In recent years, the replacement cycle of digital products such as mobile phones in the market has significantly increased, and the accurate prediction of attenuation under long-term usage conditions of the lens module, storage, and other components has become important. The vast majority of mobile phone lens modules are processed from optical resins, and the degradation of their imaging performance is mainly caused by assembly deformation and long-term creep deformation after a high-temperature reliability test. Therefore, there is an urgent need for a reliable model to describe the long-term creep deformation of the mobile phone resin lens module in a harsh temperature environment. This study proposed a modified derivation method for the parameters of the Maxwell constitutive model to predict the long-term creep deformation of the mobile phone resin lens module in a high-temperature environment. The fitting accuracy of the modified generalized Maxwell model and the time-hardening model were compared through uniaxial compression creep experiments. Long-term creep simulations and experiments were conducted on the mobile phone resin lens module; the deformation law of each component of the mobile phone resin lens module was identified; and the creep deformation mechanism was elucidated. The result shows that the modified generalized Maxwell model has much higher accuracy than the time-hardening model in predicting the long-term creep deformation of different resin materials. When considering the influence of the creep phenomenon, the simulation result matches well with the experimental result, and the high-temperature creep mechanism of the mobile phone resin lens module was clarified. In addition, it was found that the maximum deformation of the lens occurred at the lens with the largest size, which was 2.1 µm, and the position with the largest surface deviation was at the edge of the lens. The prediction method proposed in this study can provide guidance and correction suggestions for the structural design of a mobile phone resin lens module and the rationality of optical design; thus, the imaging accuracy of lens modules will be guaranteed to the greatest extent possible.