Higher Serum Bilirubin Levels Research Articles

A Modified Total Serum Cholesterol Method to Eliminate the Effect of High Bilirubin Levels

Abstract When a high molecular weight dextran sulfate solution was added to serum in the presence of calcium ions, a lipoprotein complex was precipitated that contained the total serum cholesterol. The incorporation of this precipitation step in the procedure for total cholesterol determinations eliminated errors due to high serum bilirubin levels.

Cholestasis in sickle cell anemia

A patient with sickle cell anemia who presented with marked cholestatic jaundice is described, with emphasis upon the difficulties encountered in differentiating this symptom complex from extrahepatic obstruction due to stone formation. This patient had extraordinarily high serum bilirubin levels, apparently the result of increased bilirubin formation, decreased hepatic excretion due to dysfunction of the bile secretory apparatus and, possibly, decreased urinary excretion of the bile pigment.