Abstract The design process of turbomachinery, is often constraint by aeroelastic phenomena. The design choices are limited by possible structural failure, which can be caused by high vibration amplitudes. In particular, damping has an important impact on these phenomena. In the absence of friction, damping is mainly created by aerodynamics. In this paper, additional damping created by the shaft will be investigated. This becomes relevant when blade vibrations with nodal diameters 1 and -1 couple structurally with shaft vibrations. To investigate the blade-shaft coupling, a simulation process is set up based on a full structural dynamic model of the blisk-shaft assembly and a harmonic balance CFD model to account for the aeroelastic effects. In addition, mistuning identification is performed based on an experimental modal analysis at standstill. All results are incorporated into a structural reduced order model that calculates the vibrational behavior of the blading. These results are compared to damping determined during operation using an acoustic excitation system and measured forced frequency responses. The numerical results agree well with the experimental results, i.e. within the measurement uncertainty. Furthermore, the blade-shaft coupling results in significant changes of the eigenfrequencies and damping. As a consequence, damping increases by up to twelve times due to the coupling. This reduces amplitudes by a factor of nine for the mistuned blade responses. Consequently, higher structural safety factors can be achieved by taking the blade-shaft coupling into account so that the remaining potentials in the aerodynamic design could be better exploited.