Edward J. was frequently co-cited, while Kapogiannis Dimitrios was the most prolific author in this discipline with the greatest number of articles. Lee Mijung et al. have been prominent in the last two years in exosomes in AD. The Journal of Alzheimer's Disease was the most widely read publication, and Alzheimers & Dementia had the highest impact factor. The Journal of Biological Chemistry, Proceedings of the National Academy of Sciences of the United States of America, and Journal of Alzheimer's Disease were the three journals with more than 1,000 citations. The primary emphasis of this field was Alzheimer's disease, exosomes, and extracellular vesicles; since 2017, the number of phrases pertaining to the role of exosomes in AD pathogenesis has increased annually. "Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case-control study" was the reference with the greatest citing power, indicating the future steered direction in this field. Using bibliometrics, we have compiled the research progress and tendencies on exosomes in Alzheimer's disease for the first time. This helps determine the objectives and paths for future study.

Socioeconomic Status and Race Are Rarely Reported in Randomized Controlled Trials for Achilles Tendon Pathology in the Top 10 Orthopaedic Journals: A Systematic Review.

Randomized controlled trials (RCTs) are crucial in comparative research, and a careful approach to randomization methodology helps minimize bias. However, confounding variables like socioeconomic status (SES) and race are often underreported in orthopaedic RCTs, potentially affecting the generalizability of results. This study aimed to analyze the reporting trends of SES and race in RCTs pertaining to Achilles tendon pathology, considering 4 decades of data from top-tier orthopaedic journals. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and used PubMed to search 10 high-impact factor orthopaedic journals for RCTs related to the management of Achilles tendon pathology. The search encompassed all articles from the inception of each journal until July 11, 2023. Data extraction included year of publication, study type, reporting of SES and race, primary study location, and intervention details. Of the 88 RCTs identified, 68 met the inclusion criteria. Based on decade of publication, 6 articles (8.8%) reported on SES, whereas only 2 articles (2.9%) reported on race. No RCTs reported SES in the pre-1999 period, but the frequency of reporting increased in subsequent decades. Meanwhile, all RCTs reporting race were published in the current decade (2020-2030), with a frequency of 20%. When considering the study location, RCTs conducted outside the United States were more likely to report SES compared with those within the USA. This review revealed a concerning underreporting of SES and race in Achilles tendon pathology RCTs. The reporting percentage remains low for both SES and race, indicating a need for comprehensive reporting practices in orthopaedic research. Understanding the impact of SES and race on treatment outcomes is critical for informed clinical decision making and ensuring equitable patient care. Future studies should prioritize the inclusion of these variables to enhance the generalizability and validity of RCT results.

Unveiling the gender gap in research: a bibliometric analysis of the 100 most-cited articles on food-borne pathogen outbreaks from 1990 to 2020.

Despite a recent increase in the representation of female authors in scientific literature, a significant gap persists concerning the inclusion of women in research. This necessitates the analysis of published literature from a gender perspective. This study aimed to provide gender distribution in authorship in the 100 most-cited articles on food-borne pathogen outbreaks from 1990 to 2020. Bibliometric analysis was conducted using the Scopus database. Two reviewers were selected to search the database. We included the 100 most-cited articles on foodborne outbreak investigations. The analysis was conducted using Statistical Package for Social Sciences (SPSS) version 26 and Microsoft Excel version 2016. The citation data, including total citations, citations per year, and representation of women as first and senior authors, was analyzed in terms of frequencies, mean, median, and interquartile range. The correlation between journal impact factor and the representation of women in high-impact factor journals was determined. A p-value of <0.05 was considered significant. Most of the top-cited articles were published between 2001 and 2010 (n=47). The top 3 most-cited articles were from the USA. Of the total 100 articles, women were the first and last authors in 46% and 28% of the articles, respectively, reflecting a significant gender gap. However, the proportion of females as principal investigators gradually increased from 25% (n=10/30) to 52% (n=24/47) during the period 2001-2010 and to 92% (n=12/13) during 2011-2020. The USA had the highest number of included articles (n=48), and women were principal authors in 56% (n=27) of them. The lowest representation of women was observed in Austria, Denmark, Japan, Netherlands, New Zealand, Nigeria, Portugal, and the United Kingdom. Women are under-represented in published literature on food-borne pathogen outbreaks. Although the representation of women as principal authors has recently increased, disparities still exist at the senior-author level, calling for women's advancement in academic science.

