Areas Of High Wall Shear Stress Research Articles

Exploring the hemodynamic behavior of residual aneurysms after coiling and clipping: A computational flow dynamic analysis

Background: Residual intracranial aneurysms post-clipping or coiling pose a poorly established risk of rupture. Computational fluid dynamic (CFD) offers insights into hemodynamic changes following such interventions. This study aims to assess hemodynamic parameters in residual aneurysms pre- and post-treatment with surgical clips or coils using CFD. Methods: A retrospective analysis of consecutive patients between January 2015 and January 2024 was conducted. Digital subtraction angiography images were reconstructed using 3D modeling techniques, and hemodynamic parameters were analyzed with ANSYS® software. Results: Six aneurysms were analyzed: Five unruptured and one ruptured. The aneurysms were located at the basilar apex (2), middle cerebral artery bifurcation (2), and origin of the posterior communicating artery (2). Post-treatment, there was a significant reduction in both aneurysm area (median reduction of 33.73%) and volume (median reduction of 25.3%). Five of the six cases demonstrated fewer low wall shear stress (WSS) areas, which could indicate a reduction in regions prone to thrombus formation and diminished risk of rupture. In the unruptured aneurysms, there was a median increase of 137.6% in average WSS. Notably, the only case with increased low WSS area also had the highest increase in average WSS. One basilar artery aneurysm showed increased WSS across all parameters, suggesting a higher rupture risk. Conclusion: The increase in average and high WSS area, along with a decrease in low WSS area, reflects a complex balance between factors of stability and rupture risk. However, a simultaneous increase in all WSS parameters may represent the highest rupture risk due to increased mechanical stress on the aneurysm wall, necessitating closer monitoring.

Hemodynamic Comparison of Treatment Strategies for Intracranial Vertebral Artery Fusiform Aneurysms.

ObjectiveThis study comparatively analyzed the hemodynamic changes resulting from various simulated stent-assisted embolization treatments to explore an optimal treatment strategy for intracranial vertebral artery fusiform aneurysms. An actual vertebral fusiform aneurysm case treated by large coil post-stenting (PLCS) was used as a control.Materials and MethodsA single case of an intracranial vertebral artery fusiform aneurysm underwent a preoperative and eight postoperative finite element treatment simulations: PLCS [single and dual Low-profile Visualized Intraluminal Support (LVIS)], Jailing technique (single and dual LVIS both simulated twice, Pipeline Embolization Device (PED) with or without large coils (LCs). Qualitative and quantitative assessments were performed to analyze the most common hemodynamic risk factors for recurrence.ResultsJailing technique and PED-only had a high residual flow volume (RFV) and wall shear stress (WSS) on the large curvature of the blood flow impingement region. Quantitative analysis determined that PLSC and PED had a lower RFV compared to preoperative than did the jailing technique [PED+LC 2.46% < PLCS 1.2 (dual LVIS) 4.75% < PLCS 1.1 (single LVIS) 6.34% < PED 6.58% < Jailing 2.2 12.45% < Jailing 1.2 12.71% < Jailing 1.1 14.28% < Jailing 2.1 16.44%]. The sac-averaged flow velocity treated by PLCS, PED and PED+LC compared to preoperatively was significantly lower than the jailing technique [PED+LC = PLCS 1.2 (dual LVIS) 17.5% < PLCS 1.1 (single LVIS) = PED 27.5% < Jailing 1.2 = Jailing 2.2 32.5% < Jailing 1.1 37.5% < Jailing 2.1 40%]. The sac-averaged WSS for the PLCS 1.2 (dual LVIS) model was lower than the PED+LC, while the high WSS area of the Jailing 1 model was larger than for Jailing 2 [PLCS 1.2 38.94% (dual LVIS) < PED+LC 41% < PLCS 1.1 43.36% (single LVIS) < PED 45.23% < Jailing 2.1 47.49% < Jailing 2.2 47.79% < Jailing 1.1 48.97% < Jailing 1.2 49.85%].ConclusionsFor fusiform aneurysms, post large coil stenting can provide a uniform coil configuration potentially reducing the hemodynamic risk factors of recurrence. Flow diverters also may reduce the recurrence risk, with long-term follow-up required, especially to monitor branch blood flow to prevent postoperative ischemia.

