High Fluidity Research Articles

Stability analysis of the false roof made of cemented tailings backfill in deep mine: A case study

The overall stability of cemented tailings backfill (CTB) false roof, as an important support structure in the quarry, is of great significance for realizing the safe recovery of the ore body. This paper aims at the practical problem of ore body mining under the condition of deep broken rock mass. By analyzing the typical process characteristics of underhand cut-and-fill mining method, the dangerous mechanical state of CTB false roof is determined, and the CTB false roof strength model based on the maximum tensile stress failure criterion and deep mining coefficient is established. Based on the measured load value of CTB false roof, the minimum required strength of CTB false roof is obtained. Through the performance tests of CTB under different proportioning schemes, the mechanical strength of CTB false roof (UTS：0.43MPa, UCS：6.22MPa) is designed，the proportioning parameters of CTB with "high strength, high fluidity, quick setting and low cost" are put forward. Finally, based on FLAC3D numerical simulation and field monitoring, the stability of CTB false roof with recommended ratio parameters is analyzed. The results show that the CTB false roof has not been violently displaced and destabilized in the process of service ore body mining, has good strength reserve, and is able to provide a safe workspace for mining, verifies the reliability and reasonableness of the CTB false roof proportioning parameter, and provides a new way for the study of false roof stability.

An improved prediction of high-performance concrete compressive strength using ensemble models and neural networks

Traditional methods for proportioning of high-performance concrete (HPC) have certain shortcomings, such as high costs, usage constraints, and nonlinear relationships. Implementing a strategy to optimize the mixtures of HPC can minimize design expenses, time spent, and material wastage in the construction sector. Due to HPC's exceptional qualities, such as high strength (HS), fluidity and resilience, it has been broadly used in construction projects. In this study, we employed Generalized Regression Neural Network (GRNN), Nonlinear AutoRegressive with exogenous inputs (NARX neural network), and Random Forest (RF) models to estimate the Compressive Strength (CS) of HPC in the first scenario. In contrast, the second scenario involved the development of an ensemble model using the Radial Basis Function Neural Network (RBFNN) to detect inferior performance of standalone model combinations. The output variable was the 28 Days CS in MPa, while the input variables included slump (S), water-binder ratio (W/B) %, water content (W) kg/m3, fine aggregate ratio (S/a) %, silica fume (SF)%, and superplasticizer (SP) kg/m3. An RF model was developed by using R Studio; GRNN and NARX-NN models were developed by using the MATLAB 2019a toolkit; and the pre- and post-processing of data was carried out by using E-Views 12.0. The results indicate that in the first scenario, the Combination M1 of the RF model outperformed other models, with greater prediction accuracy, yielding a PCC of 0.854 and MAPE of 4.349 during the calibration phase. In the second scenario, the ensemble of RF models surpassed all other models, achieving a PCC of 0.961 and MAPE of 0.952 during the calibration phase. Overall, the proposed models demonstrate significant value in predicting the CS of HPC.

Improved Friction Reduction and Wear Resistance of Steel Using a Subnanometer Nanowires-Poly-α-Olefin Gel Lubricant.

Lubricating oil is commonly utilized due to its excellent lubricating properties in mechanical motion systems. However, high fluidity in lubricating oil often leads to leakage during machine operation, causing mechanical components to fail. Herein, a gel lubricant of SNWs-PAO6 was devised by combining subnanometer nanowires (SNWs) with poly α-olefin 6 (PAO6) at room temperature, effectively confining PAO6 and preventing PAO6's creeping and leakage while enhancing its load-bearing capacity. SNWs-PAO6 outperforms PAO6 in reducing friction and wear for steel-on-steel interfaces. The friction coefficient is markedly diminished by 57.53%, from 0.223 to 0.095, while the wear rate is significantly curtailed by 84.98%. Furthermore, SNWs-PAO6 remains stable even after 180 000 cycles at 200 N and 25 Hz, withstanding high-speed centrifugation without releasing PAO6. It remained stable over 6 months of resting and can well withstand low temperatures. Surface analysis of the wear scar and the formed tribochemical film after friction has demonstrated that PW12O403- is more likely to adsorb onto the steel surface, forming a lubricating medium film through tribochemical reactions and thus reducing interfacial friction and wear. This method facilitates the development of domain-limited nanomaterials-based gels for mass production and their applications in engineering moving parts.

Bioactive Peptide Hydrogel Scaffold with High Fluidity, Thermosensitivity, and Neurotropism in 3D Spatial Structure for Promoted Repair of Spinal Cord Injury.

