High Fiber Intake Research Articles

Dietary intakes of women with Type 1 diabetes before and during pregnancy: a pre-specified secondary subgroup analysis among CONCEPTT participants.

AimTo describe the dietary intakes of women with Type 1 diabetes before and during pregnancy.MethodsThis was a pre‐specified subgroup analysis of CONCEPTT involving 63 women planning pregnancy and 93 pregnant women from 14 sites in England, Scotland and Ireland. Two hundred and forty‐six 3‐day food diaries (104 planning pregnancy, 142 pregnant) were matched to data source and food reference codes, and analysed using dietary software. Participants were informed that food diaries would be de‐identified and used only for research purposes.ResultsMean (sd) daily energy intake was 1588 (346) kcal and 1673 (384) kcal in women planning pregnancy and pregnant women respectively. Total carbohydrate intake was consistent with dietary guideline recommendations [180 (52) g planning pregnancy, 198 (54) g pregnant], but non‐recommended sources (e.g. sugars, preserves, confectionery, biscuits, cakes) contributed to 46% of total daily carbohydrate intake. Fat consumption exceeded guideline recommendations [70 (21) g planning pregnancy, 72 (21) g pregnant]. Fibre [15.5 (5.3) g planning pregnancy, 15.4 (5.1) g pregnant], fruit and vegetable intakes [3.5 (2.2) and 3.1 (1.8) serves/day] were inadequate. Twelve women planning pregnancy (19%) and 24 pregnant women (26%) did not meet micronutrient requirements.ConclusionsThe diets of pregnant women from England, Scotland and Ireland are characterized by high fat, low fibre and poor‐quality carbohydrate intakes. Fruit and vegetable consumption is inadequate, with one in four women at risk of micronutrient deficiencies. Further research is needed to optimize maternal nutrition for glycaemic control and for maternal and offspring health.

Early educators' practices and opinions in relation to pre-schoolers' dietary intake at pre-school: case Finland.

We aimed to examine associations between early educators' feeding practices and opinions and children's dietary intake at pre-school, in a context where uniform meals are served and pre-schools are highly regulated. Cross-sectional study. Food consumption data of the children consisted of two-day food records from pre-school kept by early educators. Early educators also reported their feeding practices and opinions on pre-school food. Serving style was observed. Municipal pre-schools in Southern and Western Finland.ParticipantsPre-schoolers (n 586) aged 3-6 years and early educators (n 378). Early educators' positive opinion of the food served at pre-school and the opinion that sufficient vegetables were available for the children were positively associated with children's vegetable consumption. Early educators' role modelling and a positive opinion of the food were negatively associated with children's energy intake. Encouragement to eat fruit and vegetables was associated with higher fibre intake. Intake of added sugar was low (4·4 % of energy). Some of the feeding practices and opinions of early educators were related to healthier dietary intake (higher vegetable consumption and fibre intake) among the children. However, in some respects, the results contradicted previous findings. Overall, early educators' feeding practices and opinions contribute to children's dietary intake and should be taken into account when promoting healthy food intake among pre-school children.

Mevalonate signaling, COPD and cancer: the statins and beyond

Evidence suggests that smoking confers a persistent and/or exaggerated inflammatory response in the lungs that, with underlying genetic susceptibility, may result in lung remodeling and impaired repair. The innate immune...

The validity and reliability of the Dietary Index for a Child's Eating in 2-8-year old children living in New Zealand.

This study aimed to examine the validity and reliability of the Dietary Index for a Child's Eating (DICE) in children living in New Zealand (NZ). Caregivers of healthy children aged 2-8years completed a 4-day estimated food record (4DFR) for their child and completed the DICE online on two separate occasions, 8weeks apart. Relative validity was assessed by comparing the DICE and 4DFR total score and component subscores using the Wilcoxon test, Spearman rank correlation coefficients, cross-classification, and weighted kappa (ĸ) statistic. For evaluating construct validity, the DICE total score was compared with energy and nutrient intake from the 4DFR using linear contrast analysis. Intraclass correlation coefficients (Cronbach's α) and Bland-Altman plots were used to assess the reliability of DICE. From a possible score of 100, the mean±standard deviation of DICE was 78.2±11.5 and from the 4DFR, was 73.8±10.8, with a positive correlation (r=0.72; p<0.001) and moderate agreement (ĸ=0.49). Cross-classification showed 61.9% were correctly categorised into the same tertile group from DICE and the 4DFR. Participants in the highest tertile of DICE had higher intakes of fibre, vitamin C, vitamin A, vitamin D, folate, and calcium. Good agreement (α=0.87) was found for reliability. DICE is a valid and reliable tool for the assessment of children's adherence to a healthy diet, as recommended by the NZ Ministry of Health Food and Nutrition guidelines.