Gender disparity between first and senior authors on liver cancer research in the top journals of Gastroenterology and Hepatology.

Gender disparity is pervasive in academic medicine. This study aimed to assess the disparity between men and women with regard to first and senior author positions in primary studies on liver cancer over the last two decades. We conducted a review of articles published in high-impact factor journals of the field of Gastroenterology and Hepatology in 2005, 2010, 2015 and 2020. First and senior authors of all ages were considered as the study population. The authors' genders were determined using the online artificial intelligence tool genderize.io (https://genderize.io/). The disparity between men and women authors was assessed using the linear-by-linear association test. 665 original articles from 10 journals were reviewed. The point prevalence of first women authors was 25.0% compared with 75.0% for men. The point prevalence of senior women authors was 16.3% compared with 83.7% for men. From 2000 to 2020, the proportion of first women authors increased 14.4% to 26.8% compared with 85.6%-73.2% for men (P = 0.009), and the proportion of senior women authors increased from 7.4% to 19.5%, compared with 92.6%-80.5% for men (P = 0.035). The factor independently associated with a reduced representation of women among first authors was the region of author. The factor independently associated with a reduced representation of women among senior authors was the impact factor of journals. The findings indicated a remarkable increase in the proportion of women, both first and senior authors, over the past two decades in the field of liver cancers. However, the representation of women authors in this area is far less than that of men.

Abstract

Yoga as a mind-body intervention being used for wellness is increasingly used as an add-on therapy in the management of several NCDs. The first RCT on Yoga on hypertension, published by Dr Chandra Patel in the Lancet in 1975, laid the foundation for vigorous research into the practice of yoga as a therapy. Yoga a wellness and fitness fad started moving from studios and home environments to hospitals in the late 90s. There has been an increasing trend for research publications in Yoga since International Day of Yoga was declared by UN in the year 2014. There has been an increase in publications on Yoga by 143% and meditation by 172% in the last 9 years. Putting together yoga and meditation keywords account for more than 18000 articles on PubMed. The US is the leading contributor, followed by India in terms of publications. Regarding clinical trials as registered on the WHO International clinical trials registry platform, we have India as a leading country in registered clinical trials in yoga. However, in comparison to the number of publications, the number of RCT publications is quite low. Very few articles are published in high-impact factor journals (Above 8.0). Most of the publications and studies have small sample sizes and are hypotheses generated. There is a need for large multicentric studies in Yoga. Though Yoga studies have found their way in some guideline documents in oncology and cardiology, a lot needs to be done to generate level 1 evidence to have Yoga incorporated as an integrative medicine in management of various clinical conditions. This presentation will highlight the journey where we stand today and what needs to be done in the future.

Maximizing Journal Article Impact: Strategies for Enhanced Visibility in Today's Academic Sphere

In the dynamic realm of academia, researchers face the dual challenge of generating groundbreaking insights and ensuring widespread visibility for their contributions. This article explores the evolving strategies employed by researchers to enhance the visibility of their journal articles in the changing landscape of academic technology. Online publishing platforms have transformed scholarly communication, democratizing knowledge through open-access journals, preprint servers, and institutional repositories. Beyond traditional metrics, we delve into innovative methods, collaboration, and technology-driven solutions that amplify the reach and impact of scholarly articles. Visibility extends beyond dissemination, encapsulating the art of captivating diverse audiences and transcending disciplinary boundaries. This research article illuminates the path towards heightened visibility, empowering researchers to contribute to the collective tapestry of knowledge through means such as Academia.edu, ISSUU, Scribd, ResearchGate, social media, Search Engine Optimization (SEO), and ORCID. Enhanced visibility offers multifaceted advantages, including increased citations, higher impact factors, knowledge dissemination, international collaboration, career advancement, public engagement, and job opportunities within the scholarly community. Researchers are equipped with the insights needed to thrive in the evolving landscape of journal article visibility in the digital cosmos. Keywords academic publishing; article visibility; journal impact; research visibility; article promotion; citation indexing; academic visibility strategies; research impact factors

