Higher Cognition Research Articles

Outcomes and Weight-bearing Status During Rehabilitation After Arthroplasty for Hip Fractures

To examine the association of weight-bearing status with patient-related variables and outcomes of inpatient rehabilitation after hip arthroplasty for acute hip fracture. A multi-site prospective observational cohort study. Eighteen skilled nursing and inpatient rehabilitation facilities. Patients with hip fractures (N = 224) treated with hip arthroplasty and admitted to either skilled nursing or inpatient rehabilitation facilities; a subset (N = 84) with telephone follow-up outcomes 8 months after rehabilitation discharge. Measurements included demographic variables, medical severity using the Comprehensive Severity Index, and functional levels using the Functional Independence Measure. MAIN OUTCOMES MEASUREMENT: Cognitive, motor, and total Functional Independence Measure scores at rehabilitation discharge and at 8-month follow-up; living location at discharge and follow-up. Patients on average (standard deviation) were 76.8 ± 11.4 years old, mainly women (78%), and mainly white (87%). In unadjusted analysis, weight bearing as tolerated (WBAT) was associated with less osteoarthritis (P = .025) and lower admission medical severity (ACSI) (P = .014). One participating facility had a significant preponderance of restricted weight-bearing cases. WBAT had no bivariate association with cognitive or motor function at discharge. Therapists cited restricted weight bearing as a barrier to therapy in 11% of cases. In logistic regressions, lower medical admission severity, older age, and one specified site significantly predicted WBAT (c statistic = 0.714). Significant predictors for home discharge included lower maximum severity (P < .001), younger age (P < .001), higher cognition (P = .037), and WBAT (P = .051) (c statistic = 0.863). WBAT is associated with a greater likelihood of home discharge and had similar functional outcomes compared with restricted weight bearing. These findings add support for allowing WBAT after arthroplasty for hip fracture.

MDMA and 5‐HT neurotoxicity: the empirical evidence for its adverse effects in humans – no need for translation

In this issue of the BJP, Green et al. suggest that animal data could not be used to predict the adverse effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans and that MDMA did not produce 5-HT neurotoxicity in the human brain. This proposal was, however, not accompanied by a review of the empirical evidence in humans. The neuroimaging data on 5-HT markers in abstinent recreational ecstasy/MDMA users are extensive and broadly consistent. Reduced levels of the 5-HT transporter (SERT) have been found by research groups worldwide using a variety of assessment measures. These SERT reductions occur across the higher brain regions and remain after controlling for potential confounds. There are also extensive empirical data for impairments in memory and higher cognition, with the neurocognitive deficits correlating with the extent of SERT loss. Hence, MDMA is clearly damaging to humans, with extensive empirical data for both structural and functional deficits.

The Research of Digital Learning Applying to Industrial Wiring Course Excerpt

“Industrial Wiring” Generally Use in Industrial Circle for High Pressure Switchboard, Low Pressure Switchboard, Motor Starters and Control Panel Etc. Assembly, and Is One of the Main Events of Vocational Training. in Traditional Learning, Teachers Will Explain the Circuit and Do the Demonstration, and then Students Will Proceed Self Study or Practice Etc Training Method. in this Kind of Method, Students Mostly Can Not Prove Immediately and Cause Inaccuracy with Wiring Concept. in View of Digital Teaching Material Is Producing and Developing Maturely, and it Has Been Promoted Generally as a Popular Way for Teaching. Digital Learning’s Advantages Include No Time Limit or Space Limit, Saving the Human Recourse and Consumables Cost, and Lively and Abundant in Teaching Material. as a Result, this Research Would Put Digital Learning into Industrial Wiring Course, to Create Digital Teaching Material to Build up Learning Benefit Result and to Spirit up Learning Interest. this Research Takes 70 Electric Machinery and Electron Students from Vocational High School and the Experiment Makes Two People as a Group to Proceed Academic and Technical Learning. during the Experiment, 36 Students Will Use Computer Simulated Mode as Digital Learning, and the other 34 Students Learn by Dictated Demonstration in Traditional Learning Way. after the Class, the Two Groups of Class Take a Quiz Separately, Including Electrical Science Basic Ability Test, Industrial Wiring Achievement Test, Cognition Load Chart and Space Ability Test to Comprehend the Benefit Result of Applying Digital Learning. Students’ Composite Grade Indicates that Digital Learning (M=24.87) Overmatch the Traditional Learning (M=19.63). Therefore Could Make Four Conclusions. First, Digital Learning Benefit Is Better than Traditional Learning. Second, Digital Learning Create a Higher Cognition Load than Traditional Learning Does. Third, Digital Learning’s Learning Result Does Not Have any Difference for Different Space Ability Learner. Fourth, Computer Is a Useful Communication Tool in Digital Learning and it Helps to Group Interaction.

Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions

Classic cognitive theory conceptualizes executive functions as involving multiple specific domains, including initiation, inhibition, working memory, flexibility, planning, and vigilance. Lesion and neuroimaging experiments over the past two decades have suggested that both common and unique processes contribute to executive functions during higher cognition. It has been suggested that a superordinate fronto-cingulo-parietal network supporting cognitive control may also underlie a range of distinct executive functions. To test this hypothesis in the largest sample to date, we used quantitative meta-analytic methods to analyze 193 functional neuroimaging studies of 2,832 healthy individuals, ages 18-60, in which performance on executive function measures was contrasted with an active control condition. A common pattern of activation was observed in the prefrontal, dorsal anterior cingulate, and parietal cortices across executive function domains, supporting the idea that executive functions are supported by a superordinate cognitive control network. However, domain-specific analyses showed some variation in the recruitment of anterior prefrontal cortex, anterior and midcingulate regions, and unique subcortical regions such as the basal ganglia and cerebellum. These results are consistent with the existence of a superordinate cognitive control network in the brain, involving dorsolateral prefrontal, anterior cingulate, and parietal cortices, that supports a broad range of executive functions.

Investigating the Role of Denial of Cognition, Capacity for Morality and Perception of Child-likeness in Infrahumanization

Secondary emotions (for example, guilt, shame, and tenderness) are uniquely human, indicate higher cognition, moral capacity, and develop with age, compared with primary emotions (for example, pain, fear , happiness), which humans also share with animals. According to Leyers and colleagues people designate outgroups as less human, that is, infrahumanize them through ascribing them less uniquely human emotions. This paper reports two studies that examined the role of denial of cognition, capacity for morality and perception of child-likeness in denial of secondary emotions to outgroups. In Study 1, it was hypothesized that a sample of psychology students would deny secondary emotions to people with a learning disability, Down syndrome, as a function of denying them cognitive capacities, compared with people with physical disabilities and the ingroup. S tudy 2 tested denial of secondary emotions to the three tar get groups as a function of not only denial of cognition, but also of moral capacities, and a tendency to liken the mental capacities of adults to children's. Both studies showed that only people with Down syndrome are denied secondary emotions. In S tudy 1, denial of secondary emotions to people with Down syndrome was mediated by denial of cognitive capacities. In S tudy 2, denial of secondary emotions was mediated by an average index of denial of cognitive and moral capacities, and likening mental capacities of the target groups to children's. Both studies also showed greater denial of positive than negative secondary emotions to people with Down syndrome. Results are discussed in terms of infrahumanization theory and romanticization of learning disabilities. Implications of results to people with Down syndrome are also discussed.

Sensitivity, Reproducibility, and Reliability of Self-Paced Versus Fixed Stimulus Presentation in an fMRI Study on Exact, Non-Symbolic Arithmetic in Typically Developing Children Aged Between 6 and 12 Years

Fixed stimulus presentation times pose several methodological problems for developmental functional magnetic resonance imaging (fMRI) studies that can be avoided by self-paced study designs. Yet, methodological issues of self-paced stimulus presentation for fMRI studies are largely understudied. Therefore, we compared sensitivity, reproducibility, and reliability of neural activation of a fixed and a self-paced design for an exact, non-symbolic addition paradigm in a sample of children aged 6–12 years. Both design types were comparable in sensitivity, and the self-paced design was superior in reproducibility and reliability. Therefore, self-paced study designs seem to be a valid option for developmental fMRI studies on higher cognition.

Intuitive physical reasoning about occluded objects by inexperienced chicks

Questions concerning the role of nature and nurture in higher cognition appear to be intractable if one restricts one's attention to development in humans. However, in other domains, such as sensory development, much information has been gained from controlled rearing studies with animals. Here, we used a similar experimental strategy to investigate intuitive reasoning about occluded objects. Newborn domestic chicks (Gallus gallus) were reared singly with a small object that became their social partner. They were then accustomed to rejoin such an imprinting object when it was made to move and disappear behind either one of two identical opaque screens. After disappearance of the imprinting object, chicks were faced with two screens of different slants, or of different height or different width, which may or may not have been compatible with the presence of the imprinting object hidden beneath/behind them. Chicks consistently chose the screen of slant/height/width compatible with the presence of the object beneath/behind it. Preventing chicks from touching and pecking at the imprinting object before testing did not affect the results, suggesting that intuitive reasoning about physical objects is largely independent of specific experience of interaction with objects and of objects' occluding events.

