Higher Risk Of Overweight Research Articles

Effects of built environment factors on obesity risk across three types of residential community in Beijing

IntroductionThere is strong evidence in Western cities that neighborhood-level characteristics of the built environment are linked with a higher risk of overweight or obesity among residents. Due to the rapid urbanization during the last several decades, many types of residential community have formed and coexisted in the major cities of China. These communities provide residents with different built-environment features and lifestyles. However, it remains unclear whether the community type affects the risk of overweight and obesity among residents. MethodsThe present study investigated the associations of built-environment characteristics and the bodyweight status (normal vs. overweight or obese) of 4,440 residents from three main types of community (i.e., commercial, work-unit, and traditional communities) in Shijingshan district, Beijing. Multilevel logistic regression and the random forest approach were adopted to investigate both the significance and relative importance of neighborhood-level factors of the built environment. ResultsThe results of multilevel logistic regression suggest that the community type has a significant association with the obesity risk. In addition, the land-use mix, the number of water features, the number of supermarkets and groceries, street intersections, and the normalized difference vegetation index are negatively related to the odds of obesity. The number of transit stops is positively associated with the odds of obesity. Random forest analysis reveals significant disparities in the relative importance of population structure and the built environment factors among the three types of community. Furthermore, we find a notable difference between the results of the multilevel logistic model and random forest model. Hence, both the significance and relative importance of neighborhood-level factors of the built environment should be considered. ConclusionsThe findings indicate that the community type has a significant association with the risk of overweight. Tailored policies and urban renewal interventions should be developed for different community types.

Longitudinal association between the timing of adiposity peak and rebound and overweight at seven years of age

BackgroundThe timing of adiposity peak (AP) or adiposity rebound (AR) is a determinant of overweight or obesity in adolescence and adulthood. However, limited studies have reported the association in young school-age children. We aimed to evaluate this association and explore the role of health behaviours in it.MethodsRoutinely collected, sequential, anthropometric data from the 1st to 80th months of age were used to estimate AP and AR timings in 2330 children born in Shanghai between 2010 and 2013. Multivariate regression analyses were applied to identify the associations between the AP or AR timings and the risk of developing overweight or obesity in first-grade school children. The roles of health behaviours, including dietary patterns, physical activity level, sleep and snacking habits, and screen time, were also evaluated.ResultsChildren with a late AP or an early AR were at higher risk of overweight but not obesity or central obesity in their first grade. A high physical activity level was associated with a lower risk of having overweight in children with a late AP, and limited screen time was associated with a decreased risk of having overweight or obesity in children with an early AR. The absence of a late-night snacking habit in children with a non-early AR indicated a decreased risk of having overweight. However, this association was not observed among children with an early AR.ConclusionThe timings of AP and AR are tied to overweight in middle childhood. Prevention strategies are suggested to move forward to control late AP and early AR.

Protein intake in children and growth and risk of overweight or obesity: A systematic review and meta-analysis.

ObjectivesThe aim of this study was to examine the evidence for an association between the dietary protein intake in children and the growth and risk of overweight or obesity up to 18 years of age in settings relevant for the Nordic countries.MethodsWe searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Scopus up to February 26, 2021 for randomized controlled trials (RCTs) or prospective cohort studies assessing for protein intake from foods (total and from different sources) in children. The outcomes include weight, height/length, adiposity indices, and/or risk of overweight and/or obesity. The risk of bias was evaluated with instruments for each respective design (Cochrane’s Risk of Bias 2.0 and RoB-NObS). A meta-analysis of five cohort studies was performed. The evidence was classified according to the criteria of the World Cancer Research Fund.ResultsThe literature search resulted in 9,132 abstracts, of which 55 papers were identified as potentially relevant. In total, 21 studies from 27 publications were included, of which five were RCTs and 16 were cohort studies. The RCTs found generally null effects of high-protein intake in infants on weight gain, nor that lower protein diets negatively affected growth. All included RCTs had some concern regarding the risk of bias and were limited by small sample sizes. Total protein intake and BMI were assessed in 12 cohorts, of which 11 found positive associations. The meta-analysis revealed a pooled effect estimate of 0.06 (95% CI 0.03, 0.1) kg/m2 BMI per one E% increment in total protein (I2 = 15.5). Therefore, the evidence for a positive relationship between total protein intake and BMI was considered probable. Furthermore, there was probable evidence for an association between higher intake of animal protein and increased BMI. There was limited, suggestive evidence for an effect of total protein intake and higher risk of overweight and/or obesity, while no conclusions could be made on the associations between animal vs. plant protein intake and risk of overweight and/or obesity.DiscussionIn healthy, well-nourished children of Western populations, there is probably a causal relationship between a high-protein intake in early childhood (≤ 18 months) – particularly protein of animal origin – and higher BMI later in childhood, with consistent findings across cohort studies. A lack of RCTs precluded a stronger grading of the evidence.

