High Level Of Certainty Research Articles

An Encryption Approach Using Information Fusion Techniques Involving Prime Numbers and Face Biometrics

The work shows a novel solution to create an access key which can be used within the transactions of electronic currencies, blockchain as well as in the field of computer security to guarantee a high level of secrecy, but also, with a high level of certainty, to provide a person identity through Information Fusion (IF) techniques and biometric data encryption. Specifically, two non-connected areas have been joined, Face Biometrics and Public-key Cryptography. This choice was taken in order to get through the limits these two approaches have found singularly and to give a suitable solution in the context of electronic and digital exchanges (electro-currencies, Internet of Things). An innovative and original algorithm has been developed, which can do fusion operations between Face Biometrics and numerical data, that is an algorithm of Hybrid Information Fusion, named FIF (Face Information Fusion). We decided to use a digital face as a biometric component, and the product of two prime numbers as a numerical component, that is the module in RSA algorithm.

Trends in Transmissibility of 2019 Novel Coronavirus-Infected Pneumonia in Wuhan and 29 Provinces in China

Background: The 2019 novel coronavirus infected pneumonia (COVID-19) represents a significant public health threat. The COVID-19 emerged in December 2009 in Wuhan, China and rapidly spread to other regions and countries. The variation in transmission patterns and disease spread in regard to time or among different locations, partially reflecting the public health intervention effects, remains to be quantified. As most transmissibility-related epidemic parameters are unknown, we sought, with minimal assumptions, to estimate real-time transmissibility and forecast new cases using dynamic modelling. Methods: Using the cases reported from the National Health Commission of China and transportation data, including the total number of travelling hours through railway, airplane, and car outbound from Wuhan, we have built a time-series model to estimate real-time underlying transmission rates of newly generated cases sequentially from January 20, 2020 to Feb 13, 2020 in Wuhan, Hubei province and other 28 provinces in China. We quantified the instantaneous transmission rate and relative reproduction number (Rt) of COVID-19, and evaluated whether public health intervention affected the case transmissibility in each province. Based on the current estimates, we have predicted the trend of disease spread with a high level of certainty. Findings: We estimated that Rt declined from the range of 4 to 5 towards 1 and remained below unity, while there was an initial growth followed by a decline in a shorter period in Hubei and other provinces. The ratio of transmission rates decreased dramatically from January 23 to 27 likely due to the rigorous public health intervention implemented by the government beginning on January 23, 2020. The mean duration of the infectious period was 6 to 9 days. We have predicted the trend of infection sizes which became stable in provinces around February 19 to 24, 2020, and the date of containment would be one-week later in Wuhan. Interpretation: Public health interventions implemented at both the social and personal levels are effective in preventing outbreaks of COVID-19 in Wuhan and other provinces. Model prediction results suggested that COVID-19 will be contained around the end of February 2020 in China. Funding Statement: The research was partially supported by National Natural Science Foundation of China (Nos. 11931014 and 11829101) and Fundamental Research Funds for the Central Universities (No. JBK1806002) of China. Declaration of Interests: The authors declare no competing interests.

Highly Available Nuclear Power for Mission-Critical Applications

Some energy consumers require power on an anytime, all-year-round basis with a high level of certainty, including defense installations, isolated communities, and some industrial processes. For these customers, interruptions in electricity or heat can mean substantial financial loss or even loss of life. In the absence of grid-scale energy storage, a high level of power availability can be accomplished only through the robustness and redundancy of power generators. The NuScale small modular reactor design is well suited to provide highly available power because of several features related to both the nuclear steam supply system and the overall plant design. In analogy to Redundant Array of Independent Disks (RAID) systems used to provide highly reliable data storage, a NuScale plant can assure sustained power generation by virtue of its Redundant Array of Integral Reactors (RAIR).This paper describes the NuScale RAIR plant features and summarizes the results of a rigorous analysis of RAIR availability as a function of power or, conversely, the RAIR plant output power as a function of power availability. The analysis utilized the Matrix Laboratory code (MATLAB) and included probability distributions for the frequency and duration of module outages due to planned and unplanned events. The study also evaluated the impact of implementing turbine bypass rather than module shutdown and using one or more modules to supply house loads in the case of loss of off-site power (LOOP). Availability results are presented for a 12-module RAIR plant with and without turbine bypass enabled during a LOOP and for different possible connections to the off-site power distribution grid and dedicated service loads. Results indicate that a very high level of availability can be achieved at relatively high power output levels, regardless of turbine bypass and dedicated load connection, compared to the operating fleet.

