TPS 682: Long-term health effects of air pollutants 2, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Quality of life (Quol) in young people in Brazil related to health phenomena is little studied. Frequently evaluated by ISAAC. Few are the indicators and instruments of quality of life for general population exposed air pollution seeking to identify predictive respiratory factors. This exploratory analysis aims to identify the quality of life of young people living in high polluted cities, compared with a lower polluted city, all located in the countryside of the State of São Paulo/Brazil. Two cities have high levels of air pollution PM10: 60 to 100μg/m3. The third one is a touristic city, without PM10 monitoring. 509 volunteers in a transversal study.Age 15-18 yo. The K 27, with 5 domains, was answered by the young person himself. 51.9% were women. The questionnaire, added to a simple question “do you need frequent health care or have a serious illness?” 15.3% reported to be ill with 13% indicating atopic disease (AD). We evaluate the use of the K27 in atopic (report isolated or in combination of bronchitis, rhinitis or sinusitis, and dermatitis) and non-atopic. We use SPSS. Results: K27 population total score in all the dimensions of the polluted cities were inferior to the Brazilian study (Br) and normal range values. Physical Well-being was 41.7 ±10 lower than the Br population (48.1) and the normal range values (50 ±10). Psychological Well Being 43.8; Br =47.1 Autonomy & Parent Relation =42.0; Br = 44.2; Social Support & Peers= 49.3; Br=49.5; School = 43.0; Br= 51.0. There were no differences among cities. Of them, 94% were residents in polluted cities: K27 for dimension Physical Well-being was 36.6±8, significantly different form non-AD and non polluted city (42.4±10) (p=0.1). Conclusions: K27 might be useful to predict Quol impairment in susceptible adolescents with atopic respiratory diseases living in high polluted cities.