Increased fiber intake predicts the decrease in 2nd phase glucose-induced hyperinsulinemia following a hypocaloric diet in obese subjects

Background and aimsHigher fiber intake is associated with increased insulin sensitivity (IS) and reduced glucose-induced insulin secretion (GIIS) during isocaloric-diets; however, its role in hypocaloric-diets is unclear. We examined whether increased fiber intake predicts the amelioration in IS and GIIS following a hypocaloric-diet. Methods and resultsThis is a post-hoc analysis of 55 adult subjects (BMI > 27 kg/m2) who completed a 6-month hypocaloric-diet (−500 kcal/day). Dietary intake was assessed using 3-day food records at baseline and post-intervention. We evaluated glucose-induced insulin and C-peptide secretions as AUC of plasma insulin and C-peptide during intravenous-glucose-tolerance tests (IVGTT) and IS via hyperinsulinemic-euglycemic clamps. Data analysis employed regression models and 2-way RM ANOVAs. Post-intervention % change in fiber intake was associated positively with ISclamp (r = 0.30) and negatively with % change in total (r = −0.37) and 2nd phase GIISIVGTT (r = −0.44) but not C-peptide secretion. It remained associated with lower 2nd phase GIISIVGTT after adjustment for sex and % changes in BMI and energy-intake, independently of other macronutrients. Subjects who increased fiber intake (to 28.7 ± 9.0 g/day) had a greater decrease in 2nd phase GIISIVGTT, not C-peptide secretion, independently of sex or changes in adiposity or energy-intake compared to subjects who decreased intake (to 20.0 ± 6.8 g/day). ConclusionHigher fiber intake is an independent predictor of reduced 2nd phase glucose-induced hyperinsulinemia after a hypocaloric-diet. It was not associated with plasma C-peptide, suggesting a role in faster insulin clearance rather reduced insulin secretion. Promoting high-fiber intake may increase the effectiveness of hypocaloric-diets in preventing type 2 diabetes. RegistrationISRCTN14476404, BioMedCentral.com. Clinical trial registrationThis trial was registered at BioMed Central as ISRCTN14476404, on July 28th, 2017.

Diet quality on days without breakfast or lunch – Identifying targets to improve adolescents’ diet

Dietary intake in adolescents does often not align with the recommended dietary guidelines. Excess intakes of added sugar and saturated fat, and insufficient vegetable intake are among the identified challenges, which can affect future health negatively. Identifying targets to improve dietary practices is therefore essential. The current study aimed to examine the prevalence of meal skipping and if meal skipping days had a different diet quality than other days, using data from a recent Norwegian dietary survey in adolescents (n = 689, age 12–14 years). Their dietary intake was recorded for four days, using a web-based record system. Differences between days with, and without, breakfast or lunch were explored using mixed effect models, adjusting for correlated data and covariates, including weekday-weekend effect. In total, 8% and 11% were days without breakfast and lunch, respectively. Days with breakfast or lunch were associated with higher intake of fibre, and higher odds of consuming fruits and berries, juice and smoothie, than days without breakfast or lunch. Weekdays with lunch were also associated with lower intakes of added sugar and total fat (in % of energy), and discretionary foods, compared to weekdays without lunch. Skipping breakfast and lunch was associated with reduced diet quality in adolescents. Targeting these meals, and in particular school lunch, is a potential way forward to improve adolescents’ dietary intake.