Intralesional measles–mumps–rubella is associated with a higher complete response in cutaneous warts: a systematic review and meta-analysis of randomized controlled trial including GRADE qualification

Introduction Warts can be difficult to treat and progressing to chronic and resistant disease. Several studies have reported the successful application of mumps–measles–rubella (MMR) vaccine resulting in clearance of warts via immunomodulation and induction of immune system. Methods We performed a comprehensive search on the role of intralesional MMR in warts from several electronic databases. Complete response is defined as complete clearance of warts lesion. Results There were a total of 425 subjects from five studies. Intralesional injection of MMR was associated with an increased complete response (OR 9.43 [5.78, 15.37], p < .001; I 2: 5%, p = .38). Subgroup analysis on patients receiving injection for every 2 weeks for a maximum of five injections revealed an OR of 11.70 [6.40, 21.38], p < .001; I 2: 20%, p = .29. Patients receiving intralesional MMR were associated with a lower partial response (OR 0.54 [0.33, 0.88], p = .01; I 2: 0%, p = .66). Intralesional MMR was associated with a reduced no-response (OR 0.16 [0.06, 0.43], p < .001; I 2: 69%, p = .01). Funnel plot analysis for complete response was asymmetrical, indicating the risk of publication bias. There were statistically significant small-study effects for intralesional MMR on complete response upon analysis using Harbord’s test (p = .047). Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment showed that intralesional MMR injection has high level of certainty (quality of evidence) for complete response in warts with an absolute increase of 505 per 1000. Conclusion Intralesional MMR injection was associated with a higher complete response and lower no-response with a high level of certainty.

Uncertain Certainty?: Making Sense of the European Court of Human Rights’ Standard of Proof

The European Court of Human Rights (ECtHR) declares a single standard of proof (‘SoP’): proof beyond reasonable doubt (‘brd’). Yet the accuracy of this claim and the threshold’s appropriateness have both been challenged. This article uniquely considers and clarifies the Court’s interpretation and application of its SoP. Demonstrating SoP is capable of both broad and narrow interpretations, it shows the Court interprets SoP only narrowly. This understanding confirms brd as the applicable standard, whose use is then considered through detailed examination of the case law. The analysis shows that although the Court’s conception and approach to brd necessarily accommodate some doubt, violations are found with a consistently high level of certainty. There is however, a striking inconsistency in references made to the Rules of Court. Moreover, the Rules do not fully capture the Court’s approach. Addressing this, as the article proposes, would strengthen both the consistency and legitimacy of relevant decisions.

GRAVITATY POTENTIAL FOR CURRENCY ALLIANCES’ INTRARIGIONAL TRADE

The paper develops the concept of regional monetary integration, the framework of which includes three alternative exchange rate arrangements: currency board, full or parallel dollarization and currency union. Each of them has its own peculiarities of formation and development, its own advantages and disadvantages, but the common feature is unconditional exchange rate unification. The concept of currency proto-integration was introduced, which foresees the exchange of information on monetary initiatives between monetary authorities, consideration of counterparties’ interests to minimize risks or maximize common benefits in the field of monetary relations.In order to assess the effectiveness of monetary integration for the development of intra-regional trade flows, we use gravity modeling based on a sample of more than 105 thousand observations of bilateral trade flows within monetary integrational and proto-integrational alliances. Gravity model includes the parameters of the volumes of bilateral trade, gross domestic product, weighted distances between states and the system of dummy-variables for the determination of monetary associations, common language and borders between trading states. The applied gravity model demonstrates a fairly high level of certainty for South America, Europe, South and East Asia (R2 for them was 0.71, 0.63 and 0.54, respectively). It was established that among the monetary alliances, the integrational and proto-integrational structures of South America, Asia and Europe were most effective in the aspect of intensifying intraregional trade. Between the African monetary blocks, the regular growth of mutual trade was observed only in the West African Economic and Monetary Union, while the rest was characterized by reverse dependence.