Commonalities between Perception and Cognition

Perception and cognition are highly interrelated. Given the influence that these systems exert on one another, it is important to explain how perceptual representations and cognitive representations interact. In this paper, I analyze the similarities between visual perceptual representations and cognitive representations in terms of their structural properties and content. Specifically, I argue that the spatial structure underlying visual object representation displays systematicity – a property that is considered to be characteristic of propositional cognitive representations. To this end, I propose a logical characterization of visual feature binding as described by Treisman’s Feature Integration Theory and argue that systematicity is not only a property of language-like representations, but also of spatially organized visual representations. Furthermore, I argue that if systematicity is taken to be a criterion to distinguish between conceptual and non-conceptual representations, then visual representations, that display systematicity, might count as an early type of conceptual representations. Showing these analogies between visual perception and cognition is an important step toward understanding the interface between the two systems. The ideas here presented might also set the stage for new empirical studies that directly compare binding (and other relational operations) in visual perception and higher cognition.

The Effect of Language on Visual Contrast Sensitivity

Embodied cognition and perceptual symbol theories assume that higher cognition interacts with and is grounded in perception and action. Recent experiments have shown that language processing interacts with perceptual processing in various ways, indicating that linguistic representations have a strong perceptual character. In the present study, we have used signal detection theory to investigate whether the comprehension of written sentences, implying either horizontal or vertical orientation, could improve the participants' visual sensitivity for discriminating between horizontal or vertical square-wave gratings and noise. We tested this prediction by conducting one main and one follow-up experiment. Our results indicate that language can, indeed, affect perception at such a low level of the visual process and thus provide further support for the embodied theories of cognition.

Higher Blood Pressure Associated With Higher Cognition and Functionality Among Centenarians in Australia

The objective of this study was to examine blood pressure (BP) and cholesterol levels among centenarians in Australia, and to compare the relationship between these biological parameters with cognitive and functional status. We performed BP (n = 142) and cholesterol (n = 67) measurements using the Omron automated sphygmomanometer (Omron Healthcare, Melbourne, Australia) and the LDX Cholestech Analyzer (Inverness Medical, San Diego, CA), respectively. A medical history was also obtained. Cognitive and functional statuses were assessed using the Mini-Mental State Examination (MMSE) and Katz Index of Independence in Activities of Daily Living (Katz ADL), respectively. Average age of participants was 101.1 years. Hypertension was demonstrated in 1% according to the WHO criterion (≥140/90 mm Hg). However, 38% of centenarians were hypertensive, defined as having a medical diagnosis of hypertension, and/or being on antihypertensive medications, and/or having a BP measurement ≥ 140/90 mm Hg. Mean values were: systolic = 130 mm Hg (90-182 mm Hg), diastolic = 70 mm Hg (44-98 mm Hg), and pulse pressure (PP) = 60 mm Hg (20-130 mm Hg). Hypercholesterolaemia was only detected in 8% of participants. Hypertension was not associated with increased risk of hypercholesterolaemia. Low systolic BP (SBP) and narrower PP was associated with lower MMSE scores. High SBP and wider PP was associated with better functional status. Centenarians have a very low prevalence of high BP and high cholesterol compared with the general population. There seems to be an inverse relationship between the risk factors for cardiovascular disease vs. the risk factors for dementia in our sample. There appears to be a complex interaction between BP and health in old age.

Does working memory training work? The promise and challenges of enhancing cognition by training working memory

A growing body of literature shows that one's working memory (WM) capacity can be expanded through targeted training. Given the established relationship between WM and higher cognition, these successful training studies have led to speculation that WM training may yield broad cognitive benefits. This review considers the current state of the emerging WM training literature, and details both its successes and limitations. We identify two distinct approaches to WM training, strategy training and core training, and highlight both the theoretical and practical motivations that guide each approach. Training-related increases in WM capacity have been successfully demonstrated across a wide range of subject populations, but different training techniques seem to produce differential impacts upon the broader landscape of cognitive abilities. In particular, core WM training studies seem to produce more far-reaching transfer effects, likely because they target domain-general mechanisms of WM. The results of individual studies encourage optimism regarding the value of WM training as a tool for general cognitive enhancement. However, we discuss several limitations that should be addressed before the field endorses the value of this approach.

