Higher-order Cognitive Mechanisms Research Articles

Visual Perception in Autism Spectrum Disorder: A Review of Neuroimaging Studies.

Although autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social impairments, patients with ASD frequently manifest atypical sensory behaviors. Recently, atypical sensory perception in ASD has received much attention, yet little is known about its cause or neurobiology. Herein, we review the findings from neuroimaging studies related to visual perception in ASD. Specifically, we examined the neural underpinnings of visual detection, motion perception, and face processing in ASD. Results from neuroimaging studies indicate that atypical visual perception in ASD may be influenced by attention or higher order cognitive mechanisms, and atypical face perception may be affected by disrupted social brain network. However, there is considerable evidence for atypical early visual processing in ASD. It is likely that visual perceptual abnormalities are independent of deficits of social functions or cognition. Importantly, atypical visual perception in ASD may enhance difficulties in dealing with complex and subtle social stimuli, or improve outstanding abilities in certain fields in individuals with Savant syndrome. Thus, future research is required to elucidate the characteristics and neurobiology of autistic visual perception to effectively apply these findings in the interventions of ASD.

Perceptual mechanisms of social affiliation in zebrafish

Social living animals need to recognize the presence of conspecifics in the environment in order to engage in adaptive social interactions. Social cues can be detected through different sensory modalities, including vision. Two main visual features can convey information about the presence of conspecifics: body form and biological motion (BM). Given the role that oxytocin plays in social behavior regulation across vertebrates, particularly in the salience and reward values of social stimuli, we hypothesized that it may also be involved in the modulation of perceptual mechanisms for conspecific detection. Here, using videoplaybacks, we assessed the role of conspecific form and BM in zebrafish social affiliation, and how oxytocin regulates the perception of these cues. We demonstrated that while each visual cue is important for social attraction, BM promotes a higher fish engagement than the static conspecific form alone. Moreover, using a mutant line for one of the two oxytocin receptors, we show that oxytocin signaling is involved in the regulation of BM detection but not conspecific form recognition. In summary, our results indicate that, apart from oxytocin role in the regulation of social behaviors through its effect on higher-order cognitive mechanisms, it may regulate social behavior by modulating very basic perceptual mechanisms underlying the detection of socially-relevant cues.

Dominios cognitivos en la depresión unipolar. Teorías multimodales y nuevas perspectivas terapéuticas

Major depressive disorder (MDD) is considered the prototype of pathology heterogeneous group of Depressive Disorders (DSM-5). The MDD is a pleomorphic pathology and multisystem polygenic disorder emerging from different levels of interacting genes and environmental factors. Unfortunately, the increasing cost of depression and related affective disorders has not been paralleled by improvements in the efficacy of antidepressant treatment. Current challenges are focused on finding therapeutic targets capable of modulating different pathophysiological levels from the genome (eg. histone deacetylase inhibitors), and systemic metabolic variables (eg. drugs that interact at the level of oxidative and inflammatory phenomena), to higher order cognitive mechanisms (eg. executive functions). This brief review aims to analyze the neuropsychological terms we considered necessary in the clinical assessment of patients with MDD and the pathophysiological mechanisms and new therapeutic seeking to overcome current limitations.

The cognitive underpinnings of creative thought: A latent variable analysis exploring the roles of intelligence and working memory in three creative thinking processes

The field of creativity has largely focused on individual differences in divergent thinking abilities. Recently, contemporary creativity researchers have shown that intelligence and executive functions play an important role in divergent thought, opening new lines of research to examine how higher-order cognitive mechanisms may uniquely contribute to creative thinking. The present study extends previous research on the intelligence and divergent thinking link by systematically examining the relationships among intelligence, working memory, and three fundamental creative processes: associative fluency, divergent thinking, and convergent thinking. Two hundred and sixty five participants were recruited to complete a battery of tasks that assessed a range of elementary to higher-order cognitive processes related to intelligence and creativity. Results provide evidence for an associative basis in two distinct creative processes: divergent thinking and convergent thinking. Findings also supported recent work suggesting that intelligence significantly influences creative thinking. Finally, working memory played a significant role in creative thinking processes. Recasting creativity as a construct consisting of distinct higher-order cognitive processes has important implications for future approaches to studying creativity within an individual differences framework.

