The root causes of the spread of antibiotic resistance are multifactorials and interconnected. It basically caused by inappropriate, irrational, high consumption, and profligate use of antibiotics, combined by a low level of compliance of the patients. The unavailability of a health insurance system that covered most of the citizens in those countries has played a part to the irrational use of antibiotics. For example in Indonesia, almost 86% of the populations are not covered by any insurance scheme [13], thus, they have to pay in cash everytime they have medical problem. This condition has forced medical doctors to sometimes skip the supporting diagnosis to confirm the bacterial infections, and directly prescribe antibiotics whenever they suspect infections. With the high number of antibiotic prescription, patients believed that antibiotic is a magical medicine that will cure them. From the patients point of view, those with lower income will skip medical consultation and choose for self medication for common diseases, including with non-prescribed antibiotic. They tend to duplicate their previous prescriptions for self medication by making notes of prescribed medicines for future reference if similar medical problems reoccur [14]. Indonesian government has legally included antibiotics to prescription-only medicines whose sale are restricted to hospitals, public health centers, and community pharmacies. However without a strict supervision, antibiotics are easily purchased at a low