Primary Care Family Physicians’ Experiences with Clinical Integration: A Scoping Review of Qualitative and Mixed Reviews

Background: Clinical (service) integration in primary care settings describes how healthcare services are coordinated over time across healthcare contexts to meet patient care needs. Promoting integrated care with interventions that lack systematic approaches can unintentionally increase the complexity and fragmentation of the healthcare system. To improve care integration and healthcare service planning, a systematic approach to understanding its many influencing factors is paramount. This phase I study aims to generate a comprehensive map of family physician (FP) perceived factors, across diseases and patient demographics, influencing how services are integrated for patients. &#x0D; Methods: The protocol development is guided by Arksey and O’Malley’s scoping review methodology framework. Keywords and MeSH terms were contributed by a multidisciplinary team of healthcare professionals, researchers, and patient representatives through an iterative discussion. An Information Specialist with clinical research expertise tested keywords and MeSH terms to build a search strategy using MEDLINE. The strategy was then adjusted for the EMBASE and CINAHL databases. All identified articles were imported into Covidence platform, and 228 duplicates were removed. Two independent reviewers screened 1,771 studies by their titles and abstracts. Of them, 264 studies were reviewed in full text against the selection criteria and their references were hand-searched. A total of 91 articles were included, and over 2,800 factors were extracted. The factors are being or will be coded into themes the Clinical Integration Framework, a merging of two existing models identified from literature and modified. Within each theme, similar codes are clustered together as a subtheme. &#x0D; Discussion: The identified factors will help develop a survey in Phase II study to ascertain high impact factors for intervention(s), as well as thematic and evidence gaps to guide future research. The study findings will be shared with stakeholders to promote awareness of clinical integration issues through multiple channels: publications and conferences for researchers and care providers, an executive summary for clinical leaders and policy makers, and social media for the public.

METHODOLOGICAL CORRECTNESS OF RESEARCH IN MEASURING IMPLICIT ATTITUDES: A SYSTEMATIC REVIEW

Implicit measures of attitudes provide an assessment of attitudes that respondents are unwilling to express or might not be aware of. This paper presents a systematic review of scientific literature in the field of measuring implicit attitudes, in which the current state and position of this construct are reviewed with the aim of assessing the meeting of scientific methodological criteria of knowledge acquisition. Empirical materials were obtained in February 2023 through the following search engines and platforms: Google, Google Scholar, SAGE, APA PsycNet, EBSCO, ScienceDirect, ResearchGate and JSTOR. Inclusion criteria: a paper published in a scientific journal, in English, available in its entirety in electronic form, in the field of psychology/social sciences, published from 2000 to the date of the search. In most reviewed sources, the Implicit Association Test (IAT) instrument was used, so this was added as an inclusion criterion. The final number of studies for analysis was 22 – five review papers and 17 research papers, mostly experimental studies. The papers were published in scientific journals with a high impact factor, written in the IMRAD format, the methods used were adequately presented, systematically controlled research procedures and appropriate statistical techniques were used, the conclusions were based on data, and the critical attitude of the researchers is present. The metric characteristics of the instruments are generally at an acceptable level – adequate internal consistency reliability, convergent and internal validity, predictive ability, but there are problems in the domain of construct and ecological validity.

(Invited) How, Where and Why Do and Should We Publish Our Findings?