Reduced Dysbindin Expression Mediates N-Methyl-D-Aspartate Receptor Hypofunction and Impaired Working Memory Performance

Schizophrenia is a heritable disorder associated with disrupted neural transmission and dysfunction of brain systems involved in higher cognition. The gene encoding dystrobrevin-binding-protein-1 (dysbindin) is a putative candidate gene associated with cognitive impairments, including memory deficits, in both schizophrenia patients and unaffected individuals. The underlying mechanism is thought to be based in changes in glutamatergic and dopaminergic function within the corticostriatal networks known to be critical for schizophrenia. This hypothesis derives support from studies of mice with a null mutation in the dysbindin gene that exhibit memory dysfunction and excitatory neurotransmission abnormalities in prefrontal and hippocampal networks. At a cellular level, dysbindin is thought to mediate presynaptic glutamatergic transmission. We investigated the relationship between glutamate receptor dynamics and memory performance in dysbindin mutant mice. We assessed N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor function in prefrontal cortex pyramidal neurons in vitro with whole-cell recordings, molecular quantitative analyses (reverse transcription-polymerase chain reaction) of the mandatory NMDA receptor subunit NR1, and cognitive function with a spatial working memory task. Decreases in dysbindin are associated with specific decreases in NMDA-evoked currents in prefrontal pyramidal neurons, as well as decreases in NR1 expression. Furthermore, the degree of NR1 expression correlates with spatial working memory performance, providing a mechanistic explanation for cognitive changes previously associated with dysbindin expression. These data show a significant downregulation of NMDA receptors due to dysbindin deficiency and illuminate molecular mechanisms mediating the association between dysbindin insufficiency and cognitive impairments associated with schizophrenia, encouraging study of the dysbindin/NR1 expression association in humans with schizophrenia.

Précis of Doing without Concepts

In this precis, I review the main points and arguments developed at greater length in Doing without Concepts, and I explain why eliminating the notion of concept would contribute to the progress of the psychology of higher cognition.

Cognitive Architecture and the Epistemic Gap: Defending Physicalism without Phenomenal Concepts

The novel approach presented in this paper accounts for the occurrence of the epistemic gap and defends physicalism against anti-physicalist arguments without relying on so-called phenomenal concepts. Instead of concentrating on conceptual features, the focus is shifted to the special characteristics of experiences themselves. To this extent, the account provided is an alternative to the Phenomenal Concept Strategy. It is argued that certain sensory representations, as accessed by higher cognition, lack constituent structure. Unstructured representations could freely exchange their causal roles within a given system which entails their functional unanalysability. These features together with the encapsulated nature of low level complex processes giving rise to unstructured sensory representations readily explain those peculiarities of phenomenal consciousness which are usually taken to pose a serious problem for contemporary physicalism. I conclude that if those concepts which are related to the phenomenal character of conscious experience are special in any way, their characteristics are derivative of and can be accounted for in terms of the cognitive and representational features introduced in the present paper.

Network architecture of the long-distance pathways in the macaque brain.

Understanding the network structure of white matter communication pathways is essential for unraveling the mysteries of the brain's function, organization, and evolution. To this end, we derive a unique network incorporating 410 anatomical tracing studies of the macaque brain from the Collation of Connectivity data on the Macaque brain (CoCoMac) neuroinformatic database. Our network consists of 383 hierarchically organized regions spanning cortex, thalamus, and basal ganglia; models the presence of 6,602 directed long-distance connections; is three times larger than any previously derived brain network; and contains subnetworks corresponding to classic corticocortical, corticosubcortical, and subcortico-subcortical fiber systems. We found that the empirical degree distribution of the network is consistent with the hypothesis of the maximum entropy exponential distribution and discovered two remarkable bridges between the brain's structure and function via network-theoretical analysis. First, prefrontal cortex contains a disproportionate share of topologically central regions. Second, there exists a tightly integrated core circuit, spanning parts of premotor cortex, prefrontal cortex, temporal lobe, parietal lobe, thalamus, basal ganglia, cingulate cortex, insula, and visual cortex, that includes much of the task-positive and task-negative networks and might play a special role in higher cognition and consciousness.

