High-temperature Method Research Articles

Optimization of Co4Sb11.5Te0.5 thermoelectric performance through Al filling under high temperature and high pressure

So far, the method of optimizing the thermoelectric properties of skutterudite CoSb3 is usually to achieve a breakthrough in high-properties thermoelectric merit by selecting excellent doping atoms and determining a reasonable percentage of atoms. In this study, we achieved the preparation of small atomic radius Al-filled Co4Sb11.5Te0.5 compounds by high-temperature and high-pressure (HTHP) synthesis methods. The thermoelectric properties of the samples AlxCo4Sb11.5Te0.5 were optimized from two dimensions: synthesis pressures (1.0 GPa, 1.5 GPa, 2.0 GPa) and Al filling concentration (x = 0.1, 0.2, 0.3, 0.5), ultimately achieving effective decoupling of electron-phonon transport properties. The experimental results show that Al doping can optimize the electrical transport properties of materials effectively, rapid synthesis method of HTHP can introduce abundant grain boundaries, diversification of grain sizes, a large number of dislocations and widely distributed nano second phase, etc. These microstructures in bulk materials form a multi-scale phonon scattering network in situ, which can effectively scatter phonons and reduce the lattice thermal conductivity effectively. After optimizing the synthesis pressure and Al filling concentration through orthogonal transformation, the sample Al0.3Co4Sb11.5Te0.5 prepared at a synthesis pressure of 1.5 GPa obtained a minimum lattice thermal conductivity value of 0.88 W m−1 K−1, a maximum power factor of 40.96 μ W cm−1 K−2 and a maximum zT value of 1.18 at 773.15 K.

Structure, J-O analysis, and near-infrared luminescence of Er3+/Yb3+ doped SiO2–B2O3-GdF3-CaO-Bi2O3 glass

SiO2–B2O3-GdF3-CaO-Bi2O3 doped glasses containing Er3+/Yb3+ ions at varying concentrations were successfully synthesized using a high-temperature melting method. The glass samples' physicochemical properties and amorphous structure were characterized through density, XRD, XPS, FT-IR, and Raman analyses. Thermal expansion coefficient testing indicated good thermal stability of the glass system. Increasing the Yb3+ doping concentration enhanced near-infrared luminescence at 1.53 μm, with maximum luminescence intensity at approximately 3.2 mol% doping concentration. The energy transfer mechanism of Er3+/Yb3+ doped SiO2–B2O3-GdF3-CaO-Bi2O3 glass was elucidated through fluorescence spectrum analysis, revealing J-O parameters Ω2 = 11.2 × 10−20 cm2, Ω4 = 8.9 × 10−20 cm2, and Ω6 = 9.59 × 10−20 cm2. Calculations for absorption cross-section, cross-section of emission, and gain curve additionally reinforced the glass's capability for laser uses.

Cr3+ and Ni2+ Co-doped near-infrared dual-emission garnet phosphor for spectroscopic applications

Near infrared spectroscopy is a simple, fast, and non-invasive technique for detecting the composition of substances. However, most NIR phosphors cannot cover the near-infrared I and II regions, which limits the types of substances that can be detected. Herein, Cr3+, Ni2+ co-activated NIR Y3Al2Ga3O12(YAGG) garnet phosphors were synthesized via high-temperature solid-phase method. Due to the energy transfer from Cr3+ to Ni2+, the emission spectra of YAGG: Cr3+, Ni2+ are composed of NIR I emission of Cr3+ at 710 nm and NIR II emission of Ni2+ at 1420 nm. The measured internal and external quantum efficiencies of YAGG: 0.08Cr3+, 0.005Ni2+ under 450 nm excitation are 54.4 %, and 26.7 %, respectively. This sample was selected to fabricate pc-LEDs, and fill the emission spectrum gap with Mg2GeO4: 0.01Cr3+. The pc-LED fabricated with PiG film do not exhibit strong characteristic absorption in NIR II region, significantly reduce the re-absorption and thermal quenching of the phosphors. The electro-optical conversion efficiency of PiG pc-LED reaches 6.49 % at 10 mA; The results indicate that YAGG: Cr3+, Ni2+ and the fabricated NIR pc-LED are good near-infrared substance detection light source scheme.