Your publishing of your scientific findings has many facets; it is the publish-or-perish paradigm, it is a demand to get your degree, it is evaluated at all levels of your future carrier, etc. And surely you are also busy right now with writing your next manuscript to be submitted as soon as possible to a journal with an as high impact factor as possible? But as an early carrier researcher, why not already now stop and reflect a little on your own (future) publication pattern and habits? Have a solid re-think about it, come out more motivated and with a thought-through idea on who you want to be in the publishing landscape. And for those of you in the field of batteries, you will be armed with a bit of concrete input based on some statistics as well as guidelines.1-5 References ”Good practice guide for papers on batteries for the Journal of Power Sources”Li, C. Arbizzani, S. Kjelstrup, J. Xiao, Y.-y Xia, Y. Yu, Y. Yang, I. Belharouak,T. Zawodzinski, S.-T. Myung, R. Raccichini, S. Passerini,J. Power Sources 2020, 452, 227824.”An Experimental Checklist for Reporting Battery Performances”Yang-Kook Sun, ACS Energy Lett. 2021, 6, 2187–2189.”Standardized Battery Reporting Guidelines”K. Stephan, Joule 2021, 5, 1–2.”What can text mining tell us about lithium-ion battery researchers’ habits?”El-Bouysidy, T. Lombardo, E. Primo, M. Duquesnoy, M. Morcrette, P. Johansson, P. Simon, A. Grimaud and A. A. Franco, Batteries & Supercaps, 2021, 4, 758-766.”Ten Ways to Fool the Masses When Presenting Battery Research”Johansson, S. Alvi, P. Ghorbanzade, M. Karlsmo, L. Loaiza, V. Thangavel, K. Westman andF. Årén, Batteries & Supercaps, 2021, 4, 1785-1788.

Participation of the Mexican General Surgery in International Journals

Background: Scientific publications are essential for disseminating knowledge and updates among physicians. Integrating scientific research into clinical practice and medical education is crucial for improving patient care. Developing scientific skills alongside clinical skills is essential for applying the scientific method in evidence-based medicine. Publishing research findings in journals is the final step in the scientific process, but it is sometimes overlooked, affecting a country's scientific output. Aim: The aim of this study is to quantify Mexico's contribution to the most significant international journals in the field of surgery. Material and methods: Descriptive bibliometric study, of articles published in a 5-year period between 2018 and 2022 in one of the top 10 journals with the highest impact factor in the field of general surgery, articles were included if it was identified that one of the authors was affiliated with a Mexican institution. Results: 59 articles published in 10 of the journals with the highest impact in the area of surgery. The journals with the most publications were the British Journal of Surgery with 11 articles (17.2%), Mexico City representing 83.2% of the total publications. The average number of citations for each article was 20.36 ± 31.4 (range 0-198). The institution with the highest number of publications was the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán with 15 (25%). Conclusion This study provides a comprehensive overview of general surgery research in Mexico, highlighting both achievements and areas for improvement. By understanding the current landscape and identifying key challenges, Mexican surgeons and researchers can chart a course for continued growth and advancement in their specialty.

Evaluation of the presence of double-organ bias in published randomised controlled dacryocystorhinostomy studies.

The aim of this study is to show whether journals pay attention to double-organ bias in studies on dacryocystorhinostomy (DCR) treatment. Most statistical tests are based on the assumption that each data entry is independent of the other. However, we wanted to understand whether the eye, which is a double organ in the human body, is a cause of bias and whether sufficient attention has been paid to it in published articles. A PubMed search was conducted between November 1997 and November 2021 in the field of ophthalmology and otolaryngology with the terms 'dacryocystorhinostomy' and the limitations of 'people' and 'randomly controlled studies'. Publications containing DCR were searched. The publications published in the 15 journals with the highest impact were selected. The scope of the journal, the scope of the authors, the relevance of the articles, the presence of randomisation, the type of study (drug, endoscopic surgery, laser surgery and external surgery) and the statistical approach to bilateral organ bias were evaluated by two independent observers. A total of 83 publications were found by Pubmed search. Fifty-six publications were included in the study. Double-organ bias was present in 41% (n = 23) of the cases. Of the 23 biased publications, 46.4% were found to be in the Quartile 1 group. Quartile 4 journals showed bias in only four journals. Double-organ bias can also be seen in journals with high impact factors and published in recent years. Journals may need to pay more attention to double-organ bias in the publication acceptance process.