Letter of interest for a neutrino beam from Protvino to KM3NeT/ORCA

The Protvino accelerator facility located in the Moscow region, Russia, is in a good position to offer a rich experimental research program in the field of neutrino physics. Of particular interest is the possibility to direct a neutrino beam from Protvino towards the KM3NeT/ORCA detector, which is currently under construction in the Mediterranean Sea 40 km offshore Toulon, France. This proposal is known as P2O. Thanks to its baseline of 2595 km, this experiment would yield an unparalleled sensitivity to matter effects in the Earth, allowing for the determination of the neutrino mass ordering with a high level of certainty after only a few years of running at a modest beam intensity of approx ~90~hbox {kW}. With a prolonged exposure (approx 1500hbox { kW},,hbox {year}), a 2sigma sensitivity to the leptonic CP-violating Dirac phase can be achieved. A second stage of the experiment, comprising a further intensity upgrade of the accelerator complex and a densified version of the ORCA detector (Super-ORCA), would allow for up to a 6sigma sensitivity to CP violation and a 10^circ {-}17^circ resolution on the CP phase after 10 years of running with a 450 kW beam, competitive with other planned experiments. The initial composition and energy spectrum of the neutrino beam would need to be monitored by a near detector, to be constructed several hundred meters downstream from the proton beam target. The same neutrino beam and near detector set-up would also allow for neutrino-nucleus cross section measurements to be performed. A short-baseline sterile neutrino search experiment would also be possible.

Triassic sand supply to the Slyne Basin, offshore western Ireland – new insights from a multi-proxy provenance approach

To assess provenance data and derive basin infill models with a higher level of certainty it is vital to understand how minerals used in sedimentary provenance behave in the sedimentary system. A multi-proxy approach helps ensure rigour in how provenance data are interpreted. U–Pb geochronology of refractory zircon and relatively less stable apatite, and Pb isotopic analysis of labile K-feldspar are employed in this study to reassess the provenance of Triassic sandstones in the Slyne Basin, offshore western Ireland. This approach aims at reducing the potential bias in each method, producing a complementary dataset. U–Pb zircon and apatite geochronology yields Archean–Paleoproterozoic ages, Caledonian ages and previously unrecognized Permo-Triassic ages. Pb isotopic analysis of K-feldspar does not identify the Permo-Triassic as a source. The detection of Permo-Triassic-aged detritus may suggest that volcanism was more widespread than previously recognized. These results support the hypothesis of a Triassic drainage divide between the basins offshore western Ireland and those onshore Britain and in the Irish Sea. Sand supply was dominantly from the north, with significant input from the flanks of the basin, and previously unrecorded sources, such as Permian-aged rocks, playing an important role. The provenance signal is consistent and homogenized throughout the sampled sequence indicating that the drainage system was long-lived. Supplementary material: Details of laboratory and sample preparation, data tables and summary pie charts for each sample are available at https://doi.org/10.6084/m9.figshare.c.4571096

Classical Taxonomy as the Foundation for Automating Fossil Identification: Using virtual paleontology and geometric morphometrics to identify Jurassic Nerineoidea gastropods

