Introduction: Stroke's far-reaching impact encompasses societal, economic, and healthcare dimensions. A country's Human Development Index (HDI), comprising its performance in health, education, and living standards, offers insights into the nation's capacity in stroke management. The Association of Southeast Asian Nations' (ASEAN) adaptive growth strategy, accommodating the diverse developmental stages of its members, presents a unique context for exploring the relationship between HDI and stroke burden in the region. Methods: Data regarding the burden of stroke, expressed in the form of stroke-related mortality and Disability-Adjusted Life Years (DALY) rates, within the current 10 members of ASEAN were sourced from the 2019 Global Burden of Disease (GBD) study. Data on the 2019 HDI for these countries were obtained using the tool on the United Nations Development Programme (UNDP) website. Statistical analysis included normality testing and correlation assessments using Pearson and Spearman methods across 3 age groups (all-ages, 20+, 55+) with 3 sex sub-groups (both-sexes, female, male) in each age category. Results: In terms of mortality, higher HDI correlated significantly with lower mortality rates in all three age groups for both-sexes and female sub-groups. The male sub-groups also showed similar findings in the 20+ and 55+ age groups, but no significant correlation was found in the all-ages group (Table 1). For DALY, a significant correlation was observed between higher HDI and reduced DALY rates in the 20+ and 55+ age groups across all sex sub-group, but no significant correlation emerged in the all-ages group for any of its sex sub-groups (Table 2). Conclusion: These findings collectively suggest that higher levels of human development, as indicated by HDI, are associated with lower stroke-related mortality and DALY rates in ASEAN countries, emphasizing the importance of effective strategies to alleviate the burden of stroke in the region.