Geographic Representation of Authorship in Ophthalmic Research from Low- and Middle-Income Countries

ABSTRACT Purpose Low- and middle-income countries (LMICs) are underrepresented in ophthalmic research, despite carrying the highest burden of visual impairment. To assess the representation of local authors in global ophthalmic research, this cross-sectional, bibliometric analysis measured the proportion of LMIC-affiliated authorship in LMIC-based ophthalmic research. Methods We sampled original, primary research conducted in LMICs and published in 1 of 7 high-impact ophthalmic journals between 2017 and 2021. For each article, we extracted the number and name of country study site(s), country affiliation(s) of first and last author, proportion of LMIC-affiliated authors, funding sources, and study design. Results Of the 1,333 studies exclusively conducted in LMICs, 89.4% of first authors and 80.6% of last authors were exclusively LMIC-affiliated. Representation of LMIC-affiliated first authors were lower in studies based in low-income countries (25.0%) or in sub-Saharan Africa (26.5%), published in journals with higher impact factors (68.0% in Ophthalmology), funded by high-income countries (HICs) (41.4%), or conducted in both LMICs and HICs (27.1%). The United States, United Kingdom, and Australia had the 3rd, 6th, and 8th largest shares of last authors. There were only 12 single-country studies conducted in low-income countries, namely Ethiopia, the Gambia, Guinea, Liberia, the Niger, and Sierra Leone. Of these countries, only three held first authorship and one held last authorship. Conclusions Although LMIC-based ophthalmic research has demonstrated higher local authorship representation compared to other fields, underrepresentation can be exacerbated by country income level, journal “prestige,” and degree of HIC involvement. These discrepancies highlight the need for more equitable data ownership in global ophthalmic research.

Methodological quality of systematic reviews in dentistry including animal studies: a cross-sectional study

BackgroundThe overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall confidence in the results of those systematic reviews.Material & methodsPubMed, Web of Science and Scopus were searched for systematic reviews including animal studies in dentistry published later than January 2010 until 18th of July 2022. Overall confidence in the results was assessed using a modified version of the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) checklist. Checklist items were rated as yes, partial yes, no and not applicable. Linear regression analysis was used to investigate associations between systematic review characteristics and the overall adherence to the AMSTAR-2 checklist. The overall confidence in the results was calculated based on the number of critical and non-critical weaknesses presented in the AMSTAR-2 items and rated as high, moderate, low and critical low.ResultsOf initially 951 retrieved systematic reviews, 190 were included in the study. The overall confidence in the results was low in 43 (22.6%) and critically low in 133 (70.0%) systematic reviews. While some AMSTAR-2 items were regularly reported (e.g. conflict of interest, selection in duplicate), others were not (e.g. funding: n = 1; 0.5%). Multivariable linear regression analysis showed that the adherence scores of AMSTAR-2 was significantly associated with publication year, journal impact factor (IF), topic, and the use of tools to assess risk of bias (RoB) of the systematic reviews.ConclusionAlthough the methodological quality of dental systematic reviews of animal models improved over the years, it is still suboptimal. The overall confidence in the results was mostly low or critically low. Systematic reviews, which were published later, published in a journal with a higher IF, focused on non-surgery topics, and used at least one tool to assess RoB correlated with greater adherence to the AMSTAR-2 guidelines.

Hybridized artificial intelligence models with nature-inspired algorithms for river flow modeling: A comprehensive review, assessment, and possible future research directions

River flow (Qflow) is a hydrological process that considerably impacts the management and sustainability of water resources. The literature has shown great potential for nature-inspired optimized algorithms (NIOAs), like hybrid artificial intelligence (HAI) models, for Qflow modeling. Qflow forecasting needs to be accurate, robust, reliable, and capable of resolving complex non-linear problems to support the decision authority in local and national governments and NGOs. This extensive survey provides a literature review of 100-plus high-impact factor journal articles on developing NIOAs models during 2000–2022. This encompasses a comprehensive review of the established research in different climatic zones, NIOA types, artificial intelligence (AI) models, the input parameters used for model development, Qflow on different time scales, and model evaluation using a wide range of performance metrics. The review also assessed and evaluated several components of relevant literature, along with detailing the existing research gaps. Moreover, the global research gap with future direction is discussed based on current research limitations and possibilities. The data availability evaluation and futuristic suggestions are drafted logically. The review revealed the superiority of the NIOAs among all applied algorithms in the literature. Further, the review concludes that there is a need to improve technical aspects of Qflow forecasting and bridge the gap between scientific research, hydrometeorological model development, and real-world flood and drought management using probabilistic nature inspired (NI) forecasts, especially through effective communication.