Cardiorespiratory fitness, screen time and cardiometabolic risk in South Brazilian school children

Background Cardiorespiratory fitness (CRF) is considered a beneficial effect of physical activity (PA). PA and excessive screen time have implications for cardiometabolic risk. Objective To verify the association between screen time and CRF grouped by cardiometabolic risk factors. Subjects and methods Cross-sectional study evaluated 1,253 schoolchildren (54.2% girls) aged seven to 17 years from southern Brazil. The outcomes were body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), and diastolic (DBP), glucose, and lipid profile. Exposure was a combined variable of self-reported screen time (television, video game, computer) and CRF. Results The main result is that CRF had a more consistent association with anthropometric factors than with metabolic variables. Low CRF students, regardless of screen time, showed a 15% increase in the risk of elevated WC (p < 0.001) and a 24% (<2 h screen time) and 19% (≥2 h) higher risk of overweight (p < 0.001). Second, the increase in SBP was associated with a combination of the two risk factors, ≥2 h screen time/low CRF was associated with a 7% increase in elevated SBP (p = 0.025). Conclusion Low CRF was a risk factor for elevated BMI and WC, regardless of screen time. High screen time and low CRF were associated with higher SBP values.

Association of Blood Mercury Levels with the Risks of Overweight and High Waist-to-Height Ratio in Children and Adolescents: Data from the Korean National Health and Nutrition Examination Survey.

A previous study in adults demonstrated the substantial role of mercury exposure in the development of overweight and obesity. Although children and adolescents are more susceptible to the toxic effects of mercury than adults, studies on the association of overweight and obesity with mercury exposure is limited. This study aimed to investigate the association of blood mercury levels with the body mass index (BMI) and waist-to-height ratio (WHtR) as obesity indices in Korean children and adolescents. The analyzed cross-sectional data were obtained from 1327 participants (age: 10–18 years; 672 male and 655 female) who completed the Korean National Health and Nutrition Examination Survey 2010–2013. The covariates included sociodemographic factors (age, sex, and household income), dietary factors (fish, shellfish, and seaweed consumption), lifestyle factors (alcohol consumption, smoking status, and exercise), and blood hematocrit levels. The adjusted geometric mean blood mercury level was 2.19 µg/L, and the level of mercury was significantly higher in the overweight (BMI ≥ 85th gender and age-specific percentiles) and high WHtR (cutoff: ≥0.5) groups than in the normal group. In all the participants, the blood mercury levels were significantly positively associated with the BMI and WHtR after adjusting for all covariates (p < 0.05). All the participants in the highest blood mercury level quartile were at a higher risk for overweight and a high WHtR than those in the lowest quartile after adjusting for all covariates (p < 0.05). Our study suggests a significant association between mercury exposure and the risks of overweight and high WHtR in Korean children and adolescents.

Socioeconomic Determinants of Diet Quality on Overweight and Obesity in Adults Aged 40-59 Years in Inner Mongolia: A Cross-Sectional Study.