Hemodynamic Analysis on the Anastomosis Angle in Arteriovenous Graft Using Multiphase Blood Model

Numerical analysis was performed for the effect of the venous anastomosis angle in a forearm arteriovenous graft for hemodialysis using a multiphase blood model. The geometry of the blood vessel was generated based on the patient-computed tomography data. The anastomosis angles were set at 15°, 30°, and 45°. The hematocrit was set at 34%, 45%, and 58%. The larger anastomosis angle, high wall shear stress area &gt;11 Pa, increases to the side of the vein wall away from the anastomosis site. Further, the relatively low wall shear stress area, &lt;3 Pa, occurs near the anastomosis site in larger anastomosis angles. Therefore, the effect of high wall shear stress has advantages in the vicinity of the anastomosis, as the anastomosis angle is larger, but disadvantages as the distance from the anastomosis increases. Moreover, patients with low hematocrit are advantageous for WSS area.

Aortic Hemodynamics of Spiral-Flow-Generated Mechanical Assistance

Mechanical circulatory support devices are being increasingly used as destination therapy in end-stage heart failure patients. Although current devices have significantly improved survival rates, the resulting hemodynamics remains nonphysiological. Spiral forms of blood flow are known to exist in the large arteries (eg, aorta) and serve as a biomimetic-motivation for generating these physiologically adapted flow regimes. We aimed to study the potential benefits of generating spiral flow at the mechanical circulatory support outflow graft and the resultant flow-fields in the aorta, including recirculation zones and endothelial wall shear stress (WSS) areas. A three-dimensional model of an outflow graft virtually anastomosed end-to-side to an image-derived aortic arch was used in computational fluid dynamic simulations. To study the impact of both spiral flow modulation (clockwise/counterclockwise helical-flow content) and the outflow graft anastomosis angle (inferiorly/superiorly directed, anteriorly/posteriorly directed), flow velocities were measured, low/high WSS were computed, and fluid streamlines were visualized. Increased helical-flow content reduced regions of low velocity (<5 cm/s), minimized areas exhibiting low WSS (<3 dyn/cm2), and concomitantly increased areas of high WSS (>80 dyn/cm2). The outflow graft anastomosis angle was a key determinant of aortic root washout and fluid-jet wall impingement. Despite counterclockwise spiral flow predominance in diminishing the size of recirculation/stasis zones compared to straight/clockwise flow, exceptions to this were noted with the superiorly directed and posteriorly directed graft placements. Spiral flow-forms better tailored to the underlying three-dimensional aortic curvature and graft angle positioning is expected to help attenuate atherogenesis, preventing vascular remodeling and minimizing plaque formation/erosion in mechanically assisted circulation.

Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation

BackgroundPortal vein stenosis develops in 3.4–14% of split liver transplantation1–3 and its early detection and treatment are essential to achieve long-term graft survival,2–5 although the diagnostic capability of conventional modalities such as Doppler ultrasound and computed tomography is limited.1,4,5 MethodsThis study used computational fluid dynamics to analyze portal vein hemodynamics in the management of post-transplant portal vein stenosis. To perform computational fluid dynamics analyses, three-dimensional portal vein model was created using computed tomographic DICOM data. The inlet flow condition was set according the flow velocity measured on Doppler ultrasonography. Finally, portal vein flow was simulated on a fluid analysis software (Software Cradle, Japan). ResultsAn 18-month-old girl underwent liver transplantation using a left lateral graft for biliary atresia. At the post-transplant 1-week evaluation, the computational fluid dynamics streamline analysis visualized vortices and an accelerated flow with a velocity ratio < 2 around the anastomotic site. The wall shear stress analysis revealed a high wall shear stress area within the post-anastomotic portal vein. At the post-transplant 6-month evaluation, the streamline analysis illustrated the increased vortices and worsening flow acceleration to reach the proposed diagnostic criteria (velocity ratio > 3:1).3,5 The pressure analysis revealed a positive pressure gradient of 3.8 mmHg across the stenotic site. Based on the findings, the patient underwent percutaneous transhepatic portal venoplasty with balloon dilation. The post-treatment analyses confirmed the improvement of a jet flow, vortices, a high wall shear stress, and a pressure gradient. DiscussionThe computational fluid dynamics analyses are useful for prediction, early detection, and follow-up of post-transplant portal vein stenosis and would be a promising technology in post-transplant management.

Preliminary study on the hemodynamics of Cognard type IV dural arteriovenous fistulas with venous aneurysm