Trends in the Use of Proper Methods for Estimating Mutation Rates in Fluctuation Experiments

The accurate quantification of mutation rates holds significance across diverse fields, including evolution, cancer research, and antimicrobial resistance. Eighty years ago, Luria and Delbrück demonstrated that the proper quantification of mutation rates requires one to account for the non-linear relationship between the number of mutations and the final number of mutants in a cell population. An extensive body of literature has since emerged, offering increasingly efficient methods to account for this phenomenon, with different alternatives balancing accuracy and user-friendliness for experimentalists. Nevertheless, statistically inappropriate approaches, such as using arithmetic averages of mutant frequencies as a proxy for the mutation rate, continue to be commonplace. Here, we conducted a comprehensive re-analysis of 140 publications from the last two decades, revealing general trends in the adoption of proper mutation rate estimation methods. Our findings demonstrate an upward trajectory in the utilization of best statistical practices, likely due to the wider availability of off-the-shelf computational tools. However, the usage of inappropriate statistical approaches varies substantially across specific research areas, and it is still present even in journals with the highest impact factors. These findings aim to inspire both experimentalists and theoreticians to find ways to further promote the adoption of best statistical practices for the reliable estimation of mutation rates in all fields.

Trends of impact factor contributors to the Injury Journal: A bibliometric analysis

PurposeThis study aims to analyse papers concerning journal impact factors published in the Injury-International Journal of the Care of the Injured between 1997 and 2022. Through this analysis, the research offers valuable insights into the publication performance and contributors to the journal impact factor, encompassing papers, authors, institutions, and countries. MethodsArticles and reviews published in the Injury between 1995 and 2021 were examined using the Science Citation Index Expanded database. The study employed the journal impact factor contributing indicator to compare highly cited and high journal impact factor papers across various aspects, including papers, authors, institutions, and countries. ResultsA notable correlation exists between prolific authors, institutions, and countries, alongside those who contribute to high journal impact factors. However, a less distinct connection was observed between highly cited papers/authors and high journal impact factor contributors. The Injury serves as a well-regarded international journal. Notably, editorial members of the journal play a substantial role, serving as model editors and contributing significantly to the journal's success.Out of the Top 25 IF contributing papers with the CN of 34 or more the following themes were noted to dominate: bone healing/tissue regeneration (40 %) of papers, covid-19 pandemic (24 %), polytrauma/coagulopathy (12 %) and infection (8 %). ConclusionsUtilizing the journal impact factor to assess research performance at the individual, institutional, or national levels appears not to be the most appropriate method. The results show that highly cited authors did not hold the distinction of being the primary contributors to the IF. Analysis revealed a low significant relationship among the primary contributors to the IF, highly cited papers, and the most influential papers in 2022. A more effective indicator could involve considering the total number of citations a publication receives from its year of publication up to the end of the most recent year.

Drug Development for Leukemia : Comprehensive Analysis of Clinical Trial Success Rates Presented at the American Society Hematology (ASH) Annual Meetings