A samarium (Ⅲ)-activated tantalum-based double perovskite phosphor with high thermostability

Inorganic double perovskite phosphor materials have received much attention in solid-state lighting domain due to efficient and versatile luminescence colors. This study employs a high-temperature solid-phase method to synthesize a series of Sm3+-activated Sr2YTaO6 (SYTO):Sm3+ phosphors with double perovskite structure. The structure, morphology, and content/temperature-dependent orange-red emissions are thoroughly elucidated. For SYTO:3 mol%Sm3+, the luminescence intensity at 423 K remains 95 % of that at 298 K, verifying high thermostability. Meanwhile, the phosphor exhibits good resistance to color shifting. A high Sm3+ content induces luminescence quenching due to dipole–dipole interaction. Finally, the synthesized material is utilized to fabricate a satisfactory and warm white light-emitting diode.

CsPbBr3 perovskite quantum dots by mesoporous silica encapsulated for enhancing water and thermal stability via high temperature solid state method

All inorganic perovskite quantum dots (PQDs) have great application prospects in the lighting and display fields due to their excellent photoelectric properties. However, their instabilities in water and high temperature lead to photoluminescence (PL) quenching, and colloidal synthesis methods usually use a mass of organic solvents, limiting their practical application. Herein, we successfully synthesized mesoporous silica (m-SiO2) and employed a confinement effect to successfully synthesize CsPbBr3@m-SiO2 powders using a simple high-temperature solid-phase synthesis method in an air atmosphere. When the m-SiO2 content is 0.2 g, optimal green luminous intensity is achieved with a peak wavelength of 522 nm and a full width at half maximum (FWHM) of 23 nm. CsPbBr3@m-SiO2 powders have excellent thermal stability, the PL spectral shapes do not change and the PL intensity can maintain 88.1 % of the original level after 10 heating cycles (200 °C). In addition, CsPbBr3@m-SiO2 powders exhibit excellent water stability, which can still be well dispersed after 30 days exposure to water, and the PL strength remain basically unchanged. This study presents a novel approach for the advancement of stable perovskite luminescent materials.

Study on the novel green magnetoplumbite-type oxide BaZn6-xNixTi6O19: synthesis, structure and properties

Magnetoplumbite-type oxides display various properties and find applications in multiple fields. In this study, a novel magnetoplumbite-type solid solution BaZn6-xNixTi6O19 (0 ≤ x ≤ 4) with vivid green color was synthesized through a high-temperature solid-phase method for the first time. The as-synthesized BaZn6-xNixTi6O19 solid solution crystallizes in the space group of P63/mmc. The solid solution exhibits excellent green property, and its color is adjustable with increasing doping levels of Ni2+. The depth of color originates from the content and position of Ni2+ in the solid solution. BaZn6-xNixTi6O19 is suitable for PMMA (Polymethyl methacrylate) pigment and hydrophobic coating. Colored PMMA containing BaZn6-xNixTi6O19 exhibits vibrant colors with high saturation, showing excellent application potential. The hydrophobic coating compounded with BaZn6-xNixTi6O19 exhibits near-superhydrophobic properties and demonstrates excellent self-cleaning effects under simulated natural environmental conditions.

Iron-based theranostic nanoenzyme for combined tumor magneto-photo thermotherapy and starvation therapy

To address the issue of high-dose treatment agents in magnetic hyperthermia-mediated multi-model tumor therapy, a unique iron-based theranostic nanoenzyme with excellent magnetothermal and catalytic properties was constructed. By using a high-temperature arc method, the iron carbon nanoparticles (MF1-3) with a particle size between 13.7 and 27.6 nm and shell thickness between 1 and 5 nm were prepared. After screening, we selected MF3 as the magnetic core due to its high Ms. value and excellent thermal properties. Under the magneto-photo dual thermal conditions, MF3 exhibited a remarkable specific absorption rate (SAR) of 4917 W/g, which was 20 times more than that of iron oxide. Notably, MF3 also exhibited best peroxidase (POD)-like catalytic in pH 5.0 and maintained stable catalytic performance at 45 °C. Considering the “starvation” strategy of cutting off the energy supply to tumor cells and killing them, the glucose oxidase (GOX) and chitosan oligosaccharide (COS) was further grafted onto MF3, forming the MF3/GOX/COS. This multifunctional therapeutic nanoenzyme not only exhibited significant peroxidase-like activity, but also had glucose decomposition and glutathione (GSH) consumption capabilities. The thermal effect significantly promoted the uptake of MF3/GOX/COS by 4T1 cells, and the IC50 value of MF3/GOX/COS reached low to 3.75 μg/mL. In vivo anti-tumor experiment, compared with single treatment methods, the combined therapy of MF3/GOX/COS mediated magneto-photo thermotherapy (M-PTT) and starvation therapy (ST) exhibited higher tumor inhibition rate of 82.1 % by increased cell apoptosis through the mitochondrial pathway. Overall, MF3/GOX/COS therapeutic nanoenzyme combined the advantages of nano-catalysis, M-PTT and ST, providing a solution for achieving sustained, stable, and effective tumor inhibition rates at lower dose levels.

