Twenty-six patients from a general practice suffering with clear-cut seasonal rhinitis due to grass pollen were treated with 3 injections, at 10 to 14 day intervals, of a modified grass pollen allergens tyrosine adsorbate ('Pollinex'), prior to the 1975 pollen season. Of the 26 patients, only 6 had previously had variable forms of hyposensitization. Despite the very high pollen counts in the 1975 pollen season the overall success rate of the hyposensitization was 73% and results were better in the patients who had not been previously hyposensitized. There was only one adverse local reaction to the injection which was not severe enough to discontinue the treatment.