Objectives: This study investigated the relationship of socioeconomic status (SES), diet quality and overweight and obesity in adults aged 40–59 years in Inner Mongolia. Methods: This cross-sectional study was based on the survey of Chronic Disease and Nutrition Monitoring in Adults in Inner Mongolia in 2015. Diet quality was evaluated by the Alternate Mediterranean Diet score (aMeds). SES was measured by household annual income. Generalized estimating equations and path analysis were performed to determine the association of SES, diet quality and overweight and obesity. Results: Among participants, 63.0% had overweight and obesity. In high SES group, 66.4% had overweight and obesity. Higher SES was associated with a higher risk of overweight and obesity (OR = 1.352, 95%CI: 1.020–1.793). And higher aMeds was associated with a lower risk of overweight and obesity (OR = 0.597, 95%CI: 0.419–0.851). There was a positive correlation between SES and the intake of red and processed meat (r = 0.132, p < 0.05). Higher intake of red and processed meat was associated with lower diet quality (β = −0.34). And lower diet quality was associated with a higher risk of overweight and obesity (β = −0.10). Conclusion: In Inner Mongolia, during the period of economic transition, people aged 40–59 years in high SES had poor diet quality, which was related to a higher risk of overweight and obesity.

Foetal tobacco and cannabis exposure, body fat and cardio‐metabolic health in childhood

SummaryBackgroundFoetal tobacco and cannabis exposure may have persistent cardio‐metabolic consequences in the offspring.ObjectiveWe examined the associations of maternal and paternal tobacco and cannabis use during pregnancy with offspring body fat and cardio‐metabolic outcomes.MethodsIn a population‐based prospective cohort study among 4792 mothers, fathers, and children, we assessed parental substance use by questionnaires. Childhood outcomes included body mass index (BMI), body fat, blood pressure, and lipid, glucose and insulin concentrations at 10 years.ResultsChildren exposed to maternal tobacco use during pregnancy had a higher android/gynoid fat mass ratio (difference 0.22 SDS, 95% confidence interval [CI]: 0.13, 0.30), fat mass index (difference 0.20 SDS, 95% CI: 0.12, 0.28), triglyceride concentrations (difference 0.15 SDS, 95% CI: 0.04, 0.26), and a higher risk of overweight (odds ratio [OR] 1.35, 95% CI: 1.07, 1.71), compared to non‐exposed. Children exposed to maternal cannabis during pregnancy had a higher BMI (difference 0.26 SDS, 95% CI: 0.08, 0.44), android/gynoid fat mass ratio (difference 0.21 SDS, 95% CI: 0.04, 0.39), and fat‐free mass index (difference 0.24 SDS, 95% CI: 0.06, 0.41), compared to non‐exposed. The associations for paternal substance use with child cardio‐metabolic health outcomes were similar as those for maternal use.ConclusionsSimilar associations for maternal and paternal substance use during pregnancy suggest that these findings may be explained by shared family‐based social and lifestyle factors, rather than by direct foetal programming.

Neighborhood Socioeconomic Disadvantage and Childhood Body Mass Index Trajectories From Birth to 7 Years of Age.

The epidemic of increasing childhood overweight and obesity is a major global health concern, with local contextual factors identified as possible contributors. Robust research is needed to establish an evidence base supporting health policy decisions to reverse the trend. We aimed to examine the association between neighborhood socioeconomic disadvantage and trajectories of body mass index (BMI) from birth to age 7. The present study included 11,023 children born within the Southwest Finland Birth Cohort who were free of severe conditions affecting growth with adequate exposure and growth data. We obtained child growth data until school age from municipal follow-up clinics. We based cumulative childhood neighborhood socioeconomic disadvantage on the average annual income, unemployment, and level of education in a residential area defined using a geographic grid at a spatial resolution of 250 m by 250 m. Cumulative neighborhood socioeconomic disadvantage was associated with distinct childhood BMI z score trajectories from birth to age 7. Despite being born in the lowest BMI z scores, children growing up in disadvantaged neighborhoods subsequently exhibited a trajectory of increasing BMI z scores starting at 4 years of age, ending up with a higher risk of overweight at the end of the follow-up (30%) as compared with children living in more affluent neighborhoods (22%). The corresponding risk of obesity was 5 % for those in affluent neighborhoods and 9 % and those in disadvantaged neighborhoods. Cumulative exposure to neighborhood socioeconomic disadvantage is independently associated with unfavorable BMI development and obesity in childhood.