Spinal cord injury (SCI) has been considered a clinically challenging disease that is characterized by local disturbance of the microenvironment, which inhibits post-injury neural regeneration. The simulation of a microenvironment conducive to the regeneration of spinal cord is beneficial for SCI repair. In this study, bioactive composite hydrogels are developed that mimic the regenerative microenvironment of spinal cord for enhanced SCI repair. The fabricated composite hydrogels (CRP) based on chitosan (CS), RADA16 nanofibers, and nerve-promoted peptide (PPFLMLLKGSTR) exhibit excellent injectability, superior biodegradability and biocompatibility. In addition, the CRP hydrogels can formquickly (a few minutes) by mixing three components at human body temperature, showing high potential as a biomimetic matrix for in situ repair of SCI. The in vitro studies demonstrate that the CRP hydrogels can not only promote the proliferation and migration of bone marrow mesenchymal stem cells but also induce the proliferation and differentiation of neural stem cells (NSCs) into neurons. Meanwhile, the hydrogels reveal the efficiency of protecting neurons and promoting axonal growth. Furthermore, the in vivo tests prove that the CRP hydrogels can reduce post-SCI inflammatory responses, inhibit reactive astrocyte over-proliferation, and promote the migration, proliferation, and differentiation of endogenous NSCs, which agree well with the in vitro results. The pre-clinical test demonstrates that the CRP hydrogels restore the motor function in completely transected spinal cord rats, and the SCI repair mechanism may involve the activation of the PI3K/AKT/mTOR pathway. It is believed that the strategies shown in this work will be valuable for the design and synthesis of novel hydrogels for biomedical and tissue engineering applications.

Preparation of environmentally friendly hydrophobic paper by coating method

Abstract Non-Newtonian viscous fluids such as yogurt, honey, etc., due to their extremely high viscosity and complex fluidity, remain on food containers after use, where adhesion and staining occurs, which is a great inconvenience and causes a lot of wasted resources. Hydrophobic coatings can be an excellent candidate for eliminating liquid waste. Inexpensive wollastonite nanoparticles were used to build rough micro- and nano-structures, and chitosan was used to emulsify rice bran wax to prepare green and low surface energy emulsions. The above two were mechanically mixed to obtain the hydrophobic emulsion, and coated on the paper surface and heat-treated to prepare the hydrophobic paper. Contact angles up to 157.3°. The coating exhibits good self-cleaning properties for a wide range of non-Newtonian viscous food liquids and shows excellent resistance to repeated machine bending and multiple abrasion damages, while maintaining its hydrophobicity. After 40 cycles of friction, the contact angle is 148.1°, which is still close to 150° and has good hydrophobicity. In addition, the coating has great potential for application to the interior surfaces of various food packages to reduce or even eliminate liquid food residues.

Construction of multi-functional silicone rubber/reduced graphene oxide/multi-walled carbon nanotube composites with segregated structure by surfactant-free Pickering emulsion method

Polymer composites with segregated structure (PC–S) have the advantages of low filler usage and excellent functionality. Emulsion blending combined with direct molding technology is the main method for the preparation of PC-S. However, due to the high fluidity of low-viscosity silicone rubber (SR), PC-S cannot be prepared by this technique. In addition, surfactants affect the heat resistance of the final SR composites (SRC). In order to solve the above problems, in this study, a Pickering emulsification combined with pre-crosslinking technology for SR was successfully developed by using graphene oxides (GO)/multi-walled carbon nanotubes (MWCNTs) hybrid fillers (GM) as emulsifiers, and SR/reduced GO (RGO)/MWCNTs composites with segregated structure (SSGM) were prepared. When RGO content is 4.5 wt%, MWCNTs content is 3.2 wt%, SSGM shows the highest electrical conductivity of 12.5 S/m, the highest electromagnetic interference shielding efficiency (EMI SE) of 41.4 dB, and an excellent flame retardant performance. The whole preparation process avoids the use of organic solvents and surfactants, which reduces the production cost of SSGM and the environmental pollution, and provides a feasible preparation route for the industrialized production of SSGM.

In Situ Constructing Robust Interface by Deep Eutectic Polymeric Electrolyte Enables High Performance Lithium Metal Batteries with High-Loading Cathode.