High fiber and high carbohydrate intake and its association with the metabolic disease using the data of KNHANES 2013 ~ 2017

본 연구는 2013 ~ 2017년 국민건강영양조사의 검진조사에 참여한 만 20세 이상 성인을 대상으로 고식이섬유 섭취 및 고탄수화물 섭취와 대사질환 간의 연관성을 확인하였다. 한국 성인의 평균 식이섬유 섭취량은 24.1 g/일이었으며, 탄수화물 섭취 수준이 증가할수록 식이섬유 섭취량도 증가하는 경향을 보였다. 고식이섬유 섭취와 대사증후군과의 연관성을 확인하기 위해 식이섬유 섭취량을 5분위수로 분류하였을 때, 충분섭취량 이상의 고식이섬유 섭취는 대사증후군 위험 감소와 연관이 있었다. 또한, 식이섬유 섭취가 탄수화물 섭취와 밀접한 관련이 있다는 점을 반영하여 고탄수화물 섭취와 대사질환과의 연관성을 식이섬유 섭취수준에 따라 확인하고자 하였다. 이에 식이섬유 충분섭취량을 기준으로 하여 성별로 저식이섬유 섭취 그룹과 고식이섬유 섭취 그룹으로 분류한 후, 탄수화물 에너지섭취비율과 대사질환과의 연관성을 분석한 결과 식이섬유 섭취수준에 따라 고탄수화물 섭취와 대사질환과의 연관성이 다름을 확인하였다. 저식이섬유 섭취 그룹에서는 남자의 경우 탄수화물 섭취가 삼분위군 일 때 일분위군에 비해 대사증후군과 죽상경화성 이상지질혈증의 교차비가 유의적으로 증가하고, 여자의 경우 탄수화물 섭취가 이분위군일 때 일분위군에 비해 고콜레스테롤혈증의 교차비가 유의적으로 증가하였다. 그리고 고식이섬유 섭취 그룹에서는 남자의 경우 탄수화물 섭취비율이 증가할수록 고중성지방혈증의 위험도가 증가하는 경향을 보였다. 본 연구의 결과는 한국 성인의 고식이섬유 섭취가 대사증후군의 낮은 위험도와 관련이 있다는 근거를 제시하였으며, 특히 남자의 경우 고탄수화물 섭취와 대사지표와의 연관성을 살펴볼 때 식이섬유 섭취 수준을 살펴보는 것이 필요함을 제시했다는데 의의가 있다. 따라서, 향후 우리나라 사람들을 대상으로 전향적인 연구를 실시하여 식이섬유, 탄수화물 섭취와 대사질환과의 인과관계를 검증할 필요가 있으며, 이를 통해 탄수화물의 질적 섭취에 대한 실질적인 섭취 지침을 마련할 필요가 있다.

A review on dietary fiber in cereals and its characterization

The consequence of food fiber has led to the expansion of a potential market for fiber-rich products and ingredients. Now days, research is being carried on novel resources of dietary fiber (DF), such as agronomic by-products which have traditionally been undervalued. The dietary fibers have its vital role in many physiological processes as well as in the avoidance of many ailments. However, dietary fibers have a number of scientific properties that can be applied in the formulation of foods resulting in surface modification and augmentation of the stability of the foods during their manufacturing and storage. There is a limited study on the effects of dietary fiber on vitamins. This signifies that less-fiber diets can increase the risk of ailment like colon cancer. The usage of fibers from new origins that are currently not fully exploited such as from bacteria, mosses, seaweeds, fruits and vegetables and the prospect of modifying the fibers joining them with other constituents and enhancing their nutritional and sensory attributes, would possibly broaden the field of application for dietary fibers. The present review assesses the classification, nutritional properties, physico-chemical properties and therapeutic functions of dietary fiber. The diets with the high intake of fiber are known to have positive effects on the health.