Constructing ultralow-loading Cu single atoms/Fe2O3 particles on Nb2C MXenes for efficient utilization of atomic H to boost electrochemical debromination

Bromate is a commonly identified carcinogenic and genotoxic disinfection byproduct in water. Electrochemical debromination is an environmentally friendly and effective approach but it often suffers the limited reducing atomic H (H*) ability and high metal catalyst dosage. In this study, a unique composite catalyst comprised of ultra-low loading Cu single atoms (0.016 wt%) and Fe2O3 nanoparticles supported on a Nb2C MXene (denoted as Cu0.2/Fe0.1/Nb2C) was synthesized by one-step high-temperature molten salt method. The Cu0.2/Fe0.1/Nb2C significantly outperformed the Nb2C, Cu0.2/Nb2C and Fe0.1/Nb2C counterparts in the electrochemical debromination with a 94.2 % removal efficiency of bromate. It is revealed that the introducing of Cu single atoms, efficiently promotes the adsorption of H* and inhibition of competitive H2 evolution. The incorporation of Fe2O3 nanoparticles significantly increased the electronic metal-support interaction effect between the metal components and Nb2C, thereby forming a noticeable electronic cloud bridge to facilitate efficient charge transfer. Ultimately, the synergistic interplay between Cu single atoms and Fe2O3 nanoparticles plays a crucial role in achieving the remarkable removal performance of bromate. This work not only presents a significant instance of a synergistic catalyst involving metal single atoms and metal nanoparticles for effective electrochemical debromination but also advances the understanding of the electronic metal-support interaction.

Efficient and Near-Zero Thermal Quenching Cr3+-Doped Garnet-Type Phosphor for High-Performance Near-Infrared Light-Emitting Diode Applications.

In recent years, near-infrared (NIR) phosphors have attracted great research interest due to their unique physical properties and broad application prospects. However, obtaining NIR phosphors with both high quantum efficiency and excellent thermal stability remains a great challenge. In this study, novel NIR Ca3Mg2ZrGe3O12:Cr3+ phosphors were successfully prepared using a high-temperature solid-phase method, and the structure and luminescent properties of the material were systematically investigated. Ca3Mg2ZrGe3O12:0.01Cr3+ emits NIR light in the range of 600 to 900 nm with a peak at 758 nm and a half-height width of 89 nm under the excitation of 457 nm blue light. NIR luminescence shows considerable quantum efficiency, and the internal quantum efficiency of the optimized sample is up to 68.7%. Remarkably, the Ca3Mg2ZrGe3O12:0.01Cr3+ phosphor exhibits a near-zero thermal quenching behavior, and the luminescence intensity of the sample at 250 °C maintains 92% of its intensity at room temperature. The mechanism of high thermal stability has been elucidated by calculating the Huang Kun factor and activation energy. Finally, NIR pc-LED devices prepared from Ca3Mg2ZrGe3O12:0.01Cr3+ phosphor with commercial blue LED chips have good performance, proving that this Ca3Mg2ZrGe3O12:0.01Cr3+ NIR phosphor has potential applications in night vision and biomedical imaging.

Ultrafast and Highly Efficient Laser Extraction of Matrine and Oxymatrine from Sophora flavescens for the Anticancer Activity.

Matrine and oxymatrine are mainly obtained from Sophora flavescens using the high-temperature and prolonged solvent extraction methods currently employed in industries. In this study, an ultrafast and highly efficient method for extracting matrine and oxymatrine from S. flavescens at room temperature using laser technology, specifically, laser extraction, was demonstrated. The laser extraction rates for matrine and oxymatrine from S. flavescens at room temperature for 1 min were 266.40 and 936.80 mg(g·h)-1, respectively. These rates were 1400 times higher than those achieved with conventional solvent extraction. These results mean that 1 min of laser extraction is equivalent to 24 h of solvent extraction. The reason for such a high efficiency is that laser-induced cavitation can accelerate the rapid release of alkaloid molecules in plant cells. Mass spectrum, nuclear magnetic resonance, and Fourier-transform infrared spectrum analyses of the extracted matrine and oxymatrine compounds confirmed that they are the same as the products of solvent extraction. Furthermore, it was found that the anticancer activity of laser-extracted compounds is slightly better than that of conventionally solvent-extracted ones, likely due to the slight change in the microstructure or conformation of these compounds under laser irradiation. These findings demonstrated that the laser extraction method was ultrafast and highly efficient, unveiling a novel approach to alkaloid extraction. This discovery will have significant implications for the extraction and utilization of alkaloids from plants.

