The present study tested the hypothesis that proneness to shame would predict self-rumination (and personal distress) whereas proneness to guilt would predict self-reflection (and perspective taking, and empathic concern). Results supported the majority of these predictions, and revealed that self-reflection mediates the relationship between guilt and perspective taking. Additional results provided some support for the hypothesis that self-rumination mediates the relationship between shame and personal distress. However, results also revealed that shame mediated the relationship between self-rumination and personal distress, suggesting that shame and self-rumination may feed each other within a reciprocal cycle that is likely to result in a maladaptive empathic response (i.e., personal distress). Empathic concern was associated with higher levels of guilt, but results failed to replicate earlier findings demonstrating a positive relationship between empathic concern and self-reflection. The present results replicate and extend past research and suggest several promising avenues for future research.