Accurate identification of fossils forms the foundation for many aspects of geological research, including biostratigraphy and paleoecology. Yet, many taxa are identified qualitatively based on their morphology, which requires extensive expertise in specific taxonomic groups. The often-subjective identification of specimens is difficult to verify and can cause misinterpretation and inaccuracies. Thus, finding new ways to objectively identify fossils will be of great value. A prime example of the ‘taxonomic impediment’ in the fossil record is exhibited in the Nerineoidea, a group of extinct gastropods that form a major component of Mesozoic shallow marine environments. Taxonomically diverse and numerically abundant assemblages of Nerineoidea are found across a wide range of paleo-latitudes, and used for biostratigraphy and paleoecology. The group is distinctly recognized by the presence of internal spiral folds that developed inside the internal cavity of the shell during ontogeny. The number and position of folds is constant within a species, and form the basis of their classification. Their paleoecological and biostratigraphical importance is represented by vast scientific literature and abundant fossil collections worldwide. However, identification and uniform classification of this group is lacking due to two major factors: inconsistent systematic position and subdivision, and the classification procedure is largely based on polished cross-sections of specimens that reveal the important internal structure and destroy whole specimens, thus preventing any further verification. Therefore, identification of specimens is largely based on expert judgment and difficult to replicate. inconsistent systematic position and subdivision, and the classification procedure is largely based on polished cross-sections of specimens that reveal the important internal structure and destroy whole specimens, thus preventing any further verification. Therefore, identification of specimens is largely based on expert judgment and difficult to replicate. Micro-computed tomography (micro-CT) is revolutionizing species identification by modeling the internal anatomy of fossils in 3D, and allowing the study of structures that would previously have been impossible to visualize. We present the first automated taxonomic identification method of Nerineoidea fossils, by combining modern non-destructive imaging techniques with classic identification methods. Fifty-eight Jurassic Nerineoidea specimens were examined from Europe, Arabia, and Africa. Images of polished cross-sections of specimens were compiled from online databases, literature, and fossil collections. Three successive longitudinal whorl cross-sections showing the internal folds were analyzed for each specimen. The shape of each whorl was captured using thirty evenly spaced semi-landmarks. In addition, twenty eight specimens from the Geological Survey of Israel and the Natural History Museum (UK) were scanned using micro-CT. Optimal longitudinal slices were selected from the 3D reconstructions for each specimen using Amira (v. 6.3), and their whorl outlines were captured as described above. Canonical variate analysis shows that whorl outlines significantly differentiate between Nerineoidea, independent of the data source or the location of the whorl in the spire. The Jackknife estimate of future identification is high (73.25%), and suggests that the method can be applied to accurately assign the taxonomic family of future specimens reliably and effectively. Moreover, the high variation in whorl outlines between genera can be used to identify specimens to the species level with a high level of certainty. We demonstrate that shape analysis of the whorl outlines is an objective and quantitative method for identifying different taxa of Nerineoidea. The advantages of the method include its application to mass accumulation of specimens, as well as to two-dimensional images from various sources. This will enable future quantitative study of polished cross-sections of specimens from museum collections, scientific publications and online databases. The quantitative and objective taxonomic identification of Nerineoidea fossils could revolutionize their classification and improve the paleoecological reconstruction of Mesozoic carbonate platforms. This will enhance interpretations of faunal biogeographic response to changing environmental conditions along shelf ecosystems.

Climate Scientists’ Wide Prediction Intervals May Be More Likely but Are Perceived to Be Less Certain

AbstractThe use of interval forecasts allows climate scientists to issue predictions with high levels of certainty even for areas fraught with uncertainty, since wide intervals are objectively more likely to capture the truth than narrow intervals. However, wide intervals are also less informative about what the outcome will be than narrow intervals, implying a lack of knowledge or subjective uncertainty in the forecaster. In six experiments, we investigate how laypeople perceive the (un)certainty associated with wide and narrow interval forecasts, and find that the preference for accuracy (seeing wide intervals as “objectively” certain) versus informativeness (seeing wide intervals as indicating “subjective” uncertainty) is influenced by contextual cues (e.g., question formulation). Most important, we find that people more commonly and intuitively associate wide intervals with uncertainty than with certainty. Our research thus challenges the wisdom of using wide intervals to construct statements of high certainty in climate change reports.

