The paper presents the results of a study of associations between empathy and defensivecoping communication in medical residents with different level of perfectionism. Psychiatry and neurology residents (n = 100) aged 22–29 filled out the following validated instruments: “Three-Factor Perfectionism Inventory” (Garanyan N. G., et al.); “The Interpersonal Reactivity Index (IRI)” (M. Davis); “Diagnosis of the dominant strategy of psychological defense in communication” (V. V. Boyko). The sample was divided into three groups with high (n = 37), medium (n = 33) and low (n = 30) levels of perfectionism. The obtained data indicate a positive correlation between empathy factor “Perspective taking” and strategy of defensive communication “Peacefulness” in all the three groups of residents with different levels of perfectionism. In residents with medium level of perfectionism “Peacefulness” also correlated with “Empathic concern”, and “Avoidance” correlated with “Personal distress”. In residents with high level of perfectionism “Aggression” negatively correlated with “Perspective taking” and “Empathic concern”. The collected data contribute to a more complete understanding of associations between empathy and defensive communication in psychiatry and neurology residents and can be applied to specify psychological targets of residents training.