Natural Deep Eutectic Solvents (NADES) represent a new group of green and environmentally friendly solvents that comply with all the principles of green chemistry. NADES are formed via hydrogen bonding by combining hydrogen bond donors (HBD) and hydrogen bond acceptors (HBA). In this paper, we presented ten NADES systems based on choline chloride and different polyphenols. The basic physicochemical and biological properties were evaluated (stability, density, viscosity, FTIR, ORAC, antibacterial activity). It was shown that all the systems had a high densities and high dynamic viscosities. The densities ranged from 1.096 – 1.221 mg/mL for ChCl – resveratrol and ChCl – rutin, respectfully. The dynamic viscosities ranged from 0.247–1.662 Pa S for ChCl – gallic acid and ChCl – chlorogenic acid, respectfully. The viscosity could be lowered by increasing the molar ratio of choline chloride. Four NADES systems, comprising catechin, rosmarinic acid, gallic acid and chlorogenic acid could be diluted with water without affecting the stability of those systems. This finding could increase the usability of those systems. The FT-IR analysis of the selected systems showed that the peaks are widened and slightly shifted, without formation of new peaks, which proves the formation of hydrogen bonds between the NADES constituents. All tested systems showed high ORAC value (426.94–874.96 Trolox eq/mL) and antibacterial activity (0.625–2.5 % NADES).