742Analyzing the statistical pitfalls of treating mediators as confounders

Abstract Background Numerous studies indicated that infants born small-for-gestational-age (SGA) are at higher risk of overweight. However, the association between SGA and overweight may be due to overcontrolling for body size. This study aimed to analyze the effect of controlling for child’s weight and height in the association between SGA and overweight in children born preterm. Methods Data were obtained from the Preterm Infant Multicenter Growth Study (n = 1089). The association between SGA and overweight at 36 months corrected age (CA) was analyzed using logistic regression models: 1) crude, 2) adjusted for baseline covariates, 3) adjusted for baselines covariates with additional adjustments separately for child’s weight and height at 21 months CA. Marginal structural models (MSM) with stabilized inverse probability weights were used to estimate the direct effect of SGA on overweight. Results The crude and adjusted models yielded a null association (OR, 95% CI: 0.88, 0.26-2.96; 0.95, 0.28-3.29). Adjusting for later height reversed the effect (OR, 95% CI: 2.31, 0.52-10.26), and adjusting for later weight reversed the effect and provided a significant association (OR, 95% CI: 6.60, 1.10-37.14). The MSMs with height and weight considered as mediators indicated no direct effect of SGA on overweight (OR, 95% CI: 0.83, 0.14-5.01; 0.71, 0.18-2.81). Conclusions Overcontrolling for body size can falsely induce an association between SGA and overweight. Key messages Mediators should not be treated as confounders.

Cross-sectional associations between objectively measured sleep characteristics and body mass index in European children and adolescents

BackgroundShort sleep duration has been found to be associated with a higher risk for overweight and obesity. However, previous studies have mainly relied on subjective measures of sleep duration and other sleep characteristics (eg quality, timing) have often been neglected. Therefore, we aimed to investigate associations between several, mainly objectively measured sleep characteristics and body mass index (BMI). Further, we aimed to identify distinct sleep subtypes based on these sleep characteristics and to study their association with BMI. MethodsChildren aged 9–16 years participating in the European I.Family study (N = 559, 51.2% girls, 32.9% overweight/obese) wore an accelerometer for one week on their wrist and recorded their daily wake-up and lights-off times in a sleep diary. Information on sleep duration, sleep efficiency and sleep latency was derived. To identify sleep subtypes, we conducted a latent class analysis using all five sleep variables. Associations between single sleep variables, sleep subtype and age- and sex-specific BMI z-score were investigated using linear mixed-effects regression models to accommodate clustering among siblings. ResultsNo statistically significant associations were observed between the single sleep variables (sleep duration, sleep efficiency, sleep latency, wake-up and lights-off times) and BMI z-score. Four sleep subtypes were identified and children were assigned to one of the groups based on their highest probability for latent group membership: “early birds” (17.5% of the sample), “short sleep duration” (14.7%), “optimal sleep” (47.6%) and “poor sleep quality” (20.2%). Sleep subtype was not associated with BMI z-score. ConclusionsUsing objective sleep data, we did not find convincing evidence for associations between the sleep variables under investigation and BMI.

Prevalence and correlates of overweight and obesity among primary school children in Kilimanjaro, Tanzania.