The low Li+ transport and poor interface have consistently been two major impediments to practical applications of Polyacrylonitrile (PAN)-based composite solid-state electrolytes (PCPE). In this work, a polymerizable deep eutectic electrolyte is meticulously designed with high fluidity which consists of Poly (Ethylene Glycol) Diacrylate (PEGDA), Fluoroethylene Carbonate (FEC), Succinonitrile (SN) and dual salts (LiTFSI/LiDFOB) to promote Li+ transport and ameliorate the interface of PCPE. Inclusion of PEGDA monomers and FEC alters the crystallinity of SN, enhancing the wettability of thick electrode, and formation of polymeric 3D network from polymerization of PEGDA can anchor SN and suppress the side reactions between SN and lithium metal. Consequently, the modified PCPE exhibit an enhanced conductivity of 4.47×10-4Scm-1 with Li-ion transference number of 0.60, and show an excellent lithium stability. LiCoO2(LCO)/SP-PCPE/Li batteries with higher loading (3-4.4V, 6mgcm-2) can work for over 300 cycles at 0.5 C. Even with an ultra-high loading of 16mgcm-2, LCO/SP-PCPE/Li batteries achieve an excellent cycling performance. This work provides new insights into how to construct a robust interface for solid-state batteries with high-loading cathode.

Fluid Modernity and Virtual Communities: An Analysis of the Popularity of MBTI on Social Media

This paper, rooted in Zygmunt Baumans theory of modernity, examines the formation of virtual communities and the characteristics of liquid modernity as manifested in the widespread phenomenon of Myers-Briggs Type Indicator (MBTI) on social media. As a psychological assessment tool, MBTI has pervaded social media platforms, engendering virtual communities characterized by high fluidity and consumerist tendencies. Through participatory observation and online ethnography, this study delves into the MBTI virtual communities on the "Xiaohongshu" platform, exploring their consumerism-driven formation mechanisms and cultural attributes. In modern society, virtual communities exhibit dynamic stability and structural elasticity, with identity constantly being reshaped and redefined within these virtual spaces. The popularity of MBTI underscores the anxieties surrounding identity in contemporary society and reflects the liquid nature of modern identity formation. Under the influence of technology and consumerism, virtual communities have emerged as a significant social form in modern society.

Study on Bionic Design and Tissue Manipulation of Breast Interventional Robot.

Minimally invasive interventional surgery is commonly used for diagnosing and treating breast cancer, but the high fluidity and deformability of breast tissue reduce intervention accuracy. This study proposes a bionic breast interventional robot that mimics the scorpion's predation process, actively manipulating tissue deformation to control target displacement and enhance accuracy. The robot's structure is designed using a modular method, and its kinematics and workspace are analyzed and solved. To address the nonlinear breast tissue deformation problem, a hierarchical tissue method is proposed to simplify the three-dimensional problem into a two-dimensional one. A two-dimensional tissue deformation solver is established based on the minimum energy method for quick resolution. The problem is treated as quasi-static, deriving the displacement relationship between external manipulation points and internal tissue targets. The method of active manipulation of tissue deformation is simulated using MATLAB (2019-b) software to verify the feasibility of the method. Results show maximum errors of 1.7 mm for prostheses and 2.5 mm for in vitro tissues in the X and Y directions. This method improves intervention accuracy in breast surgery and offers a new solution for breast cancer diagnosis and treatment.

Interface-Interactive Nanoarchitectonics: Solid and/or Liquid.

The methodology of nanoarchitectonics is to construct functional materials using nanounits such as atoms, molecules, and nanoobjects, just like architecting buildings. Nanoarchitectonics pursues the ultimate concept of materials science through the integration of related fields. In this review paper, under the title of interface-interactive nanoarchitectonics, several examples of structure fabrication and function development at interfaces will be discussed, highlighting the importance of architecting materials with nanoscale considerations. Two sections provide some examples at the solid and liquid surfaces. In solid interfacial environments, molecular structures can be precisely observed and analyzed with theoretical calculations. Solid surfaces are a prime site for nanoarchitectonics at the molecular level. Nanoarchitectonics of solid surfaces has the potential to pave the way for cutting-edge functionality and science based on advanced observation and analysis. Liquid surfaces are more kinetic and dynamic than solid interfaces, and their high fluidity offers many possibilities for structure fabrications by nanoarchitectonics. The latter feature has advantages in terms of freedom of interaction and diversity of components, therefore, liquid surfaces may be more suitable environments for the development of functionalities. The final section then discusses what is needed for the future of material creation in nanoarchitectonics.

