The application of LIGA Ni and nanocrystalline binary Ni-X(X = W, Mo, Fe) alloys in the micro-electro-mechanical systems is severely limited due to their strength and ductility trade-off at elevated temperatures. Aiming at such a problem, here we designed Ni/Ni–W laminated nanocomposites with heterogeneous interfaces, and investigated their mechanical behavior at 400 °C. We found that the strength of the laminated nanocomposites with different thickness ratios of Ni layers to Ni–W layers at 400 °C could reach 400–620 MPa, being two to three times larger than that of traditional LIGA Ni, and their elongation to failure is above or equal to 10%. Introduced heterogeneous interfaces greatly improved the high-temperature tensile properties through the transition of the grain growth direction in the Ni layers from deposition direction to the loading direction and the geometrically constrained premature failure of relaxed Ni–W layers. These findings can offer a potential opportunity to apply the heterogeneous nanocomposites in the field of high-temperature micro-electro-mechanical system devices.