Taiwanese nurses' cognition and attitudes towards the Magnet Hospitals Recognition Programme

To explore the relevance and feasibility of using the Magnet Recognition Programme (MRP) at a Taiwanese hospital. Since no hospitals in Taiwan have applied for American Nurses Credentialing Center Magnet Recognition, and the American medical system and customs are different from those in Taiwan, this study explores whether or not the MRP is appropriate for Taiwanese hospitals. This study used a cross-sectional design with data collected from 905 nurses at a 1200-bed Taiwanese military hospital. The authors created the structured questionnaire from a framework based on the 14 Forces of Magnetism. The study used descriptive and inferential statistical analyses to explain the nurses' cognitions and attitudes towards the MRP and to discover if variations in these concepts occurred across nurses' demographics and their job classification. The mean nurses' cognitive score on each item varies from 3.3 to 4.1, and the mean nurses' attitude score on each item varies from 3.0 to 4.0 (both with the highest possible score related to the 14 Forces of Magnetism being 5.0). Using regression analysis, overall cognitive score, working in the operating room, or the sub-critical Neonatal Care Unit, and part-time hours of work explained 42% of the variance in the total attitude score towards the MRP. The findings indicate that when nurses have a higher cognition towards MRP, the more positive are their attitudes towards seeking the MRP. Using these findings and information about the nurses, the authors suggest strategies that hospital executives and nursing supervisors can use to improve nurses' cognition and attitudes when preparing to seek recognition through the MRP.

Neuropsychiatric Illness: A Case for Impaired Neuroplasticity and Possible Quantum Processing Derailment in Microtubules

There is a great deal of evidence that cytoskeletal proteins, in particular microtubules, are dysfunctional in mental illnesses such as schizophrenia and affective disorder. Since cytoskeletal proteins are major arbitrators of neuroplasticity, this evidence fits with recent theories suggesting that neuroplasticity is compromised in mental illness and that the efficacy of antidepressant and antipsychotic drugs may depend, at least in part, on their ability to enhance neuroplasticity. Quantum theories of mind, particularly those implementing information processing in microtubules, are useful on many levels. Quantum theories attempt to explain the more enigmatic features of mind, some of which are disrupted in mental illness. Quantum information processing theories also attempt to link molecular events at the atomic level to higher cognition. These approaches are highly ambitious, and multiple potential obstacles abound as a consequence of working in largely uncharted territory.

Role of deep brain stimulation in modulating memory formation and recall

Deep brain stimulation (DBS) has become an increasingly popular tool for treating a variety of medically refractory neurological and psychiatric disorders such as Parkinson disease, essential tremor, depression, and obsessive-compulsive disorder. Several targets have been identified for ablation or stimulation based on their anatomical location and presumed function. Areas such as the subthalamic nucleus, globus pallidus, and thalamus, for example, are believed to play a key role in motor control and execution, and they are commonly used in the treatment of motor disorders. Limbic structures such as the cingulate cortex and ventral striatum, believed to be important in motivation, emotion, and higher cognition, have also been targeted for treatment of a number of psychiatric disorders. In all of these settings, DBS is largely aimed at addressing the deleterious aspects of these diseases. In Parkinson disease, for example, DBS has been used to reduce rigidity and tremor, whereas in obsessive-compulsive disorder it has been used to limit compulsive behavior. More recently, however, attention has also turned to the potential use of DBS for enhancing or improving otherwise nonpathological aspects of cognitive function. This review explores the potential role of DBS in augmenting memory formation and recall, and the authors discuss recent studies and future trends in this emerging field.

Introspection, confabulation, and dual-process theory

AbstractThis excellent target article helps to resolve a problem for dual-process theories of higher cognition. Theorists posit two systems, one of which appears to be conscious and volitional. It seems to control some behaviours but to confabulate explanations for others. I argue that this system is only conscious in an illusory sense and that all self-explanations are confabulatory, as Carruthers suggests.

Building and applying a human cognition model for visual analytics

It is well known that visual analytics addresses the difficulty of evaluating and processing large quantities of information. Less often discussed are the increasingly complex analytic and reasoning processes that must be applied in order to accomplish that goal. Success of the visual analytics approach will require us to develop new visualization models that predict how computational processes might facilitate human insight and guide the flow of human reasoning. In this paper, we seek to advance visualization methods by proposing a framework for human 'higher cognition' that extends more familiar perceptual models. Based on this approach, we suggest guidelines for the development of visual interfaces that better integrate complementary capabilities of humans and computers. Although many of these recommendations are novel, some can be found in existing visual analytics applications. In the latter case, much of the value of our contribution lies in the deeper rationale that the model provides for those principles. Lastly, we assess these visual analytics guidelines through the evaluation of several visualization examples.