Abstract Objectives: Lower socioeconomic status (SES), among other factors, presents a barrier to healthcare delivery and is associated with worse health outcomes. Integrated healthcare systems (IHS) in which barriers to care are minimized would be ideal settings to identify factors associated with mortality disparities. The aim of this study was to compare outcomes of colon cancer cases diagnosed at one of the largest IHS in California, Kaiser Permanente Southern California (KPSC), to other private insurance (OPI) to determine how SES influence differences in mortality. Methods: This retrospective cohort study included all insured adults in Southern California diagnosed with colon cancer between 2009 and 2014 using data from the California Cancer Registry (CCR). The main outcome was all-cause (overall) mortality, and subjects were followed through December 31, 2017. Person-year mortality rates were calculated for the two groups, KPSC and OPI. Multivariate adjusted hazard ratios were calculated for the association between SES and overall mortality within each group. Results: A total of 16,646 patients were diagnosed with colon cancer in Southern California, 4552 patients (27.3 %) within KPSC and 12,094 patients (72.3%) in OPI. 5937 deaths occurred during the follow-up period; 1428 (24.1%) deaths within KPSC, 4509 (75.9%) deaths in non-KPSC. Mortality rates per 1000 year follow-up with 95% confidence interval revealed a lower overall rate of 103.8 (98.5 – 109.3) in KPSC compared to 139.3 (135.2 – 143.4.) in OPI. Compared to the highest SES group, lower SES was not significantly associated with mortality in the KPSC population, even after adjusting for race/ethnicity and other factors (lowest SES HR 1.13 95% CI 0.93-1.38). However, in OPI patients, lower SES was significantly associated with higher HR with the greatest disparity in the lower-middle (HR 1.27 95% CI 1.15-1.40) and lowest (HR 1.26 95% CI 1.13-1.40) SES groups. Conclusions: Comparing mortality rates in an integrated health system such as KPSC to OPI hospitals revealed that lower SES was associated with worse outcomes within the OPI group. However, within KPSC no association was found between SES and overall mortality in patients with colon cancers. Systems that optimize care coordination for all patients may reduce disparities for the most at risk patients. Citation Format: Vikram Attaluri, Robert M. Cooper, Reina Haque, Jay Patel, Joan J. Ryoo, David P. Wu, Joanie WL Chung. Reduced socioeconomic status disparity in colon cancer mortality in an insured population treated in an integrated healthcare system [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-222.
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