The medicinal crop, Asparagus racemosus is valued for its tuberous roots that are used in medicinal and tonic preparations. Root is diuretic and galactogouge. Its demand is ever increasing as it is indispensable for ayurvedic medicine manufacturing units for the formulation of umpteen drugs and neutaceuticals. An experiment was conducted to standardize the eco-physiological requirements for sustainable utilization of natural resources and cultural inputs to achieve higher productivity without affecting the quality of officinal parts. The experiment was conducted in Factorial RBD with two replication. The technical programme consisted of combinations of six containers, viz, Polythene bags bags partially buried in soil, empty cattle feed bags partially buried in soil, micro site enrichment with lining, micro site enrichment without lining, pit followed by mound and control, two rooting medium, viz,special rooting medium for root induction and root development and control; and two soil moisture levels, viz, rain fed condition and irrigated condition. The experiment was continued for eighteen months and vine length, number of branches, yield and yield attributes, viz, number, length and girth of tubers were recorded and biochemical constituents estimated. Economic analysis of the system was carried out. Cultivation of Asparagus under irrigated condition in empty cattle feed bags filled with enriched rooting medium and partially buried in soil recorded the highest tuber yield and enhanced gross income, profit and benefit cost ratio besides improving quality attributes like osmotic potential and oleoresin.