The purpose of this paper is to investigate the use of rational Chebyshev (RC) collocation method for solving high-order linear ordinary differential equations with variable coefficients. Using the rational Chebyshev collocation points, this method transforms the high-order linear ordinary differential equations and the given conditions to matrix equations with unknown rational Chebyshev coefficients. These matrices together with the collocation method are utilized to reduce the solution of higher-order ordinary differential equations to the solution of a system of algebraic equations. The solution is obtained in terms of RC functions. Numerical examples are given to demonstrate the validity and applicability of the method. The obtained numerical results are compared with others existing methods and the exact solution where it shown to be very attractive and maintains better accuracy.