Introduction: Slow progress in drug development is an ongoing issue even more critical for oncologic drugs, which have lower likelihood for approval than other therapeutic areas. Early clinical trials are frequently conducted and few eventually lead to drug approvals. We analyzed success rates of anti-leukemic drugs presented at the annual ASH meetings to identify rates of progression to advanced development and factors associated with clinical trial (CT) success. Methods: Our eligibility criteria included ASH meetings abstracts reporting CT assessing investigational anti-leukemic drugs conducted in the United States from 2011 to 2015. We searched ClinicalTrials.gov, PubMed, and Food and Drug Administration (FDA) websites to track the transition at each clinical phase (from Phase 1 to Phase 3), regulatory history, and publication as full-length manuscripts. We assessed the success rate (number of CT approved by FDA divided by the total number of CT) by study, drug and outcomes features using chi-square or Fisher's exact test. To verify the correlation between the impact factor (IF) of the journal in which the CT was published with the success of the study, the FDA-approval status (No vs Yes) was considered ordinal variable and the Pearson correlation coefficient was calculated. Results: Among the 3,929 abstracts for leukemia reviewed, 488 were main CT reports. Based on our eligibility criteria, 235 abstracts were identified including Phase 1 (121), Phase 2 (100), and Phase 3 (14) CT. Of these CT abstracts, only 45 (19.1%) eventually led to FDA approval. Among the unsuccessful studies, 37 (15.7%) progressed to the next one or two phases, and 153 (65.1%) did not transition any phase forward. Abstracts in acute myeloid leukemia (AML, 47%) and chronic lymphocytic leukemia (CLL, 30.2%) were the most common, followed by acute lymphocytic leukemia (ALL, 15.6%) and chronic myeloid leukemia (CML, 6.5%). Investigational New Drug (IND) combined with FDA-approved regimens (41.7%) or as monotherapy (40.9%) were the most commonly investigated therapy modalities. Combinations of multiple IND (9.8%) and new uses for FDA-approved drugs or regimens (7.7%) were evaluated less frequently. The overall success rate of CT was 6%. Although CML and ALL were the least studied types of leukemia, they had the highest approval success rates, 47% and 24.4%, respectively (p&amp;lt;0.001). Monotherapy INDs were more frequently approved by FDA (32.3%) than when combined with FDA-approved drugs (11.2%, p&amp;lt;0.001). FDA approval was also more frequent for advanced CT phase (p&amp;lt;0.001) and more recent (by year) presentation of the abstract (p=0.008). Tumor status (untreated vs relapsed and/or refractory [R/R] vs untreated and R/R) and the age of the patients included in the CT (adults including older adults vs older adults only vs pediatric vs adults and pediatric) were not significantly associated with approval rates (p&amp;gt;0.05). CT including drugs and regimens that led to FDA approval were published in journals with higher impact factors (R=0.368, p=0.0002), such as Lancet Oncology (24.1%), Blood (17.2%), Lancet Haematology (13.8%), and New England Journal of Medicine (13.8%). Blood was the journal that published the highest number of unsuccessful CT (15.3%). During the study period, CT assessing Enasidenib as monotherapy for R/R AML with IDH2 mutation, Ponatinib for CML and Philadelphia chromosome (Ph+) ALL, and Venetoclax for R/R CLL transitioned directly from Phase 2 to FDA approval. Conclusion: CT success rates for hematologic malignancies improved modestly over the last years. The high investment in CT for AML and CLL management has not resulted in increased approval rates proportional to reported CT.

Bibliometric and Visualized Analysis of Global Evolution of Research in Lung Ultrasound: A Rapidly Developing Field.

Lung ultrasound (LUS) is gaining recognition as an indispensable diagnostic tool in critical care. The study aimed to characterize the global research landscape and trend of LUS with quantification and visualization approaches. Documents related to LUS published between 2007 and 2023 were selected from the Web of Science Core Collection and identified. Visualization and statistical analysis were conducted with the VOSviewer 1.6.18, CiteSpace 5.7.R5, and Bibliometrix 4.1.0 Package, including analysis of the trend of global publications, prominent countries, active institutions, and funding agencies, key authors and journals, co-cited references, and keywords. A total of 3010 publications, including 2434 articles and 576 reviews, were retrieved. The output of LUS-related research has increased steadily over the years, especially after 2018. Italy (n=756; 25.12%) has shown the highest output, being the country with the highest total citations (23423 times). The most influential author was Gargani Luna with 52 documents, who worked at the Consiglio Nazionale delle Ricerche. Chest and Intensive Care Medicine with high citations and impact factor scores were the most influential journals. Besides "lung ultrasonography", the keywords developed included "coronavirus disease 2019 (COVID-19)", "acute respiratory distress syndrome", and "acute heart failure". Research output on LUS has increased steadily, especially after 2018. Italy and the United States are staying ahead in this field. Research collaboration still needs to be strengthened. This comprehensive analysis has presented the global research landscape and trends of LUS-related research, providing valuable information for researchers to pursue further exploration.