Body Mass Index Mediates the Association between Dietary Fiber and Symptomatic Knee Osteoarthritis in the Osteoarthritis Initiative and the Framingham Osteoarthritis Study

Dietary fiber reduces body weight and inflammation in clinical trials. It is unclear whether body mass index (BMI) and inflammation might explain the observed association between higher fiber intake and the lower risk of symptomatic knee osteoarthritis (SXKOA). We quantified the extent to which BMI and inflammation influenced the relation between dietary fiber and SXKOA. We used longitudinal data from the Osteoarthritis Initiative (OAI) and the Framingham Offspring Osteoarthritis Study. At baseline of each study, men and women (mean age: 61 y) with or at risk of knee osteoarthritis were followed for 48 mo in the OAI. Adults (mean age: 53 y) were followed for 9.5 y in the Framingham study. Dietary fiber intake was estimated using a validated food-frequency questionnaire. Measured weight and height were used to calculate BMI. Serum high-sensitivity C-reactive protein (CRP) was measured in the Framingham study only. Incident SXKOA was defined as new onset of a combination of knee pain and radiographic osteoarthritis. We applied marginal structural models to quantify the mediation through BMI in the OAI and the sequential mediation through BMI and CRP in the Framingham study. Incident SXKOA occurred in 861 knees among 2876 persons in the OAI and in 143 knees among 971 persons in the Framingham study. In persons whose fiber intake was ≥21 g/d compared with those with intakes <21 g/d, the OR (95% CI) was 0.70 (0.53, 0.91) for the overall association with SXKOA and was 0.93 (0.92, 0.95) for the mediation via BMI (per kg/m2) in the OAI. In the Framingham study, the overall association was 0.57 (0.30, 1.09), the mediation through BMI (via BMI and the influence of BMI on CRP) was 0.94 (0.85, 1.02), and the mediation through CRP (per milligram per liter) was 0.99 (0.84, 1.19). Our findings suggest that the inverse association of fiber intake and the risk of incident symptomatic knee osteoarthritis is partially mediated by BMI.

Diet, physical activity and screen time but not body mass index are associated with the gut microbiome of a diverse cohort of college students living in university housing: a cross-sectional study

BackgroundModifiable lifestyle factors (e.g. dietary intake and physical activity) are important contributors to weight gain during college. The purpose of this study was to evaluate whether associations exist between body mass index, physical activity, screen time, dietary consumption (fat, protein, carbohydrates, and fiber), and gut microbial diversity during the first year of college. Racially/ethnically diverse college students (n = 82; 61.0% non-white) at a large Southwestern university completed self-reported physical activity and 24-h recall dietary assessments, height and weight measurements, and provided one fecal sample for gut microbiome analysis. Fecal microbial community composition was assessed with Illumina MiSeq next-generation sequencing of PCR amplified 16S rRNA genes. Post-hoc analyses compared microbial diversity by groups of high and low physical activity and fiber intake using QIIME and LEfSe bioinformatics software.ResultsNo statistically significant differences were observed between body mass index and gut microbiome abundance and diversity. Median daily consumption of dietary fiber was 11.2 (7.6, 14.9) g/d, while the median self-reported moderate-to-vigorous physical activity (MVPA) was 55.7 (27.9, 79.3) min/d and screen time 195.0 (195.0, 315.0) min/d. Microbial analysis by LEfSe identified Paraprevotellaceae, Lachnospiraceae, and Lachnospira as important phylotypes in college students reporting greater MVPA, while Enterobacteriaceae and Enterobacteriales were more enriched among students reporting less MVPA (p < 0.05). Barnesiellaceae, Alphaproteobacteria, and Ruminococcus were more abundant taxa among those consuming less than the median fiber intake (p < 0.05). Post-hoc analyses comparing weighted UniFrac distance metrics based on combined categories of high and low MVPA and fiber revealed that clustering distances between members of the high MVPA-low fiber group were significantly smaller when compared to distances between members of all other MVPA-fiber groups (p < 0.0001).ConclusionsHabitual fiber consumption and MVPA behaviors help explain the differential abundance of specific microbial taxa and overall gut microbial diversity differences in first-year college students.

Egg Intake Has No Adverse Association With Blood Lipids Or Glucose In Adolescent Girls

