A rotating fluidized bed imposes a strong centrifugal force to form the dense annular bed with high interphase slip velocity for significantly enhanced gas-solids contact. The fundamental fluidization behaviors in rotating fluidized beds have been well understood in small-scale systems. The current study focuses on the scale-up of a rotating fluidized bed from lab-scale to commercial-scale through computational fluid dynamics modeling. The computational model was first validated against a lab-scale horizontal rotating fluidized bed for the general flow behavior and pressure drop. The validated computational model with a column diameter of 0.12 m was then scaled up to 0.48 m and 1.92 m to investigate the flow hydrodynamics at larger scales. By comparing the solids distribution and other flow field variables, major limitations in the stable operation of a rotating fluidized bed at large scales were identified. The challenges faced in the scale-up of an annular fluidized bed with centrifugal acceleration are discussed and ways to overcome such challenges are explored.