PurposeThe aim of this study is to determine the relationship of social media with loneliness and anger levels of adolescents living in Turkey. Design and methodsThis study used a cross-sectional descriptive design. Loneliness and anger were measured with “University of California, Los Angeles Loneliness Scale” and “Adolescent Anger Rating Scale”. Data collection forms were prepared on Google Form and form’ link was sent to adolescents. ResultsA total of 1176 adolescents aged 13–18 years within four high schools were included. The results obtained show use of Facebook and duration of Facebook use of adolescents were not related to mean scores of loneliness. Adolescents with high duration of Instagram use was to be found that loneliness scores were statistically high, but anger scores were similar. Twitter users had lower loneliness mean scores and higher anger scores. TikTok use was not related with loneliness scores. ConclusionIn conclusion, this study found that high duration of Instagram use was associated with higher loneliness scores in adolescents, while Twitter users had lower loneliness scores and higher anger scores. The use of Facebook and TikTok did not significantly affect loneliness and anger levels. Practice implicationsThis study suggest that pediatric nurses can play a significant role in promoting balanced social media use and healthy coping strategies to mitigate the negative impact of excessive social media use on adolescent mental health. Pediatric nurses can support adolescent emotional wellbeing and promote a healthier digital environment.