Prevalence of childhood overweight and obesity in low- and middle-income countries is on the rise. We focused on multiple factors which could influence body mass index. A cross sectional school-based study was conducted in Moshi, Tanzania. Primary school children aged 9-11 years were recruited from 20 schools through a multistage sampling technique. Questionnaires were used to collect information on physical activity and diet by food frequency questionnaire. Height and weight measurements were taken and body mass index z scores for age and sex (BMIZ) calculated using the WHO AnthroPlus. Children were considered thin if BMIZ was <-2 standard deviations and overweight or obese if BMIZ was >1 SD. Information on school policies and environment was obtained from headteachers. Correlates of overweight and obesity were examined using a multinomial multilevel logistic regression. A total of 1170 primary school children, of whom 636 (54%) were girls, were recruited from 20 schools. The prevalence of overweight and obesity was 15% overall (overweight 9% and obesity 6%) and most prevalent in urban areas (23%) and in private schools (24%). Moreover, thinness was found to be (10%) overall, most prevalent in rural areas (13%) and in government schools (14%). At school level, residing in urban (adjusted relative risk ratio [aRRR] 3.76; 95% confidence interval [CI] 2.49,5.68) and being in private school (aRRR 4.08; 95% CI 2.66,6.25) were associated with a higher risk of overweight and obesity while availability of playgrounds in schools (aRRR 0.68; 95% CI 0.47, 0.97) was associated with a lower risk of overweight and obesity. At home level, availability of sugary drinks (aRRR 1.52; 95% CI 1.01,2.28) was associated with a higher risk of overweight and obesity. Overweight and obesity are common in private schools and in urban settings. Efforts should be taken to ensure availability of playgrounds in schools and encouraging children to engage in physical activities.

Double burden of underweight and overweight among Indian adults: spatial patterns and social determinants.

The current study explores the spatial patterns of underweight and overweight among adult men and women in districts of India and identifies the micro-geographical locations where the risks of underweight and overweight are simultaneously prevalent, after accounting for demographic and socio-economic factors. We relied on BMI (weight (kg)/height squared (m2)), a measure of nutritional status among adult individuals, from the 2015-2016 National Family and Health Survey. Underweight was defined as <18·5 kg/m2 and overweight as ≥25·0 kg/m2. We adopted Bayesian structured additive quantile regression to model the underlying spatial structure in underweight and overweight burden. Men aged 15-54 years (sample size: 108 092) and women aged 15-49 years (sample size: 642 002). About 19·7 % of men and 22·9 % of women were underweight, and 19·6 % of men and 20·6 % of women were overweight. Results indicate that malnutrition burden in adults exhibits geographical divides across the country. Districts located in the central, western and eastern regions show higher risks of underweight. There is evidence of substantial spatial clustering of districts with higher risk of overweight in southern and northern India. While finding a little evidence on double burden of malnutrition among population groups, we identified a total of sixty-six double burden districts. The current study demonstrates that the geographical burden of overweight in Indian adults is yet to surpass that of underweight, but the coexistence of double burden of underweight and overweight in selected regions presents a new challenge for improving nutritional status and necessitates specialised policy initiatives.

Addressing obesity in the first 1000 days in high risk infants: Systematic review.

Early intervention is critical for addressing the challenge of childhood obesity. Yet many preventive interventions do not target infants most at risk of future overweight or obesity. This systematic review examines interventions delivered before 2 years that aim to ameliorate excess weight gain among infants at high risk of overweight or obesity, due to sociodemographic characteristics, parental weight or health status, infant feeding or health behaviours. We searched six databases for interventions: (a) delivered before age two, (b) specifically aimed at infants at high risk of childhood obesity and (c) that reported outcomes by weight status beyond 28 days. The search identified over 27,000 titles, and 49 papers from 38 studies met inclusion criteria: 10 antenatal interventions, 16 postnatal and 12 conducted both before and after birth. Nearly all targeted infant and/or maternal nutrition. Studies varied widely in design, obesity risk factors, outcomes and quality. Overall, nine interventions of varying quality reported some evidence of significantly improved child weight trajectory, although effects tended to diminish over time. Interventions that improved weight outcomes tended to engage parents for a longer period, and most offered health professional input and support. Two studies of limited quality reported significantly worse weight outcomes in the intervention group.