From mountains to towns: DNA from ancient reindeer antlers as proxy for domestic procurement networks in medieval Norway

In medieval archaeology there are long traditions for studying foreign, exotic material culture as proxy for procurement networks of international reach. A paradox is that domestic networks, which brought products to consumers at home, has attracted little attention. During the Middle Ages (1030–1537), antler from reindeer was a north Scandinavian outland resource that found its way from remote mountains to settlements at home and abroad for use in hair combs. In the current pilot study, molecular genetic methods were employed to test whether antler debris from comb production workshops in the four medieval Norwegian towns Bergen, Trondheim, Skien and Oslo can be assigned to its original reindeer population. The study shows that ancient DNA (aDNA) can be used to provenance antler material to its origin with varying degrees of certainty: When samples from the four towns are considered as collective units, there is a high level of certainty in the discovered provenance pattern, whereas there is more uncertainty attached to provenancing individual antler fragments. Some immediate culture historical insights from the project's results are that urban comb makers used antler from the closest mountain areas, while analysis of individual-reindeer-based relationships on resource procurement adds some possible nuances to this picture. Furthermore, assigning dated antler debris to its population of origin adds new dates for commercial exploitation of reindeer resources in the specific mountain areas and adds new and high-definition empirical substance to the picture of long traditions for far-reaching procurement networks for Norwegian outland resources.

Lakes Drying and Their Adverse Effects on Human Health: A Systematic Review

One of the most important effects of many drying lakes in the world is increasing the emergence and outbreak of different diseases. For this sake, the present study aimed to systematically review the effects of lakes drying on human health. The present systematic review was designed and conducted in 2017. Data were gathered by searching the Science Direct, Cochrane Library, Google Scholar, Scopus, PubMed, and Web of Knowledge databases, along with hand search of key journals and unpublished resources and contact with experts. There was no specific time span for the search. Overall, 22 articles were selected with 20 articles about Aral Lake drying. Almost all studies were cross-sectional and retrospective. In 8 studies, the participants were children. Seventeen articles lakes drying have adverse effects on human health. Based on the type of effect, the studies were classified into 7 categories (respiratory problems, reproductive system problems, kidney and urological diseases, cancers, anemia, and diarrhea). Most studies depicted the harmful effects of lakes draught on human health; they had low level of evidence as they were mostly retrospective and cross-sectional. There is not enough evidence to accept or reject with high level of certainty the very effects of lakes drying on human health. To provide such evidence we suggest conducting middle and long term cohort and observational studies with scientific bases.

Development of a 10-Item Tool to Identify Advanced Practice Nurse Readiness to Prescribe Pre-exposure Prophylaxis.

Pre-exposure prophylaxis (PrEP), a biomedical tool to prevent the acquisition of HIV, reduces the risk of HIV in high-risk individuals by more than 90%. An online questionnaire was fielded from March 2017 to May 2017 to a random sample of licensed advanced practice nurses (APNs) from the U.S. state of Indiana. Discriminant function analysis was performed to reveal willingness to prescribe PrEP. Two discriminant functions were identified: Sexual Risk Assessment (r = .686), PrEP Barriers (r = .587), Evidence-Based Practice Implementation (r = .545), Community Awareness (r = .446), Perceived Risk (r = .356), and Organizational Climate (r = .346) were loaded on the first function, whereas PrEP Skills (r = .837) was loaded on the second function. The results suggest APN's willingness to learn and knowledge about PrEP-influenced implementation. Findings demonstrated that readiness to prescribe PrEP by APNs in Indiana could be predicted with a high level of certainty using identified variables.

Characterizing species co-occurrence patterns of imperfectly detected stream fishes to inform species reintroduction efforts.

Species reintroduction efforts can improve the recovery of imperiled species, but successful implementation of this conservation strategy requires a thorough understanding of the abiotic and biotic factors influencing species viability. Species interactions are especially understudied, in particular by omitting the effect of imperfect detection on negative, neutral, or positive associations within a community. Using repeat surveys from 5 southern Ontario, Canada, Great Lakes tributaries, we quantified species co-occurrence patterns with the eastern sand darter (ESD) (Ammocrypta pellucida), listed as federally threatened, and characterized how imperfect detection during sampling can influence inference regarding these relationships. We used a probabilistic framework that included 3 approaches of increasing complexity: probabilistic co-occurrence analysis ignoring imperfect detection; single-species occupancy models with subsequent co-occurrence analysis; and 2-species occupancy models. We then used our occupancy models to predict suitable sites for potential future reintroduction efforts while considering the influence of negative species interactions. Based on the observed data, ESD showed several positive associations with co-occurring species; however, species associations differed when imperfect detection was considered. Specifically, a negative association between ESD and rosyface shiner (Notropis rubellus) was observed only after accounting for imperfect detection in the Grand River. Alternatively, positive associations in the Grand River between ESD and northern hogsucker (Hypentelium nigricans) and silver shiner (Notropis photogenis) were observed regardless of whether imperfect detection was accounted for. Our models predicted several potential reintroduction sites for ESD in formerly occupied watersheds with high levels of certainty. Overall, our results demonstrate the importance of investigating imperfect detection and species co-occurrence when planning reintroduction efforts.

Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis

Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis

Field developmental plan analysis: a case study of \u2018x\u2019 reservoir

Petroleum resources remain very important to the economic growth of several nations of the world even as oil price fluctuates in the current market today. The huge cost of exploration and exploitation of these resources makes it necessary for the attainment of high level of certainty in the methods adopted for its detection, quantification, planning and production. Mapping the right reservoir, understanding of reservoir characteristics most importantly; porosity, permeability, water saturation, thickness, and area extent of the reservoir, being able to reduce the uncertainties in these properties, making the right decision on when to inject water into the reservoir, where to locate these injectors and planning of where to drill new wells are very important factors that helps to determine the hydrocarbon reserves, cost of production and the degree of exploitation success rate and thus, needs to be treated with high level of certainty. This research work was, therefore, aimed at integrating several disciplines (Geologist, Reservoir Engineer, Well Engineer and Petroleum Economist) to carry out a detailed Field Development Plan (FDP) analysis for the reservoir in other to determine its success rate and economic viability. Simulations of three different cases of waterflood were analysed to decide the optimal development strategy to be applied to the field. Economic and sensitivity analyses were also carried out for all the cases suggested for the reservoir including the natural depletion case. Waterflood case 2 had NPV of $2,163,756,338 and the investment return of 47% and thus is recommended, since it is the best of all the cases.

Abstract WP365: Utility of Hyperdense Middle Cerebral Artery Sign for Earlier Activation of Endovascular Team

Introduction: The hyperdense MCA sign has been used as a marker of an underlying large vessel occlusion (LVO)/thrombus in the non-contrast head CT of acute stroke patients. However, due its low sensitivity, it has not been used routinely for definitive diagnosis of LVO. Furthermore, clinicians also have the ability to obtain further imaging with CT angiography to better visualize the vessels in most patients. However, this further imaging can take on average up to an additional 30 minutes due to delays in acquisition, patient cooperation, processing and image transmission time. We wanted to look for a simple sign on the early imaging (non-contrast HCT) to determine if we could activate the neuro interventional suite faster. Hypothesis: When present, the hyperdense MCA sign can accurately predict presence of a LVO and identify patients eligible for endovascular therapy sooner than vessel imaging. Methods: We retrospectively looked at all initial non-contrast head CTs for all consecutive stroke patients presenting to our facility in 2017 (n=86), with a last known well time (LKW) &lt; 6 hours and NIHSS &gt; 4, for the presence of a hyperdense MCA sign. We then reviewed subsequent imaging (CTA) to determine if LVO was actually present. Results: The hyperdense MCA sign was present in 17 (out of 86) cases, all of which had an LVO on CTA. The positive predictive value (PPV) was 100% indicating that there was a high probability that subjects with a positive hyperdense MCA sign will have a LVO. There were 12 cases with an LVO on CTA did not have a hyperdense MCA sign showing a sensitivity of 58.6%, thus the absence of a hyperdense MCA sign does not exclude LVO. Conclusion: Quick delivery of appropriate treatments for acute stroke patients have been linked to better outcomes. Given our analysis of cases with NIHSS &gt; 4 and LKW &lt; 6 hours, it seems that presence of a hyperdense MCA sign on the initial non-contrast HCT leads to a high level of certainty that an LVO is present. Perhaps this sign, in combination of LKW and NIHSS, can be used to activate the neuro interventional team while additional imaging is being obtained.

Bioinformatics characterisation of the (mutated) proteins related to Andersen-Tawil syndrome.