Objective: Longitudinal data on cardiometabolic effects of egg intake during adolescence are lacking. The current analyses aim to evaluate the impact of usual adolescent egg consumption on lipid levels, fasting glucose, and insulin resistance during late adolescence (age 17–20 years).Methods: Data from 1392 girls, aged 9 to 10 at baseline and followed for 10 years, in the National Heart, Lung, and Blood Institute’s National Growth and Health Study were used to examine the association between usual egg intake alone and in combination with other healthy lifestyle factors and late adolescent lipid levels, fasting glucose, and insulin resistance, measured as homeostasis model assessment of insulin resistance (HOMA-IR). Diet was assessed using 3-day food records during eight examination cycles. Girls were classified according to usual weekly egg intake, ages 9–17 years: <1 egg/wk (n = 361), 1 to <3 eggs/wk (n = 703), and ≥3 eggs/wk (n = 328). Analysis of covariance modeling was used to control for confounding by other behavioral and biological risk factors.Results: Girls with low, moderate, and high egg intakes had adjusted low-density lipoprotein cholesterol levels of 99.7, 98.8, and 95.5 mg/dL, respectively (p = 0.0778). In combination with higher intakes of fiber, dairy, or fruits and vegetables, these beneficial effects were stronger and statistically significant. There was no evidence that ≥3 eggs/wk had an adverse effect on lipids, glucose, or HOMA-IR. More active girls who consumed ≥3 eggs/wk had the lowest levels of insulin resistance.Conclusion: These results suggest that eggs may be included as part of a healthy adolescent diet without adverse effects on glucose, lipid levels, or insulin resistance.

Dietary Pattern in Relation With CRC Risk Among Moroccan Population; A Multicenter Case-Control Study

Background: Colorectal cancer (CRC) is a global public health problem, an estimated of 1.4 million cases were diagnosed worldwide in 2012. Studies in health and nutrition confirmed that dietary factors were strongly associated with CRC risk. Aim: The objective of this empirically study was to reveal unobserved dietary profiles that were associated favorably or unfavorably with CRC risk in Moroccan study population. Methods: This case-control study included a total of 2906 participants in five centers, 1453 cases and 1453 controls, and was gender, age and center matched. Statistical exploratory data reduction methods were performed in this study population based on a specific scientific hypothesis linking dietary behavior and colorectal cancer risk. Principal component analysis (PCA) was applied separately in cases and in controls as individuals and with FFQ nutritional group's heads items as variables. The correlation matrix of food variables was examined to explain most of the variation in the data, reducing a large number of food variables to a smaller set that captures the major dietary factors differences in Moroccan population. Results: Three alimentary profiles were identified for controls based on three principal component analysis, which the first one was highly positive with high cereals, fruits and nuts, legumes, fish, olive oil, dairy products and legumes consumption, and was highly negative with an increasing consumption of poultry and red meat. This component explained 26.5% of the variance in initial data and described a healthy pattern characterized with high fiber intake. In opposite, five principal components were identified for cases that indicated five nutritional profiles with a predominance of dairy products, nuts, fish consumption and low legumes, olive oil and fruits intake: its explained 15.37% of total variance. Conclusion: PCA analysis is a multidimensional factor analysis method that was used in this epidemiologic study to describe the variance in our big database in relation with CRC risk among Moroccan people. This method needs a supervised analysis such as linear discriminant analysis (LDA) to give interpretation and prediction models of CRC risk related to nutritional behavior among this study population.

Association of dietary fiber intake with general and abdominal obesity in children and adolescents: The Weight disorder survey of the CASPIAN-IV Study

BACKGROUND: Dietary fiber intake might have a protective role against obesity. The aim of this study is to explore the association of dietary fiber intake with general and abdominal obesity in Iranian children and adolescents. MATERIAL AND METHODS: This cross-sectional nationwide study was conducted on 5187 students aged 6–18 years, living in 30 provinces of Iran. They were selected randomly through cluster sampling method. Data on demographic and anthropometric indices including weight, height and waist circumference (WC) were collected by trained interviewers. A valid and reliable 168-item semi-quantitative food frequency questionnaire (FFQ) was used to assess student’s usual dietary intake including total dietary fiber. All dietary reports were converted to daily consumption (g/day) using household measures for different portion sizes. Food items were then converted to their nutrient content. Energy-adjusted dietary fiber intake (g/1000 kcal/day) was also calculated using the energy density method. Multivariate regression models were applied to explore the association between dietary fiber intake and anthropometric indices. RESULTS: The mean and standard deviation (SD) for age of participants were 11.40 (3.20) years. Of 5187 students, 52.6% were boys and 72.5% were from urban areas (participation rate: 79.7%). White bread (32.5%), white rice (17.1%) and potato (11.7%) were the most common sources of dietary fiber intake. Each 1 g/1000 Kcal increase in dietary fiber intake was significantly associated with lower weight and waist circumference (P = 0.006 and P = 0.008, respectively). CONCLUSION: Higher fiber intake was associated with lower anthropometric indices including weight and WC. Increased fiber intake should be encouraged for children and adolescents.