Objective To explore the hemodynamic features of venous aneurysms in Cognard type Ⅳ dural arteriovenous fistulas (DAVF). Methods Computational fluid dynamics analysis was conducted in 7 venous aneurysms of 4 patients who received endovascular treatment at Department of Neurosurgery, Beijing Tsinghua Changgung Hospital between July 2017 and December 2017. All 4 patients experienced no intracranial bleeding before intervention. Results Average flow velocity was 0.030 (0.002-1.567) m/s in the 7 aneurysms and 0.092 (0.050-2.235) m/s in drainage veins. The difference was not statistically significant (P=0.248). Average pressures in fistula area, venous aneurysm and drainage veins were 7 394.9(6 087.3-7 977.0) Pa, 4 882.2 (3 697.8-7 004.7) Pa and 3 439.1 (3 337.2-5 612.9) Pa, respectively. Median values of average wall shear stress (WSS) were 10.22 (4.07-13.58) Pa in fistula area, 4.11 (0.24-13.95) Pa in venous aneurysms and 7.61 (5.16-12.90) Pa in drainage veins. On the draining system, average pressure in venous aneurysms were higher when compared with drainage veins, but the difference was not significant in statistics (W=39, P=0.072), however, average WSS were significantly lower in venous aneurysms (W=8, P=0.040). For the 2 cases with multiple venous aneurysms, high WSS area was identified in the inflow area of subsequent venous aneurysms. Conclusion Preliminary results have indicated that WSS of venous aneurysms is lower compared with drainage veins, and high WSS area is present on drainage veins distal to the venous aneurysm. The relationship between WSS and venous aneurysm rupture requires further validation in future studies. Key words: Arteriovenous fistula; Hemodynamics; Dural; Venous aneurysms

Hemodynamics in a Middle Cerebral Artery Aneurysm Before Its Growth and Fatal Rupture: Case Study and Review of the Literature

Hemodynamics plays an important role in the natural history of intracranial aneurysms. However, it is difficult to obtain longitudinal aneurysm image data. In this study, we had a rare chance to follow the process of growth and rupture of a middle cerebral artery (MCA) aneurysm. The aim of this study was to investigate the role of hemodynamics for growth and rupture in this particular aneurysm patient. A 57-year-old woman presented with 2 unruptured MCA aneurysms and 1 ruptured anterior choroidal artery (AchA) aneurysm. The unruptured left MCA aneurysm grew in 7 months and ruptured at 11 months. The rupture region was confirmed during the clipping treatment. Computational fluid dynamic (CFD) simulations were conducted on the AchA and MCA aneurysms in 3 serial imaging procedures, and calculated hemodynamics was correlated with aneurysm growth and rupture. The ruptured right AchA aneurysm had much lower wall shear stress (WSS) and higher oscillatory shear index (OSI) than the unruptured left MCA aneurysm. Comparison of the aneurysm growth region with the WSS distribution showed that growth occurred in a high WSS area. During the progression of the MCA aneurysm, we observed that the high aneurysmal WSS region grew first and then the growing region changed into a low WSS level; eventually, rupture occurred in a low WSS area. This case suggests that aneurysm rupture might be associated with low WSS and high OSI, whereas aneurysm growth may be related to high WSS in this particular individual MCA aneurysm patient.

Effect of tip clearance on wall shear stress of an axial LVAD

Wall shear stress is a crucial parameter used for blood damage analysis, and typically a value of 400 Pa is set as a limit. Tip clearance is a major factor contributing to hemolysis and pump efficiency. In this study, different tip gap configurations are used to analyse the wall shear stress developed on the blade surface of a constant thickness blade design, and a varying thickness blade design using CFD analysis. It was found that, for a particular geometry, as the clearance gap reduces, flow rate over the high wall shear stress area decreases even though the high wall shear stress span is found to extend. For each design, the optimum clearance gap is iteratively attained, keeping the maximum WSS as a limiting factor. Thus a better pump designs is obtained, whose leakage flow patterns are lower than that of the initial design, hence also leading to higher pump efficiency.

High Shear Stress and Flow Velocity in Partially Occluded Aneurysms Prone to Recanalization

Hemodynamic factors are thought to play an important role in the initiation, growth, and rupture of cerebral aneurysms. However, the hemodynamic features in the residual neck of the partially embolized aneurysms and their influences on recanalization are rarely reported. In this study, we characterized the hemodynamics of partially occluded aneurysms, which were proven to undergo recanalization during follow-up using computational fluid dynamic analysis. From May 2007 to June 2009, we identified 11 partial aneurysms during follow-up, including 5 recanalized cases and 6 stable cases with 3-dimensional digital subtraction angiography. We retrospectively characterized the hemodynamic features around the residual aneurysmal pouch using the available postprocedural digital subtraction angiography image data. The occluded part of the aneurysm was regarded as completely separated from the circulation. The overall blood flow patterns before embolization were almost the same in the recanalized and stable groups. After occlusion, the flow pattern changes, wall shear stress (WSS), and velocity at the remnant neck demonstrated different changes between the 2 groups. Specifically, in the recanalized group, high WSS regions were found near the neck in all 5 cases, with 4 of them being even higher than those before occlusion. Interestingly, in all cases, the high WSS area of the remnant neck coincided with the location where the aneurysm recanalization occurred. In the stable group, 5 out of 6 cases demonstrated lower WSS and velocity at the remnant neck after occlusion. High WSS and blood flow velocity were consistently observed near the remnant neck of partially embolized aneurysms prone to future recanalization, suggesting that hemodynamic factors may have an important role in aneurysmal recurrence after endovascular treatment. The difference in flow pattern could be caused by the incomplete occlusion of the aneurysms.