Microstructural constituents in compositionally graded NiCrFeSiBC hardfacing alloy/316L SS additive manufactured deposits

Ni-Cr-Fe-Si-B-C hardfacing alloys (D50) provide excellent resistance to abrasive and adhesive wear, high temperature oxidation and corrosion. These alloys are candidate materials for hardface coatings on in-reactor components of fast breeder reactors. Conventionally these deposits are made on steels through the welding route. Due to high fluidity of the molten alloy, generation of residual stress and significant dilution of the deposit, achieving crack free deposits is often a very difficult and time consuming task. To address such issues arising out of conventional fabrication routes, compositionally graded coatings have been tried through laser additive manufacturing. A 3 layered compositionally graded deposit (D50/50D50-50SS/SS) was made on 316 L SS build plate and the phase constituents and possible correlation with micro hardness was analyzed. Uppermost D50 layer consisted of γ-Ni, γ-Ni + Ni3B and γ-Ni + Cr5B3 eutectics, CrB, Cr7C3, Cr23C6, Cr3C2 and Ni3Si precipitates. The middle layer consisted of γ-(Ni,Fe), γ-(Ni,Fe)+Cr5B3, Cr5B3, Cr3C2, Cr7C3,Cr23C6 and Ni3Si. The SS layer closest to the build plate had γ-Fe, Cr3C2 and Cr7C3 precipitates. Corresponding to the variation in microstructure a gradual change in hardness also can be seen starting from the top layer to SS build plate: 580 ± 35 HV0.1, 532 ± 17 HV0.1, 348 ± 21 HV0.1 and 230 ± 10 HV0.1, which is promising.

Spatiotemporal formation of a single liquid-like condensate and amyloid fibrils of α-synuclein by optical trapping at solution surface

Liquid-like protein condensates have recently attracted much attention due to their critical roles in biological phenomena. They typically show high fluidity and reversibility for exhibiting biological functions, while occasionally serving as sites for the formation of amyloid fibrils. To comprehend the properties of protein condensates that underlie biological function and pathogenesis, it is crucial to study them at the single-condensate level; however, this is currently challenging due to a lack of applicable methods. Here, we demonstrate that optical trapping is capable of inducing the formation of a single liquid-like condensate of α-synuclein in a spatiotemporally controlled manner. The irradiation of tightly focused near-infrared laser at an air/solution interface formed a condensate under conditions coexisting with polyethylene glycol. The fluorescent dye-labeled imaging showed that the optically induced condensate has a gradient of protein concentration from the center to the edge, suggesting that it is fabricated through optical pumping-up of the α-synuclein clusters and the expansion along the interface. Furthermore, Raman spectroscopy and thioflavin T fluorescence analysis revealed that continuous laser irradiation induces structural transition of protein molecules inside the condensate to β-sheet rich structure, ultimately leading to the condensate deformation and furthermore, the formation of amyloid fibrils. These observations indicate that optical trapping is a powerful technique for examining the microscopic mechanisms of condensate appearance and growth, and furthermore, subsequent aging leading to amyloid fibril formation.

About the structure of water

It is shown that during 10–10–10–11s, only clusters consisting of 4 or 3 water molecules can statistically form in water. It is shown that Brownian motion in water occurs as a result of collision of ice nanocrystals with Brownian particles. Brownian motion is an experimental confirmation of the nanocrystalline structure of water. It is shown that water consists of 13 % molecules and 87 % ice nanocrystals. Such a two‑phase structure provides water with structural properties, high fluidity and elasticity of steam.

Impact of Mg on the Feeding Ability of Cast Al–Si7–Mg(0_0.2_0.4_0.6) Alloys

The demand for high-performance Al–Si casting alloys is driven by their mechanical properties, making them popular in automotive, aerospace, and engineering industries. These alloys, especially hypoeutectic Al–Si–Mg, offer benefits like high fluidity, low thermal expansion, and good corrosion resistance. Silicon and magnesium primarily define their microstructure and mechanical properties. Silicon enhances fluidity, while magnesium improves strength and fatigue resistance. However, challenges like shrinkage porosity persist during solidification. Understanding solidification feeding regions is crucial, influenced by factors such as chemical composition, solidification characteristics, and casting design. This study investigates magnesium’s influence on feeding ability in hypoeutectic Al–Si7–Mg alloys through experimental tests. Increasing magnesium content from 0% to 0.6% affects the interdendritic and burst feeding regions. This could impact shrinkage porosity formation. The “Sand Hourglass” test results indicate a rise in porosity levels with higher magnesium content, which is linked to the narrowing of interdendritic channels and the formation of magnesium-rich intermetallic compounds. These changes hinder the liquid metal flow, worsening shrinkage porosity. Therefore, magnesium’s role in expanding the interdendritic region is a key factor in developing porosity in cast hypoeutectic Al–Si7–Mg alloys. This study highlights that porosity levels increase from 0% in magnesium-free Al–Si7 to 0.84% in Al–Si7–Mg0.6, underscoring magnesium’s significant impact on the occurrence of porosity in these alloys.