Association between dietary fiber intake and risk of ovarian cancer: a meta-analysis of observational studies.

ObjectiveTo evaluate the associations between dietary fiber intake and ovarian cancer risk.MethodsA literature survey was conducted by searching the PubMed, Web of Science, and Wanfang Med Online databases up to March 1st, 2018. The effect of dietary fiber intake on ovarian cancer risk was evaluated by calculating relative risks with 95% confidence intervals (95%CI) using Stata 12.0 software.ResultsA total of 17 articles with 149,177 participants including 7609 ovarian cancer patients were included in this analysis. The summarized relative risk for ovarian cancer in participants with the highest compared with the lowest fiber intake was 0.760 (95%CI=0.702–0.823), with no significant between-study heterogeneity (I2=12.4%). Subgroup analysis according to study design demonstrated positive associations in both cohort studies and case-control studies. Moreover, the results were consistent among populations from America, Europe, and Asia. No publication bias was found by Egger’s test or funnel plots.ConclusionThis meta-analysis concluded that a high intake of dietary fiber could significantly reduce the risk of ovarian cancer compared with a low fiber intake.

Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C-reactive protein levels in multi-ethnic Malaysian adults.

Individual variations of obesity-related traits can be a consequence of dietary influence on gene variants. This cross-sectional study aimed to evaluate (i) the effect of FTO rs9930506 on obesity and related parameters and (ii) the influence of diet on the above association in Malaysian adults. In total, 79 obese and 99 nonobese Malaysian adults were recruited. In comparison with Chinese and Malays, Indians had significantly higher waist circumference (P ≤ 0.001 and P = 0.016), waist-hip ratio (P = 0.001 and P < 0.001), body fat percentage (P = 0.001 and P = 0.042), fasting insulin (P = 0.001 and P = 0.001), homeostatic model assessment-insulin resistance (P = 0.001 and P = 0.001) and lower high-density lipoprotein-cholesterol levels (P < 0.001 and P < 0.001), respectively. Indians consumed significantly lower dietary cholesterol (P = 0.002), percentage energy from protein (P < 0.001) and higher fibre (P = 0.006) compared to the other two groups. Malaysian Indians expressed the highest risk allele frequency (G) of FTO rs9930506 compared to the Malays and the Chinese (P < 0.001). No significant association was found between FTO rs9930506 and obesity (dominant model). Risk allele carriers (G) consumed significantly lower vitamin E (P = 0.020) and had a higher fibre intake (P = 0.034) compared to the noncarriers (A). Gene-diet interaction analysis revealed that risk allele carriers (G) had lower high sensitivity C-reactive protein (hsCRP) levels with higher energy from protein (≥14% day-1 ; P = 0.049) and higher vitamin E (≥5.4 mg day-1 ; P = 0.038). The presence of the risk allele (G) of FTO rs9930506 was not associated with an increased risk of obesity. Malaysian Indians had a significantly higher frequency of the risk allele (G). Indian participants expressed higher atherogenic phenotypes compared to Chinese and Malays. FTO rs9930506 may interact with dietary protein and vitamin E and modulate hsCRP levels.

High intake of dietary fibre from fruit and vegetables reduces the risk of hospitalisation for diverticular disease

Backgrounds and aimsHigh intake of dietary fibres has been associated with a reduced risk of DD. However, reports on which type of dietary fibre intake that is most beneficial have been conflicting. The aim of this study was to investigate the association between different dietary fibres and hospitalisation due to diverticular disease (DD) of the colon.MethodsThis was a major cohort study. The Swedish Mammography Cohort and the Cohort of Swedish Men were linked to the Swedish Inpatient Register and the Causes of Death Register. Data on the intake of dietary fibre were collected through questionnaires. The effect of intake (in quartiles) of different types of dietary fibre on the incidence of hospitalisation due to DD was investigated using multivariable Cox regression. Estimates were adjusted according to age, BMI, physical activity, co-morbidity, intake of corticosteroids, smoking, alcohol intake and education level.ResultsWomen with intake of fruit and vegetable fibres in the highest quartile (median 12.6 g/day) had a 30% decreased risk of hospitalisation compared to those with the lowest intake (4.1 g/day). Men within the highest quartile (10.3 g/day) had a 32% decreased risk compared to those with a low intake (2.9 g/day). High intake of fibres from cereals did not affect the risk.ConclusionA high intake of fruits and vegetables may reduce the risk of hospitalisation due to DD. Intake of cereals did not influence the risk.

