In this article, we report a low-cost method to fabricate plastic optical fiber (POF) liquid-level and refractive index (RI) sensors integrated with smartphones by molds and drilling microholes in side-growing POFs (SGPOFs) with high-temperature metal wire. These sensors can be used for real-time liquid-level and RI monitoring, especially under situations requiring portability and illumination. When the liquid level changes, the change of the RI around the microholes leads to a change in the light intensity transmitted in the fiber, enabling us to measure the liquid level and RI. Utilizing one sensor with six holes (0.45 mm radius and 15 mm spacing) in 2.0-mm SGPOF, the results of level and RI measuring are in good agreement with the theory. The liquid-level measurement of the sensor is carried out for water with an RI of 1.333, the level sensitivity is 0.29%/cm ± 0.02%/cm. In the RI measurement, the RI sensitivity of the sensor is −22.8%/RIU ± 0.6%/RIU in the measurement range from 1.333 to 1.475.