The deterioration of knee structures is enhanced by the anterior cruciate ligament (ACL) tear, which also can lead to osteoarthritis following a series of events. Additionally, untreated ACL insufficiency can lead to varus malalignment. ACL reconstruction can achieve the stability of the knee and restrict the osteoarthritis progression. High tibial osteotomy (HTO) is an intervention for the correction of varus malalignment in the lower extremity. HTO efficacy has been extended for the management of ACL-deficient varus knees. The combination of ACL reconstruction with HTO may result in better outcomes. The present review aimed at assessing the outcomes of ACL reconstruction and open wedge HTO combination. Scientific databases were explored for related studies published after 2015 and using a set of keywords for the searching process. Eligible criteria of the included studies were original articles written in the English language, reporting a combination of ACL reconstruction and open wedge HTO available for full text. A total of eight articles were included as they met the determined criteria. The total number of patients was 163 cases with an age range of 18 years and less than 70 years. The follow-up period was between 12 months and 10 years. The combination of ACL reconstruction and open wedge HTO resulted in favorable outcomes. However, there were few complications and a low rate of failure.