Anaerobic Fungi in Gorilla (Gorilla gorilla gorilla) Feces: an Adaptation to a High-Fiber Diet?

Many studies have demonstrated the importance of symbiotic microbial communities for the host with beneficial effects for nutrition, development, and the immune system. The majority of these studies have focused on bacteria residing in the gastrointestinal tract, while the fungal community has often been neglected. Gut anaerobic fungi of the class Neocallimastigomycetes are a vital part of the intestinal microbiome in many herbivorous animals and their exceptional abilities to degrade indigestible plant material means that they contribute significantly to fermentative processes in the enteric tract. Gorillas rely on a highly fibrous diet and depend on fermentative microorganisms to meet their daily energetic demands. To assess whether Neocallimastigomycetes occur in gorillas we analyzed 12 fecal samples from wild Western lowland gorillas (Gorilla gorilla gorilla) from Dzanga–Sangha Protected Areas, Central African Republic, and subjected potential anaerobic fungi sequences to phylogenetic analysis. The clone library contained ITS1 fragments that we related to 45 different fungi clones. Of these, 12 gastrointestinal fungi in gorillas are related to anaerobic fungi and our phylogenetic analyses support their assignment to the class Neocallimastigomycetes. As anaerobic fungi play a pivotal role in plant fiber degradation in the herbivore gut, gorillas might benefit from harboring these particular fungi with regard to their nutritional status. Future studies should investigate whether Neocallimastigomycetes are also found in other nonhuman primates with high fiber intake, which would also benefit from having such highly efficient fermentative microbes.

Abstract 5255: A pooled analysis of dietary fiber intake and risk of prostate cancer

Abstract High dietary fiber intake has been associated with a lower risk of many cancers but evidence from epidemiological studies on dietary fiber intake and risk of advanced prostate cancer and prostate cancer mortality are limited. We examined associations between dietary fiber intakes overall and from grains, fruits, and vegetables and risk of prostate cancer in 15 cohorts in the Pooling Project of Prospective Studies of Diet and Cancer. Among 842,149 men, during maximum follow-up ranging from 9.2-21.9 years across studies, 52,683 incident prostate cancer cases were identified. Prostate cancer outcomes examined were: 1) all cases; 2) advanced cases, which included men with advanced stage prostate cancer at diagnosis (T4, N1, and/or M1) and men who died of prostate cancer during follow-up (n=4,924); 3) advanced (restricted) cases, which included only men with advanced stage prostate cancer at diagnosis (n=3,110) (men diagnosed with localized prostate cancer who died of prostate cancer were excluded) and 4) prostate cancer mortality, death due to prostate cancer (n=3,199). We adjusted dietary fiber intake for energy intake using the residual method. Cox proportional hazards models were used to calculate study-specific multivariable relative risks (MVRR); the study-specific results were pooled using random effects models. Models were adjusted for age, race/ethnicity, education, marital status, body mass index, height, smoking status, family history of prostate cancer, physical activity, history of diabetes, multivitamin use, and energy and alcohol intake. Median dietary fiber intake varied from 6-28 g/d across studies. For total dietary fiber intake, dietary fiber intake from fruits, and dietary fiber intake from vegetables, no statistically significant associations were observed for any outcome; the pooled MVRRs comparing the highest with the lowest quintile ranged from 0.95-1.02. The pooled MVRR comparing the highest with the lowest study-specific quintile of dietary fiber intake from grains was 0.84 (95% confidence interval [CI] 0.76-0.93) for advanced stage and 0.85 (0.74-0.97) for advanced (restricted) stage prostate cancer. The pooled MVRR for the same comparison was 0.78 (95% CI 0.69-0.89) for prostate cancer mortality. Similar results were observed when dietary fiber intake was categorized using common absolute intake cutpoints across studies (e.g., the pooled MVRR for prostate cancer mortality was 0.86, 95% CI 0.75-0.98 comparing ≥8 with &amp;lt;2 g/d of dietary fiber intake from grains). Further adjustment for dietary folate, calcium, and lycopene intake and red meat consumption did not substantially change the results for dietary fiber intake from grains. In this large, international consortium, we found that higher dietary fiber intake from grains, but not intake of dietary fiber overall or from fruits and vegetables, was associated with lower risk of advanced prostate cancer and prostate cancer mortality. Citation Format: Elkhansa Sidahmed, Stephen J. Freedland, Molin Wang, Kana Wu, Jeanine M. Genkinger, Stephanie A. Smith-Warner. A pooled analysis of dietary fiber intake and risk of prostate cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5255.