Associated Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, Vietnam

Background: Obesity affects multiple organ systems and is associated with a variety of vascular and several nonvascular complications. BMI and WC are the commonly-used anthropometric measurements for obesity in The aims of study to determine the prevalence of overweight and obesity, explore associated factors among secondary and high school students in Ho Chi Minh City, Vietnam. Methods: A cross-sectional survey was conducted in 12 schools located in Ho Chi Minh City, Vietnam between June 2018 and May 2019. Students were measured their height and weight and asked for demographical information. BMI-for-age-and-gender was used to categorize students into groups. Logistic regression with odd ratio was used to explore associated factors to obesity risk. Results: The mean weight of them was 59.01±12.76 kilograms, the mean height was 168.73±23.79 centimeters and the mean BMI was 22.62±1.79 kg/m2. Students who lived in remote area and do sport activities were had lower risk to be obese. Students who at the age of 13 to 15 and eat fatty food were had higher risk of overweight and obesity. Conclusion: Training programs need to be designed to provide sufficient and balanced meals and to instill a desire for physical exercise. How to Cite this Article Pubmed Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, SRP. 2020; 11(3): 337-340. doi:10.5530/srp.2020.3.40 Web Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, http://www.sysrevpharm.org/?mno=93059 [Access: March 30, 2021]. doi:10.5530/srp.2020.3.40 AMA (American Medical Association) Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, SRP. 2020; 11(3): 337-340. doi:10.5530/srp.2020.3.40 Vancouver/ICMJE Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, SRP. (2020), [cited March 30, 2021]; 11(3): 337-340. doi:10.5530/srp.2020.3.40 Harvard Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le (2020) Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, SRP, 11 (3), 337-340. doi:10.5530/srp.2020.3.40 Turabian Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. 2020. Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, Systematic Reviews in Pharmacy, 11 (3), 337-340. doi:10.5530/srp.2020.3.40 Chicago Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. Associated Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, Vietnam. Systematic Reviews in Pharmacy 11 (2020), 337-340. doi:10.5530/srp.2020.3.40 MLA (The Modern Language Association) Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le. Associated Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, Vietnam. Systematic Reviews in Pharmacy 11.3 (2020), 337-340. Print. doi:10.5530/srp.2020.3.40 APA (American Psychological Association) Style Thoai Dang Nguyen, Tram Thi Huyen Nguyen, Quang Vinh Tran, Nghiem Quan Le (2020) Factors on the Prevalence of Overweight and Obesity on Secondary and High School Students in Ho Chi Minh City, Systematic Reviews in Pharmacy, 11 (3), 337-340. doi:10.5530/srp.2020.3.40

Nutrition beyond the first 1000 days: diet quality and 7-year change in BMI and overweight in 3-year old children from the Dutch GECKO Drenthe birth cohort.

The identification of early-life determinants of overweight is crucial to start early prevention. As weight gain accelerates between 2 and 6 years, we studied the association between diet quality in children aged 3 years and the change in BMI and overweight incidence in the following 7 years. From the Dutch GECKO Drenthe birth cohort, 1001 children born in 2006 or 2007 with complete data on diet (food frequency questionnaire at the age of 3 years) and growth at the age of 3 and 10 years were included. Diet quality was estimated with the evidence-based Lifelines Diet Score (LLDS). Measured height and weight at the age of 3 and 10 years were used to calculate BMI z-scores standardized for age and sex. The associations of the LLDS (in quintiles) with BMI-z change and overweight incidence were studied with linear and logistic regression analyses. Overweight prevalence in the total study population increased from 8.3% at the age of 3 years to 16.7% at the age of 10 years. The increase in overweight prevalence ranged from 14.7% in Q1 to 3.5% in Q5. Children with a better diet quality (higher quintiles of LLDS) increased significantly less in BMI-z (confounder adjusted βLLDS = -0.064 (-0.101; -0.026)). Children with a poor diet quality at the age of 3 years had a considerably higher risk for overweight at the age of 10 years (confounder adjusted OR for Q1 vs. Q5 was 2.86 (95% CI 1.34-6.13). These results show the importance of diet in healthy development in the early life following the first 1000 days when new habits for a mature diet composed of food groups with lifelong importance are developed, providing a relevant window for overweight prevention early in life.