Effects of smoking and hypertension on wall shear stress and oscillatory shear index at the site of intracranial aneurysm formation

Objective The mechanisms by which smoking and hypertension lead to increased incidence of intracranial aneurysm (IA) formation remain poorly understood. The current study investigates the effects of these risk factors on wall shear stress (WSS) and oscillatory shear index (OSI) at the site of IA initiation. Methods Two ( n = 2) IAs from two patients with history of smoking and hypertension were artificially removed with the help of software @neuFuse (Supercomputing Solutions ®, Bologna, Italy) and the vessel geometry reconstructed to mimic the condition prior to IA formation. Two computational fluid dynamics (CFD) analyses were performed on each data-set by using in turn the normal physiological values of blood viscosity (BV), and high BV values specific to smoking and hypertension, obtained from literature. Results At normal BV, high WSS (>15 Pa) was observed at the site of IA initiation in both patients. When BV values specific to smoking and hypertension were used, both the areas affected by high WSS (>15 Pa) and the maximum WSS were increased whilst the magnitude and distribution of OSI showed no significant change. Conclusions Long-term exposure to high WSS may result in an increased risk of IA development. An incremental increase in areas of high WSS observed secondary to smoking and hypertension may indicate a further increase in the risk of IA initiation. Interestingly, the relationship between BV and the area of increased WSS was not linear, reflecting the need for patient-specific CFD analysis.

In-vivo flow simulation in coronary arteries based on computed tomography datasets: feasibility and initial results

The purpose of this paper was to non-invasively assess hemodynamic parameters such as mass flow, wall shear stress (WSS), and wall pressure with computational fluid dynamics (CFD) in coronary arteries using patient-specific data from computed tomography (CT) angiography. Five patients (two without atherosclerosis, three with atherosclerosis) underwent retrospectively electrocardiogram (ECG) gated 16-detector row CT using ECG-pulsing and geometric models of coronary arteries were reconstructed for CFD analysis. Blood flow was considered laminar, incompressible, Newtonian, and pulsatile. The mass flow, WSS, and wall pressure were quantified and flow patterns were visualized. The wall pressure continuously decreased towards distal segments and showed pressure drops in stenotic segments. In coronary segments without atherosclerotic wall changes, WSS remained low, even during phases of high flow velocity, whereas in atherosclerotic vessels, the WSS was elevated already at low flow velocities. Stenoses and post-stenotic dilatations led to flow acceleration and rapid deceleration, respectively, including a distortion of flow. Areas of high WSS and high flow velocities were found adjacent to plaques, with values correlating with the degree of stenosis. CFD provided detailed mass flow measurements. CFD analysis is feasible in normal and atherosclerotic coronary arteries and provides the rationale for further investigation of the links between hemodynamic parameters and the significance of coronary stenoses.

Circumferential vascular deformation after stent implantation alters wall shear stress evaluated with time-dependent 3D computational fluid dynamics models

The success of vascular stents in the restoration of blood flow is limited by restenosis. Recent data generated from computational fluid dynamics (CFD) models suggest that stent geometry may cause local alterations in wall shear stress (WSS) that have been associated with neointimal hyperplasia and subsequent restenosis. However, previous CFD studies have ignored histological evidence of vascular straightening between circumferential stent struts. We tested the hypothesis that consideration of stent-induced vascular deformation may more accurately predict alterations in indexes of WSS that may subsequently account for histological findings after stenting. We further tested the hypothesis that the severity of these alterations in WSS varies with the degree of vascular deformation after implantation. Steady-state and time-dependent simulations of three-dimensional CFD arteries based on canine coronary artery measurements of diameter and blood flow were conducted, and WSS and WSS gradients were calculated. Circumferential straightening introduced areas of high WSS between stent struts that were absent in stented vessels of circular cross section. The area of vessel exposed to low WSS was dependent on the degree of circumferential vascular deformation and axial location within the stent. Stents with four vs. eight struts increased the intrastrut area of low WSS in vessels, regardless of cross-sectional geometry. Elevated WSS gradients were also observed between struts in vessels with polygonal cross sections. The results obtained using three-dimensional CFD models suggest that changes in vascular geometry after stent implantation are important determinants of WSS distributions that may be associated with subsequent neointimal hyperplasia.