Effects of liquid-phase carbon combining surfactant coatings on the performance of LiMn0.2Fe0.8PO4 cathode materials

Efforts to reduce the particle size of LiFexMn1-xPO4 materials and apply conductive carbon coatings have yielded substantial benefits in terms of obtaining lithium-ion batteries (LIBs) with enhanced electrochemical performance. However, LiFexMn1-xPO4 materials with small particle sizes and uniform carbon layers cannot be obtained by the conventional high-temperature solid-phase method, which is the most convenient and applicable method for the industrial-scale preparation of the cathode materials used in commercial LIBs. The present work addresses this issue by applying the cationic surfactant cetyltrimethylammonium bromide (CTAB) in conjunction with LiMn0.2Fe0.8PO4 (LMFP) particles, and obtaining a carbon layer by replacing the conventional in-situ solid-phase carbon coating process with a secondary liquid-phase coating process using sucrose as the carbon source. The CTAB surfactant is observed to be uniformly adsorbed on the surface of LMFP particles, and maintains small LMFP particle sizes by operating as a dispersant preventing their agglomeration. Additionally, the carbon network formed by CTAB pyrolysis acts as an intermediate medium ensuring that the conductive carbon layer is uniformly and firmly adhered to the LMFP particle surfaces at a high preparation temperature of 680°C. This composite carbon layer is demonstrated to enhance lithium-ion transport, while concurrently acting as a barrier interfering with manganese diffusion within the electrolyte during charge-discharge cycling. As a result, the optimal LMFP-based cathode material achieves reversible specific capacities of 160 mAh g−1 and 120 mAh g−1 at charge-discharge rates of 0.1 C and 5 C, respectively, and the capacity retention is 88 % after 500 cycles at 1 C. Hence, the results verify that the proposed surfactant-mediated liquid-phase carbon coating process is an effective method for enhancing the overall electrochemical performance of LMFP-based cathode materials.

Precisely Tunable Instantaneous Carbon Rearrangement Enables Low-Working-Potential Hard Carbon Toward Sodium-Ion Batteries with Enhanced Energy Density.

As the preferred anode material for sodium-ion batteries, hard carbon (HC) confronts significant obstacles in providing a long and dominant low-voltage plateau to boost the output energy density of full batteries. The critical challenge lies in precisely enhancing the local graphitization degree to minimize Na+ ad-/chemisorption, while effectively controlling the growth of internal closed nanopores to maximize Na+ filling. Unfortunately, traditional high-temperature preparation methods struggle to achieve both objectives simultaneously. Herein, a transient sintering-involved kinetically-controlled synthesis strategy is proposed that enables the creation of metastable HCs with precisely tunable carbon phases and low discharge/charge voltage plateaus. By optimizing the temperature and width of thermal pulses, the high-throughput screened HCs are characterized by short-range ordered graphitic micro-domains that possess accurate crystallite width and height, as well as appropriately-sized closed nanopores. This advancement realizes HC anodes with significantly prolonged low-voltage plateaus below 0.1V, with the best sample exhibiting a high plateau capacity of up to 325mAhg-1. The energy density of the HC||Na3V2(PO4)3 full battery can therefore be increased by 20.7%. Machine learning study explicitly unveils the "carbon phase evolution-electrochemistry" relationship. This work promises disruptive changes to the synthesis, optimization, and commercialization of HC anodes for high-energy-density sodium-ion batteries.