Maternal GDM Status, Genetically Determined Blood Glucose, and Offspring Obesity Risk: An Observational Study.

The purpose of this study was to estimate the associations of genetically determined maternal blood glucose levels with obesity-related outcomes among children from pregnancies with and without gestational diabetes mellitus (GDM). A total of 1,114 mothers with (N = 560) and without (N = 554) GDM and their children were included in the present study. A maternal genetic risk score (GRS) for blood glucose was constructed on the basis of 17 single-nucleotide polymorphisms identified from a recent genome-wide association study. It was found that maternal GRS for blood glucose showed different associations with offspring risk of overweight and obesity, as well as adiposity measures (all P for interaction < 0.05). Among mothers without GDM, genetically determined maternal blood glucose levels were associated with an 89% higher risk of overweight in their children (95% CI: 42%-152% per SD increase in GRS, P = 1.40 × 10-5 ) and a 120% higher risk of obesity (44%-235%, P = 2.61 × 10-4 ) after adjustment for covariates. In addition, higher maternal GRS for blood glucose was associated with children's increased obesity-related traits (all P < 0.05). However, no significant associations were observed among children of mothers with GDM. This study indicates that GDM status may modify the relation between genetically determined glucose levels and obesity risk among children.

Demographic and Socioeconomic Determinants of Body Mass Index in People of Working Age.

Obesity is currently the most common metabolic disease, causing numerous health problems and, if untreated, leading to premature mortality. Obesity is a significant issue among people of working age since their ability to work depends directly on their health condition and psychomotor fitness. Demographic and socioeconomic factors have a significant impact on the body weight of people of working age. The aim of this study is to identify relationships between the body mass index and selected demographic and socioeconomic variables in working-age residents of the city of Wrocław, Poland. The study involved 4315 respondents (2206 women and 2109 men) aged 18–64 years from Wrocław. The sample selection was random and purposive, using multilevel stratification. The applied research tool was the authors’ own cross-sectional diagnostic questionnaire of socioeconomic status. Based on the collected data, the respondents’ body weight was categorized according to WHO criteria. The majority of respondents (60%) had a normal body weight, while 40% were categorized as overweight or obese. The difference was statistically significant (p < 0.001). Sex, age, occupational status, marital status, number of people in the household, having a steady source of income, disposable (net) income, and savings were significantly correlated (p < 0.001) with respondents’ body mass index. Public health programs aimed at promoting healthy lifestyle behaviors should be addressed primarily to groups at the highest risk of overweight and obesity.

Associations of Hair Cortisol Concentrations with General and Organ Fat Measures in Childhood.

Stress may lead to an adverse body fat distribution from childhood onwards. To examine the associations of hair cortisol concentration (HCC) at 6 years with general and organ fat measures, risk of overweight, and nonalcoholic fatty liver disease (NAFLD) at 10 years and to assess whether these were independent of adiposity measures at 6 years. HCCs were measured in hair of 6-year-old children (n = 2042) participating in the Generation R Study, a population-based prospective cohort study. Body mass index (BMI), fat mass index measured by dual-energy X-ray absorptiometry scan, and visceral fat index, pericardial fat index, liver fat fraction measured by magnetic resonance imaging and risk of overweight and NAFLD were obtained at 10 years. The associations of higher HCC at 6 years, with higher BMI, fat mass index, and increased risk of overweight at age 10 years are explained by the relationships observed at 6 years. HCCs at 6 years were associated with a higher liver fat fraction (difference 0.11 liver fat fraction standard deviation score; 95% confidence interval [CI] 0.03, 0.18) and a higher risk of NAFLD at 10 years (odds ratio 1.95; 95% CI 1.06, 3.56), independent of fat mass index at 6 years. HCCs were not associated with pericardial or visceral fat indices. Higher HCCs at 6 years were associated with higher BMI, fat mass index, liver fat fraction, and higher risks of overweight and NAFLD at 10 years. Only the associations for liver fat fraction and NAFLD were independent of fat mass index at 6 years.