In the last two decades, a group of proteins whose mutations are associated with a disease manifested by episodes of muscle weakness (periodic paralysis), changes in heart rhythm (arrhythmia), and developmental abnormalities has been under constant study. This malady is known as Andersen-Tawil syndrome, with ~60% of cases of this syndrome being caused by 16 mutations in the KCNJ2 gene [UniProt ID: P63252-01-P63252-17]. In this work, we present a computational study designed to obtain a fingerprint of Andersen-Tawil mutated proteins and differentiate them from mutated proteins associated with Brugada syndrome and from functional groups of proteins belonging to APD3, UniProt, and CPPsite databases. We show here that Andersen-Tawil mutated proteins are characterized by specific features that can be used to differentiate, with a high level of certainty (90%), proteins carrying these mutations from similar functional groups, such as mutated proteins associated with Brugada syndrome, and from different functional protein and peptide groups, such as antimicrobial peptides, Cell-Penetrating Peptides, and intrinsically disorder proteins. Therefore, our main results allow us to conjecture that it is possible to identify the group of the Andersen-Tawil mutated proteins by their "PIM profile". Furthermore, when we applied this "fingerprint PIM profile" on the UniProt database, we observed that one protein found in humans [UniProt ID: Q9NZV8], and six of all "reviewed" proteins found in living organisms, possess a very similar PIM profile as the Andersen-Tawil mutated protein group. The bioinformatics "fingerprint" of the Andersen-Tawil mutated proteins was retrieved using the in-house bioinformatics system named Polarity Index Method® and supported-at residues level- by the algorithms for the prediction of intrinsic disorder predisposition, such as PONDR® FIT, PONDR® VLXT, PONDR® VSL2, PONDR® VL3, FoldIndex, IUPred, and TopIDP.

The Physics Potential of a Neutrino Beam from Protvino to KM3NeT/ORCA

The Protvino accelerator facility located in the Moscow region, Russia, is in a good position to offer a rich experimental research program in the field of neutrino physics. Of particular interest is the possibility to direct a neutrino beam from Protvino towards the KM3NeT/ORCA detector which is currently under construction in the Mediterranean sea 40 km offshore Toulon, France. Such an experiment, nicknamed P2O (Protvino-to-ORCA), would yield an unparalleled sensitivity to matter effects in the Earth, allowing for the determination of the neutrino mass ordering with a high level of certainty due to its baseline of 2595 km after only few years of running time at a modest beam intensity up to 100 kW. A second phase of the experiment comprizes a further intensity upgrade of the accelerator complex and a significant densification of the ORCA detector. This would allow for a competitive and complementary measurement of the leptonic CP-violating Dirac phase with a Mton detector but avoiding underground excavation costs.

COST AND COMPLEXITY RESEARCH OF SOFTWARE DEVELOPMENT TO SOLVE THE PROBLEM OF INVENTORY MANAGEMENT

The article describes the process of estimating the cost and complexity of software development for the task of inventory management of a commercial enterprise to improve the decision-making process at the stage of formation of requirements for similar software products. There are different approaches to inventory management of a commercial enterprise. The algorithms implemented in the system are based on the constraint theory tool – dynamic inventory buffer management. Inventory management according to the theory of restrictions allows to provide a high level of availability of goods with minimal inventory in the system. After analyzing the subject area of inventory management and the methodology of dynamic inventory buffer management, a list of functional and non-functional software requirements was formed, and a data model was designed. The information obtained was used to compile a list of logical files and transactions specific to a particular requirement. From the resulting list of files and transactions, it is determined which elementary data, elementary records and links to files they consist of. The information obtained was used to estimate the size of the software at non-aligned functional points. To take into account the impact of non-functional requirements on the complexity of software development, the VAF alignment factor was calculated, for which it is necessary to give a qualitative assessment of the impact of system-wide requirements on the complexity of the software. The estimation of the complexity of the development was obtained using the COCOMO II methodology, namely, using seven multipliers of the complexity for the case of the initial assessment at the stage of approval of requirements. The calculations were obtained for teams with different professional level and equipment, in the conditions of a significant tightening of the development process, a high level of certainty of risks, without a rigid schedule of work. The cost of development was calculated for several common programming languages: J2EE, C#, C++.