Pre-pregnancy dietary carbohydrate quantity and quality, and risk of developing gestational diabetes: the Australian Longitudinal Study on Women's Health.

Carbohydrate quantity and quality affect postprandial glucose response, glucose metabolism and risk of type 2 diabetes. The aim of this study was to examine the association of pre-pregnancy dietary carbohydrate quantity and quality with the risk of developing gestational diabetes mellitus (GDM). We used data from the Australian Longitudinal Study on Women's Health that included 3607 women aged 25-30 years without diabetes who were followed up between 2003 and 2015. We examined carbohydrate quantity (total carbohydrate intake and a low-carbohydrate diet (LCD) score) and carbohydrate subtypes indicating quality (fibre, total sugar intake, glycaemic index, glycaemic load and intake of carbohydrate-rich food groups). Relative risks (RR) for development of GDM were estimated using multivariable regression models with generalised estimating equations. During 12 years of follow-up, 285 cases of GDM were documented in 6263 pregnancies (4·6 %). The LCD score, reflecting relatively high fat and protein intake and low carbohydrate intake, was positively associated with GDM risk (RR 1·54; 95 % CI 1·10, 2·15), highest quartile v. lowest quartile). Women in the quartile with highest fibre intake had a 33 % lower risk of GDM (RR 0·67; 95 % CI 0·45, 0·96)). Higher intakes of fruit (0·95 per 50 g/d; 95 % CI 0·90, 0·99) and fruit juice (0·89 per 100 g/d; 95 % CI 0·80, 1·00)) were inversely associated with GDM, whereas cereal intake was associated with a higher risk of GDM (RR 1·05 per 20 g/d; 95 % CI 1·01, 1·07)). Thus, a relatively low carbohydrate and high fat and protein intake may increase the risk of GDM, whereas higher fibre intake could decrease the risk of GDM. It is especially important to take the source of carbohydrates into account.

Assessment of dietary intake in Spanish university students of health sciences

IntroductionNutritional intake during early ages has been associated to disease onset later in life. This study aimed to assess dietary intake in Spanish university students of health sciences as compared to national recommended dietary intakes (DRIs). MethodsA cross-sectional study was conducted including 585 university students of health sciences aged 18–25 years. Dietary intake was assessed using a 72-h diet recall. A control group was selected from Spanish National Dietary Intake Survey (ENIDE) data. ResultsIntake of energy, protein, fat, fatty acids, and cholesterol was significantly lower (p<0.001) in university students compared to controls, while fiber intake showed the opposite trend (p<0.001). Total fat and carbohydrate intake was consistent with recommendations, but protein intake was lower than recommended. Intake of saturated fatty acids (SFAs) was markedly higher than nutrition goals, while intake of monounsaturated fatty acids (MUFAs) was lower. Both students and the reference control group did not reach the optimal dietary intake of iodine and vitamins D and E, while sodium intake was excessive in both groups. ConclusionsDietary habits of university students were mainly characterized by low intakes of energy, protein, fats, fatty acids, and cholesterol, and high intake of fiber as compared to the general population. Intake of iodine and vitamins D and E was low, while sodium intake was excessive in both university students and the general population. Dietary interventions should be considered to prevent nutritional deficiencies and to ensure a balanced diet.