A comprehensive experimental study on the high-velocity oxygen-fuel (HVOF) sprayed tungsten carbide/cobalt (WC/Co) deposits using laser cladding was conducted. A response surface methodology based on a central composite design was used to analyze, predict and optimize the WC/Co deposits of the laser-based HVOF sprayed coatings. The morphologies and microstructures of the laser clads were characterized using optical microscope, scanning electron microscope and X-ray diffraction techniques. The crack behavior and residual stress-based fractures were explored. In addition, the relationships between the residual stress of the laser clad and three factors: laser power, scanning speed and stand-off distance were examined. Further, optimization of the control factors: laser power, scanning speed and stand-off distance to minimize the residual stress was attained using a response surface methodology. The resulting lower residual stress has decreased the fracture crack activities and did not easily induce delamination in the laser clads. Findings from this study would greatly contribute to optimizing the experiments and achieve an enhanced structural evolution in the protective coating of traditional handicraft products by laser cladding.