Double Burden of Malnutrition among Chinese Women of Reproductive Age and Their Social Determinants.

This study aimed to examine the impact of a wide range of demographic, socioeconomic, and community factors on the double burden of malnutrition among women of reproductive age using longitudinal data. We used data about 11,348 women of reproductive age who participated in the China Health and Nutrition Survey (CHNS), a longitudinal survey, between 1989 and 2015. Nutritional outcomes were categorized into four groups, namely underweight, normal weight, overweight, and obesity, with normal weight as reference. A multinomial logit model was fitted due to geographic clustering and repeated observations of individuals. The prevalence of underweight decreased over time from 1991 but has tended to rise again since 2004, while the prevalence of overweight/obesity continued to rise between 1991 and 2015. Improved individual factors, socioeconomic status, and community urbanization reduced the risk of underweight but elevated the risk of overweight and obesity. The medium levels, rather than the highest levels, of household income and community urbanization are associated with a higher risk of overweight and obesity. The notable increase in underweight prevalence is a cause for concern to be addressed along with efforts to curb the rising tide of overweight. In order to enhance the nutritional status of women of reproductive age, it is essential to improving the community environment, levels of education, and living environment from a wider context. Long-term and targeted plans are urgently needed for nutrition improvements among the different populations.

Secular trends in sedentary behaviors and associations with weight indicators among Chinese reproductive-age women from 2004 to 2015: findings from the China Health and Nutrition Survey

Overweight and obesity are rising among Chinese reproductive-age women, while some studies have focused on the relationship between sedentary behavior and obesity in certain populations, none has focused on Chinese reproductive-age women specifically. This study examined secular trends in leisure time sedentary behaviors (watching television time, computer time and reading time, and the total sedentary time) among Chinese reproductive-age women and the association of those behaviors with five weight indicators-body mass index (BMI), waist circumference (WC) and overweight, obesity, and abdominal obesity status. A prospective cohort study was conducted with Chinese reproductive-age women aged 15-49 who had participated in two or more rounds of the China Health and Nutrition Survey (CHNS), and completed the questionnaire and anthropometric measurements. The exposure variables were the average weekly time spent on three leisure time sedentary behaviors (watching television, using computer, and reading) and the total sedentary time (the sum of the above three sedentary time and video game time). Mixed-effect linear models were produced to explore the secular trends of the mean hours of these sedentary behaviors and the total sedentary time after adjusting covariates. Models were also produced to study the effects of these types of sedentary behavior levels on BMI and WC. Mixed-effect logistic regression models were produced to study the effects of the sedentary behavior levels on overweight, obesity, and abdominal obesity status. The total sedentary time among the reproductive-age women increased over time across most of age, region, educational levels, and income groups from 2004 to 2015. Television hours fluctuated, it increased and then declined over time across most of age, region, and income groups. Computer hours continually increased over time across all age, region, educational level, and income groups. Reading hours gradually decreased over time across most of age, region, educational level, and income groups. Those with a moderate level of television time (14 to <35 h/week) had 1.08 cm larger WCs and were 1.31 times more likely to have abdominal obesity than those with a low level of television time (<14 h/week). Those with a high level of television time (≥35 h/week) had 1.74 cm larger WCs, 0.66 kg/m2 larger BMIs, were 1.50 times more likely to be overweight and were 1.47 times more likely to have abdominal obesity than those with a low level of television time (<14 h/week). Greater computer, reading time, and total sedentary time were not associated with WC, BMI, overweight, obesity, or abdominal obesity. These findings showed that among Chinese reproductive-age women ages 15-49, secular trends of computer time increased rapidly, reading time decreased gradually and television time fluctuated but showed not much difference from 2004 to 2015. The sharp increase in computer time far outweighed the decline in reading time. As a result, the overall sedentary behavior time of Chinese reproductive-age women gradually increased. These findings provided strong evidence that greater television time was significantly associated with higher BMI, WC, and higher risks of overweight, abdominal obesity among Chinese reproductive-age women. Computer, reading, and the total sedentary time were not associated with those weight indicators.