Preparation and flame retardant properties of new mining fireproof gel

Coal spontaneous combustion (CSC) brings great danger to mine safety. Although traditional colloidal fire-fighting materials can reside at high fire source points, their permeability and fluidity are poor, and such materials focus on their water absorption, but pay less attention to water retention and resistance, which makes their fire-fighting effect not good. This paper proposed a new type of mining fire prevention colloid material (CPS-α), which had good solid water gel formation, viscosity, fluidity, and blocking properties to compensate for traditional colloids' shortcomings. According to the single-factor experiment, polymeric polyacrylamide (PAM) as the base material, sodium carboxymethyl cellulose (CMC) as the coagulant, modified starch (SS) as the flame retardant and reduced ascorbic acid were determined. After gel treatment, compared with raw coal, the critical temperature point of spontaneous combustion of coal was increased by about 28 °C, the time to reach the critical temperature point was delayed by 190s, and the characteristic temperature points were significantly increased; the overlap area of coal and water increases by about 20 % after adding gel, and the change slope of the diffusion coefficient of water decreases, which indicated that CPS-α had good flame retardant effect.

Mao-based solid-like slippery composite coating with superior corrosion resistance and robust machinery performance upon magnesium-lithium alloy LA81

Slippery liquid-infused porous surface exhibits a great potential for corrosion management with super repulsive water properties, whilst their poor adhesion to underlying materials and durability of lubricants remains a challenge. In this work, a micro-arc oxidation (MAO)-based solid-like slippery composite coating (SSC) is developed upon Mg-Li alloy LA81 by combining mechanical pinning effects of MAO and super repulsive water performance of SSC, which maximizes adhesion strength, water repulsion and sustainable corrosion protection. The SSC coatings exhibit liquid-to-solid transition under the curing effect of epoxy resin. Efficient sealing of the MAO layer is yielded through high fluidity of the liquid phase of SSC. Cured SSC can further strengthen the interface bonding with respect to underlying MAO layer, and significantly alleviate lubricant loss.

Effect of Activated Siliceous Wastes Incorporated as Mineral Admixtures on the Rheological Properties of Cement Paste: Insights into Their Physicochemical Interactions in Suspension.

Mechanical grinding is a common method used to enhance the pozzolanic activity of tailings, and these activated tailings can be used as supplementary cementitious materials in cement production. However, the addition of activated tailings usually reduces the workability of cement paste, and the mechanism of influence of different minerals in tailings on workability varies. In this study, three kinds of principal silicate minerals in tailings-quartz, feldspar, and mica-were mechanically activated. The influence of these activated minerals on the rheological properties of cement paste were studied in the absence or presence of PCE (polycarboxylate ether) superplasticizers, and the influence mechanism was investigated using rheology, TOC, contact angles, zeta potential, XPS, ICP-OES, and XRD. The results showed that quartz has the highest fluidity, and mica has the lowest. An increase in hydrophilicity decreased the flowability of the blended cement paste. The increase in the metal cation dissolution rate was the main reason for the decrease in the fluidity of PCE-blended cement pastes. The knowledge gained provides a valuable reference for the utilization of activated tailings in cement production.

Body movement and emotion: Investigating the impact of audiovisual tempo manipulations on emotional arousal and valence

The perception of emotions in humans moving can be influenced by several movement features such as fluidity, complexity, and tempo. Manipulations of movement tempo by acceleration or deceleration are widely employed in media, yet there has been limited research on how these affect perceived emotions. The current study examined how tempo-manipulated point-light displays (PLDs) of human dance-like movements, compared to their tempo-original counterparts, influence the perceived emotional arousal and valence by altering the tempo and hence the underlying movement characteristics. In an online perceptual experiment, we presented tempo-original and tempo-manipulated PLDs at three tempi, with and without synchronized drumbeats. Participants were asked to judge the PLDs based on their emotional arousal, valence, and naturalness. Results suggest that movements with higher fluidity were perceived as lower in arousal than those with low fluidity. Stimuli higher in naturalness were perceived to be more positive in valence than those low in naturalness. Audiovisual stimuli, including the drumbeats, received higher arousal but lower valence ratings than visual-only stimuli. Furthermore, decelerated movements were associated with increased fluidity compared to accelerated or tempo-original ones. Tempo deceleration was associated with lower naturalness compared to tempo-original movements. These findings indicate that tempo manipulation can be identified via kinematic feature changes, consequently altering emotional attributes perceived in the movements.