Smoke Points: A Crucial Factor in Cooking Oil Selection for Public Health

: Cooking oils and fats play a significant role in our daily diet and culinary practices by enhancing flavours, textures, and nutritional value. However, overheating these fats can compromise the quality and safety of cooked foods. When oils and fats exceed their smoke points, they undergo chemical breakdown, producing volatile compounds, off-flavours, and undesirable odors, including harmful substances like small chain fatty acids, trans fats, acrylamides, and polycyclic aromatic hydrocarbons. It is crucial to avoid overheating oils to mitigate the formation of these toxic substances and instead opt for those with higher smoke points for high-temperature cooking methods. The smoke point, indicating the temperature at which visible smoke is emitted, serves as a critical indicator of thermal stability and suitability for various cooking oils and fats. Therefore, understanding and considering the smoke points of different oils and fats are essential for maintaining food quality and safety in culinary practices. This review consolidates existing knowledge on the smoke points of various oils and fats and methods for determining smoke points, providing a list of fifty-one oils and fats with their respective smoke points and highlighting their applications in cooking. By considering the smoke point, chefs, cooks, and food manufacturers can select oils that optimize cooking, frying, taste, texture, flavour enhancement, salad dressings, marinades, baking, and overall safety in their culinary practices. Mindfulness of the smoke point helps prevent the degradation of nutritional value and the generation of harmful compounds during the cooking process.

Nucleation promotion for the atomic layer deposition of HfO2 onto carbon nanotubes for device applications

Abstract The potential of semiconducting single-walled carbon nanotubes (CNTs) as the next-generation semiconductor information material as a successor to silicon-based technology is promising. However, a significant challenge for CNT based electronics at device level lies in the obtainment of high-quality gate dielectrics such as HfO2 on the dangling bond-free and chemically inert surface of CNTs. To address this issue, this paper studies the atomic layer deposition (ALD) of HfO2 onto the surface of carbon-based materials, and focuses on how to promote the nucleation via two methods, i.e. low-temperature Nanofog method and high-temperature variable parameter method. Both methods are confirmed to be effective in improving the continuity and uniformity of ALD HfO2 films.

Study on the Synthesis of BTA@MSNs Nanocarriers

Abstract Mesoporous silica, characterized by its adjustable pore size, uniform distribution, stable structure, and non-toxicity, is widely used as an encapsulating material for corrosion inhibitors. This study initially established that, compared to the high-temperature calcination method, the removal of surfactants via the solvent extraction method yields mesoporous silica with uniform size and better dispersibility. Results from N2 adsorption-desorption tests indicated that the mesoporous silica prepared by the solvent extraction method had an average pore diameter of 2.41 nm, a volume of 0.42 cc/g, and a specific surface area of 69.73 m2/g. SEM and TEM analyses showed that the BTA@MSNs nanoparticles synthesized via a one-step method were approximately 100 nm in size, whereas those prepared by the vacuum loading method were about 50 nm, both exhibiting ordered mesoporous structures. UV-vis spectrophotometry results revealed that the loading capacity of BTA in the nanoparticles produced by the one-step synthesis method was significantly lower than that in the BTA@MSNs nanoparticles prepared via the vacuum impregnation method.

Epoxy Composite Films Filled with Sintered Multifaceted Boron Nitride for Thermal and Dielectric Applications

The miniaturization of electronic devices has led to an increase in power density and functional integration, resulting in rapid heat accumulation that adversely affects operational stability and service life. Dielectric composite films with excellent thermal conductivity and insulating properties are highly desired for addressing thermal management issues in electronic packaging applications. Hexagonal boron nitride (h-BN) is a promising filler for such composites due to its outstanding thermal conductivity, insulating properties, and chemical stability. However, the inherent platelike structure of h-BN causes significant anisotropy and poor miscibility with polymers, limiting the uniform conduction of heat. This study proposes a high-temperature sintering method that transforms flaky h-BN plates into irregular multifaceted particles. This transformation reduces thermal anisotropy and creates uniform heat conduction pathways. The resulting sintered BN/Epoxy (s-BN/EP) composite films exhibit exceptional thermal conductivity, with in-plane thermal conductivity increased by 36% to 6.0 W m-1 K-1 and through-plane thermal conductivity increased by 39% to 1.2 W m-1 K-1 compared to pristine h-BN/epoxy composites. Moreover, s-BN/EP films could maintain low dielectric constant (Dk, 3.22) and dielectric loss (Df, 0.015) at 5 GHz. This innovative approach provides a significant advancement in the development of high-performance insulating polymer composites, offering a promising solution for thermal management in high-power-density electronic packaging.