Interacting Cortical and Basal Ganglia Networks Underlying Finding and Tapping to the Musical Beat

Humans are able to find and tap to the beat of musical rhythms varying in complexity from children's songs to modern jazz. Musical beat has no one-to-one relationship with auditory features-it is an abstract perceptual representation that emerges from the interaction between sensory cues and higher-level cognitive organization. Previous investigations have examined the neural basis of beat processing but have not tested the core phenomenon of finding and tapping to the musical beat. To test this, we used fMRI and had musicians find and tap to the beat of rhythms that varied from metrically simple to metrically complex-thus from a strong to a weak beat. Unlike most previous studies, we measured beat tapping performance during scanning and controlled for possible effects of scanner noise on beat perception. Results showed that beat finding and tapping recruited largely overlapping brain regions, including the superior temporal gyrus (STG), premotor cortex, and ventrolateral PFC (VLPFC). Beat tapping activity in STG and VLPFC was correlated with both perception and performance, suggesting that they are important for retrieving, selecting, and maintaining the musical beat. In contrast BG activity was similar in all conditions and was not correlated with either perception or production, suggesting that it may be involved in detecting auditory temporal regularity or in associating auditory stimuli with a motor response. Importantly, functional connectivity analyses showed that these systems interact, indicating that more basic sensorimotor mechanisms instantiated in the BG work in tandem with higher-order cognitive mechanisms in PFC.

The hierarchical and functional connectivity of higher-order cognitive mechanisms: neurorobotic model to investigate the stability and flexibility of working memory

Higher-order cognitive mechanisms (HOCM), such as planning, cognitive branching, switching, etc., are known to be the outcomes of a unique neural organizations and dynamics between various regions of the frontal lobe. Although some recent anatomical and neuroimaging studies have shed light on the architecture underlying the formation of such mechanisms, the neural dynamics and the pathways in and between the frontal lobe to form and/or to tune the stability level of its working memory remain controversial. A model to clarify this aspect is therefore required. In this study, we propose a simple neurocomputational model that suggests the basic concept of how HOCM, including the cognitive branching and switching in particular, may mechanistically emerge from time-based neural interactions. The proposed model is constructed such that its functional and structural hierarchy mimics, to a certain degree, the biological hierarchy that is believed to exist between local regions in the frontal lobe. Thus, the hierarchy is attained not only by the force of the layout architecture of the neural connections but also through distinct types of neurons, each with different time properties. To validate the model, cognitive branching and switching tasks were simulated in a physical humanoid robot driven by the model. Results reveal that separation between the lower and the higher-level neurons in such a model is an essential factor to form an appropriate working memory to handle cognitive branching and switching. The analyses of the obtained result also illustrates that the breadth of this separation is important to determine the characteristics of the resulting memory, either static memory or dynamic memory. This work can be considered as a joint research between synthetic and empirical studies, which can open an alternative research area for better understanding of brain mechanisms.

The implicit cognition of relationship maintenance: Inattention to attractive alternatives

The temptation of alternative mating partners can threaten satisfaction with and commitment to an existing romantic relationship. Consequently, people exhibit cognitive processes that help protect their relationship when faced with desirable relationship alternatives. Previous studies have focused primarily on processes that involve explicit, higher-order cognitive mechanisms such as overt judgments and choices (e.g., judging the alternative as less attractive). The current studies, in contrast, examined automatic, early-stage attentional processes that may help protect against threats posed by exposure to alternative mating partners. Whereas single participants responded to implicit mating primes by increasing early-stage attention to physically attractive opposite sex targets, participants in a committed romantic relationship were inattentive to those attractive alternatives. This research provides a novel approach for studying implicit cognitive mechanisms involved in maintaining close relationships.

Shepard's mirrors or Simon's scissors?

Shepard promotes the important view that evolution constructs cognitive mechanisms that work with internalized aspects of the structure of their environment. But what can this internalization mean? We contrast three views: Shepard's mirrors reflecting the world, Brunswik's lens inferring the world, and Simon's scissors exploiting the world. We argue that Simon's scissors metaphor is more appropriate for higher-order cognitive mechanisms and ask how far it can also be applied to perceptual tasks. [Barlow; Kubovy & Epstein; Shepard]

Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism.

To investigate the functional integrity of cerebellar and frontal systems in autism using oculomotor paradigms. Cerebellar and neocortical systems models of autism have been proposed. Courchesne and colleagues have argued that cognitive deficits such as shifting attention disturbances result from dysfunction of vermal lobules VI and VII. Such a vermal deficit should be associated with dysmetric saccadic eye movements because of the major role these areas play in guiding the motor precision of saccades. In contrast, neocortical models of autism predict intact saccade metrics, but impairments on tasks requiring the higher cognitive control of saccades. A total of 26 rigorously diagnosed nonmentally retarded autistic subjects and 26 matched healthy control subjects were assessed with a visually guided saccade task and two volitional saccade tasks, the oculomotor delayed-response task and the antisaccade task. Metrics and dynamics of the visually guided saccades were normal in autistic subjects, documenting the absence of disturbances in cerebellar vermal lobules VI and VII and in automatic shifts of visual attention. Deficits were demonstrated on both volitional saccade tasks, indicating dysfunction in the circuitry of prefrontal cortex and its connections with the parietal cortex, and associated cognitive impairments in spatial working memory and in the ability to voluntarily suppress context-inappropriate responses. These findings demonstrate intrinsic neocortical, not cerebellar, dysfunction in autism, and parallel deficits in higher order cognitive mechanisms and not in elementary attentional and sensorimotor systems in autism.