Experimental analyses of CO2 sequestration potential in mineralized fly ash and its efficacy in mitigating coal spontaneous ignition risks in underground mine goafs

To effectively utilize fly ash solid waste and realize fly ash resource utilization, carbon sequestration and emission reduction, as well as mine fire prevention and suppression, this paper analyses the components of fly ash by X-ray fluorescence spectrometer (XRF), rheological experiments, the CO2 sequestration experiments by the mineralization of fly ash, thermogravimetric analysis experiments, and flame-retardant property experiments. Additionally, the changes in the physical structure and morphology of fly ash before and after mineralization were analyzed by X-ray diffraction (XRD) and scanning electron microscope (SEM). The carbon sequestration capacity and fluidity of fly ash slurry, as well as the ability of mineralized fly ash slurry to inhibit spontaneous coal combustion are comprehensively investigated. The research results indicate that CO2 is sequestered as calcite on the fly ash surface after mineralization. The optimal CO2 sequestration capacity of fly ash is 65.12 kg/t when 0.5 mol/L NaHCO3 is used as an additive. The fluidity of mineralized fly ash slurry is greater than that of fly ash slurry, and the lower the water-cement ratio is, the worse the fluidity. Mineralized fly ash slurry with a water-cement ratio of 3:1 has a strong carbon sequestration capacity and high fluidity, making it suitable for preventing coal spontaneous ignition in mine goafs. Mineralized fly ash slurry exhibits a regular trend where the better the mineralization effect, the lower the CO release during the low-temperature oxidation stage of coal, and the higher the cross-point temperature. Mineralized fly ash slurry has a stronger ability to inhibit spontaneous coal combustion than does ordinary fly ash slurry.

Multifactor Analyses of Frontal Cortex Lipids in the APP/PS1 Model of Familial Alzheimer's Disease Reveal Anomalies in Responses to Dietary n-3 PUFA and Estrogenic Treatments.

Brain lipid homeostasis is an absolute requirement for proper functionality of nerve cells and neurological performance. Current evidence demonstrates that lipid alterations are linked to neurodegenerative diseases, especially Alzheimer's disease (AD). The complexity of the brain lipidome and its metabolic regulation has hampered the identification of critical processes associated with the onset and progression of AD. While most experimental studies have focused on the effects of known factors on the development of pathological hallmarks in AD, e.g., amyloid deposition, tau protein and neurofibrillary tangles, neuroinflammation, etc., studies addressing the causative effects of lipid alterations remain largely unexplored. In the present study, we have used a multifactor approach combining diets containing different amounts of polyunsaturated fatty acids (PUFAs), estrogen availabilities, and genetic backgrounds, i.e., wild type (WT) and APP/PS1 (FAD), to analyze the lipid phenotype of the frontal cortex in middle-aged female mice. First, we observed that severe n-3 PUFA deficiency impacts the brain n-3 long-chain PUFA (LCPUFA) composition, yet it was notably mitigated by hepatic de novo synthesis. n-6 LCPUFAs, ether-linked fatty acids, and saturates were also changed by the dietary condition, but the extent of changes was dependent on the genetic background and hormonal condition. Likewise, brain cortex phospholipids were mostly modified by the genotype (FAD>WT) with nuanced effects from dietary treatment. Cholesterol (but not sterol esters) was modified by the genotype (WT>FAD) and dietary condition (higher in DHA-free conditions, especially in WT mice). However, the effects of estrogen treatment were mostly observed in relation to phospholipid remodeling in a genotype-dependent manner. Analyses of lipid-derived variables indicate that nerve cell membrane biophysics were significantly affected by the three factors, with lower membrane microviscosity (higher fluidity) values obtained for FAD animals. In conclusion, our multifactor analyses revealed that the genotype, diet, and estrogen status modulate the lipid phenotype of the frontal cortex, both as independent factors and through their interactions. Altogether, the outcomes point to potential strategies based on dietary and hormonal interventions aimed at stabilizing the brain cortex lipid composition in Alzheimer's disease neuropathology.