A perspective to efficient synthesis of zirconium carbide via novel pyro-vacuum method: lower temperatures and enhanced purity

The use of ultra-high temperature ceramics (UHTCs) as a novel additive in the refractory industry is becoming increasingly popular. However, the synthesis of such materials is associated with some commercial obstacles, mainly high-temperature synthesis methods. In the present study, the pyro-vacuum method is presented as a new method to decrease the final product's synthesis temperature and oxygen content. Some thermodynamic aspects and phase evolution of the materials during the synthesis procedure are described for the synthesis of non-oxide material. Conclusively, it seems that by applying vacuum conditions, the final UHTC phases can be synthesized at significantly lower temperatures (>400 °C lower, for ZrC), if adequate powder mixtures are considered. Also due to phase analysis, it was found that the oxygen content of the final phase is lower than the conventional routes and other references. The process provides promising prospects for the economic synthesis of UHTCs.

Pt nanoparticles loaded on three-dimensional porous carbon as electrocatalysts for hydrogen evolution reaction

The electrochemical catalytic hydrogen evolution reaction (HER) holds significant potential for the sustainable production of environmentally friendly hydrogen energy. Currently, the precious metal Pt is widely acknowledged as the most superior electrocatalyst. However, its limited availability and exorbitant cost impede its extensive application. In this study, low Pt-loaded three-dimensional (3D) porous carbon composites were successfully synthesized as catalysts using a template-free method and a high-temperature pyrolysis method. By evaluating the HER performance of different Pt concentrations of the catalysts Pt/C-X (X=0, 0.05, 0.1, 0.2, 0.4, 0.7 mmol) in acid solution, it was observed that the overpotential of Pt/C-0.2 reached as low as 17 mV with a significantly low Tafel slope value of 48 mV cm−2. Meanwhile, the Bilayer capacitance (Cdl) reached an impressively high value of 247.5 mF cm−2. Consequently, this also provides a promising way to enhance the catalytic performance of the loaded catalysts.

Enhanced luminescence performance in double perovskite CaSrLaSbO6: Mn4+ red emission phosphors for indoor plant growth via cation doping

Novel CaSrLaSbO6: Mn4+ red-emitting phosphors with double perovskite structure were successfully synthesized by the high-temperature solid-phase method. CaSrLaSbO6:Mn4+ phosphor showed a broad excitation band with different excitation peaks from 250 nm to 600 nm owing to the Mn4+-O2- charge transfer and 4A2g → (4T1g, 2T2g, and 4T2g) transitions of Mn4+ ions and exhibited intense deep-red emission at 678 nm attributed to the 2Eg → 4A2g transition of Mn4+ ions. To further enhance the performance of the phosphor, a cation doping method was adopted in this paper to synthesize CaSrLa1-xLnxSbO6: Mn4+ (Ln = Gd, Y) phosphors. The luminescence intensity of the samples was enhanced after doping with different cations, and the related mechanism was discussed. In addition, the microstructure and crystal field environment were systematically investigated. The luminescence intensity of the CaSrLa0.85Y0.15SbO6: Mn4+ phosphor was about 1.82 times higher than that of CaSrLaSbO6: Mn4+phosphor. The emission spectrum of the sample matched well with the absorption band of plant pigments. Furthermore, the plant growth LEDs and light-conversion film were prepared by using the optimized CaSrLa0.85Y0.15SbO6: Mn4+. The results indicate that the designed phosphors have great potential applications in agricultural cultivation.

Mitigating In-Column Artificial Modifications in High-Temperature LC-MS for Bottom-Up Proteomics and Quality Control of Protein Biopharmaceuticals.

Elevating the column temperature is an effective strategy for improving the chromatographic separation of peptides. However, high temperatures induce artificial modifications that compromise the quality of the peptide analysis. Here, we present a novel high-temperature LC-MS method that retains the benefits of a high column temperature while significantly reducing peptide modification and degradation during reversed-phase liquid chromatography. Our approach leverages a short inline trap column maintained at a near-ambient temperature installed upstream of a separation column. The retentivity and dimensions of the trap column were optimized to shorten the residence time of peptides in the heated separation column without compromising the separation performance. This easy-to-implement approach increased peak capacity by 1.4-fold within a 110 min peptide mapping of trastuzumab and provided 10% more peptide identifications in exploratory LC-MS proteomic analyses compared with analyses conducted at 30 °C while maintaining the extent of modifications close to the background level. In the peptide mapping of biopharmaceuticals, where in-column modifications can falsely elevate the levels of some critical quality attributes, the method reduced temperature-related artifacts by 66% for N-terminal pyroGlu and 63% for oxidized Met compared to direct injection at 60 °C, thus improving reliability in quality control of protein drugs. Our findings represent a promising advancement in LC-MS methodology, providing researchers and industry professionals with a valuable tool for improving the chromatographic separation of peptides while significantly reducing the unwanted modifications.